PE20001427A1 - Compuestos de benzimidazol que son antagonistas del receptor de vitronectina - Google Patents
Compuestos de benzimidazol que son antagonistas del receptor de vitronectinaInfo
- Publication number
- PE20001427A1 PE20001427A1 PE1999001198A PE00119899A PE20001427A1 PE 20001427 A1 PE20001427 A1 PE 20001427A1 PE 1999001198 A PE1999001198 A PE 1999001198A PE 00119899 A PE00119899 A PE 00119899A PE 20001427 A1 PE20001427 A1 PE 20001427A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- aryl
- aralkyl
- cycloalkyl
- vitronectin receptor
- Prior art date
Links
- 102100022337 Integrin alpha-V Human genes 0.000 title abstract 2
- 108010048673 Vitronectin Receptors Proteins 0.000 title abstract 2
- 239000002464 receptor antagonist Substances 0.000 title abstract 2
- 229940044551 receptor antagonist Drugs 0.000 title abstract 2
- 150000001556 benzimidazoles Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 208000017442 Retinal disease Diseases 0.000 abstract 1
- 206010038923 Retinopathy Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 208000037803 restenosis Diseases 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 230000002792 vascular Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/14—Radicals substituted by nitrogen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A COMPUESTOS DE BENCIMIDAZOL DE FORMULA I, DONDE: n, p, q Y r SON 0-1; a, b, c, d SON C, N; NO MAS DE DOS a, b, c, d SON N; Y E Y1 SON ALQUILO, ALCOXI, HALO, CF3, COOH; R1 ES ALQUILO, ARILO, ARALQUILO, ARILCICLOALQUILO, HETEROARILO, CICLOALQUILO, NHRA, NHCORA, ENTRE OTROS; R2 ES H, ALQUILO, ARILO, ARALQUILO, ARILCICLOALQUILO, ENTRE OTROS; R3 ES H, ALQUILO, ARALQUILO, ARILCICLOALQUILO, CICLOALQUILALQUILO, CORD, SO2RE, CONRFRG, ENTRE OTROS; RD, RE, RF, RG SON H, ALQUILO, ARILO, ARALQUILO, ARILCICLOALQUILO, HETEROARILO, ENTRE OTROS; O RF Y RG JUNTOS FORMAN UN ANILLO DE 5-7 MIEMBROS CON 0-1 O, S; 1-2 N; R3 ES OPCIONALMENTE SUSTITUIDO CON HALO, ALQUILO, ARILO, ENTRE OTROS; R4 ES H, ALQUILO, ARALQUILO, ARILCICLOALQUILO, CICLOALQUILALQUILO, ENTRE OTROS; R5, R6, R7, R8, R9, R10, R11, R12 SON H, ALQUILO C1-C3. EL COMPUESTO I ES UN ANTAGONISTA DEL RECEPTOR DE VITRONECTINA Y PUEDE SER UTIL PARA EL TRATAMIENTO DE CANCER, RETINOPATIA, ATEROSCLEROSIS, RESTENOSIS VASCULAR, OSTEOPOROSIS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20161198A | 1998-11-30 | 1998-11-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20001427A1 true PE20001427A1 (es) | 2000-12-18 |
Family
ID=22746536
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1999001198A PE20001427A1 (es) | 1998-11-30 | 1999-11-30 | Compuestos de benzimidazol que son antagonistas del receptor de vitronectina |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1135374B9 (es) |
| JP (1) | JP4480117B2 (es) |
| CN (1) | CN1161340C (es) |
| AR (1) | AR021427A1 (es) |
| AT (1) | ATE338751T1 (es) |
| AU (1) | AU1908400A (es) |
| CA (1) | CA2353063C (es) |
| CO (1) | CO5140112A1 (es) |
| DE (1) | DE69933135T2 (es) |
| ES (1) | ES2273517T3 (es) |
| PE (1) | PE20001427A1 (es) |
| WO (1) | WO2000032578A1 (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1172359A4 (en) * | 1999-04-07 | 2002-09-11 | Santen Pharmaceutical Co Ltd | N, N'-SUBSTITUTED UREA DERIVATIVES AND THEIR USE AS TNF-A (A) PRODUCTION INHIBITORS |
| CA2373892A1 (en) * | 1999-05-17 | 2000-11-23 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
| FR2809396B1 (fr) | 2000-05-24 | 2005-10-14 | Centre Nat Rech Scient | Nouvelles molecules possedant une activite calcimimetique et leur mode de preparation |
| US6562807B2 (en) | 2000-06-23 | 2003-05-13 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
| DK2164958T3 (en) | 2007-06-07 | 2014-11-24 | Novozymes As | A process for preparing a dough-based product |
| WO2012010592A1 (en) | 2010-07-21 | 2012-01-26 | Novozymes A/S | Process for preparing a baked product with anti -staling amylase and peptidase |
| JP6534675B2 (ja) | 2014-02-11 | 2019-06-26 | バイエル・ファルマ・アクティエンゲゼルシャフト | ｍＩＤＨ１阻害剤としてのベンズイミダゾール−２−アミン |
| US9951027B2 (en) | 2014-02-11 | 2018-04-24 | Bayer Pharma Aktiengesellschaft | Benzimidazol-2-amines as MIDH1 inhibitors |
| CN104694290A (zh) * | 2014-05-07 | 2015-06-10 | 宁波职业技术学院 | 一种洗脚皂 |
| ES2822654T3 (es) | 2014-10-23 | 2021-05-04 | Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts | Benzimidazol-2-aminas como inhibidores de mIDH1 |
| CN107108554B (zh) | 2014-10-23 | 2020-11-06 | 德国癌症研究中心 | 作为midh1抑制剂用于治疗肿瘤的1-环己基-2-苯基氨基苯并咪唑 |
| CN107810176B (zh) | 2015-06-08 | 2020-10-16 | 德国癌症研究公共权益基金会 | 作为mIDH1抑制剂的N-薄荷基苯并咪唑类化合物 |
| US10414734B2 (en) | 2015-07-16 | 2019-09-17 | Bayer Pharma Aktiengesellschaft | 5-hydroxyalkylbenzimidazoles as mIDH1 inhibitors |
| TW202146416A (zh) | 2019-12-11 | 2021-12-16 | 德商拜耳廠股份有限公司 | 吡唑并三𠯤 |
| JP2023517034A (ja) | 2020-03-06 | 2023-04-21 | バイエル アクチェンゲゼルシャフト | Ｃｄｋ１２の阻害を介してがんに作用するイミダゾトリアジン |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2186720T3 (es) * | 1994-05-27 | 2003-05-16 | Merck & Co Inc | Composiciones para inhibir la reabsorcion osea mediada por osteoclastos. |
| AU702661B2 (en) * | 1994-06-29 | 1999-02-25 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
-
1999
- 1999-09-29 CN CN99815842.9A patent/CN1161340C/zh not_active Expired - Fee Related
- 1999-11-29 DE DE69933135T patent/DE69933135T2/de not_active Expired - Lifetime
- 1999-11-29 AR ARP990106061A patent/AR021427A1/es unknown
- 1999-11-29 JP JP2000585220A patent/JP4480117B2/ja not_active Expired - Lifetime
- 1999-11-29 EP EP99962691A patent/EP1135374B9/en not_active Expired - Lifetime
- 1999-11-29 CA CA002353063A patent/CA2353063C/en not_active Expired - Fee Related
- 1999-11-29 ES ES99962691T patent/ES2273517T3/es not_active Expired - Lifetime
- 1999-11-29 WO PCT/US1999/026023 patent/WO2000032578A1/en not_active Ceased
- 1999-11-29 AU AU19084/00A patent/AU1908400A/en not_active Abandoned
- 1999-11-29 AT AT99962691T patent/ATE338751T1/de not_active IP Right Cessation
- 1999-11-30 PE PE1999001198A patent/PE20001427A1/es not_active Application Discontinuation
- 1999-11-30 CO CO99075257A patent/CO5140112A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP4480117B2 (ja) | 2010-06-16 |
| CN1161340C (zh) | 2004-08-11 |
| ES2273517T3 (es) | 2007-05-01 |
| WO2000032578A1 (en) | 2000-06-08 |
| AU1908400A (en) | 2000-06-19 |
| AR021427A1 (es) | 2002-07-17 |
| WO2000032578A8 (en) | 2002-02-07 |
| EP1135374A1 (en) | 2001-09-26 |
| DE69933135D1 (de) | 2006-10-19 |
| DE69933135T2 (de) | 2007-08-09 |
| EP1135374B1 (en) | 2006-09-06 |
| EP1135374B9 (en) | 2007-02-21 |
| CA2353063C (en) | 2009-06-16 |
| CN1333755A (zh) | 2002-01-30 |
| JP2002531441A (ja) | 2002-09-24 |
| CO5140112A1 (es) | 2002-03-22 |
| CA2353063A1 (en) | 2000-06-08 |
| ATE338751T1 (de) | 2006-09-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |