AR021427A1 - Compuestos de benzimidazol que son antagonistas de receptor de vitronectina - Google Patents
Compuestos de benzimidazol que son antagonistas de receptor de vitronectinaInfo
- Publication number
- AR021427A1 AR021427A1 ARP990106061A ARP990106061A AR021427A1 AR 021427 A1 AR021427 A1 AR 021427A1 AR P990106061 A ARP990106061 A AR P990106061A AR P990106061 A ARP990106061 A AR P990106061A AR 021427 A1 AR021427 A1 AR 021427A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- arylcycloalkyl
- heterocycloalkylalkyl
- heteroaralkyl
- cycloalkylalkyl
- Prior art date
Links
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical class C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 5
- 125000004350 aryl cycloalkyl group Chemical group 0.000 abstract 5
- 125000003118 aryl group Chemical group 0.000 abstract 5
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 5
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 5
- 125000005843 halogen group Chemical group 0.000 abstract 5
- 125000004475 heteroaralkyl group Chemical group 0.000 abstract 5
- 125000001072 heteroaryl group Chemical group 0.000 abstract 5
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 5
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 abstract 5
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/14—Radicals substituted by nitrogen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invencion proporciona compuestos que tienen la formula (1), en donde n, p, q y r son cada uno independientemente seleccionados entre0 o 1; a, b, c y d representan cada uno independientemente un átomo de carbono o nitrogeno, con la condicion que no más de dos a, b, c y d sean átomosde nitrogeno; Y e Y1 representan cada uno independientemente 1-4 sustituyentes opcionales seleccionados entre alquilo, alcoxi, halo, -CF3 y -C(O)OH; R1 es Halquilo, arilo, aralquilo, arilcicloalquilo, heteroarilo, cicloalquilo, heterocicloalquilo, heteroaralquilo, cicloalquilalquilo, heterocicloalquilalquilo,NHRA, -NHC(O)RA, -NHSO2RA, NHC(O)NHRA, o -NHC(O)ORA; R1 es opcionalmente sustituido con 1-3 grupos seleccionados entre halo, alquilo, -CF3, -CN, -ORB, -SRB,SRB, -CO2RB, -C(O)RB, -OC(O)RB, -OC(O)ORB y -SO2RB, y RA y RB son independientemente seleccionados entre H, alquilo, arilo, aralquilo, arilcicloalquilo,heteroarilo, cicloalquilo, heterocicloalquilo, heteroaralquilo, cicloalquilalquilo o heterocicloalquilalquilo, con la condicion que cuando R1 es alquilo,R1 no es sustituido con halo, la condicion que cuando R1 es -NHSO2RA o -NHC(O)ORA, RA no es H, y la condicion que para -SO2RB o -OC(O)ORB, RB no esH; R2 es H, alquilo, arilo, aralquilo,arilcicloalquilo, heteroarilo, cicloalquilo, heterocicloalquilo, heteroaralquilo, cicloalquilalquilo,o heterocicloalquilalquilo; R2 es opcionalmente sustituido con 1-3 grupos seleccionados entre halo, alquilo, -CF3, -CN, -ORC, -SRC, -CO2RC, -C(O)RC,-OC(O)RC,-OC(O)ORC y -SO2RC, en donde RC se selecciona entre H, alquilo, arilo, aralquilo, arilcicloalquilo, heteroarilo, cicloalquilo, heterocicloalquilo,heteroaralquilo, cicloalquilalquilo o heterocicloalquilalquilo, con la condicion que cuando R2es alquilo, R2 no es sustituido con halo, y la condicion quepara -SO2RC o -OC(O)ORC, RC no es H; R3 es H, alquilo, aralquilo, arilcicloalquilo, cicloalquilalquilo, heterocicloalquilalquilo, heteroaralquilo, arilo,heteroarilo, cicloalquilo, heterocicloalquilo, -C(O)RD, -C(O)ORD, -SO2RE, -C(O)NRFRG, -C(O)NRFSO2RE, o -C(=S)NRFRG, en donde RD, RE, RF y RG son
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20161198A | 1998-11-30 | 1998-11-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR021427A1 true AR021427A1 (es) | 2002-07-17 |
Family
ID=22746536
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990106061A AR021427A1 (es) | 1998-11-30 | 1999-11-29 | Compuestos de benzimidazol que son antagonistas de receptor de vitronectina |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1135374B9 (es) |
| JP (1) | JP4480117B2 (es) |
| CN (1) | CN1161340C (es) |
| AR (1) | AR021427A1 (es) |
| AT (1) | ATE338751T1 (es) |
| AU (1) | AU1908400A (es) |
| CA (1) | CA2353063C (es) |
| CO (1) | CO5140112A1 (es) |
| DE (1) | DE69933135T2 (es) |
| ES (1) | ES2273517T3 (es) |
| PE (1) | PE20001427A1 (es) |
| WO (1) | WO2000032578A1 (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1172359A4 (en) * | 1999-04-07 | 2002-09-11 | Santen Pharmaceutical Co Ltd | N, N'-SUBSTITUTED UREA DERIVATIVES AND THEIR USE AS TNF-A (A) PRODUCTION INHIBITORS |
| CA2373892A1 (en) * | 1999-05-17 | 2000-11-23 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
| FR2809396B1 (fr) | 2000-05-24 | 2005-10-14 | Centre Nat Rech Scient | Nouvelles molecules possedant une activite calcimimetique et leur mode de preparation |
| US6562807B2 (en) | 2000-06-23 | 2003-05-13 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
| DK2164958T3 (en) | 2007-06-07 | 2014-11-24 | Novozymes As | A process for preparing a dough-based product |
| WO2012010592A1 (en) | 2010-07-21 | 2012-01-26 | Novozymes A/S | Process for preparing a baked product with anti -staling amylase and peptidase |
| JP6534675B2 (ja) | 2014-02-11 | 2019-06-26 | バイエル・ファルマ・アクティエンゲゼルシャフト | ｍＩＤＨ１阻害剤としてのベンズイミダゾール−２−アミン |
| US9951027B2 (en) | 2014-02-11 | 2018-04-24 | Bayer Pharma Aktiengesellschaft | Benzimidazol-2-amines as MIDH1 inhibitors |
| CN104694290A (zh) * | 2014-05-07 | 2015-06-10 | 宁波职业技术学院 | 一种洗脚皂 |
| ES2822654T3 (es) | 2014-10-23 | 2021-05-04 | Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts | Benzimidazol-2-aminas como inhibidores de mIDH1 |
| CN107108554B (zh) | 2014-10-23 | 2020-11-06 | 德国癌症研究中心 | 作为midh1抑制剂用于治疗肿瘤的1-环己基-2-苯基氨基苯并咪唑 |
| CN107810176B (zh) | 2015-06-08 | 2020-10-16 | 德国癌症研究公共权益基金会 | 作为mIDH1抑制剂的N-薄荷基苯并咪唑类化合物 |
| US10414734B2 (en) | 2015-07-16 | 2019-09-17 | Bayer Pharma Aktiengesellschaft | 5-hydroxyalkylbenzimidazoles as mIDH1 inhibitors |
| TW202146416A (zh) | 2019-12-11 | 2021-12-16 | 德商拜耳廠股份有限公司 | 吡唑并三𠯤 |
| JP2023517034A (ja) | 2020-03-06 | 2023-04-21 | バイエル アクチェンゲゼルシャフト | Ｃｄｋ１２の阻害を介してがんに作用するイミダゾトリアジン |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2186720T3 (es) * | 1994-05-27 | 2003-05-16 | Merck & Co Inc | Composiciones para inhibir la reabsorcion osea mediada por osteoclastos. |
| AU702661B2 (en) * | 1994-06-29 | 1999-02-25 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
-
1999
- 1999-09-29 CN CN99815842.9A patent/CN1161340C/zh not_active Expired - Fee Related
- 1999-11-29 DE DE69933135T patent/DE69933135T2/de not_active Expired - Lifetime
- 1999-11-29 AR ARP990106061A patent/AR021427A1/es unknown
- 1999-11-29 JP JP2000585220A patent/JP4480117B2/ja not_active Expired - Lifetime
- 1999-11-29 EP EP99962691A patent/EP1135374B9/en not_active Expired - Lifetime
- 1999-11-29 CA CA002353063A patent/CA2353063C/en not_active Expired - Fee Related
- 1999-11-29 ES ES99962691T patent/ES2273517T3/es not_active Expired - Lifetime
- 1999-11-29 WO PCT/US1999/026023 patent/WO2000032578A1/en not_active Ceased
- 1999-11-29 AU AU19084/00A patent/AU1908400A/en not_active Abandoned
- 1999-11-29 AT AT99962691T patent/ATE338751T1/de not_active IP Right Cessation
- 1999-11-30 PE PE1999001198A patent/PE20001427A1/es not_active Application Discontinuation
- 1999-11-30 CO CO99075257A patent/CO5140112A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP4480117B2 (ja) | 2010-06-16 |
| CN1161340C (zh) | 2004-08-11 |
| ES2273517T3 (es) | 2007-05-01 |
| WO2000032578A1 (en) | 2000-06-08 |
| AU1908400A (en) | 2000-06-19 |
| WO2000032578A8 (en) | 2002-02-07 |
| EP1135374A1 (en) | 2001-09-26 |
| DE69933135D1 (de) | 2006-10-19 |
| DE69933135T2 (de) | 2007-08-09 |
| EP1135374B1 (en) | 2006-09-06 |
| EP1135374B9 (en) | 2007-02-21 |
| PE20001427A1 (es) | 2000-12-18 |
| CA2353063C (en) | 2009-06-16 |
| CN1333755A (zh) | 2002-01-30 |
| JP2002531441A (ja) | 2002-09-24 |
| CO5140112A1 (es) | 2002-03-22 |
| CA2353063A1 (en) | 2000-06-08 |
| ATE338751T1 (de) | 2006-09-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |