ES8401961A1 - Procedimiento para la preparacion de nuevas n-(4-indolil-piperidino-alcohil-bencimidazolonas sustituidas. - Google Patents
Procedimiento para la preparacion de nuevas n-(4-indolil-piperidino-alcohil-bencimidazolonas sustituidas.Info
- Publication number
- ES8401961A1 ES8401961A1 ES517988A ES517988A ES8401961A1 ES 8401961 A1 ES8401961 A1 ES 8401961A1 ES 517988 A ES517988 A ES 517988A ES 517988 A ES517988 A ES 517988A ES 8401961 A1 ES8401961 A1 ES 8401961A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- benzimidazolones
- piperidino
- indolyl
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000008641 benzimidazolones Chemical class 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 230000003266 anti-allergic effect Effects 0.000 abstract 1
- 239000000043 antiallergic agent Substances 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE NUEVAS N-(4-INDOLIL-PIPERIDINO-ALCOHIL)-BENCIMIDAZOLONAS SUSTITUIDAS.CONSISTE EN REACCIONAR, POR ALCOHILACION, EN PRESENCIA DE UN DISOLVENTE ORGANICO COMO ETANOL Y A TEMPERATURAS ENTRE 20JC Y LA TEMPERATURA DE EBULLICION DEL DISOLVENTE, UN 3-(4-PIPERIDIL)-INDOL DE FORMULA (III) CON UNA N-(V-HALOGENOALCOHIL)-BENCIMIDAZ OLONA DE FORMULA (II), EN LA QUE X SIGNIFICA UN ATOMO DE CLORO, BROMO; PARA OBTENER UN N-(4-INDOLIL-PIPERIDINO-ALCOHIL)-BENCIMIDA1ZOLONA SUSTITUIDAS DE FORMULA (I), EN LA QUE R1 SIGNIFICA HIDROGENO, DONDE R2 SIGNIFICA HIDROGENO, O UN RADICAL ALCOHILO INFERIOR,EN LA QUE R3 SIGNIFICA HIDROGENO, Y EN QUE R4 SIGNIFICA HIDROGENO O UN RADICAL ALQUENILO DE C 3, Y N SIGNIFICA NUMEROS DE 2 A 6. LOS COMPUESTOS DE FORMULA (I) SON BASICOS, QUE FORMAN SALES POR ADICION DE ACIDOS ORGANICOS E INORGANICOS, TALES COMO ACIDO CLORHIDRICO, O ACIDO BUTIRICO OBTENIENDOSE LOS CLORHIDRATOS Y BUTIRATOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/237,966 US4359468A (en) | 1981-02-25 | 1981-02-25 | Antiallergic N-[4-(indolyl)-piperidino-alkyl]-benzimidazolones |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8401961A1 true ES8401961A1 (es) | 1984-01-01 |
| ES517988A0 ES517988A0 (es) | 1984-01-01 |
Family
ID=22895956
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES509871A Granted ES509871A0 (es) | 1981-02-25 | 1982-02-24 | "procedimiento para la preparacion de nuevas n-(4-indolil-piperidino-alcohil)-bencimidazolonas sustituidas". |
| ES517988A Granted ES517988A0 (es) | 1981-02-25 | 1982-12-07 | Procedimiento para la preparacion de nuevas n-(4-indolil-piperidino-alcohil-bencimidazolonas sustituidas. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES509871A Granted ES509871A0 (es) | 1981-02-25 | 1982-02-24 | "procedimiento para la preparacion de nuevas n-(4-indolil-piperidino-alcohil)-bencimidazolonas sustituidas". |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US4359468A (es) |
| EP (1) | EP0058975B1 (es) |
| JP (1) | JPS57156484A (es) |
| KR (1) | KR890000008B1 (es) |
| AR (1) | AR228475A1 (es) |
| AT (1) | ATE10742T1 (es) |
| AU (1) | AU543948B2 (es) |
| CA (1) | CA1191137A (es) |
| CS (1) | CS227343B2 (es) |
| DD (1) | DD202562A5 (es) |
| DE (1) | DE3261497D1 (es) |
| DK (1) | DK151017C (es) |
| ES (2) | ES509871A0 (es) |
| FI (1) | FI71558C (es) |
| GB (1) | GB2093455B (es) |
| GR (1) | GR74778B (es) |
| HU (1) | HU187652B (es) |
| IE (1) | IE52562B1 (es) |
| IL (1) | IL65097A0 (es) |
| NO (1) | NO157296C (es) |
| NZ (1) | NZ199822A (es) |
| PH (1) | PH17889A (es) |
| PL (1) | PL135472B1 (es) |
| PT (1) | PT74481B (es) |
| SU (1) | SU1088665A3 (es) |
| UA (1) | UA7228A1 (es) |
| YU (1) | YU42758B (es) |
| ZA (1) | ZA821196B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4548939A (en) * | 1984-10-01 | 1985-10-22 | Janssen Pharmaceutica N. V. | 1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones |
| IE58370B1 (en) * | 1985-04-10 | 1993-09-08 | Lundbeck & Co As H | Indole derivatives |
| US4742057A (en) * | 1985-12-05 | 1988-05-03 | Fujisawa Pharmaceutical Co., Ltd. | Antiallergic thiazole compounds |
| FR2613222B1 (fr) * | 1987-04-03 | 1991-06-14 | Guigon Nadine | Composition pour les soins locaux de l'epiderme, notamment du cuir chevelu |
| DK733788A (da) * | 1988-01-14 | 1989-07-15 | Fujisawa Pharmaceutical Co | Indolylpiperidinderivater og fremgangsmaade til fremstilling deraf |
| GB8908085D0 (en) * | 1989-04-11 | 1989-05-24 | Lundbeck & Co As H | New therapeutic use |
| US5238945A (en) * | 1989-04-11 | 1993-08-24 | H. Lundbeck A/S | Method of treating psychoses |
| FR2658823B1 (fr) * | 1990-02-27 | 1992-04-30 | Adir | Nouveaux derives d'aminomethylpiperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent . |
| TW203049B (es) * | 1990-04-13 | 1993-04-01 | Yamanouchi Pharma Co Ltd | |
| DE4414113A1 (de) * | 1994-04-22 | 1995-10-26 | Merck Patent Gmbh | 3-Indolylpiperidine |
| JPH10503501A (ja) * | 1994-08-03 | 1998-03-31 | アスタ メディカ アクチエンゲゼルシャフト | 抗喘息、抗アレルギー、抗炎症及び免疫修飾作用を有するインドール、インダゾール、ピリドピロール及びピリドピラゾール誘導体 |
| US5521196A (en) * | 1994-10-05 | 1996-05-28 | Eli Lilly And Company | 5-HT1F agonists for the treatment of migraine |
| US5521197A (en) * | 1994-12-01 | 1996-05-28 | Eli Lilly And Company | 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists |
| KR19980703048A (ko) * | 1995-03-20 | 1998-09-05 | 피터쥐.스트링거 | 5-치환-3-(1,2,3,6-테트라히드로피리딘-4-일)- 및 3-(피페리딘-4-일)-1ｈ-인돌: 신규한 5-ｈｔ1ｆ 아고니스트 |
| GB9825413D0 (en) | 1998-11-19 | 1999-01-13 | Lilly Co Eli | Pharmaceutical compounds |
| GB9903784D0 (en) * | 1999-02-18 | 1999-04-14 | Lilly Co Eli | Pharmaceutical compounds |
| WO2004047769A2 (en) * | 2002-11-26 | 2004-06-10 | Isis Pharmaceuticals, Inc. | Benzimidazoles and analogs thereof as antibacterials |
| WO2006117314A2 (en) * | 2005-04-30 | 2006-11-09 | Boehringer Ingelheim International Gmbh | Novel piperidin- substituted indoles and their use as ccr-3 modulators |
| JP2009515833A (ja) * | 2005-10-24 | 2009-04-16 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ３−ピペリジン−４−イル−インドールｏｒｌ−１受容体モジュレーター |
| US8462477B2 (en) | 2010-09-13 | 2013-06-11 | Analog Devices, Inc. | Junction field effect transistor for voltage protection |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE794333A (fr) * | 1972-01-20 | 1973-07-19 | Wyeth John & Brother Ltd | Composes heterocycliques azotes therapeutiques |
| US3954764A (en) * | 1973-03-30 | 1976-05-04 | Hoffmann-La Roche Inc. | Dibenzo [b,f]thiepins bearing piperazinyl substitution |
| DE2322470A1 (de) * | 1973-05-04 | 1974-11-21 | Boehringer Sohn Ingelheim | Neue indolyl-piperidino-(bzw. 1,2,5,6tetrahydro-pyridyl-)butyrophenone und verfahren zu ihrer herstellung |
| ZA76475B (en) * | 1975-03-10 | 1977-08-31 | Ciba Geigy Ag | Indolyalkylpiperidines |
| US4147786A (en) * | 1976-02-02 | 1979-04-03 | Ciba-Geigy Corporation | 1-Indolylalkyl-3-or 4-trimethyleneurido-piperidines |
| FR2469411A1 (fr) * | 1979-11-15 | 1981-05-22 | Science Union & Cie | Nouveaux derives de la piperidylbenzimidazolinone, leurs procedes de preparation et les compositions pharmaceutiques les renfermant |
| US4254127A (en) * | 1980-04-03 | 1981-03-03 | Janssen Pharmaceutica, N.V. | 1,3-Dihydro-1-[(1-piperidinyl)alkyl]-2H-benzimidazol-2-one derivatives |
-
1981
- 1981-02-25 US US06/237,966 patent/US4359468A/en not_active Expired - Lifetime
-
1982
- 1982-02-19 PH PH26888A patent/PH17889A/en unknown
- 1982-02-20 EP EP82101315A patent/EP0058975B1/de not_active Expired
- 1982-02-20 DE DE8282101315T patent/DE3261497D1/de not_active Expired
- 1982-02-20 AT AT82101315T patent/ATE10742T1/de not_active IP Right Cessation
- 1982-02-22 GR GR67368A patent/GR74778B/el unknown
- 1982-02-22 DD DD82237583A patent/DD202562A5/de not_active IP Right Cessation
- 1982-02-23 FI FI820594A patent/FI71558C/fi not_active IP Right Cessation
- 1982-02-23 CS CS821228A patent/CS227343B2/cs unknown
- 1982-02-23 PL PL1982235187A patent/PL135472B1/pl unknown
- 1982-02-24 CA CA000396960A patent/CA1191137A/en not_active Expired
- 1982-02-24 IE IE401/82A patent/IE52562B1/en not_active IP Right Cessation
- 1982-02-24 YU YU410/82A patent/YU42758B/xx unknown
- 1982-02-24 NO NO820583A patent/NO157296C/no unknown
- 1982-02-24 HU HU82566A patent/HU187652B/hu not_active IP Right Cessation
- 1982-02-24 JP JP57028704A patent/JPS57156484A/ja active Granted
- 1982-02-24 PT PT74481A patent/PT74481B/pt not_active IP Right Cessation
- 1982-02-24 ZA ZA821196A patent/ZA821196B/xx unknown
- 1982-02-24 AR AR288538A patent/AR228475A1/es active
- 1982-02-24 NZ NZ199822A patent/NZ199822A/en unknown
- 1982-02-24 ES ES509871A patent/ES509871A0/es active Granted
- 1982-02-24 GB GB8205386A patent/GB2093455B/en not_active Expired
- 1982-02-24 IL IL65097A patent/IL65097A0/xx not_active IP Right Cessation
- 1982-02-24 UA UA3396888A patent/UA7228A1/uk unknown
- 1982-02-24 SU SU823396888A patent/SU1088665A3/ru active
- 1982-02-24 DK DK079882A patent/DK151017C/da not_active IP Right Cessation
- 1982-02-25 KR KR8200868A patent/KR890000008B1/ko not_active Expired
- 1982-02-25 AU AU80783/82A patent/AU543948B2/en not_active Ceased
- 1982-12-07 ES ES517988A patent/ES517988A0/es active Granted
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19971001 |