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PE20010126A1 - Pirrolotriazinas como inhibidores de cinasas - Google Patents

Pirrolotriazinas como inhibidores de cinasas

Info

Publication number
PE20010126A1
PE20010126A1 PE2000000484A PE0004842000A PE20010126A1 PE 20010126 A1 PE20010126 A1 PE 20010126A1 PE 2000000484 A PE2000000484 A PE 2000000484A PE 0004842000 A PE0004842000 A PE 0004842000A PE 20010126 A1 PE20010126 A1 PE 20010126A1
Authority
PE
Peru
Prior art keywords
alkyl
cancer
aryl
heterocycle
pyrrolotriazines
Prior art date
Application number
PE2000000484A
Other languages
English (en)
Inventor
Rajeev S Bhide
John T Hunt
Robert M Borzilleri
Ligang Qian
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20010126A1 publication Critical patent/PE20010126A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
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    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
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  • Pain & Pain Management (AREA)
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  • Cardiology (AREA)
  • Obesity (AREA)
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  • Hospice & Palliative Care (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
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Abstract

SE REFIERE A PIRROLOTRIAZINAS DE FORMULA I DONDE: X E Y SON O, OCO, S, SO, SO2, CO, NR10, NR11CO, ENTRE OTROS; Z ES O, S, N, CR20; R1 ES H, CH3, OH, OCH3, SH, SCH3, OCOR21, SOR22, SO2R23, ENTRE OTROS; R2 Y R3 SON H, ALQUILO, ALQUENILO, ENTRE OTROS; CUANDO X ES HALO, NITRO, CIANO, R2 ESTA AUSENTE; CUANDO Y ES HALO, NITRO, CIANO, R3 ESTA AUSENTE; R4 Y R5 SON H, ALQUILO, ARILO, HETEROCICLO, ENTRE OTROS; R6 ES H, ALQUILO, ARILO, HETEROCICLO, NR7R8, OR9, ENTRE OTROS; R7, R8, R9, R13, R14, R21 SON H, ALQUILO, ARILO, HETERICICLO; R22, R23 SON ALQUILO, ARILO, HETEROCICLO; R2 NO ES H; SI X ES SO, SO2, NR13CO2, NR14SO2; R3 NO ES H SI Y ES SO, SO2, NR13CO2, NR14SO2. SON COMPUESTOS PREFERIDOS N-(4-CLOROFENIL)PIRROLO[2,1-f][1,2,4]TRIAZIN-4-AMINA, 2-METIL-5-(PIRROLO[2,1-f][1,2,4]TRIAZIN-4-ILAMINO)FENOL, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION QUE COMPRENDE ADEMAS UN AGENTE ANTICANCEROSO O CITOTOXICO TAL COMO TAMOXIFEN, TOREMIFEN, RALOXIFENO, DROLOXIFENO, YODOXIFENO, ACETATO DE MEGESTROL, ANASTROZOL, LETRAZOL, BORAZOL, EXEMESTANO, FLUTAMIDA, EPOTILONA, ENTRE OTROS. EL COMPUESTO I ES UN INHIBIDOR DE TIROSINCINASA, DE LOS RECEPTORES DEL FACTOR DE CRECIMIENTO Y TIENE EFECTO ANTIANGIOGENICO, EFECTO REDUCTOR DE LA PERMEABILIDAD VASCULAR Y PUEDE SER UTIL PARA EL TRATAMIENTO DE ENFERMEDADES PROLIFERATIVAS, AUTOINMUNES, CANCER, INFLAMACION
PE2000000484A 1999-05-21 2000-05-22 Pirrolotriazinas como inhibidores de cinasas PE20010126A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13526599P 1999-05-21 1999-05-21
US19372700P 2000-03-31 2000-03-31

Publications (1)

Publication Number Publication Date
PE20010126A1 true PE20010126A1 (es) 2001-04-22

Family

ID=26833147

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000000484A PE20010126A1 (es) 1999-05-21 2000-05-22 Pirrolotriazinas como inhibidores de cinasas

Country Status (28)

Country Link
EP (1) EP1183033B1 (es)
JP (2) JP4649046B2 (es)
KR (1) KR100666514B1 (es)
CN (1) CN1351498B (es)
AR (1) AR043087A1 (es)
AT (1) ATE318603T1 (es)
AU (1) AU770377B2 (es)
BR (1) BR0010482A (es)
CA (1) CA2373990C (es)
CZ (1) CZ303660B6 (es)
DE (2) DE60026297T2 (es)
DK (1) DK1183033T3 (es)
EG (1) EG24027A (es)
ES (2) ES2258459T3 (es)
HK (1) HK1041599B (es)
HU (1) HUP0301005A3 (es)
IL (2) IL144977A0 (es)
MX (1) MXPA01011832A (es)
MY (1) MY128370A (es)
NO (1) NO322214B1 (es)
NZ (1) NZ516292A (es)
PE (1) PE20010126A1 (es)
PL (1) PL204437B1 (es)
RU (1) RU2331640C2 (es)
TR (1) TR200103352T2 (es)
TW (1) TWI238163B (es)
UY (1) UY26150A1 (es)
WO (1) WO2000071129A1 (es)

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EP1183033A1 (en) 2002-03-06
KR20020015041A (ko) 2002-02-27
CN1351498B (zh) 2012-08-15
HUP0301005A3 (en) 2006-05-29
EP1183033A4 (en) 2002-07-17
PL351720A1 (en) 2003-06-02
HUP0301005A2 (hu) 2003-07-28
NO20015650L (no) 2001-11-20
IL144977A0 (en) 2002-06-30
AU770377B2 (en) 2004-02-19
MY128370A (en) 2007-01-31
NZ516292A (en) 2004-01-30
IL144977A (en) 2006-12-10
EG24027A (en) 2008-03-26
UY26150A1 (es) 2000-12-29
JP2011037878A (ja) 2011-02-24
JP4649046B2 (ja) 2011-03-09
WO2000071129A1 (en) 2000-11-30
DE60042620D1 (de) 2009-09-03
MXPA01011832A (es) 2002-06-21
DK1183033T3 (da) 2006-06-06
CA2373990A1 (en) 2000-11-30
EP1183033B1 (en) 2006-03-01
PL204437B1 (pl) 2010-01-29
CZ20014169A3 (cs) 2002-10-16
HK1041599B (en) 2006-09-15
ES2258459T3 (es) 2006-09-01
CA2373990C (en) 2007-05-08
TWI238163B (en) 2005-08-21
AU4852400A (en) 2000-12-12
RU2331640C2 (ru) 2008-08-20
JP2003500359A (ja) 2003-01-07
DE60026297D1 (de) 2006-04-27
TR200103352T2 (tr) 2005-03-21
DE60026297T2 (de) 2006-11-02
HK1041599A1 (en) 2002-07-12
NO20015650D0 (no) 2001-11-20
AR043087A1 (es) 2005-07-20
CN1351498A (zh) 2002-05-29
ES2328269T3 (es) 2009-11-11

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