ES8502440A1 - PROCEDURE TO PREPARE ACEPINE INDOLES. - Google Patents
PROCEDURE TO PREPARE ACEPINE INDOLES.Info
- Publication number
- ES8502440A1 ES8502440A1 ES522008A ES522008A ES8502440A1 ES 8502440 A1 ES8502440 A1 ES 8502440A1 ES 522008 A ES522008 A ES 522008A ES 522008 A ES522008 A ES 522008A ES 8502440 A1 ES8502440 A1 ES 8502440A1
- Authority
- ES
- Spain
- Prior art keywords
- compound
- formula
- procedure
- alky
- acepine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR ACEPINOINDOLES.CONSISTE EN: A) TRATAR UN COMPUESTO DE FORMULA (II) CON UNA FUENTE DE ION HIDRUROS, PARA DAR UN COMPUESTO DE FORMULA (III); Y B) INTRODUCIR EL COMPUESTO DE FORMULA (III) O UNA SAL DE ADICION DEL MISMO, Y RECUPERAR EL COMPUESTO DE FORMULA (I) EN FORMA DE BASE LIBRE O EN FORMA DE SAL DE ADICION DE ACIDOS, DONDE R1 Y R2 SIGNIFICAN, INDEPENDIENTEMENTE ENTRE SI, HIDROGENO, HALOGENO CON UN NUMERO ATOMICO DE 9 A 35, ALQUILO DE C 1 A 4, ALCOXI DE C 1 A 4, ALQUILTIO DE C 1 A 4, O TRIFLUOROMETILO; R1 Y R2 SIGNIFICAN, INDEPENDIENTEMENTE ENTRE SI, H, HALOGENO CON NUMERO ATOMICO DE 9 A 35, ALQUILO DE C 1 A 4 O ALCOXI DE C 1 A 4; Y R3 REPRESENTA H, ALQUILO DE C 1 A 4, CICLOALQUILO DE C 3 A 6, CICLOALQUILALQUILO DE C 4 A 9, ALQUENILO DE C 3 A 5, ALQUINILO DE C 3 A 5.PROCEDURE FOR PREPARING ACEPINOINDOLES. IT CONSISTS OF: A) TREATING A COMPOUND OF FORMULA (II) WITH A SOURCE OF HYDRIDE ION, TO GIVE A COMPOUND OF FORMULA (III); AND B) INTRODUCING THE COMPOUND OF FORMULA (III) OR AN ADDITION SALT THEREOF, AND RECOVERING THE COMPOUND OF FORMULA (I) IN THE FORM OF THE FREE BASE OR IN THE FORM OF AN ADDITION SALT OF ACIDS, WHERE R1 AND R2 MEAN, INDEPENDENTLY BETWEEN SI, HYDROGEN, HALOGEN WITH AN ATOMIC NUMBER 9 TO 35, C 1 TO 4 ALKY, C 1 TO 4 ALCOXY, C 1 TO 4 ALKY, OR TRIFLUOROMETHYL; R1 AND R2 MEAN, INDEPENDENTLY FROM EACH OTHER, H, HALOGEN WITH ATOMIC NUMBER FROM 9 TO 35, ALKY FROM C 1 TO 4 OR ALCOXY FROM C 1 TO 4; AND R3 REPRESENTS H, C 1 TO 4 ALKYL, C 3 TO 6 CYCLOALKYL, C 4 TO 9 CYCLOALKYL, C 3 TO 5 ALKENYL, C 3 TO 5 ALKYNYL.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH2806/82A CH649553A5 (en) | 1982-05-06 | 1982-05-06 | AZEPINOINDOLS AND METHOD FOR THE PRODUCTION THEREOF. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8502440A1 true ES8502440A1 (en) | 1985-01-01 |
| ES522008A0 ES522008A0 (en) | 1985-01-01 |
Family
ID=4242007
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES522008A Granted ES522008A0 (en) | 1982-05-06 | 1983-05-02 | PROCEDURE TO PREPARE ACEPINE INDOLES. |
Country Status (17)
| Country | Link |
|---|---|
| JP (1) | JPS58203993A (en) |
| AU (1) | AU1425683A (en) |
| BE (1) | BE896590A (en) |
| CH (1) | CH649553A5 (en) |
| DE (1) | DE3315467A1 (en) |
| DK (1) | DK199883A (en) |
| ES (1) | ES522008A0 (en) |
| FI (1) | FI831475L (en) |
| FR (1) | FR2526434A1 (en) |
| GB (1) | GB2120662B (en) |
| HU (1) | HU189275B (en) |
| IL (1) | IL68576A0 (en) |
| IT (1) | IT1197644B (en) |
| NL (1) | NL8301552A (en) |
| PT (1) | PT76632B (en) |
| SE (1) | SE8302554L (en) |
| ZA (1) | ZA833266B (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL8500370A (en) * | 1984-02-22 | 1985-09-16 | Sandoz Ag | DIAZEPINOINDOLS, METHODS FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM. |
| AU582564B2 (en) * | 1985-02-20 | 1989-04-06 | Sandoz Ltd. | 2,3,4,5-tetrahydro-11-phenyl-1H-``1,4``diazepino``1,7-a`` indoles, their production and pharmaceutical compositions containing them |
| PE20020510A1 (en) | 2000-09-20 | 2002-06-12 | Upjohn Co | DERIVATIVES OF AZEPYL [4,5b] INDOLINE SUBSTITUTE AS LIGANDS OF SEROTONIN (5-HT) RECEPTORS |
| JP2005526691A (en) * | 2001-08-08 | 2005-09-08 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | Therapeutic agent 1H-pyrido [4,3-b] indole |
| AU2007207508B2 (en) * | 2006-01-19 | 2011-08-18 | Athersys, Inc. | Thiophenyl and pyrrolyl azepines as serotonin 5-HT2c receptor ligands and uses thereof |
| JP5501251B2 (en) | 2008-01-11 | 2014-05-21 | アルバニー モレキュラー リサーチ， インコーポレイテッド | (1-Azinone) substituted pyridoindoles as MCH antagonists |
| WO2011003007A1 (en) | 2009-07-01 | 2011-01-06 | Albany Molecular Research, Inc. | Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof |
| EP2448585B1 (en) | 2009-07-01 | 2014-01-01 | Albany Molecular Research, Inc. | Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine mch-1 antagonists, methods of making, and use thereof |
| WO2011003012A1 (en) | 2009-07-01 | 2011-01-06 | Albany Molecular Research, Inc. | Azinone-substituted azapolycycle mch-1 antagonists, methods of making, and use thereof |
| WO2011003021A1 (en) | 2009-07-01 | 2011-01-06 | Albany Molecular Research, Inc. | Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof |
| WO2012088038A2 (en) | 2010-12-21 | 2012-06-28 | Albany Molecular Research, Inc. | Piperazinone-substituted tetrahydro-carboline mch-1 antagonists, methods of making, and uses thereof |
| US8993765B2 (en) | 2010-12-21 | 2015-03-31 | Albany Molecular Research, Inc. | Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE12641T1 (en) * | 1979-11-02 | 1985-04-15 | Sandoz Ag | AZEPININDOLS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
-
1982
- 1982-05-06 CH CH2806/82A patent/CH649553A5/en not_active IP Right Cessation
-
1983
- 1983-04-27 FR FR8307089A patent/FR2526434A1/en active Pending
- 1983-04-28 BE BE1/10774A patent/BE896590A/en not_active IP Right Cessation
- 1983-04-28 DE DE19833315467 patent/DE3315467A1/en not_active Withdrawn
- 1983-04-29 FI FI831475A patent/FI831475L/en not_active Application Discontinuation
- 1983-05-02 ES ES522008A patent/ES522008A0/en active Granted
- 1983-05-03 NL NL8301552A patent/NL8301552A/en not_active Application Discontinuation
- 1983-05-04 DK DK199883A patent/DK199883A/en not_active Application Discontinuation
- 1983-05-04 HU HU831531A patent/HU189275B/en unknown
- 1983-05-04 GB GB08312159A patent/GB2120662B/en not_active Expired
- 1983-05-04 IL IL68576A patent/IL68576A0/en unknown
- 1983-05-04 PT PT76632A patent/PT76632B/en unknown
- 1983-05-04 SE SE8302554A patent/SE8302554L/en not_active Application Discontinuation
- 1983-05-04 JP JP58078869A patent/JPS58203993A/en active Pending
- 1983-05-05 AU AU14256/83A patent/AU1425683A/en not_active Abandoned
- 1983-05-06 IT IT48232/83A patent/IT1197644B/en active
- 1983-05-06 ZA ZA833266A patent/ZA833266B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IT1197644B (en) | 1988-12-06 |
| AU1425683A (en) | 1983-11-10 |
| BE896590A (en) | 1983-10-28 |
| DK199883A (en) | 1983-11-07 |
| FI831475A7 (en) | 1983-11-07 |
| GB2120662A (en) | 1983-12-07 |
| FI831475L (en) | 1983-11-07 |
| IT8348232A1 (en) | 1984-11-06 |
| FR2526434A1 (en) | 1983-11-10 |
| DE3315467A1 (en) | 1983-11-17 |
| DK199883D0 (en) | 1983-05-04 |
| IT8348232A0 (en) | 1983-05-06 |
| ES522008A0 (en) | 1985-01-01 |
| GB8312159D0 (en) | 1983-06-08 |
| JPS58203993A (en) | 1983-11-28 |
| GB2120662B (en) | 1985-09-11 |
| NL8301552A (en) | 1983-12-01 |
| IL68576A0 (en) | 1983-09-30 |
| SE8302554L (en) | 1983-11-07 |
| HU189275B (en) | 1986-06-30 |
| PT76632B (en) | 1986-01-27 |
| ZA833266B (en) | 1984-12-24 |
| PT76632A (en) | 1983-06-01 |
| SE8302554D0 (en) | 1983-05-04 |
| CH649553A5 (en) | 1985-05-31 |
| FI831475A0 (en) | 1983-04-29 |
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