ES8301219A1 - Procedimiento para la preparacion de 2-fenilamino-imidazoli-nas-(2) sustituidas - Google Patents
Procedimiento para la preparacion de 2-fenilamino-imidazoli-nas-(2) sustituidasInfo
- Publication number
- ES8301219A1 ES8301219A1 ES506103A ES506103A ES8301219A1 ES 8301219 A1 ES8301219 A1 ES 8301219A1 ES 506103 A ES506103 A ES 506103A ES 506103 A ES506103 A ES 506103A ES 8301219 A1 ES8301219 A1 ES 8301219A1
- Authority
- ES
- Spain
- Prior art keywords
- acid addition
- addition salts
- imidazoline
- derivatives
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003839 salts Chemical class 0.000 title abstract 3
- 239000002253 acid Substances 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 125000003006 2-dimethylaminoethyl group Chemical group [H]C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 230000000059 bradycardiac effect Effects 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE 2-FENILAMINO-IMIDAZOLINAS-(2)SUSTITUIDAS Y DE SUS SALES DE ADICION DE ACIDO, DE FORMULA (I), EN LA QUE R -R PUEDEN SER VARIOS TIPOS DE RADICALES Y N VALE 0 O 1. CONSISTE EN LA REACCION DE UN DERIVADO DE IMIDAZOLINA DE FORMULA (II), O SU ANION, CON UN HALOGENURO DE FORMULA HAL-R , EN LAS QUE HAL ES CLORO, BROMO O YODO; Y R -R Y N TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO, EN PRESENCIA DE UN AGENTE FIJADOR DE ACIDOS, A UNA TEMPERATURA ENTRE 40<025>C Y 120<025>C. >ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE ENFERMEDADES CORONARIAS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19792947563 DE2947563A1 (de) | 1979-11-26 | 1979-11-26 | Neue substituierte 2-phenylamino-imidazoline-(2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES506103A0 ES506103A0 (es) | 1982-11-16 |
| ES8301219A1 true ES8301219A1 (es) | 1982-11-16 |
Family
ID=6086893
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES497105A Granted ES497105A0 (es) | 1979-11-26 | 1980-11-25 | Procedimiento para la preparacion de 2-fenilamino-imidazoli nas-(2)sustituidas. |
| ES506103A Expired ES8301219A1 (es) | 1979-11-26 | 1981-10-08 | Procedimiento para la preparacion de 2-fenilamino-imidazoli-nas-(2) sustituidas |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES497105A Granted ES497105A0 (es) | 1979-11-26 | 1980-11-25 | Procedimiento para la preparacion de 2-fenilamino-imidazoli nas-(2)sustituidas. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4361575A (es) |
| EP (1) | EP0029505B1 (es) |
| JP (1) | JPS5687568A (es) |
| AT (1) | ATE9333T1 (es) |
| AU (1) | AU539870B2 (es) |
| DE (2) | DE2947563A1 (es) |
| DK (1) | DK146688C (es) |
| ES (2) | ES497105A0 (es) |
| FI (1) | FI68616C (es) |
| IE (1) | IE50570B1 (es) |
| IL (1) | IL61560A (es) |
| NO (1) | NO150436C (es) |
| ZA (1) | ZA807337B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2499991A1 (fr) * | 1981-02-19 | 1982-08-20 | Sandoz Sa | Nouveaux 2,1,3-benzothiadiazoles et 2,1,3-benzoxadiazoles, leur preparation et leur application comme medicaments |
| US4461904A (en) * | 1981-11-20 | 1984-07-24 | Alcon Laboratories, Inc. | 2-(Trisubstituted phenylimino)-imidazolines |
| US4515800A (en) * | 1981-11-20 | 1985-05-07 | Icilio Cavero | Method of lowering intraocular pressure using phenylimino-imidazoles |
| DE3514351A1 (de) * | 1985-04-20 | 1986-11-06 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue substituierte 2-(n-alkinyl-n-phenyl)amino)-imidazolinderivate, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung |
| CA2196792A1 (en) | 1994-08-04 | 1996-02-15 | Yoon T. Jeon | Novel benzimidazole derivatives |
| US6495583B1 (en) | 1997-03-25 | 2002-12-17 | Synaptic Pharmaceutical Corporation | Benzimidazole derivatives |
| US6737433B1 (en) * | 2002-12-16 | 2004-05-18 | Laboratoire Theramex | 1-N-phenylamino-1H-imidazole derivatives as aromatase inhibitors and pharmaceutical compositions containing them |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE759048A (fr) * | 1969-11-17 | 1971-05-17 | Boehringer Sohn Ingelheim | Nouvelles n-aminoalcoyl-arylamino-imidazolines-(2) substituees et procedes pour les fabriquer |
| BE759125A (fr) * | 1969-11-19 | 1971-05-18 | Boehringer Sohn Ingelheim | Nouvelles n-allyl-2-arylamino-imidazolines-(2) substituees et procedes pour les fabriquer |
| US3850926A (en) * | 1971-01-21 | 1974-11-26 | Boehringer Sohn Ingelheim | 2-(n-substituted-phenylamino)-imidazolines-(2) |
| BE787683A (fr) * | 1971-08-20 | 1973-02-19 | Boehringer Sohn Ingelheim | 2-phenylimino-imidazolidines, leurs sels d'addition avec des acides et procedes pour les fabriquer |
| DE2259160A1 (de) * | 1972-12-02 | 1974-06-06 | Boehringer Sohn Ingelheim | Neue substituierte 2-phenylaminoimidazoline, deren saeureadditionssalze und verfahren zur herstellung derselben sowie ihre verwendung als arzneimittel |
| DE2457979A1 (de) * | 1974-12-07 | 1976-06-16 | Beiersdorf Ag | 2-n-aryl-hydroxyamino-imidazoline-(2) und verfahren zu deren herstellung |
| DE2523103C3 (de) * | 1975-05-24 | 1979-11-29 | C.H. Boehringer Sohn, 6507 Ingelheim | Substituierte 2-[N-Progargyl-N-(2-chlorphenyl)amino] -imidazoline-^), deren Säureadditionssalze, Verfahren zu ihrer Herstellung und deren Verwendung |
| DE2636732A1 (de) * | 1976-08-14 | 1978-02-16 | Boehringer Sohn Ingelheim | Neue substituierte 2-phenylamino- imidazoline- (2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben |
| DE2830278A1 (de) * | 1978-07-10 | 1980-01-31 | Boehringer Sohn Ingelheim | Neue substituierte 2-phenylamino-imidazoline-(2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben |
| DE2831234A1 (de) * | 1978-07-15 | 1980-01-31 | Boehringer Sohn Ingelheim | Neue substituierte 2-phenylamino-imidazoline-(2) deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben |
| DE2831671A1 (de) * | 1978-07-19 | 1980-02-07 | Boehringer Sohn Ingelheim | Neue substituierte 2-phenylamino-imidazoline-(2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben |
-
1979
- 1979-11-26 DE DE19792947563 patent/DE2947563A1/de not_active Withdrawn
-
1980
- 1980-10-21 DE DE8080106396T patent/DE3069173D1/de not_active Expired
- 1980-10-21 EP EP80106396A patent/EP0029505B1/de not_active Expired
- 1980-10-21 AT AT80106396T patent/ATE9333T1/de not_active IP Right Cessation
- 1980-11-24 FI FI803654A patent/FI68616C/fi not_active IP Right Cessation
- 1980-11-25 JP JP16577780A patent/JPS5687568A/ja active Pending
- 1980-11-25 NO NO803547A patent/NO150436C/no unknown
- 1980-11-25 AU AU64691/80A patent/AU539870B2/en not_active Ceased
- 1980-11-25 ZA ZA00807337A patent/ZA807337B/xx unknown
- 1980-11-25 DK DK501480A patent/DK146688C/da active
- 1980-11-25 IE IE2445/80A patent/IE50570B1/en unknown
- 1980-11-25 ES ES497105A patent/ES497105A0/es active Granted
- 1980-11-25 IL IL61560A patent/IL61560A/xx unknown
-
1981
- 1981-06-23 US US06/276,703 patent/US4361575A/en not_active Expired - Fee Related
- 1981-10-08 ES ES506103A patent/ES8301219A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ZA807337B (en) | 1982-08-25 |
| DK146688C (da) | 1984-05-21 |
| DK146688B (da) | 1983-12-05 |
| NO150436C (no) | 1984-10-17 |
| NO150436B (no) | 1984-07-09 |
| DE2947563A1 (de) | 1981-06-04 |
| ES506103A0 (es) | 1982-11-16 |
| JPS5687568A (en) | 1981-07-16 |
| ATE9333T1 (de) | 1984-09-15 |
| FI803654L (fi) | 1981-05-27 |
| IE802445L (en) | 1981-05-26 |
| IE50570B1 (en) | 1986-05-14 |
| DE3069173D1 (en) | 1984-10-18 |
| ES8201140A1 (es) | 1981-12-01 |
| NO803547L (no) | 1981-05-27 |
| FI68616B (fi) | 1985-06-28 |
| DK501480A (da) | 1981-05-27 |
| IL61560A (en) | 1984-09-30 |
| US4361575A (en) | 1982-11-30 |
| IL61560A0 (en) | 1980-12-31 |
| AU6469180A (en) | 1981-06-04 |
| EP0029505A1 (de) | 1981-06-03 |
| AU539870B2 (en) | 1984-10-18 |
| EP0029505B1 (de) | 1984-09-12 |
| FI68616C (fi) | 1985-10-10 |
| ES497105A0 (es) | 1981-12-01 |
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