PE20010229A1 - Pirimidonas sustituidas de arilos y heteroarilos policiclicos utiles para la inhibicion selectiva de la cascada de coagulacion - Google Patents
Pirimidonas sustituidas de arilos y heteroarilos policiclicos utiles para la inhibicion selectiva de la cascada de coagulacionInfo
- Publication number
- PE20010229A1 PE20010229A1 PE2000000575A PE0005752000A PE20010229A1 PE 20010229 A1 PE20010229 A1 PE 20010229A1 PE 2000000575 A PE2000000575 A PE 2000000575A PE 0005752000 A PE0005752000 A PE 0005752000A PE 20010229 A1 PE20010229 A1 PE 20010229A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- aryls
- coagulation cascade
- substituted
- group
- Prior art date
Links
- 150000008318 pyrimidones Chemical group 0.000 title abstract 3
- 230000015271 coagulation Effects 0.000 title abstract 2
- 238000005345 coagulation Methods 0.000 title abstract 2
- 230000005764 inhibitory process Effects 0.000 title 1
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 229910052717 sulfur Inorganic materials 0.000 abstract 3
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- -1 AMINO Chemical class 0.000 abstract 1
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical class N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 abstract 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 abstract 1
- 102000012479 Serine Proteases Human genes 0.000 abstract 1
- 108010022999 Serine Proteases Proteins 0.000 abstract 1
- 150000001409 amidines Chemical class 0.000 abstract 1
- 208000026106 cerebrovascular disease Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000001732 thrombotic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
Abstract
SE REFIERE A PIRIMIDONAS SUSTITUIDAS DE ARILOS Y HETEROARILOS POLICICLICOS DE FORMULA I, DONDE: B ES UN GRUPO b; R9-R13, R32-R36 SON ACETAMIDO, HALOACETAMIDO, ENTRE OTROS; R9-R13 SON HETEROARILO, HETEROCICLILO SI R9-R13 NO SON SUSTITUYENTES DE B; R16, R19, R32-R36 SON Qb, UNO DE R16 Y R19 ES Qb Y Qb ES Qbe; B ES TRIALQUILSILILO, ALQUILO C2-C8, ENTRE OTROS; A ES UN ENLACE, (W7)rr-(CH(R15))pa, ENTRE OTROS; rr ES 0-1; pa ES 0-6; W7 ES O, S, C(O), (R7)NC(O), ENTRE OTROS; R7 ES OH, ALQUILO; R15 ES OH, HALO, ALQUILO, HALOALQUILO; ES NH, NOH; M ES N, R1-C; R1 ES ALQUILO, CIANO, ENTRE OTROS; R2 ES Z°-Q; Z° ES (CR41R42)q; q ES 1-3; R41 Y R42 SON AMIDINO, HIDROXIAMINO, ENTRE OTROS; Q ES UN GRUPO II; D1, D2, J1, J2, K1 SON C, N, O, S, UN ENLACE; K ES (CR4aRb)n; n ES 1-2; R4a Y R4b SON HALO, HIDROXIALQUILO, ALQUILO; E° ES E1; E1 ES CO, CS, CONR7, SO2, ENTRE OTROS; Y° ES GRUPO IV, ENTRE OTROS; D5, D6, J5, J6 SON C, N, O, S, ENTRE OTROS; Qb ES AMINOALQUILENILO, ENTRE OTROS; Qbe ES NR6CNR25NR23R24, ENTRE OTROS. NO MAS DE UNO DE R20 Y R21 o R23 Y R24 SON OH, AMINO, ENTRE OTROS; R20 A R26 SON ALQUILO, OH, ENTRE OTROS. LOS COMPUESTOS DE PIRIMIDONAS SUSTITUIDAS SON INHIBIDORES DE PROTEASAS DE SERINA DE LA CASCADA DE COAGULACION POR LO QUE PUEDEN SER UTILES PARA EL TRATAMIENTO DE ENFERMEDADES TROMBOTICAS, CORONARIAS, CEREBROVASCULARES
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13479499P | 1999-05-19 | 1999-05-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20010229A1 true PE20010229A1 (es) | 2001-03-07 |
Family
ID=22465042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000000575A PE20010229A1 (es) | 1999-05-19 | 2000-06-09 | Pirimidonas sustituidas de arilos y heteroarilos policiclicos utiles para la inhibicion selectiva de la cascada de coagulacion |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1178970A1 (es) |
| JP (1) | JP2002544262A (es) |
| KR (1) | KR20010114271A (es) |
| CN (1) | CN1157380C (es) |
| AR (1) | AR030021A1 (es) |
| AU (2) | AU771718B2 (es) |
| BR (1) | BR0010758A (es) |
| CA (1) | CA2373614A1 (es) |
| CZ (1) | CZ20014116A3 (es) |
| EA (1) | EA004867B1 (es) |
| HU (1) | HUP0201242A3 (es) |
| IL (1) | IL146243A0 (es) |
| MX (1) | MXPA01011804A (es) |
| NO (1) | NO20015604L (es) |
| NZ (1) | NZ514874A (es) |
| PE (1) | PE20010229A1 (es) |
| PL (1) | PL352827A1 (es) |
| SK (1) | SK15852001A3 (es) |
| TW (1) | TWI222445B (es) |
| UY (1) | UY26156A1 (es) |
| WO (1) | WO2000069832A1 (es) |
| ZA (2) | ZA200109339B (es) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6750342B1 (en) | 1999-05-19 | 2004-06-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
| US6716838B1 (en) | 1999-05-19 | 2004-04-06 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents |
| US6653316B1 (en) | 1999-05-19 | 2003-11-25 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
| KR20010113969A (ko) * | 1999-05-19 | 2001-12-28 | 추후보정 | 항응고제로서의 치환된 폴리시클릭 아릴 및 헤테로아릴우라실 |
| US7015230B1 (en) | 1999-05-19 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
| US6664255B1 (en) | 1999-05-19 | 2003-12-16 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade |
| US6458952B1 (en) | 1999-05-19 | 2002-10-01 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
| US6867217B1 (en) | 1999-05-19 | 2005-03-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade |
| US6852761B2 (en) | 2000-03-13 | 2005-02-08 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade |
| CA2405561A1 (en) | 2000-04-05 | 2001-10-18 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 4-pyrones useful for selective inhibition of the coagulation cascade |
| EP1268428A2 (en) | 2000-04-05 | 2003-01-02 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade |
| US6686484B2 (en) | 2000-04-17 | 2004-02-03 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 1,4-quinones useful for selective inhibition of the coagulation cascade |
| WO2001087851A1 (en) * | 2000-05-18 | 2001-11-22 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
| US6710058B2 (en) | 2000-11-06 | 2004-03-23 | Bristol-Myers Squibb Pharma Company | Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors |
| US7015223B1 (en) | 2000-11-20 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade |
| US7119094B1 (en) | 2000-11-20 | 2006-10-10 | Warner-Lambert Company | Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade |
| MXPA03004458A (es) | 2000-11-20 | 2005-01-25 | Pharmacia Corp | Arilpiridinas y heteroarilpiridinas sustituidas utiles para inhibicion selectiva de la cascada de coagulacion. |
| WO2003029216A1 (en) | 2001-10-03 | 2003-04-10 | Pharmacia Corporation | 6-membered heterocyclic compounds useful for selective inhibition of the coagulation cascade |
| WO2003029224A1 (en) * | 2001-10-03 | 2003-04-10 | Pharmacia Corporation | 6-membered unsaturated heterocyclic compounds useful for selective inhibition of the coagulation cascade |
| AU2002367752A1 (en) | 2001-10-03 | 2003-11-17 | Pharmacia Corporation | Substituted 5-membered polycyclic compounds useful for selective inhibition of the coagulation cascade |
| JP2005532268A (ja) | 2002-02-22 | 2005-10-27 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | 置換されたピリミジノンおよびピリミジンチオン |
| TW200307667A (en) | 2002-05-06 | 2003-12-16 | Bristol Myers Squibb Co | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors |
| US7217794B2 (en) | 2003-04-02 | 2007-05-15 | Daiamed, Inc. | Compounds and methods for treatment of thrombosis |
| US7182738B2 (en) | 2003-04-23 | 2007-02-27 | Marctec, Llc | Patient monitoring apparatus and method for orthosis and other devices |
| CA2610400A1 (en) * | 2005-06-07 | 2006-12-14 | Pharmacopeia, Inc. | Azinone and diazinone v3 inhibitors for depression and stress disorders |
| CN104311537B (zh) * | 2014-09-19 | 2016-08-24 | 广东东阳光药业有限公司 | 含有嘧啶酮乙酰基取代基吡唑类化合物及其组合物及用途 |
| AU2020396565C1 (en) * | 2019-12-04 | 2025-05-15 | Omeros Corporation | MASP-2 inhibitors and methods of use |
| CN115779953B (zh) * | 2022-12-19 | 2024-06-21 | 中南大学 | 铜负载碳基单原子材料及其制备方法和应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5441960A (en) * | 1992-04-16 | 1995-08-15 | Zeneca Limited | 1-pyrimidinylacetamide human leukocyte elastate inhibitors |
| US5948785A (en) * | 1995-04-27 | 1999-09-07 | The Green Cross Corporation | Heterocyclic amide compounds and pharmaceutical use of the same |
-
2000
- 2000-05-17 JP JP2000618249A patent/JP2002544262A/ja active Pending
- 2000-05-17 CN CNB008077479A patent/CN1157380C/zh not_active Expired - Fee Related
- 2000-05-17 WO PCT/US2000/009806 patent/WO2000069832A1/en not_active Ceased
- 2000-05-17 CA CA002373614A patent/CA2373614A1/en not_active Abandoned
- 2000-05-17 PL PL00352827A patent/PL352827A1/xx not_active Application Discontinuation
- 2000-05-17 AU AU49734/00A patent/AU771718B2/en not_active Ceased
- 2000-05-17 KR KR1020017014753A patent/KR20010114271A/ko not_active Withdrawn
- 2000-05-17 BR BR0010758-1A patent/BR0010758A/pt not_active IP Right Cessation
- 2000-05-17 NZ NZ514874A patent/NZ514874A/en unknown
- 2000-05-17 IL IL14624300A patent/IL146243A0/xx unknown
- 2000-05-17 EP EP00931928A patent/EP1178970A1/en not_active Withdrawn
- 2000-05-17 EA EA200101214A patent/EA004867B1/ru not_active IP Right Cessation
- 2000-05-17 SK SK1585-2001A patent/SK15852001A3/sk unknown
- 2000-05-17 HU HU0201242A patent/HUP0201242A3/hu unknown
- 2000-05-17 CZ CZ20014116A patent/CZ20014116A3/cs unknown
- 2000-05-17 MX MXPA01011804A patent/MXPA01011804A/es unknown
- 2000-05-19 AR ARP000102446A patent/AR030021A1/es unknown
- 2000-05-19 UY UY26156A patent/UY26156A1/es not_active Application Discontinuation
- 2000-06-09 PE PE2000000575A patent/PE20010229A1/es not_active Application Discontinuation
- 2000-07-25 TW TW089109595A patent/TWI222445B/zh not_active IP Right Cessation
-
2001
- 2001-11-13 ZA ZA200109339A patent/ZA200109339B/xx unknown
- 2001-11-16 NO NO20015604A patent/NO20015604L/no not_active Application Discontinuation
-
2004
- 2004-01-21 ZA ZA200400448A patent/ZA200400448B/xx unknown
- 2004-05-31 AU AU2004202375A patent/AU2004202375A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU771718B2 (en) | 2004-04-01 |
| AR030021A1 (es) | 2003-08-13 |
| UY26156A1 (es) | 2000-12-29 |
| BR0010758A (pt) | 2003-06-10 |
| HUP0201242A2 (hu) | 2002-12-28 |
| TWI222445B (en) | 2004-10-21 |
| EA200101214A1 (ru) | 2002-06-27 |
| KR20010114271A (ko) | 2001-12-31 |
| NZ514874A (en) | 2004-11-26 |
| AU2004202375A1 (en) | 2004-06-24 |
| AU4973400A (en) | 2000-12-05 |
| ZA200400448B (en) | 2004-09-29 |
| EP1178970A1 (en) | 2002-02-13 |
| EA004867B1 (ru) | 2004-08-26 |
| SK15852001A3 (sk) | 2003-06-03 |
| HUP0201242A3 (en) | 2003-02-28 |
| WO2000069832A1 (en) | 2000-11-23 |
| PL352827A1 (en) | 2003-09-08 |
| NO20015604L (no) | 2002-01-11 |
| IL146243A0 (en) | 2002-07-25 |
| ZA200109339B (en) | 2004-05-26 |
| CN1351593A (zh) | 2002-05-29 |
| NO20015604D0 (no) | 2001-11-16 |
| CZ20014116A3 (cs) | 2002-06-12 |
| CN1157380C (zh) | 2004-07-14 |
| CA2373614A1 (en) | 2000-11-23 |
| JP2002544262A (ja) | 2002-12-24 |
| MXPA01011804A (es) | 2003-09-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20010229A1 (es) | Pirimidonas sustituidas de arilos y heteroarilos policiclicos utiles para la inhibicion selectiva de la cascada de coagulacion | |
| PE20010290A1 (es) | Pirazinonas sustituidas de arilos y heteroarilos policiclicos utiles para la inhibicion selectiva de la cascada de coagulacion | |
| PE20010217A1 (es) | Uracilos sustituidos de arilos y heteroarilos policiclicos utiles para la inhibicion selectiva de la cascada de coagulacion | |
| MX9200817A (es) | Derivados de piranil cianoguanidina y proceso para su preparacion. | |
| TR199802767T2 (xx) | Trombin �nleyiciler olarak yeni amidino t�revleri. | |
| AR026102A1 (es) | Un proceso para estabilizar un mocrolido de polietileno, una mezcla de forma solida, una composicion farmaceutica, un derivado de rapamicina y un procesopara su purificacion | |
| NO950168D0 (no) | O-benzyloksimeterivater og deres anvendelse som pestisider | |
| MY136789A (en) | Metalloproteinase inhibitors | |
| NO982748D0 (no) | FremgangsmÕte for nitrogenfjernelse fra forbrenningsavgasser | |
| ATE134644T1 (de) | Weitere antivirale pyrimidin-nukleosiden | |
| ES2086326T3 (es) | Metodo para intensificar la quimiluminiscencia. | |
| PT1152993E (pt) | Processo de fabrico de um ligante hidraulico a base de nidrite iii ou alfa e o ligante hidraulico assim obtido | |
| DE69128477D1 (de) | Benzopyranderivat | |
| DK0595557T3 (da) | Nye substituerede azetidoner som antiinflammatoriske og antidegenerative midler | |
| ES8802223A1 (es) | Procedimiento para la preparacion de derivados de 2-oxi-4h-3, 1-benzoxazin-4-ona | |
| DE3786961D1 (de) | Alpha-1-antitrypsin-varianten, besonders verwendbar als kallikrein-inhibitoren. | |
| NO975679L (no) | Fremgangsmåte for fremstilling av N-monosubstituerte og N,N'-disubstituerte, usymmetriske, cykliske ureaer | |
| FI901610A0 (fi) | Foerfarande foer malning av portlandcementklinker foer framstaellning av gipsfria portlandcementer. | |
| DK666689A (da) | Modificeret krystallinsk aluminosilikat og fremgangsmaade til fremstilling af det samme | |
| IL155958A0 (en) | Cysteine protease inhibitors | |
| ES2094521T3 (es) | Procedimiento para la obtencion de un granulado de tetrahidro-3,5-dimetil-1,3,5-tiadiazin-2-tiona ampliamente exento de polvo. | |
| PE20000474A1 (es) | Inhibidores de la oxido nitrico sintasa | |
| FR2753972B1 (fr) | Composition de lactitol et son procede de preparation | |
| DE3378978D1 (de) | Tetrahydro-benzo(e) isoindolines | |
| PE20010201A1 (es) | Piridonas sustituidas de arilo policiclico y heteroarilo que son utiles para la inhibicion selectiva de la cascada de coagulacion |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |