HUP0000553A1 - Hattagú, nitrogéntartalmú heteroaromás karbonsavszármazékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk gyógyszerkészítmények előállítására - Google Patents
Hattagú, nitrogéntartalmú heteroaromás karbonsavszármazékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk gyógyszerkészítmények előállításáraInfo
- Publication number
- HUP0000553A1 HUP0000553A1 HU0000553A HUP0000553A HUP0000553A1 HU P0000553 A1 HUP0000553 A1 HU P0000553A1 HU 0000553 A HU0000553 A HU 0000553A HU P0000553 A HUP0000553 A HU P0000553A HU P0000553 A1 HUP0000553 A1 HU P0000553A1
- Authority
- HU
- Hungary
- Prior art keywords
- group
- optionally substituted
- general formula
- atom
- pharmaceutical compositions
- Prior art date
Links
- -1 heteroaromatic carboxylic acid derivatives Chemical class 0.000 title abstract 5
- 239000008194 pharmaceutical composition Substances 0.000 title 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 4
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000000304 alkynyl group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- 125000001624 naphthyl group Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 3
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 208000009304 Acute Kidney Injury Diseases 0.000 abstract 1
- 206010007558 Cardiac failure chronic Diseases 0.000 abstract 1
- 229940118365 Endothelin receptor antagonist Drugs 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000033626 Renal failure acute Diseases 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 201000011040 acute kidney failure Diseases 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000003302 alkenyloxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000005133 alkynyloxy group Chemical group 0.000 abstract 1
- IYABWNGZIDDRAK-UHFFFAOYSA-N allene Chemical group C=C=C IYABWNGZIDDRAK-UHFFFAOYSA-N 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 208000020832 chronic kidney disease Diseases 0.000 abstract 1
- 208000022831 chronic renal failure syndrome Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000002308 endothelin receptor antagonist Substances 0.000 abstract 1
- 125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 abstract 1
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000001434 methanylylidene group Chemical group [H]C#[*] 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/18—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
- C07D237/16—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
- C07D253/10—Condensed 1,2,4-triazines; Hydrogenated condensed 1,2,4-triazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A találmány tárgyát az új (I) általános képletű karbonsavszármazékok-, ahol R1 tetrazolil- vagy (a) általános képletű csoport; X nitrogénatom vagy metincsoport; Y nitrogénatom vagy CR9 általános képletű csoport; Z nitrogénatom vagy CR10 általános képletű csoport; R2 adott esetben szubsztituált alkil-, alkenil- vagy alkinilcsoport,hidrogén-, halogénatom, alkoxi-, halogén-alkoxi-, alkenil-oxi-,alkinil-oxi-, alkil-tio-, alkil-karbonil-, alkoxi-karbonil-csoport,mono- vagy dialkil-amino-csoport, hidroxi-, karboxi-, aminocsoport;vagy CR2 CR9-cel vagy CR10-zel együtt 5 vagy 6 tagú, adott esetbenszubsztituált alkilén- vagy alkeniléngyűrűt alkot; R3 és R4 azonosak vagy különbözők, és jelentésük adott esetbenszubsztituált fenil- vagy naftilcsoportok, vagy fenil- vagynaftilcsoportok, amelyek orto-helyzetben közvetlenül egy metilén-,etilén- vagy eteniléncsoporton, illetve oxigén- vagy szénatomon, vagySO2-, NH- vagy N-alkil-csoporton keresztül egymássalösszekapcsolódnak, adott esetben szubsztituált cikloalkilcsoportok; R5 hidrogénatom, adott esetben szubsztituált alkil-, alkenil- vagyalkinilcsoport, adott esetben szubsztituált fenil- vagy naftil-, öt-vagy hattagú heteroaromás vagy cikloalkilcsoport; R9 és R10 azonosak vagy különbözők, és jelentésük hidrogénatom,hidroxi-, amino-, mono- vagy dialkil-amino-csoport, halogénatom,alkoxi-, halogén-alkoxi- vagy alkil-tio-csoport, adott esetbenszubsztituált alkil-, alkenil-, alkinilcsoport, vagy CR9 vagy CR10CR2-vel együtt 5 vagy 6 tagú gyűrűt alkot; W kén-, oxigénatom vagy kémiai kötést kifejező vegyértékvonal; Q oxigén- vagy nitrogénatom -, valamint gyógyszerkészítményekelőállítására történő alkalmazásuk képezi. Az (I) általános képletűvegyületek endotelinreceptor-antagonista hatásúak, így többek közöttkrónikus szívelégtelenség, magas vérnyomás, akut/krónikusveseelégtelenség kezelésére alkalmazhatóak. (a) Ó
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1996152763 DE19652763A1 (de) | 1996-12-18 | 1996-12-18 | Heterozyklische Carbonsäurederivate, ihre Herstellung und Verwendung als Endothelinrezeptorantagonisten |
| DE1997100884 DE19700884A1 (de) | 1997-01-13 | 1997-01-13 | Heterozyklische Carbonsäurederivate, ihre Herstellung und Verwendung als Endothelinrezeptorantagonisten |
| PCT/EP1997/006778 WO1998027070A1 (de) | 1996-12-18 | 1997-12-04 | Heterozyklische carbonsäurederivate, ihre herstellung und verwendung als endothelinrezeptorantagonisten |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0000553A1 true HUP0000553A1 (hu) | 2001-04-28 |
| HUP0000553A3 HUP0000553A3 (en) | 2001-08-28 |
Family
ID=26032394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0000553A HUP0000553A3 (en) | 1996-12-18 | 1997-12-04 | Sixmembered nitrogencontained heteroaromatic carboxylic acid derivatives, pharmaceutical compositions containing them, and their use for producing pharmaceutical compositions |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6448248B1 (hu) |
| EP (1) | EP0946524A1 (hu) |
| JP (1) | JP2001506243A (hu) |
| KR (1) | KR20000057642A (hu) |
| CN (1) | CN1247533A (hu) |
| AR (1) | AR010359A1 (hu) |
| AU (1) | AU740351B2 (hu) |
| BG (1) | BG103502A (hu) |
| BR (1) | BR9714047A (hu) |
| CA (1) | CA2275256A1 (hu) |
| CO (1) | CO4930270A1 (hu) |
| HR (1) | HRP970686A2 (hu) |
| HU (1) | HUP0000553A3 (hu) |
| ID (1) | ID26234A (hu) |
| IL (1) | IL130251A0 (hu) |
| NO (1) | NO313519B1 (hu) |
| NZ (1) | NZ336157A (hu) |
| PL (1) | PL334014A1 (hu) |
| SK (1) | SK77799A3 (hu) |
| TR (1) | TR199901416T2 (hu) |
| WO (1) | WO1998027070A1 (hu) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ299741B6 (cs) * | 1997-09-26 | 2008-11-05 | Abbott Gmbh & Co. Kg | Kombinace endotelinového antagonisty a RAS inhibitoru a její použití, farmaceutický prostredek s jejím obsahem a zpusob výroby tohoto prostredku |
| DE19743143A1 (de) | 1997-09-30 | 1999-04-01 | Knoll Ag | Pharmazeutische Kombinationspräparate |
| HU0900792D0 (en) * | 1997-10-17 | 2010-03-01 | Ark Therapeutics Ltd | Use of renin-angiotensin inhibitors |
| DE19806438A1 (de) * | 1998-02-17 | 1999-08-19 | Basf Ag | Neue Carbonsäurederivate mit 5-substituiertem Pyrimidinring, ihre Herstellung und Verwendung |
| DE19858779A1 (de) * | 1998-12-18 | 2000-06-21 | Basf Ag | Neue ß-Amido und ß-Sulfonamidocarbonsäurederivate, ihre Herstellung und Verwendung als Endothelinrezeptorantagonisten |
| DE19924892A1 (de) * | 1999-06-01 | 2000-12-07 | Basf Ag | Neue Carbonsäurederivate mit arylsubstituierten Stickstoffheterocyclen, ihre Herstellung und Verwendung als Endothelin Rezeptorantagonisten |
| IL148841A0 (en) * | 1999-10-06 | 2002-09-12 | Basf Ag | INHIBITORS OF THE ENDOTHELIN SIGNALLING PATHWAY AND αvβ3 INTEGRIN RECEPTOR ANTAGONISTS FOR COMBINATION THERAPY |
| DE10101307A1 (de) * | 2001-01-12 | 2002-08-01 | Fumapharm Ag Muri | Fumarsäurederivate als NF-kappaB-Inhibitor |
| FI20010233A0 (fi) * | 2001-02-08 | 2001-02-08 | Orion Corp | Menetelmä sydämen vajaatoiminnan hoitoon |
| WO2003006041A1 (fr) * | 2001-07-12 | 2003-01-23 | Takeda Chemical Industries, Ltd. | Agents prophylactiques/therapeutiques contre les tumeurs malignes |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2671551B1 (fr) * | 1991-01-15 | 1993-03-12 | Adir | Nouveaux composes de structure aryl triazinique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| DE19533023B4 (de) | 1994-10-14 | 2007-05-16 | Basf Ag | Neue Carbonsäurederivate, ihre Herstellung und Verwendung |
| DE19614542A1 (de) | 1996-04-12 | 1997-10-16 | Basf Ag | Neue Carbonsäurederivate, ihre Herstellung und Verwendung |
| DE19614533A1 (de) * | 1996-04-12 | 1997-10-16 | Basf Ag | Neue alpha-Hydroxysäurederivate, ihre Herstellung und Verwendung |
| DE19614534A1 (de) * | 1996-04-12 | 1997-10-16 | Basf Ag | Neue Carbonsäurederivate, ihre Herstellung und Verwendung |
-
1997
- 1997-12-04 AU AU56594/98A patent/AU740351B2/en not_active Ceased
- 1997-12-04 TR TR1999/01416T patent/TR199901416T2/xx unknown
- 1997-12-04 BR BR9714047-3A patent/BR9714047A/pt not_active IP Right Cessation
- 1997-12-04 PL PL97334014A patent/PL334014A1/xx unknown
- 1997-12-04 IL IL13025197A patent/IL130251A0/xx unknown
- 1997-12-04 WO PCT/EP1997/006778 patent/WO1998027070A1/de not_active Ceased
- 1997-12-04 EP EP97952876A patent/EP0946524A1/de not_active Withdrawn
- 1997-12-04 ID IDW990558A patent/ID26234A/id unknown
- 1997-12-04 US US09/319,876 patent/US6448248B1/en not_active Expired - Fee Related
- 1997-12-04 NZ NZ336157A patent/NZ336157A/xx unknown
- 1997-12-04 CN CN97181869A patent/CN1247533A/zh active Pending
- 1997-12-04 CA CA002275256A patent/CA2275256A1/en not_active Abandoned
- 1997-12-04 SK SK777-99A patent/SK77799A3/sk unknown
- 1997-12-04 JP JP52724798A patent/JP2001506243A/ja active Pending
- 1997-12-04 HU HU0000553A patent/HUP0000553A3/hu unknown
- 1997-12-04 KR KR1019990705445A patent/KR20000057642A/ko not_active Withdrawn
- 1997-12-16 HR HR19700884.4A patent/HRP970686A2/hr not_active Application Discontinuation
- 1997-12-16 AR ARP970105907A patent/AR010359A1/es not_active Application Discontinuation
- 1997-12-17 CO CO97073662A patent/CO4930270A1/es unknown
-
1999
- 1999-06-17 NO NO19992976A patent/NO313519B1/no not_active IP Right Cessation
- 1999-06-18 BG BG103502A patent/BG103502A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU5659498A (en) | 1998-07-15 |
| BG103502A (en) | 2000-07-31 |
| KR20000057642A (ko) | 2000-09-25 |
| WO1998027070A1 (de) | 1998-06-25 |
| AU740351B2 (en) | 2001-11-01 |
| JP2001506243A (ja) | 2001-05-15 |
| SK77799A3 (en) | 2000-02-14 |
| AR010359A1 (es) | 2000-06-07 |
| EP0946524A1 (de) | 1999-10-06 |
| HRP970686A2 (en) | 1998-10-31 |
| NO992976L (no) | 1999-06-17 |
| CN1247533A (zh) | 2000-03-15 |
| CA2275256A1 (en) | 1998-06-25 |
| ID26234A (id) | 2000-12-07 |
| HUP0000553A3 (en) | 2001-08-28 |
| TR199901416T2 (xx) | 1999-08-23 |
| PL334014A1 (en) | 2000-01-31 |
| BR9714047A (pt) | 2000-05-09 |
| NO313519B1 (no) | 2002-10-14 |
| CO4930270A1 (es) | 2000-06-27 |
| NO992976D0 (no) | 1999-06-17 |
| IL130251A0 (en) | 2000-06-01 |
| NZ336157A (en) | 2000-10-27 |
| US6448248B1 (en) | 2002-09-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUP0000553A1 (hu) | Hattagú, nitrogéntartalmú heteroaromás karbonsavszármazékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk gyógyszerkészítmények előállítására | |
| HUP9800535A1 (hu) | Pirimidinszármazékok alkalmazása rák megelőzésére szolgáló gyógyászati készítmények előállítására | |
| TW200603736A (en) | Chemical compounds | |
| NO960630D0 (no) | Heterocykler anvendelige som neurokinin antagonister | |
| NZ331741A (en) | use of a quinazolin-4-one derivative having an (S)-configuration to treat dyskinesia associated with dopamine agonist therapy | |
| YU104690A (sh) | Supstituisani imidazo-kondenzovani 6-člani heterocikli kao antagonisti angiotenzina 2 | |
| ES2082875T3 (es) | 3,5-di-terc-butil-4-hidroxifenilmetileno-derivados de tiazolidinonas, oxazolidinonas e imidazolidinonas 2-sustituidas utiles como agentes antiinflamatorios. | |
| MX9708782A (es) | Heterociclos de 5 anillos como inhibidores de la adhesion de leucocitos y antagonistas de vla-4. | |
| MY119623A (en) | Quinoline and quinazoline compounds useful in therapy, particularly in the treatment of benign prostatic hyperplasia | |
| GEP20074144B (en) | Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function | |
| BG49275A3 (en) | Method for preparing diazobicycloalkylchinolin carbonate acids | |
| TR200402069T4 (tr) | Difenilüre türevleri ve bunların alfa 2/5-HT2c antagonisti olarak kullanılması | |
| DE69516540D1 (de) | AMINO-IMIDAZO [4,5-c] CHINOLINE | |
| HUP0004437A2 (hu) | Raf kinázt gátló hatású, szimmetrikusan és aszimmetrikusan szubsztituált difenil-karbamid-származékok és ezeket a vegyületeket tartalmazó gyógyászati készítmények | |
| TR200000025T2 (tr) | Azetidinilpropilpiperidin türevleri, ara bağlarıyla tacikinin antagonistleri olarak kullanımları. | |
| FI980471A0 (fi) | 1,3-substituoidut sykloalkeenit ja sykloalkaanit keskushermostoon vaikuttavina aineina | |
| HUP0204354A2 (hu) | Új heterociklusos vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
| TR200401716T4 (tr) | Yeni üç yerdeğiştirme gruplu fenil türevleri ve analogları | |
| TR199901381A2 (xx) | Diaza-spiro$3,5]nonan t�revleri. | |
| TW429148B (en) | Pharmaceutical agents for the treatment of acute and chronic inflammatory diseases | |
| HUP0004590A2 (hu) | Endotelin-antagonista imidazolszármazékokat és béta receptor blokkolókat tartalmazó kombinációs gyógyszerkészítmények | |
| HUP9700983A2 (hu) | 1,4-Diaril-2-fluor-2-butén-származékok, intermedierjeik, előállításuk és alkalmazásuk, valamint hatóanyagként ezeket a vegyületeket tartalmazó inszekticid és akaricid készítmények | |
| HUP0101311A1 (hu) | 3-Szubsztituált 3,4,5,7-tetrahidro-pirrolo[3',4':4,5]tieno[2,3-d]pirimidin-származékok, eljárás előállításukra és alkalmazásuk 5-HT antagonistákként | |
| MX9705649A (es) | Compuestos de fenilo substituidos como antagonistas de endotelinas. | |
| SE9701682D0 (sv) | Compounds |