[go: up one dir, main page]

ZA200400455B - Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade. - Google Patents

Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade.

Info

Publication number
ZA200400455B
ZA200400455B ZA200400455A ZA200400455A ZA200400455B ZA 200400455 B ZA200400455 B ZA 200400455B ZA 200400455 A ZA200400455 A ZA 200400455A ZA 200400455 A ZA200400455 A ZA 200400455A ZA 200400455 B ZA200400455 B ZA 200400455B
Authority
ZA
South Africa
Prior art keywords
useful
coagulation cascade
selective inhibition
polycyclic aryl
substituted polycyclic
Prior art date
Application number
ZA200400455A
Other languages
English (en)
Inventor
Michael S South
Brenda Case
Michael J Hayes
Gary W Franklin
Currie Kusturin
David B Reitz
Rhonda Wood
John J Parlow
Tom Dice
Melvin L Rueppel
Horng-Chih Huang
Scott A Long
John I Trujillo
Qingping Zeng
Darin E Jones
Richard Lindmark
Rick Fenton
Wei Huang
William L Neumann
Ching-Cheng Wang
Matthews W Mahoney
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of ZA200400455B publication Critical patent/ZA200400455B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
ZA200400455A 1999-05-19 2004-01-21 Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade. ZA200400455B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13495899P 1999-05-19 1999-05-19

Publications (1)

Publication Number Publication Date
ZA200400455B true ZA200400455B (en) 2004-09-29

Family

ID=22465803

Family Applications (2)

Application Number Title Priority Date Filing Date
ZA200109341A ZA200109341B (en) 1999-05-19 2001-11-13 Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade.
ZA200400455A ZA200400455B (en) 1999-05-19 2004-01-21 Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ZA200109341A ZA200109341B (en) 1999-05-19 2001-11-13 Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade.

Country Status (24)

Country Link
EP (1) EP1202975B1 (xx)
JP (1) JP2002544264A (xx)
KR (1) KR20010113971A (xx)
CN (1) CN1351595A (xx)
AR (1) AR029752A1 (xx)
AT (1) ATE292629T1 (xx)
AU (1) AU775229B2 (xx)
BR (1) BR0011295A (xx)
CA (1) CA2372617A1 (xx)
CZ (1) CZ20014115A3 (xx)
DE (1) DE60019296T2 (xx)
EA (1) EA005031B1 (xx)
ES (1) ES2240100T3 (xx)
HU (1) HUP0202191A3 (xx)
IL (1) IL146245A0 (xx)
MX (1) MXPA01011807A (xx)
NO (1) NO20015605L (xx)
NZ (1) NZ514876A (xx)
PE (1) PE20010290A1 (xx)
PL (1) PL352368A1 (xx)
SK (1) SK15872001A3 (xx)
UY (1) UY26155A1 (xx)
WO (1) WO2000069834A1 (xx)
ZA (2) ZA200109341B (xx)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA58636C2 (uk) 1999-06-04 2003-08-15 Мерк Енд Ко., Інк. Піразинонові інгібітори тромбіну, фармацевтична композиція, спосіб інгібування утворення тромбів у крові, спосіб лікування станів, пов'язаних із тромбоутворенням
JP2003514905A (ja) 1999-11-23 2003-04-22 メルク エンド カムパニー インコーポレーテッド ピラジノン系トロンビン阻害薬
US6506754B1 (en) * 2000-04-14 2003-01-14 Corvas International, Inc. Non-covalent thrombin inhibitors
AU2001255399A1 (en) * 2000-04-14 2001-10-30 Corvas International, Inc. Pyridine and pyrazine derivatives as thrombin inhibitors
US6710058B2 (en) 2000-11-06 2004-03-23 Bristol-Myers Squibb Pharma Company Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors
US7243153B2 (en) 2001-06-26 2007-07-10 Eastman Kodak Company System and method for managing images over a communication network
MXPA04003167A (es) * 2001-10-03 2004-07-08 Pharmacia Corp Compuestos heterociclicos insaturados de 6 miembros utiles para la inhibicion selectiva de la cascada de coagulacion.
JP2005525413A (ja) * 2001-10-03 2005-08-25 ファルマシア・コーポレーション 凝固カスケードの選択的抑制に有用な置換５員多環状化合物
BR0213129A (pt) * 2001-10-03 2004-08-10 Pharmacia Corp Pró-drogas de compostos policìclicos substituìdos, úteis para inibição seletiva da cascata da coagulação
TW200307667A (en) 2002-05-06 2003-12-16 Bristol Myers Squibb Co Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors
EP1526131A1 (en) * 2003-10-22 2005-04-27 Graffinity Pharmaceuticals Aktiengesellschaft Aminoalkyl-pyrazinones and -pyridones as thrombin inhibitors
US7905872B2 (en) * 2004-06-04 2011-03-15 The Procter & Gamble Company Absorbent articles comprising a slow recovery stretch laminate
US9017305B2 (en) 2010-11-12 2015-04-28 The Procter Gamble Company Elastomeric compositions that resist force loss and disintegration
US11584714B2 (en) 2018-05-29 2023-02-21 Omeros Corporation MASP-2 inhibitors and methods of use
CN117964683A (zh) 2018-05-29 2024-05-03 奥默罗斯公司 Masp-2抑制剂和使用方法
EP4017586A1 (en) 2019-08-21 2022-06-29 Kalvista Pharmaceuticals Limited Enzyme inhibitors
AU2020396565C1 (en) * 2019-12-04 2025-05-15 Omeros Corporation MASP-2 inhibitors and methods of use
KR20220110529A (ko) 2019-12-04 2022-08-08 오메로스 코포레이션 Masp-2 억제자 및 사용 방법
JP7721142B2 (ja) 2019-12-04 2025-08-12 オメロス コーポレーション Ｍａｓｐ－２阻害剤および使用方法
AU2020398241B2 (en) 2019-12-04 2025-03-20 Omeros Corporation MASP-2 inhibitors and methods of use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2224437A1 (en) * 1995-06-27 1997-01-16 Merck & Co., Inc. Pyridinone-thrombin inhibitors
WO1999011267A1 (en) * 1997-09-05 1999-03-11 Merck & Co., Inc. Pyrazinone thrombin inhibitors
SK145398A3 (en) * 1996-04-23 1999-05-07 Merck & Co Inc Pyrazinone thrombin inhibitors
AU728006B2 (en) * 1997-03-24 2001-01-04 Merck & Co., Inc. Thrombin inhibitors
CA2329914A1 (en) * 1998-05-19 1999-11-25 Merck & Co., Inc. Pyrazinone thrombin inhibitors
JP2002516326A (ja) * 1998-05-26 2002-06-04 メルク エンド カムパニー インコーポレーテッド イミダゾピリジン系トロンビン阻害薬
WO1999064446A1 (en) * 1998-06-11 1999-12-16 3-Dimensional Pharmaceuticals, Inc. Pyrazinone protease inhibitors

Also Published As

Publication number Publication date
CN1351595A (zh) 2002-05-29
NZ514876A (en) 2005-03-24
NO20015605L (no) 2002-01-18
KR20010113971A (ko) 2001-12-28
DE60019296T2 (de) 2006-03-09
JP2002544264A (ja) 2002-12-24
HUP0202191A3 (en) 2003-02-28
MXPA01011807A (es) 2003-09-04
EP1202975B1 (en) 2005-04-06
AU4972300A (en) 2000-12-05
EA200101212A1 (ru) 2002-06-27
CA2372617A1 (en) 2000-11-23
AU775229B2 (en) 2004-07-22
UY26155A1 (es) 2000-12-29
IL146245A0 (en) 2002-07-25
HUP0202191A2 (hu) 2002-12-28
EP1202975A1 (en) 2002-05-08
CZ20014115A3 (cs) 2002-05-15
DE60019296D1 (de) 2005-05-12
AR029752A1 (es) 2003-07-16
PE20010290A1 (es) 2001-03-07
PL352368A1 (en) 2003-08-25
NO20015605D0 (no) 2001-11-16
EA005031B1 (ru) 2004-10-28
WO2000069834A1 (en) 2000-11-23
ZA200109341B (en) 2004-05-26
BR0011295A (pt) 2002-05-28
ES2240100T3 (es) 2005-10-16
ATE292629T1 (de) 2005-04-15
SK15872001A3 (sk) 2002-10-08

Similar Documents

Publication Publication Date Title
ZA200109340B (en) Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade.
ZA200109341B (en) Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade.
NO20015156D0 (no) 5-pyridyl-1,3-Azol forbindelser, fremgangsmåte for produksjon av de samme og deres anvendelse
ZA993364B (en) Novel 4-phenylpiperidines for the treatment of pruritic dermatoses.
NO20013369D0 (no) Arylpiperazinyl-cykloheksyl-indol-derivater for behandling av depresjon
ZA200106721B (en) Process for the manufacture of furfural.
DE60019556D1 (de) 2-amino-benzoxazinonderivate zur behandlung von fettleibigkeit
DK1143977T3 (da) 2-oxy-benzoxazinonderivater til behandling af obesitas
AU6989800A (en) Diamino-1,2,4-triazole-carboxylic and derivatives as gsk-3 inhibitors
ZA200109338B (en) Substituted polycyclic aryl and heteroaryl uracils as anti-coagulative agents.
IL159540A0 (en) Heterocyclic compounds as selective bacterial dhfr inhibitors and the uses thereof
AU2001243598A1 (en) Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade
MXPA03004303A (es) DERIVADOS SUSTITUIDOS DE ACIDO AMINO-FURAN-2-IL-ACETICO Y ACIDO AMINO-TIEN-2-IL-ACETICO Y SU USO PARA EL TRATAMIENTO DE MIGRAnA Y DOLOR.
FI990509A0 (fi) Häiriönpoistomenetelmä
AU2001219236A1 (en) Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
AU2002367752A8 (en) Substituted 5-membered polycyclic compounds useful for selective inhibition of the coagulation cascade
AU2021601A (en) Composition for the treatment of dandruff
AU2001222501A1 (en) Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
NO20003481D0 (no) FremgangsmÕte for behandling av COPD
AU2001217827A1 (en) Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
HK1047092A (en) Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade
NO983622D0 (no) Fremgangsmåte for tildanning av lededör
NL1015302A1 (nl) Werkwijze voor de productie van 2,3-dimethylbuteen-1 en 2,3-dimethylbuteen-2.
AU2002334854A1 (en) 6-membered heterocyclic compounds useful for selective inhibition of the coagulation cascade
AU4145000A (en) Dibenzoylmethane derivatives, process for the preparation of the same and uses thereof