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ES8502440A1 - Procedimiento para preparar acepinoindoles. - Google Patents

Procedimiento para preparar acepinoindoles.

Info

Publication number
ES8502440A1
ES8502440A1 ES522008A ES522008A ES8502440A1 ES 8502440 A1 ES8502440 A1 ES 8502440A1 ES 522008 A ES522008 A ES 522008A ES 522008 A ES522008 A ES 522008A ES 8502440 A1 ES8502440 A1 ES 8502440A1
Authority
ES
Spain
Prior art keywords
compound
formula
procedure
alky
acepine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES522008A
Other languages
English (en)
Other versions
ES522008A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES8502440A1 publication Critical patent/ES8502440A1/es
Publication of ES522008A0 publication Critical patent/ES522008A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR ACEPINOINDOLES.CONSISTE EN: A) TRATAR UN COMPUESTO DE FORMULA (II) CON UNA FUENTE DE ION HIDRUROS, PARA DAR UN COMPUESTO DE FORMULA (III); Y B) INTRODUCIR EL COMPUESTO DE FORMULA (III) O UNA SAL DE ADICION DEL MISMO, Y RECUPERAR EL COMPUESTO DE FORMULA (I) EN FORMA DE BASE LIBRE O EN FORMA DE SAL DE ADICION DE ACIDOS, DONDE R1 Y R2 SIGNIFICAN, INDEPENDIENTEMENTE ENTRE SI, HIDROGENO, HALOGENO CON UN NUMERO ATOMICO DE 9 A 35, ALQUILO DE C 1 A 4, ALCOXI DE C 1 A 4, ALQUILTIO DE C 1 A 4, O TRIFLUOROMETILO; R1 Y R2 SIGNIFICAN, INDEPENDIENTEMENTE ENTRE SI, H, HALOGENO CON NUMERO ATOMICO DE 9 A 35, ALQUILO DE C 1 A 4 O ALCOXI DE C 1 A 4; Y R3 REPRESENTA H, ALQUILO DE C 1 A 4, CICLOALQUILO DE C 3 A 6, CICLOALQUILALQUILO DE C 4 A 9, ALQUENILO DE C 3 A 5, ALQUINILO DE C 3 A 5.
ES522008A 1982-05-06 1983-05-02 Procedimiento para preparar acepinoindoles. Granted ES522008A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH2806/82A CH649553A5 (de) 1982-05-06 1982-05-06 Azepinoindole und verfahren zu deren herstellung.

Publications (2)

Publication Number Publication Date
ES8502440A1 true ES8502440A1 (es) 1985-01-01
ES522008A0 ES522008A0 (es) 1985-01-01

Family

ID=4242007

Family Applications (1)

Application Number Title Priority Date Filing Date
ES522008A Granted ES522008A0 (es) 1982-05-06 1983-05-02 Procedimiento para preparar acepinoindoles.

Country Status (17)

Country Link
JP (1) JPS58203993A (es)
AU (1) AU1425683A (es)
BE (1) BE896590A (es)
CH (1) CH649553A5 (es)
DE (1) DE3315467A1 (es)
DK (1) DK199883A (es)
ES (1) ES522008A0 (es)
FI (1) FI831475L (es)
FR (1) FR2526434A1 (es)
GB (1) GB2120662B (es)
HU (1) HU189275B (es)
IL (1) IL68576A0 (es)
IT (1) IT1197644B (es)
NL (1) NL8301552A (es)
PT (1) PT76632B (es)
SE (1) SE8302554L (es)
ZA (1) ZA833266B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8500370A (nl) * 1984-02-22 1985-09-16 Sandoz Ag Diazepinoindolen, werkwijzen voor hun bereiding en farmaceutische preparaten die ze bevatten.
AU582564B2 (en) * 1985-02-20 1989-04-06 Sandoz Ltd. 2,3,4,5-tetrahydro-11-phenyl-1H-``1,4``diazepino``1,7-a`` indoles, their production and pharmaceutical compositions containing them
PE20020510A1 (es) 2000-09-20 2002-06-12 Upjohn Co DERIVADOS DE AZEPILO [4,5b] INDOLINA SUSTITUIDOS COMO LIGANDOS DE LOS RECEPTORES DE SEROTONINA (5-HT)
JP2005526691A (ja) * 2001-08-08 2005-09-08 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 治療剤１Ｈ−ピリド［４，３−ｂ］インドール
AU2007207508B2 (en) * 2006-01-19 2011-08-18 Athersys, Inc. Thiophenyl and pyrrolyl azepines as serotonin 5-HT2c receptor ligands and uses thereof
JP5501251B2 (ja) 2008-01-11 2014-05-21 アルバニー モレキュラー リサーチ， インコーポレイテッド Ｍｃｈ拮抗薬としての（１−アジノン）置換ピリドインドール類
WO2011003007A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
EP2448585B1 (en) 2009-07-01 2014-01-01 Albany Molecular Research, Inc. Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine mch-1 antagonists, methods of making, and use thereof
WO2011003012A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azinone-substituted azapolycycle mch-1 antagonists, methods of making, and use thereof
WO2011003021A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
WO2012088038A2 (en) 2010-12-21 2012-06-28 Albany Molecular Research, Inc. Piperazinone-substituted tetrahydro-carboline mch-1 antagonists, methods of making, and uses thereof
US8993765B2 (en) 2010-12-21 2015-03-31 Albany Molecular Research, Inc. Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE12641T1 (de) * 1979-11-02 1985-04-15 Sandoz Ag Azepinindole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.

Also Published As

Publication number Publication date
IT1197644B (it) 1988-12-06
AU1425683A (en) 1983-11-10
BE896590A (fr) 1983-10-28
DK199883A (da) 1983-11-07
FI831475A7 (fi) 1983-11-07
GB2120662A (en) 1983-12-07
FI831475L (fi) 1983-11-07
IT8348232A1 (it) 1984-11-06
FR2526434A1 (fr) 1983-11-10
DE3315467A1 (de) 1983-11-17
DK199883D0 (da) 1983-05-04
IT8348232A0 (it) 1983-05-06
ES522008A0 (es) 1985-01-01
GB8312159D0 (en) 1983-06-08
JPS58203993A (ja) 1983-11-28
GB2120662B (en) 1985-09-11
NL8301552A (nl) 1983-12-01
IL68576A0 (en) 1983-09-30
SE8302554L (sv) 1983-11-07
HU189275B (en) 1986-06-30
PT76632B (en) 1986-01-27
ZA833266B (en) 1984-12-24
PT76632A (en) 1983-06-01
SE8302554D0 (sv) 1983-05-04
CH649553A5 (de) 1985-05-31
FI831475A0 (fi) 1983-04-29

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