PE20010290A1 - Pirazinonas sustituidas de arilos y heteroarilos policiclicos utiles para la inhibicion selectiva de la cascada de coagulacion - Google Patents
Pirazinonas sustituidas de arilos y heteroarilos policiclicos utiles para la inhibicion selectiva de la cascada de coagulacionInfo
- Publication number
- PE20010290A1 PE20010290A1 PE2000000593A PE0005932000A PE20010290A1 PE 20010290 A1 PE20010290 A1 PE 20010290A1 PE 2000000593 A PE2000000593 A PE 2000000593A PE 0005932000 A PE0005932000 A PE 0005932000A PE 20010290 A1 PE20010290 A1 PE 20010290A1
- Authority
- PE
- Peru
- Prior art keywords
- link
- useful
- alkyl
- pirazinones
- coagulation cascade
- Prior art date
Links
- 230000015271 coagulation Effects 0.000 title 1
- 238000005345 coagulation Methods 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 abstract 2
- 229910002091 carbon monoxide Inorganic materials 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 abstract 1
- 102000012479 Serine Proteases Human genes 0.000 abstract 1
- 108010022999 Serine Proteases Proteins 0.000 abstract 1
- 150000001409 amidines Chemical class 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 229940127219 anticoagulant drug Drugs 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000004678 hydrides Chemical group 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A PIRAZINONAS SUSTITUIDAS DE ARILOS Y HETEROARILOS POLICICLICOS DE FORMULA I, DONDE: B ES UN GRUPO V; D1, D2, J1, J2 Y K1 SON C, N, O, S Y UN ENLACE CON LA CONDIDICON QUE NO MAS DE UNO ES UN ENLACE, O, S, ENTRE OTRAS CONDICIONES; R9-R13 Y R32-R36 SON ACETAMIDO, HALOACETAMIDO, ENTRE OTROS; R16, R19, R32-R36 SON Qb, NO MAS DE UNO DE R16 Y R19 ES Qb; Qb ES Qbe; B ES TRIALQUILSILILO, ALQUILO C2-C8, ENTRE OTROS; A ES UN ENLACE, (W7)rr-(CH(R15))pa, rr ES 0-1, pa ES 0-6; W7 ES O, S, CO (R7)NC(O), ENTRE OTROS; R7 ES OH, ALQUILO; R15 ES OH, HALO, ALQUILO; ES NH, NOH; R1 ES ALQUILO, ALQUENILO, ENTRE OTROS; R2 ES Z°-Q; Z° ES UN ENLACE, (CR41R42)q; q ES 1-3, ENTRE OTROS; R41 Y R42 SON AMIDINO, HIDROXIAMINO, ENTRE OTROS; Q ES HIDRURO CON LA CONDICION QUE Z° NO ES UN ENLACE, GRUPO II; K ES (CR4aR4b)n, n ES 1-2; R4a Y R4b SON HALO, ENTRE OTROS; E° ES E1, CUANDO K ES (CR4aR4b)n; E1 ES CO, CS, CON(R7), ENTRE OTROS; Y° ES UN GRUPO IV; Qb ES NR20R21, AMINOALQUILENILO, Qbe; Qbe ES NR26CNR25NR23R24, CNR25NR23R24; R20-R26 SON ALQUILO, OH, ENTRE OTROS. UN COMPUESTO PREFERIDO ES 6-[3-AMINOFENIL]-5-CLORO-N-[[4-IMINOMETILFENIL]METIL]-3-[N,N-DIMETILHIDRAZINA-2-OXO-1(2H)-PIRAZINAACETAMIDA, ENTRE OTROS. LOS COMPUESTOS I SON INHIBIDORES DE LAS PROTEASAS DE SERINA Y PUEDEN SER UTILES COMO ANTICOAGULANTE, INHIBIR LA FORMACION DE PLAQUETAS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13495899P | 1999-05-19 | 1999-05-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20010290A1 true PE20010290A1 (es) | 2001-03-07 |
Family
ID=22465803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000000593A PE20010290A1 (es) | 1999-05-19 | 2000-06-15 | Pirazinonas sustituidas de arilos y heteroarilos policiclicos utiles para la inhibicion selectiva de la cascada de coagulacion |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP1202975B1 (es) |
| JP (1) | JP2002544264A (es) |
| KR (1) | KR20010113971A (es) |
| CN (1) | CN1351595A (es) |
| AR (1) | AR029752A1 (es) |
| AT (1) | ATE292629T1 (es) |
| AU (1) | AU775229B2 (es) |
| BR (1) | BR0011295A (es) |
| CA (1) | CA2372617A1 (es) |
| CZ (1) | CZ20014115A3 (es) |
| DE (1) | DE60019296T2 (es) |
| EA (1) | EA005031B1 (es) |
| ES (1) | ES2240100T3 (es) |
| HU (1) | HUP0202191A3 (es) |
| IL (1) | IL146245A0 (es) |
| MX (1) | MXPA01011807A (es) |
| NO (1) | NO20015605L (es) |
| NZ (1) | NZ514876A (es) |
| PE (1) | PE20010290A1 (es) |
| PL (1) | PL352368A1 (es) |
| SK (1) | SK15872001A3 (es) |
| UY (1) | UY26155A1 (es) |
| WO (1) | WO2000069834A1 (es) |
| ZA (2) | ZA200109341B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA58636C2 (uk) | 1999-06-04 | 2003-08-15 | Мерк Енд Ко., Інк. | Піразинонові інгібітори тромбіну, фармацевтична композиція, спосіб інгібування утворення тромбів у крові, спосіб лікування станів, пов'язаних із тромбоутворенням |
| AU2044401A (en) | 1999-11-23 | 2001-06-04 | Merck & Co., Inc. | Pyrazinone thrombin inhibitors |
| AU2001255399A1 (en) * | 2000-04-14 | 2001-10-30 | Corvas International, Inc. | Pyridine and pyrazine derivatives as thrombin inhibitors |
| US6506754B1 (en) * | 2000-04-14 | 2003-01-14 | Corvas International, Inc. | Non-covalent thrombin inhibitors |
| US6710058B2 (en) | 2000-11-06 | 2004-03-23 | Bristol-Myers Squibb Pharma Company | Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors |
| US7243153B2 (en) | 2001-06-26 | 2007-07-10 | Eastman Kodak Company | System and method for managing images over a communication network |
| CA2462601A1 (en) * | 2001-10-03 | 2003-04-10 | Pharmacia Corporation | Prodrugs of substituted polycyclic compounds useful for selective inhibition of the coagulation cascade |
| AU2002367752A1 (en) * | 2001-10-03 | 2003-11-17 | Pharmacia Corporation | Substituted 5-membered polycyclic compounds useful for selective inhibition of the coagulation cascade |
| WO2003029224A1 (en) * | 2001-10-03 | 2003-04-10 | Pharmacia Corporation | 6-membered unsaturated heterocyclic compounds useful for selective inhibition of the coagulation cascade |
| TW200307667A (en) | 2002-05-06 | 2003-12-16 | Bristol Myers Squibb Co | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors |
| EP1526131A1 (en) * | 2003-10-22 | 2005-04-27 | Graffinity Pharmaceuticals Aktiengesellschaft | Aminoalkyl-pyrazinones and -pyridones as thrombin inhibitors |
| US7905872B2 (en) * | 2004-06-04 | 2011-03-15 | The Procter & Gamble Company | Absorbent articles comprising a slow recovery stretch laminate |
| US9017305B2 (en) | 2010-11-12 | 2015-04-28 | The Procter Gamble Company | Elastomeric compositions that resist force loss and disintegration |
| US11584714B2 (en) | 2018-05-29 | 2023-02-21 | Omeros Corporation | MASP-2 inhibitors and methods of use |
| SG11202010925UA (en) | 2018-05-29 | 2020-12-30 | Omeros Corp | Masp-2 inhibitors and methods of use |
| KR20220050942A (ko) | 2019-08-21 | 2022-04-25 | 칼비스타 파마슈티컬즈 리미티드 | 효소 저해제 |
| AU2020396565C1 (en) * | 2019-12-04 | 2025-05-15 | Omeros Corporation | MASP-2 inhibitors and methods of use |
| KR20220110529A (ko) | 2019-12-04 | 2022-08-08 | 오메로스 코포레이션 | Masp-2 억제자 및 사용 방법 |
| WO2021113698A1 (en) | 2019-12-04 | 2021-06-10 | Omeros Corporation | Masp-2 inhibitors and methods of use |
| KR20220110530A (ko) | 2019-12-04 | 2022-08-08 | 오메로스 코포레이션 | Masp-2 억제자 및 사용 방법 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0835109A4 (en) * | 1995-06-27 | 1999-02-03 | Merck & Co Inc | PYRIDINONE AS A THROMBINE INHIBITOR |
| WO1999011267A1 (en) * | 1997-09-05 | 1999-03-11 | Merck & Co., Inc. | Pyrazinone thrombin inhibitors |
| AU714985B2 (en) * | 1996-04-23 | 2000-01-13 | Merck & Co., Inc. | Pyrazinone thrombin inhibitors |
| CA2283704A1 (en) * | 1997-03-24 | 1998-10-01 | Merck & Co., Inc. | Thrombin inhibitors |
| CA2329914A1 (en) * | 1998-05-19 | 1999-11-25 | Merck & Co., Inc. | Pyrazinone thrombin inhibitors |
| CA2333040A1 (en) * | 1998-05-26 | 1999-12-02 | Merck & Co., Inc. | Imidazopyridine thrombin inhibitors |
| ATE461210T1 (de) * | 1998-06-11 | 2010-04-15 | Ortho Mcneil Pharm Inc | Pyrazine protease inhibitore |
-
2000
- 2000-05-18 EP EP00931916A patent/EP1202975B1/en not_active Expired - Lifetime
- 2000-05-18 AU AU49723/00A patent/AU775229B2/en not_active Ceased
- 2000-05-18 NZ NZ514876A patent/NZ514876A/en not_active Application Discontinuation
- 2000-05-18 DE DE60019296T patent/DE60019296T2/de not_active Expired - Fee Related
- 2000-05-18 HU HU0202191A patent/HUP0202191A3/hu unknown
- 2000-05-18 CN CN00807726A patent/CN1351595A/zh active Pending
- 2000-05-18 PL PL00352368A patent/PL352368A1/xx not_active Application Discontinuation
- 2000-05-18 BR BR0011295-0A patent/BR0011295A/pt not_active IP Right Cessation
- 2000-05-18 KR KR1020017014752A patent/KR20010113971A/ko not_active Withdrawn
- 2000-05-18 ES ES00931916T patent/ES2240100T3/es not_active Expired - Lifetime
- 2000-05-18 AT AT00931916T patent/ATE292629T1/de not_active IP Right Cessation
- 2000-05-18 WO PCT/US2000/008225 patent/WO2000069834A1/en not_active Ceased
- 2000-05-18 SK SK1587-2001A patent/SK15872001A3/sk unknown
- 2000-05-18 JP JP2000618251A patent/JP2002544264A/ja active Pending
- 2000-05-18 EA EA200101212A patent/EA005031B1/ru not_active IP Right Cessation
- 2000-05-18 CA CA002372617A patent/CA2372617A1/en not_active Abandoned
- 2000-05-18 CZ CZ20014115A patent/CZ20014115A3/cs unknown
- 2000-05-18 MX MXPA01011807A patent/MXPA01011807A/es unknown
- 2000-05-18 IL IL14624500A patent/IL146245A0/xx unknown
- 2000-05-19 AR ARP000102447A patent/AR029752A1/es unknown
- 2000-05-19 UY UY26155A patent/UY26155A1/es not_active Application Discontinuation
- 2000-06-15 PE PE2000000593A patent/PE20010290A1/es not_active Application Discontinuation
-
2001
- 2001-11-13 ZA ZA200109341A patent/ZA200109341B/xx unknown
- 2001-11-16 NO NO20015605A patent/NO20015605L/no not_active Application Discontinuation
-
2004
- 2004-01-21 ZA ZA200400455A patent/ZA200400455B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20010113971A (ko) | 2001-12-28 |
| CN1351595A (zh) | 2002-05-29 |
| DE60019296T2 (de) | 2006-03-09 |
| EP1202975B1 (en) | 2005-04-06 |
| PL352368A1 (en) | 2003-08-25 |
| ZA200109341B (en) | 2004-05-26 |
| SK15872001A3 (sk) | 2002-10-08 |
| HUP0202191A3 (en) | 2003-02-28 |
| JP2002544264A (ja) | 2002-12-24 |
| EA200101212A1 (ru) | 2002-06-27 |
| BR0011295A (pt) | 2002-05-28 |
| CA2372617A1 (en) | 2000-11-23 |
| ES2240100T3 (es) | 2005-10-16 |
| AU4972300A (en) | 2000-12-05 |
| ATE292629T1 (de) | 2005-04-15 |
| NO20015605L (no) | 2002-01-18 |
| NO20015605D0 (no) | 2001-11-16 |
| AU775229B2 (en) | 2004-07-22 |
| DE60019296D1 (de) | 2005-05-12 |
| HUP0202191A2 (hu) | 2002-12-28 |
| CZ20014115A3 (cs) | 2002-05-15 |
| EA005031B1 (ru) | 2004-10-28 |
| NZ514876A (en) | 2005-03-24 |
| EP1202975A1 (en) | 2002-05-08 |
| WO2000069834A1 (en) | 2000-11-23 |
| IL146245A0 (en) | 2002-07-25 |
| UY26155A1 (es) | 2000-12-29 |
| ZA200400455B (en) | 2004-09-29 |
| AR029752A1 (es) | 2003-07-16 |
| MXPA01011807A (es) | 2003-09-04 |
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