[go: up one dir, main page]

GT200000197A - 2-(3,5-bis-trifluorometil-fenil)-n-metil-n-(6- morfolin-4-il-4-o tolil-piridin-3-il)-isobutiramida. - Google Patents

2-(3,5-bis-trifluorometil-fenil)-n-metil-n-(6- morfolin-4-il-4-o tolil-piridin-3-il)-isobutiramida.

Info

Publication number
GT200000197A
GT200000197A GT200000197A GT200000197A GT200000197A GT 200000197 A GT200000197 A GT 200000197A GT 200000197 A GT200000197 A GT 200000197A GT 200000197 A GT200000197 A GT 200000197A GT 200000197 A GT200000197 A GT 200000197A
Authority
GT
Guatemala
Prior art keywords
isobutiramide
tolil
trifluorometil
morfolin
piridin
Prior art date
Application number
GT200000197A
Other languages
English (en)
Inventor
Theresa Maria Ballard
Guy Andrew Higgins
Torsten Hoffmann
Sonia Maria Poli
Andrew Sleight
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of GT200000197A publication Critical patent/GT200000197A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

EL PRESENTE INVENTO SE REFIERE A LOS COMPUESTO DE LA FORMULA I Y A SUS SALES DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLES. EL COMPUESTO DE LA FORMULA I Y SUA SALES SE CARACTERIZAN POR VALIOSAS PROPIEDADES TERAPEUTICAS. SE HA ENCONTRADO QUE EL COMPUES DEL PRESENTE INVENTO ES UN ANTAGONISTA ALTAMENTE SELECTIVO DEL RECEPTOR NEUROQUININ 1 (NK1, SUSTANCIA P) Y POR TANTO UTIL EN EL TRATAMIENTO DE ENFERMEDADES RELACIONADAS CON ESTE RECEPTOR.
GT200000197A 1999-11-29 2000-11-28 2-(3,5-bis-trifluorometil-fenil)-n-metil-n-(6- morfolin-4-il-4-o tolil-piridin-3-il)-isobutiramida. GT200000197A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99123685 1999-11-29

Publications (1)

Publication Number Publication Date
GT200000197A true GT200000197A (es) 2002-05-22

Family

ID=8239481

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200000197A GT200000197A (es) 1999-11-29 2000-11-28 2-(3,5-bis-trifluorometil-fenil)-n-metil-n-(6- morfolin-4-il-4-o tolil-piridin-3-il)-isobutiramida.

Country Status (49)

Country Link
EP (1) EP1103545B1 (es)
JP (1) JP3480835B2 (es)
KR (1) KR100390117B1 (es)
CN (1) CN1152016C (es)
AR (1) AR033659A1 (es)
AT (1) ATE253561T1 (es)
AU (1) AU775292B2 (es)
BG (1) BG64622B1 (es)
BR (1) BRPI0005616B8 (es)
CA (1) CA2326529C (es)
CO (1) CO5251405A1 (es)
CZ (1) CZ299286B6 (es)
DE (2) DE60006340T2 (es)
DK (1) DK1103545T3 (es)
DO (1) DOP2000000106A (es)
EA (1) EA004404B1 (es)
ES (2) ES2208205T3 (es)
FR (1) FR2801590A1 (es)
GB (1) GB2356863A (es)
GC (1) GC0000151A (es)
GE (1) GEP20022763B (es)
GT (1) GT200000197A (es)
HR (1) HRP20000809A2 (es)
HU (1) HU224703B1 (es)
ID (1) ID28483A (es)
IL (1) IL139868A (es)
IS (1) IS2212B (es)
IT (1) IT1320120B1 (es)
JO (1) JO2298B1 (es)
MA (1) MA26754A1 (es)
MX (1) MXPA00011672A (es)
MY (1) MY127426A (es)
NO (1) NO317264B1 (es)
NZ (1) NZ508386A (es)
OA (1) OA11513A (es)
PA (1) PA8507201A1 (es)
PE (1) PE20010901A1 (es)
PL (1) PL195957B1 (es)
PT (1) PT1103545E (es)
SG (1) SG97171A1 (es)
SI (1) SI1103545T1 (es)
SK (1) SK285373B6 (es)
SV (1) SV2002000227A (es)
TN (1) TNSN00226A1 (es)
TR (1) TR200302077T4 (es)
UA (1) UA70326C2 (es)
UY (1) UY26458A1 (es)
YU (1) YU73400A (es)
ZA (1) ZA200006964B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2226622T3 (es) * 1999-02-24 2005-04-01 F. Hoffmann-La Roche Ag Derivados de 4-fenil piridina y su empleo como antagonistas del receptor nk-1.
BR0008489A (pt) 1999-02-24 2002-02-05 Hoffmann La Roche Derivados de fenil- e piridinila
HU230316B1 (hu) * 2000-07-14 2016-01-28 F. Hoffmann-La Roche Ag N-oxidok, mint 4-fenil-piridin-származékok előgyógyszerei, eljárás és előállításukra és az ezeket tartalmazó gyógyszerkészítmények
TWI287003B (en) * 2000-07-24 2007-09-21 Hoffmann La Roche 4-phenyl-pyridine derivatives
TWI259180B (en) * 2000-08-08 2006-08-01 Hoffmann La Roche 4-Phenyl-pyridine derivatives
US20030083345A1 (en) * 2001-07-10 2003-05-01 Torsten Hoffmann Method of treatment and/or prevention of brain, spinal or nerve injury
BR0307257A (pt) * 2002-01-31 2004-12-14 Hoffmann La Roche Polimorfismos genéticos no gene da pré-pró-taquicinina
HRP20070471T3 (hr) 2003-07-03 2007-11-30 F. Hoffmann - La Roche Ag Dvojni nk1/nk3 antagonisti za liječenje shizofrenije
TWI280239B (en) 2003-07-15 2007-05-01 Hoffmann La Roche Process for preparation of pyridine derivatives
MX2007000198A (es) 2004-07-06 2007-03-15 Hoffmann La Roche Proceso para la preparacion de derivados de carboxamida-piridina utilizados como intermediarios en la sintesis de antagonistas del receptor nk-1.
BRPI0606187A2 (pt) 2005-02-25 2009-06-09 Hoffmann La Roche comprimidos com capacidade de dispersão da substáncia do fármaco melhorada
CA2602445C (en) * 2005-03-23 2013-08-20 F.Hoffmann-La Roche Ag Metabolites for nk-i antagonists for emesis
RU2431473C2 (ru) * 2005-09-23 2011-10-20 Ф. Хоффманн-Ля Рош Аг Новая лекарственная форма
JP2010516731A (ja) 2007-01-24 2010-05-20 グラクソ グループ リミテッド ２−メトキシ−５−（５−トリフルオロメチル−テトラゾール−１−イル）−ベンジル］−（２ｓ−フェニル−ピペリジン−３ｓ−イル）−アミンを含む医薬組成物
US8426450B1 (en) 2011-11-29 2013-04-23 Helsinn Healthcare Sa Substituted 4-phenyl pyridines having anti-emetic effect
JP6463327B2 (ja) 2013-03-15 2019-01-30 グローバル ブラッド セラピューティクス インコーポレイテッド ヘモグロビンの修飾のための化合物及びその使用
KR20160078997A (ko) 2013-11-08 2016-07-05 깃세이 야쿠힌 고교 가부시키가이샤 카복시메틸피페리딘 유도체
JP6809681B2 (ja) 2014-02-07 2021-01-06 グローバル ブラッド セラピューティクス インコーポレイテッド ２−ヒドロキシ−６−（（２−（１−イソプロピル−１ｈ−ピラゾール−５−イル）ピリジン−３−イル）メトキシ）ベンズアルデヒドの遊離塩基の結晶多形
TWI649307B (zh) 2014-05-07 2019-02-01 日商橘生藥品工業股份有限公司 Cyclohexylpyridine derivative
KR101948238B1 (ko) 2016-08-19 2019-02-14 (주)케어젠 미녹시딜과 펩타이드의 결합체
KR102328682B1 (ko) 2018-08-27 2021-11-18 주식회사 대웅제약 신규한 헤테로사이클릭아민 유도체 및 이를 포함하는 약학 조성물

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1082959A1 (en) * 1991-09-20 2001-03-14 Glaxo Group Limited NK1 Antagonists for the treatment of depression
CA2099233A1 (en) * 1992-06-29 1993-12-30 Conrad P. Dorn Morpholine and thiomorpholine tachykinin receptor antagonists
IL111960A (en) * 1993-12-17 1999-12-22 Merck & Co Inc Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them
ATE364606T1 (de) * 1993-12-29 2007-07-15 Merck Sharp & Dohme Substituierte morpholinderivate und ihre verwendung als arzneimittel
IL112778A0 (en) * 1994-03-04 1995-05-26 Merck & Co Inc Substituted heterocycles, their preparation and pharmaceutical compositions containing them
NO309272B1 (no) * 1995-03-24 2001-01-08 Takeda Chemical Industries Ltd Cykliske forbindelser, preparater inneholdende forbindelsene samt mellomprodukter for fremstilling av forbindelsene
US5972938A (en) * 1997-12-01 1999-10-26 Merck & Co., Inc. Method for treating or preventing psychoimmunological disorders
ES2226622T3 (es) * 1999-02-24 2005-04-01 F. Hoffmann-La Roche Ag Derivados de 4-fenil piridina y su empleo como antagonistas del receptor nk-1.
US6303790B1 (en) * 1999-11-29 2001-10-16 Hoffman-La Roche Inc. Process for the preparation of pyridine derivatives
HU230316B1 (hu) * 2000-07-14 2016-01-28 F. Hoffmann-La Roche Ag N-oxidok, mint 4-fenil-piridin-származékok előgyógyszerei, eljárás és előállításukra és az ezeket tartalmazó gyógyszerkészítmények
TWI287003B (en) * 2000-07-24 2007-09-21 Hoffmann La Roche 4-phenyl-pyridine derivatives
TWI259180B (en) * 2000-08-08 2006-08-01 Hoffmann La Roche 4-Phenyl-pyridine derivatives

Also Published As

Publication number Publication date
MY127426A (en) 2006-11-30
NO20006012D0 (no) 2000-11-28
EA200001114A2 (ru) 2001-08-27
NO20006012L (no) 2001-05-30
UY26458A1 (es) 2001-05-31
TNSN00226A1 (fr) 2002-05-30
UA70326C2 (en) 2004-10-15
HRP20000809A2 (en) 2001-12-31
MXPA00011672A (es) 2002-08-20
AU7178700A (en) 2001-05-31
HK1036759A1 (en) 2002-01-18
DE10058310A1 (de) 2001-05-31
PL344147A1 (en) 2001-06-04
IT1320120B1 (it) 2003-11-18
EA004404B1 (ru) 2004-04-29
BR0005616A (pt) 2001-07-17
ITMI20002575A1 (it) 2002-05-29
JP2001151754A (ja) 2001-06-05
GB0028566D0 (en) 2001-01-10
HU0004725D0 (es) 2001-02-28
GEP20022763B (en) 2002-08-26
EA200001114A3 (ru) 2001-12-24
ES2208205T3 (es) 2004-06-16
IS5725A (is) 2001-05-29
JP3480835B2 (ja) 2003-12-22
SI1103545T1 (en) 2004-02-29
HUP0004725A2 (hu) 2002-04-29
AR033659A1 (es) 2004-01-07
DK1103545T3 (da) 2004-03-15
CZ20004399A3 (cs) 2001-07-11
JO2298B1 (en) 2005-09-12
KR100390117B1 (ko) 2003-07-04
FR2801590A1 (fr) 2001-06-01
ATE253561T1 (de) 2003-11-15
EP1103545B1 (en) 2003-11-05
IL139868A0 (en) 2002-02-10
EP1103545A1 (en) 2001-05-30
BG64622B1 (bg) 2005-09-30
ES2171134A1 (es) 2002-08-16
PE20010901A1 (es) 2001-09-20
CA2326529C (en) 2009-12-22
ZA200006964B (en) 2001-06-05
NO317264B1 (no) 2004-09-27
MA26754A1 (fr) 2004-12-20
ID28483A (id) 2001-05-31
YU73400A (sh) 2003-02-28
KR20010051983A (ko) 2001-06-25
PA8507201A1 (es) 2002-02-21
DE60006340T2 (de) 2004-09-09
GC0000151A (en) 2005-06-29
BG104992A (en) 2001-11-30
CZ299286B6 (cs) 2008-06-04
AU775292B2 (en) 2004-07-29
HU224703B1 (en) 2006-01-30
CO5251405A1 (es) 2003-02-28
IL139868A (en) 2009-09-01
BRPI0005616B8 (pt) 2021-07-06
SK285373B6 (sk) 2006-12-07
DE60006340D1 (de) 2003-12-11
CA2326529A1 (en) 2001-05-29
BRPI0005616B1 (pt) 2017-12-12
PT1103545E (pt) 2004-03-31
DOP2000000106A (es) 2002-07-30
GB2356863A (en) 2001-06-06
NZ508386A (en) 2003-02-28
IS2212B (is) 2007-02-15
SV2002000227A (es) 2002-02-05
PL195957B1 (pl) 2007-11-30
SK17932000A3 (sk) 2001-11-06
CN1297888A (zh) 2001-06-06
TR200302077T4 (tr) 2004-01-21
SG97171A1 (en) 2003-07-18
CN1152016C (zh) 2004-06-02
OA11513A (fr) 2004-02-03

Similar Documents

Publication Publication Date Title
GT200000197A (es) 2-(3,5-bis-trifluorometil-fenil)-n-metil-n-(6- morfolin-4-il-4-o tolil-piridin-3-il)-isobutiramida.
UY26782A1 (es) Derivados del benzotiazol
UY26872A1 (es) Derivados de la 4- fenil piridina
GT200100137A (es) Pro-drogas de derivados de 4-fenil-piridina.
ECSP034744A (es) Antagonistas de nmda/nr2b no arilo-heterociclico n-sustituidos
UY26754A1 (es) Derivados de la 1, 3, 8, -triaza-spiro (4,5) decan-4-ona
CY1106697T1 (el) Ν-υποκατεστημενες υδρομορφονες και η χρηση αυτων
AR016877A2 (es) 6-ter-butiloxicarbonilaminopiridinas 2-sustituidas y sus sales
BG66085B1 (bg) Фенилаланинови производни
CY1107956T1 (el) Χρηση υποκατεστημενων 2-αμινοτετραλινιων για την προληπτικη αντιμετωπιση της νοσου του παρκινσον
CY1107853T1 (el) Χρησεις αντισπασμωδικων αμινοξεων για τη θεραπευτικη αγωγη διπολικων διαταραχων
PT1337535E (pt) Derivados de benzodiazepina
ATE303369T1 (de) Glucocorticoid rezeptor modulatoren
NO20025641D0 (no) Substituerte 1-aminoalkyl-laktamer og deres anvendelse som muscarin-reseptor-antagonister
DE60120077D1 (de) Modulatoren des Glucocorticoid-Rezeptors
NO985518L (no) Morfinanderivater og medisinsk anvendelse derav
NO20025640D0 (no) Substituerte 1-aminoalkyl-laktamer og deres anvendelse som muscarin-reseptor-antagonister
EA200001061A1 (ru) Фармацевтическая композиция
BR0013311A (pt) Derivados substituìdos de 1,5-dihidropirrol-2-ona eficazes como antagonistas de receptores nmda para o tratamento de estados de dor
UY26851A1 (es) Derivados de la 4-fenilpiridina
DE60217843D1 (de) Ein dioxinoä2,3-güchinolin-9-carbonsäure derivat als nk3 rezeptor antagonist
MX2007004199A (es) Derivados de indol sustituidos con 5-sulfonil-1-piperidinil como antagonistas del receptor 5-ht6 para el tratamiento de trastornos del cns.
DE60221813D1 (de) Thiazolopyrimidinderivate und deren verwendung als antagonisten des cx3cr1 rezeptors
EE200100520A (et) N-(2-fenüül-4-aminobutüül)-1-naftamiidid neurokiniin-1-retseptori antagonistidena
BR0309668A (pt) Imidazolinilmetil aralquilsulfonamidas