FI854797A7 - Förfarande för framställning av terapeutiskt användbara oxetanoner - Google Patents
Förfarande för framställning av terapeutiskt användbara oxetanonerInfo
- Publication number
- FI854797A7 FI854797A7 FI854797A FI854797A FI854797A7 FI 854797 A7 FI854797 A7 FI 854797A7 FI 854797 A FI854797 A FI 854797A FI 854797 A FI854797 A FI 854797A FI 854797 A7 FI854797 A7 FI 854797A7
- Authority
- FI
- Finland
- Prior art keywords
- oxetanones
- therapeutically useful
- preparing therapeutically
- preparing
- useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
- C07D305/12—Beta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Polyesters Or Polycarbonates (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH610284 | 1984-12-21 | ||
| CH610284 | 1984-12-21 | ||
| CH393485 | 1985-09-12 | ||
| CH393485 | 1985-09-12 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI854797A0 FI854797A0 (sv) | 1985-12-04 |
| FI854797A7 true FI854797A7 (sv) | 1986-06-22 |
| FI91403B FI91403B (sv) | 1994-03-15 |
| FI91403C FI91403C (sv) | 1994-06-27 |
Family
ID=25694219
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI854797A FI91403C (sv) | 1984-12-21 | 1985-12-04 | Förfarande för framställning av terapeutiskt användbara oxetanoner |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US4931463A (sv) |
| EP (1) | EP0185359B1 (sv) |
| CN (1) | CN1012643B (sv) |
| AT (1) | ATE70061T1 (sv) |
| AU (1) | AU583569B2 (sv) |
| CA (1) | CA1270837A (sv) |
| CS (1) | CS262425B2 (sv) |
| DE (1) | DE3584829D1 (sv) |
| DK (1) | DK166724B1 (sv) |
| DO (1) | DOP1985004386A (sv) |
| FI (1) | FI91403C (sv) |
| HU (1) | HU200172B (sv) |
| IE (1) | IE58926B1 (sv) |
| IL (1) | IL77338A (sv) |
| MC (1) | MC1728A1 (sv) |
| NO (1) | NO171160C (sv) |
| NZ (1) | NZ214565A (sv) |
| PH (1) | PH26291A (sv) |
| PT (1) | PT81748B (sv) |
| ZW (1) | ZW20385A1 (sv) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1328881C (en) * | 1984-12-21 | 1994-04-26 | Pierre Barbier | Process for the manufacture of oxetanones |
| US5246960A (en) * | 1984-12-21 | 1993-09-21 | Hoffmann-La Roche Inc. | Oxetanones |
| US4895973A (en) * | 1986-08-14 | 1990-01-23 | G. D. Searle & Company | Substituted glutaric acid lactones in the treatment of hyperlipidemia |
| US4806564A (en) * | 1987-05-26 | 1989-02-21 | Merck & Co., Inc. | Antihypercholesterolemic beta-lactones |
| US4816477A (en) * | 1987-05-26 | 1989-03-28 | Merck & Co., Inc. | Antihypercholesterolemic β-lactones |
| CA2035972C (en) * | 1990-02-23 | 2006-07-11 | Martin Karpf | Process for the preparation of oxetanones |
| US5260310A (en) * | 1990-02-26 | 1993-11-09 | Hoffmann-La Roche Inc. | Oxetanone compounds and pharmaceutical compositions containing them |
| CA2098167C (en) * | 1992-06-24 | 2006-12-19 | Dorothea Isler | Foodstuffs and feedstuffs containing a lipase inhibitor |
| YU34199A (sh) * | 1997-02-05 | 2002-08-12 | F. Hoffmann-La Roche Ag. | Primena inhibitora gastrointestinalne lipaze |
| UA72439C2 (en) * | 1997-04-15 | 2005-03-15 | Pharmaceutical compositions containing appetite suppressant agent | |
| GB2355657B (en) * | 1999-10-27 | 2004-07-28 | Phytopharm Plc | Inhibitors Of Gastric Acid Secretion |
| AU1238101A (en) * | 1999-10-29 | 2001-05-14 | John Jason Gentry Mullins | Oxetanone derivatives |
| EP1132389A1 (en) | 2000-03-06 | 2001-09-12 | Vernalis Research Limited | New aza-indolyl derivatives for the treatment of obesity |
| GB2363985B (en) * | 2000-06-30 | 2004-09-29 | Phytopharm Plc | Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use |
| KR100556324B1 (ko) | 2000-07-28 | 2006-03-03 | 에프. 호프만-라 로슈 아게 | 리파제 억제제 및 담즙산 격리제를 포함하는 약학 조성물 |
| JP4727901B2 (ja) | 2000-08-09 | 2011-07-20 | エフ．ホフマン−ラ ロシュ アーゲー | リパーゼ阻害物質の使用 |
| US6900226B2 (en) | 2000-09-06 | 2005-05-31 | Hoffman-La Roche Inc. | Neuropeptide Y antagonists |
| CA2422698C (en) | 2000-10-16 | 2009-12-15 | F. Hoffmann-La Roche Ag | Indoline derivatives and their use as 5-ht2 receptor ligands |
| US6392061B1 (en) * | 2000-10-16 | 2002-05-21 | Zpro Chemical, Inc. | Process for making (2S, 3S, 5S) oxetanone derivatives |
| GB0030710D0 (en) | 2000-12-15 | 2001-01-31 | Hoffmann La Roche | Piperazine derivatives |
| ATE369368T1 (de) | 2000-12-27 | 2007-08-15 | Hoffmann La Roche | Indolderivate und deren verwendung als 5-ht2b- und 5-ht2c-rezeptorliganden |
| GB0106177D0 (en) | 2001-03-13 | 2001-05-02 | Hoffmann La Roche | Piperazine derivatives |
| KR100621287B1 (ko) | 2001-05-21 | 2006-09-13 | 에프. 호프만-라 로슈 아게 | 신경 펩타이드 ｙ 수용체에 대한 리간드로서의 퀴놀린유도체 |
| US6730319B2 (en) | 2001-06-06 | 2004-05-04 | Hoffmann-La Roche Inc. | Pharmaceutical compositions having depressed melting points |
| US20030027786A1 (en) | 2001-06-06 | 2003-02-06 | Karsten Maeder | Lipase inhibiting composition |
| US6787558B2 (en) | 2001-09-28 | 2004-09-07 | Hoffmann-La Roche Inc. | Quinoline derivatives |
| GB0202015D0 (en) | 2002-01-29 | 2002-03-13 | Hoffmann La Roche | Piperazine Derivatives |
| PL372295A1 (en) | 2002-02-04 | 2005-07-11 | F.Hoffmann-La Roche Ag | Quinoline derivatives as npy antagonists |
| JP2005526732A (ja) | 2002-02-28 | 2005-09-08 | エフ．ホフマン−ラ ロシュ アーゲー | Ｎｐｙ受容体拮抗剤としてのチアゾール誘導体 |
| WO2003088975A1 (en) * | 2002-04-17 | 2003-10-30 | The Burnham Institute | Inhibition of fatty acid synthase by beta-lactones and other compounds for inhibition of cellular proliferation |
| US7728153B2 (en) | 2002-04-17 | 2010-06-01 | The Burnham Institute For Medical Research | Method for the asymmetric synthesis of beta-lactone compounds |
| BR0312461A (pt) | 2002-07-05 | 2005-04-26 | Hoffmann La Roche | Compostos, processo para a preparação de um composto, composição farmacêutica que compreende o mesmo, sua utilização e métodos para tratamento e profilaxia |
| AU2003253364B2 (en) | 2002-08-07 | 2007-06-07 | F. Hoffmann-La Roche Ag | Thiazole derivatives |
| DK1539746T3 (da) | 2002-09-12 | 2007-03-26 | Hoffmann La Roche | N-substituerede 1H-indol-5-propionsyre-forbindelser som PPAR-agonister der er nyttige til behandling af diabetes |
| US6727277B1 (en) | 2002-11-12 | 2004-04-27 | Kansas State University Research Foundation | Compounds affecting cholesterol absorption |
| ATE405560T1 (de) | 2002-11-25 | 2008-09-15 | Hoffmann La Roche | Indolderivaten |
| GB0314967D0 (en) | 2003-06-26 | 2003-07-30 | Hoffmann La Roche | Piperazine derivatives |
| WO2005005403A2 (en) * | 2003-07-15 | 2005-01-20 | Ranbaxy Laboratories Limited | Process for preparation of oxetan-2-ones |
| BRPI0413500A (pt) | 2003-08-12 | 2006-10-10 | Hoffmann La Roche | compostos, processos para a sua preparação, composição farmacêutica que compreende os mesmos, utilização de um composto, métodos para o tratamento e profilaxia de artrite, diabetes, distúrbios alimentares e obesidade |
| KR20060037436A (ko) | 2003-08-12 | 2006-05-03 | 에프. 호프만-라 로슈 아게 | Ｎｐｙ 길항물질로서 싸이아졸 유도체 |
| US7074822B2 (en) * | 2004-02-23 | 2006-07-11 | Solvay Pharmaceuticals Gmbh | Alkyl carbamate-substituted β-lactones, process for their preparation, and pharmaceutical compositions containing them |
| DE102004009076A1 (de) * | 2004-02-23 | 2005-10-27 | Solvay Pharmaceuticals Gmbh | Alkylcarbamat-substituierte β-Lactone, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US7121355B2 (en) * | 2004-09-21 | 2006-10-17 | Cnh America Llc | Bulldozer autograding system |
| WO2006035296A1 (en) * | 2004-09-27 | 2006-04-06 | Ranbaxy Laboratories Limited | Process for the preparation of an orlistat derivative useful as reference standard in the determination of the purity of orlistat and process for the preparation of orlistat |
| EP1888585B1 (en) | 2005-05-03 | 2011-06-29 | F. Hoffmann-La Roche AG | Tetracyclic azapyrazinoindolines as 5-ht2 ligands |
| WO2007020213A2 (en) | 2005-08-18 | 2007-02-22 | F. Hoffmann-La Roche Ag | Thiazolyl piperidine derivatives useful as h3 receptor modulators |
| US20090171104A1 (en) * | 2005-10-05 | 2009-07-02 | Killol Patel | Process for the preparation of orlistat |
| CA2630270A1 (en) | 2005-11-30 | 2007-06-07 | F. Hoffmann-La Roche Ag | 5-substituted indole-2-carboxamide derivatives |
| BRPI0619268A2 (pt) | 2005-11-30 | 2011-09-20 | Hoffmann La Roche | compostos, processo para a sua manufatura, composições farmacêuticas, método para o tratamento e/ou prevenção de enfermidades que estão associadas com a modulação de receptores de h3, uso dos compostos e método para o tratamento ou prevenção de obesidade e de diabetes do tipo ii em um ser humano ou animal |
| CN101316838B (zh) | 2005-11-30 | 2013-01-30 | 霍夫曼-拉罗奇有限公司 | 用作h3调节剂的1,1-二氧代-硫代吗啉基吲哚基甲酮衍生物 |
| CA2631128A1 (en) | 2005-12-09 | 2007-06-14 | F. Hoffmann-La Roche Ag | Tricyclic amide derivatives useful for treating obesity |
| AU2006326135A1 (en) | 2005-12-15 | 2007-06-21 | F. Hoffmann-La Roche Ag | Pyrrolo[2,3-c]pyridine derivatives |
| US7351708B2 (en) | 2005-12-16 | 2008-04-01 | Hoffmann-La Roche Inc. | Pyrrolo [2,3-b] pyridine derivatives |
| BRPI0707916A2 (pt) * | 2006-01-13 | 2011-05-17 | Hoffmann La Roche | compostos, processo para a sua manufatura, composições farmacêuticas que os compreendem e uso destes compostos |
| ES2349160T3 (es) * | 2006-01-23 | 2010-12-28 | F. Hoffmann-La Roche Ag | Derivados de la ciclohexil sulfonamida con actividad frente a los receptores h3. |
| US7432255B2 (en) | 2006-05-16 | 2008-10-07 | Hoffmann-La Roche Inc. | 1H-indol-5-yl-piperazin-1-yl-methanone derivatives |
| US7902184B2 (en) * | 2006-05-30 | 2011-03-08 | Hoffmann-La Roche Inc. | Piperazinyl pyrimidine derivatives |
| US7514433B2 (en) | 2006-08-03 | 2009-04-07 | Hoffmann-La Roche Inc. | 1H-indole-6-yl-piperazin-1-yl-methanone derivatives |
| US20080146559A1 (en) | 2006-12-08 | 2008-06-19 | Li Chen | 4,5,6,7-Tetrahydro-Thieno [2,3-C] Pyridine Derivatives |
| EP2164839A2 (en) * | 2007-06-06 | 2010-03-24 | Ranbaxy Laboratories Limited | Process for the preparation of orlistat |
| BRPI0814532A2 (pt) | 2007-07-25 | 2015-01-27 | Hoffmann La Roche | Compostos, processo para a sua manufatura, composições farmacêuticas que os compreendem, método para o tratamento e/ou prevenção de enfermidades que estão associadas com a modulação dos receptores de h3, e uso desses compostos para a preparação de medicamentos. |
| WO2009059046A1 (en) * | 2007-10-31 | 2009-05-07 | Burnham Institute For Medical Research | Beta-lactone compounds |
| WO2010112569A1 (en) | 2009-03-31 | 2010-10-07 | Robert Zimmermann | Modulation of adipose triglyceride lipase for prevention and treatment of cachexia, loss of weight and muscle atrophy and methods of screening therefor |
| EP2414830A2 (en) | 2009-03-31 | 2012-02-08 | Robert Zimmermann | Modulation of adipose triglyceride lipase for prevention and treatment of cachexia, loss of weight and muscle atrophy and methods of screening therefor |
| WO2011140296A1 (en) | 2010-05-05 | 2011-11-10 | Infinity Pharmaceuticals | Triazoles as inhibitors of fatty acid synthase |
| WO2011140190A1 (en) | 2010-05-05 | 2011-11-10 | Infinity Pharmaceuticals | Tetrazolones as inhibitors of fatty acid synthase |
| BR112020000635B1 (pt) | 2017-07-12 | 2023-04-18 | Mayo Foundation For Medical Education And Research | Inibidores de lipases, seus usos e composição farmacêutica |
| CN112079821A (zh) * | 2020-09-14 | 2020-12-15 | 中山万汉制药有限公司 | 奥利司他与苯氨基嘧啶类化合物形成的缀合物及其制备方法与用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2478388A (en) * | 1945-09-28 | 1949-08-09 | Eastman Kodak Co | beta-lactones from unsaturated aldehydes and unsaturated ketones |
| JPS608117B2 (ja) * | 1977-02-08 | 1985-02-28 | 財団法人微生物化学研究会 | 新生理活性物質エステラスチンおよびその製造法 |
| GB2023604B (en) * | 1978-05-25 | 1982-07-28 | Microbial Chem Res Found | Physiologically active derivatives of esterastin and production thereof |
| JPS56128774A (en) * | 1980-03-14 | 1981-10-08 | Microbial Chem Res Found | New physiologically active substance ebelactone and its preparation |
| CA1247547A (en) * | 1983-06-22 | 1988-12-28 | Paul Hadvary | Leucine derivatives |
-
1985
- 1985-11-12 CA CA000495058A patent/CA1270837A/en not_active Expired - Lifetime
- 1985-11-15 ZW ZW203/85A patent/ZW20385A1/xx unknown
- 1985-12-04 FI FI854797A patent/FI91403C/sv not_active IP Right Cessation
- 1985-12-09 CS CS859016A patent/CS262425B2/cs not_active IP Right Cessation
- 1985-12-16 NZ NZ214565A patent/NZ214565A/xx unknown
- 1985-12-16 IL IL77338A patent/IL77338A/xx not_active IP Right Cessation
- 1985-12-16 AU AU51259/85A patent/AU583569B2/en not_active Expired
- 1985-12-17 EP EP85116096A patent/EP0185359B1/de not_active Expired - Lifetime
- 1985-12-17 DE DE8585116096T patent/DE3584829D1/de not_active Expired - Lifetime
- 1985-12-17 AT AT85116096T patent/ATE70061T1/de not_active IP Right Cessation
- 1985-12-18 PH PH33205A patent/PH26291A/en unknown
- 1985-12-18 HU HU854832A patent/HU200172B/hu unknown
- 1985-12-18 MC MC851814A patent/MC1728A1/fr unknown
- 1985-12-19 CN CN85108888A patent/CN1012643B/zh not_active Expired
- 1985-12-20 NO NO855213A patent/NO171160C/no not_active IP Right Cessation
- 1985-12-20 PT PT81748A patent/PT81748B/pt unknown
- 1985-12-20 DK DK600385A patent/DK166724B1/da not_active IP Right Cessation
- 1985-12-20 IE IE327785A patent/IE58926B1/en not_active IP Right Cessation
- 1985-12-30 DO DO1985004386A patent/DOP1985004386A/es unknown
-
1987
- 1987-12-17 US US07/134,322 patent/US4931463A/en not_active Expired - Lifetime
-
1990
- 1990-03-19 US US07/495,809 patent/US5175186A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| NO855213L (no) | 1986-06-23 |
| EP0185359A3 (en) | 1987-08-26 |
| IL77338A (en) | 1991-04-15 |
| CN85108888A (zh) | 1986-07-09 |
| CS262425B2 (en) | 1989-03-14 |
| PH26291A (en) | 1992-04-10 |
| PT81748A (en) | 1986-01-02 |
| DK600385D0 (da) | 1985-12-20 |
| AU5125985A (en) | 1986-06-26 |
| FI91403C (sv) | 1994-06-27 |
| FI854797A0 (sv) | 1985-12-04 |
| ATE70061T1 (de) | 1991-12-15 |
| DK600385A (da) | 1986-06-22 |
| ZW20385A1 (en) | 1986-03-05 |
| NZ214565A (en) | 1989-06-28 |
| IE853277L (en) | 1986-06-21 |
| MC1728A1 (fr) | 1986-12-15 |
| US4931463A (en) | 1990-06-05 |
| FI91403B (sv) | 1994-03-15 |
| NO171160C (no) | 1993-02-03 |
| HUT39440A (en) | 1986-09-29 |
| EP0185359A2 (de) | 1986-06-25 |
| EP0185359B1 (de) | 1991-12-04 |
| DOP1985004386A (es) | 1991-04-20 |
| CA1270837A (en) | 1990-06-26 |
| HU200172B (en) | 1990-04-28 |
| IE58926B1 (en) | 1993-12-01 |
| NO171160B (no) | 1992-10-26 |
| AU583569B2 (en) | 1989-05-04 |
| DE3584829D1 (de) | 1992-01-16 |
| PT81748B (pt) | 1988-07-29 |
| US5175186A (en) | 1992-12-29 |
| CN1012643B (zh) | 1991-05-22 |
| DK166724B1 (da) | 1993-07-05 |
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