PE107098A1 - Derivados de tetrahidroquinolina - Google Patents
Derivados de tetrahidroquinolinaInfo
- Publication number
- PE107098A1 PE107098A1 PE1997000718A PE00071897A PE107098A1 PE 107098 A1 PE107098 A1 PE 107098A1 PE 1997000718 A PE1997000718 A PE 1997000718A PE 00071897 A PE00071897 A PE 00071897A PE 107098 A1 PE107098 A1 PE 107098A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- amino
- alcoxy
- compounds
- heterocicle
- Prior art date
Links
- -1 AMINO Chemical class 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- 208000030507 AIDS Diseases 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 101100097467 Arabidopsis thaliana SYD gene Proteins 0.000 abstract 1
- 101150047265 COR2 gene Proteins 0.000 abstract 1
- 101100440695 Dictyostelium discoideum corB gene Proteins 0.000 abstract 1
- 101100134929 Gallus gallus COR9 gene Proteins 0.000 abstract 1
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 101100467189 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) QCR2 gene Proteins 0.000 abstract 1
- 101100495925 Schizosaccharomyces pombe (strain 972 / ATCC 24843) chr3 gene Proteins 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 150000003973 alkyl amines Chemical class 0.000 abstract 1
- 239000003194 amino acid receptor blocking agent Substances 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 208000028867 ischemia Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen(.) Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A COMPUESTOS DE FORMULA (I), EN DONDE: R ES HALOGENO, ALQUILO, ALCOXI, AMINO, ALQUILAMINO, DIALQUILAMINO, OH, CF3, OCF3, NITRO, CN, SO2R2 o COR2, DE PREFERENCIA EN LA POSICION 5 Y/O 7; R1 ES (CH2)nCN, -CH=CHR3, (CH2)nNHCOCH2R4, o O(CH2)pNR5R6; R2 ES OH, OCH3, AMINO, ALQUILAMINO o DIALQUILAMINO; R3 ES CN o COR7; R4 ES ALCOXI o NHCOR8; R5 Y R6 ES H o ALQUILO o R5 Y R6 JUNTOS CON EL NITROGENO FORMAN UN GRUPO HETEROCICLO o R5 ES H Y R6 ES COR9; R7 ES ALCOXI, AMINO o OH; R8 ES H, ALQUILO, ALCOXI, FENILO o HETEROCICLO SUSTITUIDO OPCIONALMENTE; R9 ES R8 o NR10R11; R10 ES H o ALQUILO; R11 ES ALQUILO, FENILO, HETEROCICLO o CICLOALQUILO; m ES O; 1 o 2; n ES 0; 1; 2; 3 o 4; p ES 2; 3 o 4. TAMBIEN SE REFIERE AL PROCEDIMIENTO DE PREPARACION DE LOS COMPUESTOS DE FORMULA (I). LOS COMPUESTOS OBTENIDOS ACTUAN COMO ANTAGONISTAS DE AMINOACIDOS EXCITATORIOS EN EL SITIO DE UNION DE LA GLICINA INSENSIBLE A LA ESTRICNINA PRESENTE EN EL COMPLEJO RECEPTOR N-METIL-D-ASPARTATO (NMDA) SIENDO UTILES EN EL TRATAMIENTO o PREVENCION DE DANOS NEUROTOXICOS (COMO RESULTADO DE ATAQUES CEREBRALES, ISQUEMIA) Y DE ENFERMEDADES NEURODEGENERATIVAS CRONICAS (COMO LA ENFERMEDAD DE HUNTINGTON o DE ALZHEIMER) O INDUCIDAS POR INFECCION VIRAL (COMO POR SIDA), ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9617305.9A GB9617305D0 (en) | 1996-08-17 | 1996-08-17 | Heterocyclic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE107098A1 true PE107098A1 (es) | 1999-01-15 |
Family
ID=10798623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1997000718A PE107098A1 (es) | 1996-08-17 | 1997-08-14 | Derivados de tetrahidroquinolina |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US6479488B1 (es) |
| EP (1) | EP0922034B1 (es) |
| JP (1) | JP4108129B2 (es) |
| KR (1) | KR100552864B1 (es) |
| CN (1) | CN1131214C (es) |
| AP (1) | AP877A (es) |
| AR (1) | AR008296A1 (es) |
| AT (1) | ATE221052T1 (es) |
| AU (1) | AU724473B2 (es) |
| BR (1) | BR9711311B1 (es) |
| CA (1) | CA2264118C (es) |
| CO (1) | CO4900066A1 (es) |
| CZ (1) | CZ296250B6 (es) |
| DE (1) | DE69714265T2 (es) |
| DK (1) | DK0922034T3 (es) |
| EA (1) | EA001704B1 (es) |
| ES (1) | ES2181030T3 (es) |
| GB (1) | GB9617305D0 (es) |
| HU (1) | HU225797B1 (es) |
| ID (1) | ID18095A (es) |
| IL (1) | IL128141A0 (es) |
| IS (1) | IS4953A (es) |
| MY (1) | MY116952A (es) |
| NO (1) | NO312241B1 (es) |
| NZ (1) | NZ333812A (es) |
| PE (1) | PE107098A1 (es) |
| PL (1) | PL194532B1 (es) |
| PT (1) | PT922034E (es) |
| SI (1) | SI0922034T1 (es) |
| TR (1) | TR199900336T2 (es) |
| TW (1) | TW449582B (es) |
| WO (1) | WO1998007704A1 (es) |
| YU (1) | YU6799A (es) |
| ZA (1) | ZA977326B (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9706294D0 (en) * | 1997-03-26 | 1997-05-14 | Glaxo Wellcome Spa | Heterocyclic compound |
| MY125037A (en) * | 1998-06-10 | 2006-07-31 | Glaxo Wellcome Spa | 1,2,3,4 tetrahydroquinoline derivatives |
| US6455734B1 (en) | 2000-08-09 | 2002-09-24 | Magnesium Diagnostics, Inc. | Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states |
| GB9929037D0 (en) * | 1999-12-08 | 2000-02-02 | Glaxo Wellcome Spa | Heterocyclic derivatives |
| DE10132725A1 (de) | 2001-07-05 | 2006-08-03 | Grünenthal GmbH | Substituierte γ-Lactonverbindungen |
| RU2292346C2 (ru) * | 2001-12-28 | 2007-01-27 | Акадиа Фармасьютикалз, Инк. | Гетероциклические мускариновые агонисты и композиции, их применение и способы лечения |
| US20050250767A1 (en) * | 2003-01-23 | 2005-11-10 | Weiner David M | Use of N-desmethylclozapine to treat human neuropsychiatric disease |
| KR20050092123A (ko) * | 2003-01-23 | 2005-09-20 | 아카디아 파마슈티칼스 인코포레이티드 | Ｎ-데스메틸클로자핀의 인간의 신경정신성 질환의 치료용도 |
| US20050085463A1 (en) * | 2003-01-23 | 2005-04-21 | Weiner David M. | Use of N-desmethylclozapine to treat human neuropsychiatric disease |
| EP1596867A4 (en) * | 2003-02-19 | 2006-03-22 | Merck & Co Inc | TREATMENT OF PSYCHOSIS WITH A MUSCARIN M1 RECEPTOR ECTOPIC ACTIVATOR |
| ES2324713T3 (es) * | 2003-12-22 | 2009-08-13 | Acadia Pharmaceuticals Inc. | Analogos de diaril(a,d)ciclohepteno amino-sustituidos como agonistas muscarinicos y metodos de tratamiento de trastornos neuropsiquiatricos. |
| JP2007536216A (ja) * | 2004-04-01 | 2007-12-13 | アカディア ファーマシューティカルズ，インコーポレーテッド | 固体ｎ−デスメチルクロザピンおよびその結晶形を合成および単離する方法 |
| RU2451014C2 (ru) * | 2005-07-22 | 2012-05-20 | Мотида Фармасьютикал Ко., Лтд. | Новое производное гетероциклиден ацетамида |
| US7910751B2 (en) | 2005-07-22 | 2011-03-22 | Mochida Pharmaceutical Co., Ltd. | Heterocyclidene acetamide derivative |
| US8480797B2 (en) | 2005-09-12 | 2013-07-09 | Abela Pharmaceuticals, Inc. | Activated carbon systems for facilitating use of dimethyl sulfoxide (DMSO) by removal of same, related compounds, or associated odors |
| US9427419B2 (en) | 2005-09-12 | 2016-08-30 | Abela Pharmaceuticals, Inc. | Compositions comprising dimethyl sulfoxide (DMSO) |
| US8435224B2 (en) | 2005-09-12 | 2013-05-07 | Abela Pharmaceuticals, Inc. | Materials for facilitating administration of dimethyl sulfoxide (DMSO) and related compounds |
| US7955418B2 (en) | 2005-09-12 | 2011-06-07 | Abela Pharmaceuticals, Inc. | Systems for removing dimethyl sulfoxide (DMSO) or related compounds or odors associated with same |
| WO2007053618A1 (en) * | 2005-10-31 | 2007-05-10 | Acadia Pharmaceuticals Inc. | Prodrugs of muscarinic agonists and methods of treatment of neuropsychiatric disorders |
| BRPI0921494A2 (pt) | 2008-11-03 | 2018-10-30 | Prad Reasearch And Development Ltd | método de planejamento de uma operação de amostragem para uma formação subterrãnea, método de contolar uma operação de amostragem de formação subterrânea, método de controlar uma operação de perfuração para uma formação subterrãnea, e método de realizar uma amostragem durante a operação de perfuração. |
| WO2011053874A1 (en) | 2009-10-30 | 2011-05-05 | Tandem Abela Development Group Llc | Dimethyl sulfoxide (dmso) and methylsulfonylmethane (msm) formulations to treat osteoarthritis |
| EP3718547A1 (en) | 2011-10-03 | 2020-10-07 | The University of Utah Research Foundation | Application of 5-ht6 receptor antagonists for the alleviation of cognitive deficits of down syndrome |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69029668T2 (de) * | 1989-03-08 | 1997-08-07 | Merck Sharp & Dohme | Tetrahydroquinolin-Derivate, verwendbar bei neurodegenerativen Krankheiten |
| DK0854867T3 (da) * | 1995-09-29 | 2002-12-02 | Glaxosmithkline Spa | Tetrahydroquinoliner som NMDA-antagonister |
-
1996
- 1996-08-17 GB GBGB9617305.9A patent/GB9617305D0/en active Pending
-
1997
- 1997-08-14 MY MYPI97003742A patent/MY116952A/en unknown
- 1997-08-14 NZ NZ333812A patent/NZ333812A/xx active Application Revival
- 1997-08-14 HU HU9903108A patent/HU225797B1/hu not_active IP Right Cessation
- 1997-08-14 CN CN97197233A patent/CN1131214C/zh not_active Expired - Fee Related
- 1997-08-14 AP APAP/P/1999/001459A patent/AP877A/en active
- 1997-08-14 ZA ZA977326A patent/ZA977326B/xx unknown
- 1997-08-14 KR KR1019997001280A patent/KR100552864B1/ko not_active Expired - Fee Related
- 1997-08-14 JP JP51037298A patent/JP4108129B2/ja not_active Expired - Fee Related
- 1997-08-14 AR ARP970103703A patent/AR008296A1/es active IP Right Grant
- 1997-08-14 DE DE69714265T patent/DE69714265T2/de not_active Expired - Lifetime
- 1997-08-14 TR TR1999/00336T patent/TR199900336T2/xx unknown
- 1997-08-14 ES ES97943809T patent/ES2181030T3/es not_active Expired - Lifetime
- 1997-08-14 IL IL12814197A patent/IL128141A0/xx not_active IP Right Cessation
- 1997-08-14 SI SI9730404T patent/SI0922034T1/xx unknown
- 1997-08-14 CO CO97046782A patent/CO4900066A1/es unknown
- 1997-08-14 AU AU45518/97A patent/AU724473B2/en not_active Ceased
- 1997-08-14 BR BRPI9711311-5A patent/BR9711311B1/pt not_active IP Right Cessation
- 1997-08-14 WO PCT/EP1997/004440 patent/WO1998007704A1/en not_active Ceased
- 1997-08-14 PE PE1997000718A patent/PE107098A1/es not_active Application Discontinuation
- 1997-08-14 US US09/147,568 patent/US6479488B1/en not_active Expired - Fee Related
- 1997-08-14 CZ CZ0052999A patent/CZ296250B6/cs not_active IP Right Cessation
- 1997-08-14 EP EP97943809A patent/EP0922034B1/en not_active Expired - Lifetime
- 1997-08-14 YU YU6799A patent/YU6799A/sh unknown
- 1997-08-14 PT PT97943809T patent/PT922034E/pt unknown
- 1997-08-14 AT AT97943809T patent/ATE221052T1/de not_active IP Right Cessation
- 1997-08-14 ID IDP972834A patent/ID18095A/id unknown
- 1997-08-14 CA CA002264118A patent/CA2264118C/en not_active Expired - Fee Related
- 1997-08-14 EA EA199900121A patent/EA001704B1/ru not_active IP Right Cessation
- 1997-08-14 DK DK97943809T patent/DK0922034T3/da active
- 1997-08-14 PL PL97331562A patent/PL194532B1/pl not_active IP Right Cessation
- 1997-08-30 TW TW086112442A patent/TW449582B/zh not_active IP Right Cessation
-
1999
- 1999-01-22 IS IS4953A patent/IS4953A/is unknown
- 1999-02-16 NO NO19990723A patent/NO312241B1/no not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |