FI872517A7 - Förfarande för framställning av terapeutiskt användbara makrolidföreningar - Google Patents

Förfarande för framställning av terapeutiskt användbara makrolidföreningar

Info

Publication number: FI872517A7
Authority: FI; Finland
Prior art keywords: therapeutically useful; macrolide compounds; preparing therapeutically; useful macrolide; preparing
Prior art date: 1986-06-06

Application number

FI872517A

Other languages

English (en)

Finnish (fi)

Other versions

FI872517A0 (sv

FI90663B (sv

FI90663C (sv

Inventor

Derek R Sutherland

Michael V J Ramsay

Edward P Tiley

Oswy Z Pereira

John B Ward

Neil Porter

Hazel M Noble

Richard A Fletton

David Noble

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-06-06

Filing date

1987-06-04

Publication date

1987-12-07

1986-06-06 Priority claimed from GB868613790A external-priority patent/GB8613790D0/en

1986-10-29 Priority claimed from GB868625854A external-priority patent/GB8625854D0/en

1987-04-08 Priority claimed from GB878708423A external-priority patent/GB8708423D0/en

1987-06-04 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

1987-06-04 Publication of FI872517A0 publication Critical patent/FI872517A0/sv

1987-12-07 Publication of FI872517A7 publication Critical patent/FI872517A7/sv

1992-07-30 Priority to FI923445A priority Critical patent/FI90549C/sv

1993-11-30 Publication of FI90663B publication Critical patent/FI90663B/sv

1994-03-10 Application granted granted Critical

1994-03-10 Publication of FI90663C publication Critical patent/FI90663C/sv

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N49/00—Biocides, pest repellants or attractants, or plant growth regulators, containing compounds containing the group, wherein m+n>=1, both X together may also mean —Y— or a direct carbon-to-carbon bond, and the carbon atoms marked with an asterisk are not part of any ring system other than that which may be formed by the atoms X, the carbon atoms in square brackets being part of any acyclic or cyclic structure, or the group, wherein A means a carbon atom or Y, n>=0, and not more than one of these carbon atoms being a member of the same ring system, e.g. juvenile insect hormones or mimics thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Agronomy & Crop Science (AREA)
Wood Science & Technology (AREA)
Environmental Sciences (AREA)
Dentistry (AREA)
Plant Pathology (AREA)
Pest Control & Pesticides (AREA)
Veterinary Medicine (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Insects & Arthropods (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Genetics & Genomics (AREA)
Tropical Medicine & Parasitology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

FI872517A 1986-06-06 1987-06-04 Förfarande för framställning av terapeutiskt användbara makrolidföreningar FI90663C (sv)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
FI923445A FI90549C (sv)	1986-06-06	1992-07-30	Makrolidföreningar och användning av dem vid bekämpning av skadekryp

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
GB868613790A GB8613790D0 (en)	1986-06-06	1986-06-06	Chemical compounds
GB8613790		1986-06-06
GB8625854		1986-10-29
GB868625854A GB8625854D0 (en)	1986-10-29	1986-10-29	Chemical process
GB8708423		1987-04-08
GB878708423A GB8708423D0 (en)	1987-04-08	1987-04-08	Chemical compounds

Publications (4)

Publication Number	Publication Date
FI872517A0 FI872517A0 (sv)	1987-06-04
FI872517A7 true FI872517A7 (sv)	1987-12-07
FI90663B FI90663B (sv)	1993-11-30
FI90663C FI90663C (sv)	1994-03-10

Family

ID=27263057

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
FI872517A FI90663C (sv)	1986-06-06	1987-06-04	Förfarande för framställning av terapeutiskt användbara makrolidföreningar
FI923445A FI90549C (sv)	1986-06-06	1992-07-30	Makrolidföreningar och användning av dem vid bekämpning av skadekryp

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
FI923445A FI90549C (sv)	1986-06-06	1992-07-30	Makrolidföreningar och användning av dem vid bekämpning av skadekryp

Country Status (35)

Country	Link
US (1)	US4900753A (sv)
JP (1)	JP2648147B2 (sv)
KR (1)	KR950010077B1 (sv)
CN (1)	CN1023858C (sv)
AR (1)	AR244691A1 (sv)
AT (1)	AT398571B (sv)
AU (1)	AU609399B2 (sv)
BE (1)	BE1000201A4 (sv)
BR (1)	BR8702866A (sv)
CA (1)	CA1296329C (sv)
CH (1)	CH677670A5 (sv)
DE (3)	DE3745133C2 (sv)
DK (1)	DK166498B1 (sv)
EG (1)	EG18752A (sv)
ES (1)	ES2006479A6 (sv)
FI (2)	FI90663C (sv)
FR (1)	FR2599742B1 (sv)
GB (1)	GB2192630B (sv)
GE (1)	GEP19981388B (sv)
GR (1)	GR870891B (sv)
HU (1)	HU199847B (sv)
IE (1)	IE60411B1 (sv)
IL (1)	IL82776A (sv)
IT (1)	IT1206015B (sv)
LU (2)	LU86908A1 (sv)
LV (2)	LV10280A (sv)
NL (2)	NL193376C (sv)
NZ (1)	NZ220587A (sv)
OA (1)	OA08606A (sv)
PH (1)	PH23948A (sv)
PL (3)	PL155723B1 (sv)
PT (1)	PT85018B (sv)
SE (1)	SE503399C2 (sv)
TR (1)	TR28970A (sv)
UA (1)	UA45300C2 (sv)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3750355T2 (de) *	1986-09-12	1995-04-06	American Cyanamid Co	23-Oxo(keto) und 23-Imino-Derivate von LL-F28249-Verbindungen.
US4886828A (en) *	1986-09-12	1989-12-12	American Cyanamid Company	Δ22 -derivatives of LL-F28249 compounds
EP0260537A1 (en) *	1986-09-12	1988-03-23	American Cyanamid Company	13-Deoxy-23-oxo(keto) and 23-imino derivatives of 13-deoxy C-076-aglycone compounds
GB8721377D0 (en) *	1987-09-11	1987-10-21	Glaxo Group Ltd	Chemical compounds
GB8811036D0 (en) *	1988-05-10	1988-06-15	Glaxo Group Ltd	Chemical compounds
GB8813150D0 (en) *	1988-06-03	1988-07-06	American Cyanamid Co	Chemical compounds
GB8905605D0 (en) *	1989-03-11	1989-04-26	Beecham Group Plc	Novel compounds
NZ233680A (en) *	1989-05-17	1995-02-24	Beecham Group Plc	Avermectins and milbemycins and compositions thereof
US4988824A (en) *	1989-09-11	1991-01-29	Maulding Donald R	Process for the preparation of 23-(C1-C6 alkyloxime)-LL-F28249 compounds
EP0561990B1 (en) *	1990-12-07	1998-10-07	Temple University	Stabilized insect nematode compositions
JP2855181B2 (ja)	1993-12-10	1999-02-10	敏雄鈴木	松類の枯損防止用組成物及び防止方法
DK1197215T3 (da)	2000-10-10	2006-07-10	Wyeth Corp	Anthelmintiske sammensætninger
US7348417B2 (en)	2003-08-07	2008-03-25	Wyeth	Method of purifying moxidectin through crystallization
WO2006119174A1 (en) *	2005-04-30	2006-11-09	Ocular Surface Center, P.A.	Method for treating ocular demodex
JP4939025B2 (ja) *	2005-09-30	2012-05-23	三菱電線工業株式会社	電熱ヒータ付きハンドル用グリップ部材
EP1849363A1 (en) *	2006-03-09	2007-10-31	Cheminova A/S	Synergistic combination of glutamate- and GABA-gated chloride agonist pesticide and at least one of Vitamin E or Niacin
US8128968B2 (en) *	2007-08-29	2012-03-06	Tissuetech, Inc.	Compositions and methods for treating Demodex infestations
PT3351546T (pt) *	2011-12-02	2024-03-07	Boehringer Ingelheim Vetmedica Gmbh	Formulações injectáveis de moxidectina com ação prolongada
FR2995605B1 (fr) *	2012-09-18	2014-09-19	Sanofi Sa	Derives de macrolides, leur preparation et leur application therapeutique.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PH15982A (en) *	1977-10-03	1983-05-18	Merck & Co Inc	Selective hydrogenation producta of c-076 compounds and derivatives thereof
US4289760A (en) *	1980-05-02	1981-09-15	Merck & Co., Inc.	23-Keto derivatives of C-076 compounds
US4423209A (en) *	1982-02-26	1983-12-27	Merck & Co., Inc.	Processes for the interconversion of avermectin compounds
JPS59108785A (ja) *	1982-11-25	1984-06-23	Sankyo Co Ltd	ミルベマイシン類の５−オキシム誘導体
JPS60126289A (ja) *	1983-11-14	1985-07-05	Sankyo Co Ltd	ミルベマイシン類の５−カ−ボネ−ト誘導体
DK165119C (da) *	1984-06-05	1993-03-01	American Cyanamid Co	Antibiotiske forbindelser betegnet ll-f28249alfa, beta, gamma, delta, epsilon, zeta, eta, theta, iota, kappa, my og ny og pharmaceutisk or pharmakologisk acceptable salte deraf samt fremgangsmaade til deres fremstilling
US4579864A (en) *	1984-06-11	1986-04-01	Merck & Co., Inc.	Avermectin and milbemycin 13-keto, 13-imino and 13-amino derivatives
CH666690A5 (de) *	1984-09-14	1988-08-15	Glaxo Group Ltd	Antibiotisch wirkende verbindungen der makrolidgruppe aus streptomyces-mikroorganismen, ihre herstellung und verwendung.
ES8802229A1 (es) *	1985-04-30	1988-04-16	Glaxo Group Ltd	Un procedimiento para preparar nuevos derivados lactonicos macrociclicos.
DE3750355T2 (de) *	1986-09-12	1995-04-06	American Cyanamid Co	23-Oxo(keto) und 23-Imino-Derivate von LL-F28249-Verbindungen.

1987
- 1987-05-26 CA CA000537979A patent/CA1296329C/en not_active Expired - Lifetime
- 1987-06-02 OA OA59131A patent/OA08606A/xx unknown
- 1987-06-04 FI FI872517A patent/FI90663C/sv not_active IP Right Cessation
- 1987-06-04 DK DK290287A patent/DK166498B1/da not_active IP Right Cessation
- 1987-06-04 EG EG32487A patent/EG18752A/xx active
- 1987-06-04 ES ES8701645A patent/ES2006479A6/es not_active Expired
- 1987-06-05 AU AU73873/87A patent/AU609399B2/en not_active Expired
- 1987-06-05 PL PL1987282198A patent/PL155723B1/pl unknown
- 1987-06-05 AR AR87307796A patent/AR244691A1/es active
- 1987-06-05 JP JP62140139A patent/JP2648147B2/ja not_active Expired - Lifetime
- 1987-06-05 CH CH2150/87A patent/CH677670A5/de not_active IP Right Cessation
- 1987-06-05 BE BE8700626A patent/BE1000201A4/fr not_active IP Right Cessation
- 1987-06-05 SE SE8702361A patent/SE503399C2/sv not_active IP Right Cessation
- 1987-06-05 TR TR00392/87A patent/TR28970A/xx unknown
- 1987-06-05 DE DE3745133A patent/DE3745133C2/de not_active Expired - Lifetime
- 1987-06-05 DE DE3718926A patent/DE3718926C2/de not_active Expired - Lifetime
- 1987-06-05 PL PL1987266100A patent/PL153226B1/pl unknown
- 1987-06-05 KR KR1019870005694A patent/KR950010077B1/ko not_active Expired - Lifetime
- 1987-06-05 NZ NZ220587A patent/NZ220587A/xx unknown
- 1987-06-05 LU LU86908A patent/LU86908A1/fr active Protection Beyond IP Right Term
- 1987-06-05 CN CN87104431A patent/CN1023858C/zh not_active Expired - Lifetime
- 1987-06-05 DE DE1998175029 patent/DE19875029I2/de active Active
- 1987-06-05 NL NL8701322A patent/NL193376C/nl not_active IP Right Cessation
- 1987-06-05 PH PH35347A patent/PH23948A/en unknown
- 1987-06-05 AT AT0143887A patent/AT398571B/de not_active IP Right Cessation
- 1987-06-05 IL IL82776A patent/IL82776A/xx not_active IP Right Cessation
- 1987-06-05 IT IT8748023A patent/IT1206015B/it active
- 1987-06-05 GR GR870891A patent/GR870891B/el unknown
- 1987-06-05 IE IE149687A patent/IE60411B1/en not_active IP Right Cessation
- 1987-06-05 PT PT85018A patent/PT85018B/pt unknown
- 1987-06-05 PL PL1987283187A patent/PL153036B1/pl unknown
- 1987-06-05 HU HU872583A patent/HU199847B/hu unknown
- 1987-06-05 GB GB8713239A patent/GB2192630B/en not_active Expired - Lifetime
- 1987-06-05 FR FR878707915A patent/FR2599742B1/fr not_active Expired
- 1987-06-05 BR BR8702866A patent/BR8702866A/pt not_active IP Right Cessation
- 1987-06-05 US US07/058,856 patent/US4900753A/en not_active Expired - Lifetime
1992
- 1992-07-30 FI FI923445A patent/FI90549C/sv not_active IP Right Cessation
- 1992-12-30 LV LV920561A patent/LV10280A/xx unknown
1993
- 1993-08-25 GE GEAP19931498A patent/GEP19981388B/en unknown
- 1993-09-15 UA UA93003885A patent/UA45300C2/uk unknown
- 1993-11-15 LV LVP-93-1233A patent/LV10781B/lv unknown
1996
- 1996-07-17 LU LU88790C patent/LU88790I2/fr unknown
1999
- 1999-08-18 NL NL990026C patent/NL990026I2/nl unknown

Also Published As

Publication number	Publication date
NL193376C (nl)	1999-08-03
DE3718926A1 (de)	1987-12-10
FI90549B (sv)	1993-11-15
SE503399C2 (sv)	1996-06-10
NL990026I2 (nl)	1999-12-01
TR28970A (tr)	1997-07-21
SE8702361L (sv)	1987-12-07
GB8713239D0 (en)	1987-07-08
HUT44254A (en)	1988-02-29
PT85018B (pt)	1990-03-08
FR2599742B1 (fr)	1989-05-19
IE60411B1 (en)	1994-07-13
AU609399B2 (en)	1991-05-02
LU86908A1 (fr)	1988-01-20
GEP19981388B (en)	1998-11-10
DE3718926C2 (de)	1998-01-15
NL8701322A (nl)	1988-01-04
FI923445L (sv)	1992-07-30
JPS6354375A (ja)	1988-03-08
PL153036B1 (en)	1991-02-28
UA45300C2 (uk)	2002-04-15
PH23948A (en)	1990-01-23
DE19875029I2 (de)	2001-11-22
AR244691A1 (es)	1993-11-30
SE8702361D0 (sv)	1987-06-05
JP2648147B2 (ja)	1997-08-27
HU199847B (en)	1990-03-28
LV10781B (en)	1996-10-20
ATA143887A (de)	1994-05-15
PT85018A (en)	1987-07-01
CA1296329C (en)	1992-02-25
IE871496L (en)	1987-12-06
IL82776A (en)	1992-02-16
PL153226B1 (en)	1991-03-29
PL266100A1 (en)	1988-07-21
FI923445A0 (sv)	1992-07-30
DK290287D0 (da)	1987-06-04
FI90549C (sv)	1994-02-25
KR880000441A (ko)	1988-03-25
NL193376B (nl)	1999-04-01
CN1023858C (zh)	1994-02-23
FI872517A0 (sv)	1987-06-04
US4900753A (en)	1990-02-13
BR8702866A (pt)	1988-03-01
ES2006479A6 (es)	1989-05-01
OA08606A (en)	1988-11-30
LV10781A (lv)	1995-08-20
LV10280A (lv)	1994-10-20
KR950010077B1 (ko)	1995-09-06
AT398571B (de)	1994-12-27
FI90663B (sv)	1993-11-30
PL155723B1 (en)	1991-12-31
GB2192630A (en)	1988-01-20
IL82776A0 (en)	1987-12-20
BE1000201A4 (fr)	1988-08-23
DE3745133C2 (de)	1998-01-02
IT8748023A0 (it)	1987-06-05
DK290287A (da)	1987-12-07
AU7387387A (en)	1987-12-10
NL990026I1 (nl)	1999-11-01
NZ220587A (en)	1990-05-28
IT1206015B (it)	1989-04-05
CH677670A5 (sv)	1991-06-14
CN87104431A (zh)	1987-12-30
GB2192630B (en)	1990-05-23
GR870891B (en)	1987-10-02
FR2599742A1 (fr)	1987-12-11
FI90663C (sv)	1994-03-10
DK166498B1 (da)	1993-06-01
EG18752A (en)	1993-12-30
LU88790I2 (fr)	1997-03-18

Publication	Publication Date	Title
FI872785A7 (sv)	1987-12-24	Förfarande för framställning av terapeutiskt användbara triazolföreningar
FI870903L (sv)	1987-09-08	Förfarande för framställning av terapeutiskt aktiva med alfa-heterocykler substituerade tolunitriler
FI885409A7 (sv)	1989-05-24	Förfarande för framställning av nya terapeutiskt användbara pyridazinaminderivat
FI854797A7 (sv)	1986-06-22	Förfarande för framställning av terapeutiskt användbara oxetanoner
FI900087L (sv)	1990-01-08	Förfarande för framställning av azitromycindihydrat
PT86866A (pt)	1988-03-01	Process for preparing piperazinyl-heterocyclic compounds
FI883064A7 (sv)	1988-12-25	Förfarande för framställning av terapeutiskt användbara heterocykliska föreningar
FI881180L (sv)	1988-09-14	Förfarande för framställning av terapeutiskt användbara tetrahydronaftalenderivat
FI872517A7 (sv)	1987-12-07	Förfarande för framställning av terapeutiskt användbara makrolidföreningar
FI890286A0 (sv)	1989-01-19	Förfarande för framställning av terapeutiskt användbara dideoxikarbocykliska nukleosidanaloger
FI892185L (sv)	1989-05-05	Förfarande för framställning av terapeutiskt användbara peptidföreningar
FI880467A7 (sv)	1988-08-05	Förfarande för framställning av terapeutiskt användbara substituerade 3,4-dihydro-2H-benzopyraner
FI883672A7 (sv)	1989-02-08	Förfarande för framställning av terapeutiskt användbara aminoalkoxifenylderivat
FI871670L (sv)	1988-02-06	Förfarande för produktion av en ossein-hydroxiapatitförening
FI890123L (sv)	1989-07-15	Förfarande för framställning av terapeutiskt verksamma indolylpiperidinderivat
FI875371A7 (sv)	1988-06-19	Förfarande för framställning av (+)-biotin
FI881525A7 (sv)	1988-10-02	Förfarande för framställning av nya terapeutiskt användbara N-arylpiperazinacetamidderivat
FI885560A7 (sv)	1988-11-30	Förfarande för framställning av nya terapeutiskt användbara bisfenylalkylpiperazinderivat
FI893003L (sv)	1989-12-21	Förfarande för framställning av terapeutiskt användbara neplanocinderivat
FI880716A7 (sv)	1988-08-18	Förfarande för framställning av terapeutiskt användbara arylpiperazinylalkylenfenylsubstituerade heterocykliska föreningar
FI880468A7 (sv)	1988-08-05	Förfarande för framställning av terapeutiskt användbara N-bensopyranyllaktamer
FI891144L (sv)	1989-09-10	Förfarande för framställning av nya terapeutiskt användbara saltföreningar
FI911420L (sv)	1991-09-27	Förfarande för framställning av terapeutiskt användbara föreningar
FI880103L (sv)	1988-01-11	Förfarande för framställning av terapeutiskt aktiv sialosylkolesterol
FI870373L (sv)	1987-07-29	Förfarande för framställning av som läkemedel användbara dihydrotianaftalenföreningar

Legal Events

Date	Code	Title	Description
1993-11-01	BB	Publication of examined application
2001-06-20	SPCG	Supplementary protection certificate granted	Spc suppl protection certif: L124 Extension date: 20091229
2004-08-31	FG	Patent granted	Owner name: WYETH HOLDINGS CORPORATION
2007-07-04	MA	Patent expired