PE10997A1 - NUEVOS DERIVADOS DE [3-(4-FENILPIPERACIN-1-i1)PROPILAMINO]-PIRIDINA, PIRIMIDINA Y BENCENO COMO ANTAGONISTAS DE a1-ADRENOCEPTORES, SUS EMPLEOS COMO AGENTES TERAPEUTICOS Y LOS METODOS PARA SU PREPARACION - Google Patents
NUEVOS DERIVADOS DE [3-(4-FENILPIPERACIN-1-i1)PROPILAMINO]-PIRIDINA, PIRIMIDINA Y BENCENO COMO ANTAGONISTAS DE a1-ADRENOCEPTORES, SUS EMPLEOS COMO AGENTES TERAPEUTICOS Y LOS METODOS PARA SU PREPARACIONInfo
- Publication number
- PE10997A1 PE10997A1 PE1995283893A PE28389395A PE10997A1 PE 10997 A1 PE10997 A1 PE 10997A1 PE 1995283893 A PE1995283893 A PE 1995283893A PE 28389395 A PE28389395 A PE 28389395A PE 10997 A1 PE10997 A1 PE 10997A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- pirimidine
- substitute
- formula
- phenylpiperacin
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 title 3
- WGYKZJWCGVVSQN-UHFFFAOYSA-N propylamine Chemical compound CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 title 2
- 239000005557 antagonist Substances 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title 1
- 229940124597 therapeutic agent Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N 1-propanol Substances CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 abstract 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 abstract 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 abstract 1
- 239000000674 adrenergic antagonist Substances 0.000 abstract 1
- 150000003973 alkyl amines Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 230000026030 halogenation Effects 0.000 abstract 1
- 238000005658 halogenation reaction Methods 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 201000002327 urinary tract obstruction Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A COMPUESTOS ANTAGONISTAS DE O1-ADRENOCEPTORES DE FORMULA (I), DONDE: p=0,1; t=0,1,2; X=O,S,NR6; R6=H,(C1-6)ALQUILO; Y,Z=INDEPENDIENTEMENTE CH,N; R1=H,(C1-4)ALQUILTIO,(C1-6)ALQUILO,OXAZOL-2-ILO,(C3-6)CICLOALQUILO, ENTRE OTROS; R2=H,OH,HALO,(C1-6)ALQUILO,ENTRE OTROS, EN DONDE EL ALQUILO ESTA OPCIONALMENTE SUSTITUIDO POR 1,2 O 3 HALOGENOS; R3=C(0)R7; R7=DI(C1-4)ALQUILAMINO, N-(C1-4)ALQUIL-N-(C1-4)ALQUILOXIAMINO,ENTRE OTROS; R4=H,OH,CN,ENTRE OTROS; R5=(C1-6)ALQUILO; ADEMAS DE SUS N-OXIDOS Y SALES FARMACEUTICAMENTE ACEPTABLES. TAMBIEN SE REFIERE AL PROCEDIMIENTO DE OBTENCION DE UN COMPUESTO DE FORMULA (I), QUE COMPRENDE: (A) UNA REACCION PARA LA FORMACION DE UN COMPUESTO DE FORMULA (I) QUE OCURRE EN EL SUSTITUYENTE X, ENTRE L Y -OH,-SH,-NHR6 DONDE L=GRUPO PARTIENTE Y SI Y,Z=N, L ES SUSTITUYENTE DE LA PIRIMIDINA Y SI Y,Z=CH, L ES SUSTITUYENTE DEL PROPILPIPERACINFENILO; (B) SI Y,Z=CH, X=-0H,-SH,-NHR6 QUE REACCIONA CON 3-BR-1-PROPANOL, AL QUE SE LE SUSTITUYE CON UN GRUPO PARTIENTE QUE LUEGO SE HACE REACCIONAR CON EL NITROGENO DEL PIPERACINFENILO R1,R2 SUSTITUIDO; (C) TAMBIEN REACCIONES OPCIONALES DE HALOGENACION, DEMETILACION, ENTRE OTRAS. ES USADO EN EL TRATAMIENTO DE LA OBSTRUCCION DEL TRACTO URINARIO INFERIOR CAUSADO POR HIPERPLASIA PROSTATICA BENIGNA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/336,368 US5688795A (en) | 1994-11-08 | 1994-11-08 | 3-(4-phenylpiperazin-1-yl)propyl-amino, thio and oxy!-pyridine, pyrimidine and benzene derivatives as α1 -adrenoceptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE10997A1 true PE10997A1 (es) | 1997-04-26 |
Family
ID=23315765
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1995283893A PE10997A1 (es) | 1994-11-08 | 1995-11-06 | NUEVOS DERIVADOS DE [3-(4-FENILPIPERACIN-1-i1)PROPILAMINO]-PIRIDINA, PIRIMIDINA Y BENCENO COMO ANTAGONISTAS DE a1-ADRENOCEPTORES, SUS EMPLEOS COMO AGENTES TERAPEUTICOS Y LOS METODOS PARA SU PREPARACION |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5688795A (es) |
| EP (1) | EP0711757A1 (es) |
| JP (1) | JPH08208614A (es) |
| KR (1) | KR960017658A (es) |
| CN (1) | CN1136039A (es) |
| AR (1) | AR002244A1 (es) |
| AU (1) | AU3459995A (es) |
| BR (1) | BR9505107A (es) |
| CA (1) | CA2162089A1 (es) |
| CO (1) | CO4520230A1 (es) |
| CZ (1) | CZ291095A3 (es) |
| FI (1) | FI955376A7 (es) |
| HU (1) | HUT73843A (es) |
| IL (1) | IL115844A0 (es) |
| MA (1) | MA23717A1 (es) |
| NO (1) | NO954453L (es) |
| NZ (1) | NZ280396A (es) |
| PE (1) | PE10997A1 (es) |
| PL (1) | PL311261A1 (es) |
| SG (1) | SG70950A1 (es) |
| TR (1) | TR199501387A2 (es) |
| ZA (1) | ZA959268B (es) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4425143A1 (de) | 1994-07-15 | 1996-01-18 | Basf Ag | Substituierte Pyrimidinverbindungen und deren Verwendung |
| BR9809804A (pt) * | 1997-05-12 | 2000-06-27 | Ortho Mcneil Pharm Inc | Piperazinas substituìdas com arila úteis no tratamento de hiperplasia benigna da próstata |
| DE19728996A1 (de) | 1997-07-07 | 1999-01-14 | Basf Ag | Triazolverbindungen und deren Verwendung |
| US6399614B1 (en) | 1997-08-01 | 2002-06-04 | Recordati S.A. Chemical And Pharmaceutical Company | 1-(N-phenylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring |
| IT1293807B1 (it) * | 1997-08-01 | 1999-03-10 | Recordati Chem Pharm | Derivati 1- (n-fenilaminoalchil) piperazinici sostituiti alla posizione 2 dell'anello fenilico |
| IT1293804B1 (it) | 1997-08-01 | 1999-03-10 | Recordati Chem Pharm | Diarilalchilpiperazine attive sulle basse vie urinarie |
| US20020193383A1 (en) * | 1997-08-01 | 2002-12-19 | Recordati S.A., Chemical And Pharmaceutical Comoany | 1-(N-phenylalkylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring |
| US6271234B1 (en) | 1997-08-01 | 2001-08-07 | Recordati S.A., Chemical And Pharmaceutical Company | 1,4-disubstituted piperazines |
| ZA991315B (en) * | 1998-02-20 | 2000-11-20 | Ortho Mcneil Pharm Inc | Novel substituted pyridino arylpiperazines useful in the treatment of benign prostatic hyperplasia. |
| US7045519B2 (en) * | 1998-06-19 | 2006-05-16 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
| JP4533534B2 (ja) | 1998-06-19 | 2010-09-01 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | グリコーゲンシンターゼキナーゼ３のインヒビター |
| US6465467B1 (en) | 1999-05-21 | 2002-10-15 | Biovitrum Ab | Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases |
| US6355801B1 (en) * | 1999-11-08 | 2002-03-12 | Schering Corporation | Process for preparing N-(4-hydroxyphenyl)-N′-(4′-aminophenyl)-piperazine |
| EA005975B1 (ru) | 2000-11-20 | 2005-08-25 | Биовитрум Аб | Соединения пиперазинилпиразинов в качестве антагонистов серотонин 5-ht2 рецептора |
| AP2003002810A0 (en) * | 2000-11-30 | 2003-06-30 | Ranbaxy Laboratories Ltd | 1,4-Disubstituted piperazine derivatives useful as uro-selective a, - adrenoceptor blockers |
| ATE454383T1 (de) | 2002-06-19 | 2010-01-15 | Biovitrum Ab Publ | Neue verbindungen, deren verwendung und herstellung |
| UA89035C2 (ru) * | 2003-12-03 | 2009-12-25 | Лео Фарма А/С | Эфиры гидроксамовых кислот и их фармацевтическое применение |
| MY140489A (en) * | 2003-12-26 | 2009-12-31 | Eisai R&D Man Co Ltd | 1,2-di (cyclic) substituted benzene compounds |
| US20070219213A1 (en) * | 2004-05-20 | 2007-09-20 | Soares Romeiro Luiz A | Use of Adrenergic N-Phenylpiperazine Antagonists, Pahrmaceutical Compositions Containning Them, and Methods of Preparing Them |
| US8470859B2 (en) * | 2006-10-23 | 2013-06-25 | Takeda Pharmaceutical Company Limited | Iminopyridine derivative and use thereof |
| EP2202228B1 (en) * | 2007-10-15 | 2014-12-10 | Takeda Pharmaceutical Company Limited | Amide compounds and use of the same |
| US20110039892A1 (en) * | 2008-04-23 | 2011-02-17 | Takeda Pharmaceutical Company Limited | Iminopyridine derivative and use thereof |
| US8481569B2 (en) | 2008-04-23 | 2013-07-09 | Takeda Pharmaceutical Company Limited | Iminopyridine derivatives and use thereof |
| JP5462803B2 (ja) * | 2008-04-23 | 2014-04-02 | 武田薬品工業株式会社 | イミノピリジン誘導体およびその用途 |
| CN101585781B (zh) * | 2009-07-08 | 2012-08-08 | 北京颖新泰康国际贸易有限公司 | 一种邻氨基-n,n-二甲基苯甲酰胺的制备方法 |
| CN103387531A (zh) * | 2012-05-10 | 2013-11-13 | 广州医学院 | 酰胺类芳基哌嗪衍生物及其制备方法和在抗良性前列腺增生中的应用 |
| CN114163383A (zh) * | 2021-12-24 | 2022-03-11 | 江苏丰山集团股份有限公司 | 一种烟嘧磺隆中间体烟酰胺和磺酰胺的绿色生产工艺 |
| CN115611802B (zh) * | 2022-12-02 | 2023-03-14 | 北京迪泰医药科技有限公司 | 一种3-乙酰基-2-氯吡啶的合成方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3635976A (en) * | 1967-12-20 | 1972-01-18 | Pennwalt Corp | 1 - heterocyclic alkyl-1 2 3 4-tetrahydroquinazolinones and analgesic intermediates thereof |
| BE787126A (fr) * | 1971-08-04 | 1973-02-05 | Byk Gulden Lomberg Chem Fab | Pyrimidines substituees, procedes de preparation de ces composes et medicaments contenant lesdits composes |
| DE2143730A1 (de) * | 1971-09-01 | 1973-03-08 | Byk Gulden Lomberg Chem Fab | Substituierte pyridine, verfahren zu deren herstellung und sie enthaltende arzneimittel |
| JPS49133380A (es) * | 1973-04-25 | 1974-12-21 | ||
| US4616017A (en) * | 1984-06-04 | 1986-10-07 | Merck & Co., Inc. | Aminohydroxypropoxy substituted aryl compounds |
| GB2163150B (en) * | 1984-07-19 | 1988-05-25 | Sandoz Ltd | 3-aminopropoxyaryl derivatives |
| FR2656609B1 (fr) * | 1989-12-28 | 1992-03-27 | Synthelabo | Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique. |
| FR2678272B1 (fr) * | 1991-06-27 | 1994-01-14 | Synthelabo | Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique. |
-
1994
- 1994-11-08 US US08/336,368 patent/US5688795A/en not_active Expired - Fee Related
-
1995
- 1995-10-27 EP EP95116942A patent/EP0711757A1/en not_active Withdrawn
- 1995-11-01 IL IL11584495A patent/IL115844A0/xx unknown
- 1995-11-01 SG SG1995001704A patent/SG70950A1/en unknown
- 1995-11-01 AU AU34599/95A patent/AU3459995A/en not_active Abandoned
- 1995-11-02 ZA ZA9509268A patent/ZA959268B/xx unknown
- 1995-11-03 NZ NZ280396A patent/NZ280396A/en unknown
- 1995-11-03 CA CA002162089A patent/CA2162089A1/en not_active Abandoned
- 1995-11-06 CN CN95118772A patent/CN1136039A/zh active Pending
- 1995-11-06 HU HU9503178A patent/HUT73843A/hu unknown
- 1995-11-06 PE PE1995283893A patent/PE10997A1/es not_active Application Discontinuation
- 1995-11-06 AR ARP950100065A patent/AR002244A1/es unknown
- 1995-11-07 CZ CZ952910A patent/CZ291095A3/cs unknown
- 1995-11-07 NO NO954453A patent/NO954453L/no unknown
- 1995-11-07 CO CO95052482A patent/CO4520230A1/es unknown
- 1995-11-07 BR BR9505107A patent/BR9505107A/pt not_active Application Discontinuation
- 1995-11-07 PL PL95311261A patent/PL311261A1/xx unknown
- 1995-11-07 JP JP7287753A patent/JPH08208614A/ja active Pending
- 1995-11-08 KR KR1019950040349A patent/KR960017658A/ko not_active Withdrawn
- 1995-11-08 FI FI955376A patent/FI955376A7/fi unknown
- 1995-11-08 MA MA24062A patent/MA23717A1/fr unknown
- 1995-11-08 TR TR95/01387A patent/TR199501387A2/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR960017658A (ko) | 1996-06-17 |
| HU9503178D0 (en) | 1996-01-29 |
| CO4520230A1 (es) | 1997-10-15 |
| FI955376A0 (fi) | 1995-11-08 |
| BR9505107A (pt) | 1997-09-09 |
| ZA959268B (en) | 1997-01-31 |
| PL311261A1 (en) | 1996-05-13 |
| MA23717A1 (fr) | 1996-07-01 |
| SG70950A1 (en) | 2000-03-21 |
| CN1136039A (zh) | 1996-11-20 |
| IL115844A0 (en) | 1996-01-31 |
| NO954453D0 (no) | 1995-11-07 |
| JPH08208614A (ja) | 1996-08-13 |
| NO954453L (no) | 1996-05-09 |
| EP0711757A1 (en) | 1996-05-15 |
| AR002244A1 (es) | 1998-03-11 |
| AU3459995A (en) | 1996-05-16 |
| CA2162089A1 (en) | 1996-05-09 |
| HUT73843A (en) | 1996-09-30 |
| CZ291095A3 (en) | 1996-09-11 |
| US5688795A (en) | 1997-11-18 |
| NZ280396A (en) | 1997-05-26 |
| TR199501387A2 (tr) | 1996-07-21 |
| FI955376A7 (fi) | 1996-05-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |