CO4900066A1 - Derivados de tetrahidroquinolina - Google Patents
Derivados de tetrahidroquinolinaInfo
- Publication number
- CO4900066A1 CO4900066A1 CO97046782A CO97046782A CO4900066A1 CO 4900066 A1 CO4900066 A1 CO 4900066A1 CO 97046782 A CO97046782 A CO 97046782A CO 97046782 A CO97046782 A CO 97046782A CO 4900066 A1 CO4900066 A1 CO 4900066A1
- Authority
- CO
- Colombia
- Prior art keywords
- group
- amino
- alkyl
- hydroxy
- alkoxy
- Prior art date
Links
- -1 hydroxy, methoxy, amino Chemical group 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000003282 alkyl amino group Chemical group 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 101100097467 Arabidopsis thaliana SYD gene Proteins 0.000 abstract 1
- 101150047265 COR2 gene Proteins 0.000 abstract 1
- 101100440695 Dictyostelium discoideum corB gene Proteins 0.000 abstract 1
- 101100134929 Gallus gallus COR9 gene Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 101001043818 Mus musculus Interleukin-31 receptor subunit alpha Proteins 0.000 abstract 1
- 101100467189 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) QCR2 gene Proteins 0.000 abstract 1
- 101100495925 Schizosaccharomyces pombe (strain 972 / ATCC 24843) chr3 gene Proteins 0.000 abstract 1
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical compound O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 abstract 1
- 125000002431 aminoalkoxy group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Un compuesto de la fórmula (I):una sal, o un éster lábil metabólicamente del mismo caracterizado porque R representa un grupo seleccionado a partir de halógeno, alquilo, alcoxi, amino, alquilamino, dialquilamino, hidroxi, trifluorometilo, trifluorometoxi, nitro, ciano, SO2 R2 o COR2 en donde R2 representa hidroxi, metoxi, amino, alquilamino o dialquilamino; m es cero o un entero 1 ó 2; R1 representa un grupo (CH2 )n CN, -CH=CHR3 , (CH2 )n NHCOCH2 R4 u O(CH2 )p NR5 R6 ; R3 representa ciano o el grupo COR7 ; R4 representa alcoxi o un grupo NHCOR8 ; R5 y R6 cada uno independientemente representan hidrógeno o alquilo, o R5 y R6 junto con el átomo de nitrógeno al cual ellos están unidos representan un grupo heterocíclico, o R5 es hidrógeno y R6 es el grupo COR9 ; R7 representa un grupo alcoxi, amino o hidroxilo; R8 representa un átomo de hidrógeno o un grupo alquilo opcionalmente sustituido por uno o mas grupos hidroxi, carboxilo y/o amino alcoxi opcionalmente sustituido por uno o más grupos hidroxi, carboxilo y/o amino; fenilo opcionalmente sustituido por hasta tres sustituyentes seleccionados de halógeno, alquil C1 -C4 , alcoxi C1 -C4 amino, alquilamino, hidroxi, trifluorometil, carboxilo o metoxicarboxilo o un grupo heteroarilico o heterocíclico; R9 es el grupo R8 o el grupo NR10 R11 en donde R10 representa hidrógeno o un grupo alquilo; R11 representa un grupo alquilo opcionalmente sustituido por uno o más grupos hidroxi, carboxilo y/o amino; fenilo opcionalmente sustituido por hasta tres sustituyentes seleccionados de halógeno, alquil C1 -C4 , alcoxi C1 -C4 , amino, alquilamino, hidroxi, trifluorometil, carboxilo o metoxicarboxilo; heteroarilo, heterocíclico o cicloalquilo opcionalmente sustituido por 1 o 2 grupos alquil C1 -C4 n es cero o un entero de 1 a 4; p es un entero de 2 a 4.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9617305.9A GB9617305D0 (en) | 1996-08-17 | 1996-08-17 | Heterocyclic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4900066A1 true CO4900066A1 (es) | 2000-03-27 |
Family
ID=10798623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO97046782A CO4900066A1 (es) | 1996-08-17 | 1997-08-14 | Derivados de tetrahidroquinolina |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US6479488B1 (es) |
| EP (1) | EP0922034B1 (es) |
| JP (1) | JP4108129B2 (es) |
| KR (1) | KR100552864B1 (es) |
| CN (1) | CN1131214C (es) |
| AP (1) | AP877A (es) |
| AR (1) | AR008296A1 (es) |
| AT (1) | ATE221052T1 (es) |
| AU (1) | AU724473B2 (es) |
| BR (1) | BR9711311B1 (es) |
| CA (1) | CA2264118C (es) |
| CO (1) | CO4900066A1 (es) |
| CZ (1) | CZ296250B6 (es) |
| DE (1) | DE69714265T2 (es) |
| DK (1) | DK0922034T3 (es) |
| EA (1) | EA001704B1 (es) |
| ES (1) | ES2181030T3 (es) |
| GB (1) | GB9617305D0 (es) |
| HU (1) | HU225797B1 (es) |
| ID (1) | ID18095A (es) |
| IL (1) | IL128141A0 (es) |
| IS (1) | IS4953A (es) |
| MY (1) | MY116952A (es) |
| NO (1) | NO312241B1 (es) |
| NZ (1) | NZ333812A (es) |
| PE (1) | PE107098A1 (es) |
| PL (1) | PL194532B1 (es) |
| PT (1) | PT922034E (es) |
| SI (1) | SI0922034T1 (es) |
| TR (1) | TR199900336T2 (es) |
| TW (1) | TW449582B (es) |
| WO (1) | WO1998007704A1 (es) |
| YU (1) | YU6799A (es) |
| ZA (1) | ZA977326B (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9706294D0 (en) * | 1997-03-26 | 1997-05-14 | Glaxo Wellcome Spa | Heterocyclic compound |
| MY125037A (en) * | 1998-06-10 | 2006-07-31 | Glaxo Wellcome Spa | 1,2,3,4 tetrahydroquinoline derivatives |
| US6455734B1 (en) | 2000-08-09 | 2002-09-24 | Magnesium Diagnostics, Inc. | Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states |
| GB9929037D0 (en) * | 1999-12-08 | 2000-02-02 | Glaxo Wellcome Spa | Heterocyclic derivatives |
| DE10132725A1 (de) | 2001-07-05 | 2006-08-03 | Grünenthal GmbH | Substituierte γ-Lactonverbindungen |
| RU2292346C2 (ru) * | 2001-12-28 | 2007-01-27 | Акадиа Фармасьютикалз, Инк. | Гетероциклические мускариновые агонисты и композиции, их применение и способы лечения |
| US20050250767A1 (en) * | 2003-01-23 | 2005-11-10 | Weiner David M | Use of N-desmethylclozapine to treat human neuropsychiatric disease |
| KR20050092123A (ko) * | 2003-01-23 | 2005-09-20 | 아카디아 파마슈티칼스 인코포레이티드 | Ｎ-데스메틸클로자핀의 인간의 신경정신성 질환의 치료용도 |
| US20050085463A1 (en) * | 2003-01-23 | 2005-04-21 | Weiner David M. | Use of N-desmethylclozapine to treat human neuropsychiatric disease |
| EP1596867A4 (en) * | 2003-02-19 | 2006-03-22 | Merck & Co Inc | TREATMENT OF PSYCHOSIS WITH A MUSCARIN M1 RECEPTOR ECTOPIC ACTIVATOR |
| ES2324713T3 (es) * | 2003-12-22 | 2009-08-13 | Acadia Pharmaceuticals Inc. | Analogos de diaril(a,d)ciclohepteno amino-sustituidos como agonistas muscarinicos y metodos de tratamiento de trastornos neuropsiquiatricos. |
| JP2007536216A (ja) * | 2004-04-01 | 2007-12-13 | アカディア ファーマシューティカルズ，インコーポレーテッド | 固体ｎ−デスメチルクロザピンおよびその結晶形を合成および単離する方法 |
| RU2451014C2 (ru) * | 2005-07-22 | 2012-05-20 | Мотида Фармасьютикал Ко., Лтд. | Новое производное гетероциклиден ацетамида |
| US7910751B2 (en) | 2005-07-22 | 2011-03-22 | Mochida Pharmaceutical Co., Ltd. | Heterocyclidene acetamide derivative |
| US8480797B2 (en) | 2005-09-12 | 2013-07-09 | Abela Pharmaceuticals, Inc. | Activated carbon systems for facilitating use of dimethyl sulfoxide (DMSO) by removal of same, related compounds, or associated odors |
| US9427419B2 (en) | 2005-09-12 | 2016-08-30 | Abela Pharmaceuticals, Inc. | Compositions comprising dimethyl sulfoxide (DMSO) |
| US8435224B2 (en) | 2005-09-12 | 2013-05-07 | Abela Pharmaceuticals, Inc. | Materials for facilitating administration of dimethyl sulfoxide (DMSO) and related compounds |
| US7955418B2 (en) | 2005-09-12 | 2011-06-07 | Abela Pharmaceuticals, Inc. | Systems for removing dimethyl sulfoxide (DMSO) or related compounds or odors associated with same |
| WO2007053618A1 (en) * | 2005-10-31 | 2007-05-10 | Acadia Pharmaceuticals Inc. | Prodrugs of muscarinic agonists and methods of treatment of neuropsychiatric disorders |
| BRPI0921494A2 (pt) | 2008-11-03 | 2018-10-30 | Prad Reasearch And Development Ltd | método de planejamento de uma operação de amostragem para uma formação subterrãnea, método de contolar uma operação de amostragem de formação subterrânea, método de controlar uma operação de perfuração para uma formação subterrãnea, e método de realizar uma amostragem durante a operação de perfuração. |
| WO2011053874A1 (en) | 2009-10-30 | 2011-05-05 | Tandem Abela Development Group Llc | Dimethyl sulfoxide (dmso) and methylsulfonylmethane (msm) formulations to treat osteoarthritis |
| EP3718547A1 (en) | 2011-10-03 | 2020-10-07 | The University of Utah Research Foundation | Application of 5-ht6 receptor antagonists for the alleviation of cognitive deficits of down syndrome |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69029668T2 (de) * | 1989-03-08 | 1997-08-07 | Merck Sharp & Dohme | Tetrahydroquinolin-Derivate, verwendbar bei neurodegenerativen Krankheiten |
| DK0854867T3 (da) * | 1995-09-29 | 2002-12-02 | Glaxosmithkline Spa | Tetrahydroquinoliner som NMDA-antagonister |
-
1996
- 1996-08-17 GB GBGB9617305.9A patent/GB9617305D0/en active Pending
-
1997
- 1997-08-14 MY MYPI97003742A patent/MY116952A/en unknown
- 1997-08-14 NZ NZ333812A patent/NZ333812A/xx active Application Revival
- 1997-08-14 HU HU9903108A patent/HU225797B1/hu not_active IP Right Cessation
- 1997-08-14 CN CN97197233A patent/CN1131214C/zh not_active Expired - Fee Related
- 1997-08-14 AP APAP/P/1999/001459A patent/AP877A/en active
- 1997-08-14 ZA ZA977326A patent/ZA977326B/xx unknown
- 1997-08-14 KR KR1019997001280A patent/KR100552864B1/ko not_active Expired - Fee Related
- 1997-08-14 JP JP51037298A patent/JP4108129B2/ja not_active Expired - Fee Related
- 1997-08-14 AR ARP970103703A patent/AR008296A1/es active IP Right Grant
- 1997-08-14 DE DE69714265T patent/DE69714265T2/de not_active Expired - Lifetime
- 1997-08-14 TR TR1999/00336T patent/TR199900336T2/xx unknown
- 1997-08-14 ES ES97943809T patent/ES2181030T3/es not_active Expired - Lifetime
- 1997-08-14 IL IL12814197A patent/IL128141A0/xx not_active IP Right Cessation
- 1997-08-14 SI SI9730404T patent/SI0922034T1/xx unknown
- 1997-08-14 CO CO97046782A patent/CO4900066A1/es unknown
- 1997-08-14 AU AU45518/97A patent/AU724473B2/en not_active Ceased
- 1997-08-14 BR BRPI9711311-5A patent/BR9711311B1/pt not_active IP Right Cessation
- 1997-08-14 WO PCT/EP1997/004440 patent/WO1998007704A1/en not_active Ceased
- 1997-08-14 PE PE1997000718A patent/PE107098A1/es not_active Application Discontinuation
- 1997-08-14 US US09/147,568 patent/US6479488B1/en not_active Expired - Fee Related
- 1997-08-14 CZ CZ0052999A patent/CZ296250B6/cs not_active IP Right Cessation
- 1997-08-14 EP EP97943809A patent/EP0922034B1/en not_active Expired - Lifetime
- 1997-08-14 YU YU6799A patent/YU6799A/sh unknown
- 1997-08-14 PT PT97943809T patent/PT922034E/pt unknown
- 1997-08-14 AT AT97943809T patent/ATE221052T1/de not_active IP Right Cessation
- 1997-08-14 ID IDP972834A patent/ID18095A/id unknown
- 1997-08-14 CA CA002264118A patent/CA2264118C/en not_active Expired - Fee Related
- 1997-08-14 EA EA199900121A patent/EA001704B1/ru not_active IP Right Cessation
- 1997-08-14 DK DK97943809T patent/DK0922034T3/da active
- 1997-08-14 PL PL97331562A patent/PL194532B1/pl not_active IP Right Cessation
- 1997-08-30 TW TW086112442A patent/TW449582B/zh not_active IP Right Cessation
-
1999
- 1999-01-22 IS IS4953A patent/IS4953A/is unknown
- 1999-02-16 NO NO19990723A patent/NO312241B1/no not_active IP Right Cessation
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