ES420210A1 - Un procedimiento para preparar 4-hidroxi-6-arilpirimidinas. - Google Patents
Un procedimiento para preparar 4-hidroxi-6-arilpirimidinas.Info
- Publication number
- ES420210A1 ES420210A1 ES420210A ES420210A ES420210A1 ES 420210 A1 ES420210 A1 ES 420210A1 ES 420210 A ES420210 A ES 420210A ES 420210 A ES420210 A ES 420210A ES 420210 A1 ES420210 A1 ES 420210A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- formula
- amino
- phenyl
- furyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- -1 monosubstituted pyridyl Chemical group 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000004442 acylamino group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000002541 furyl group Chemical group 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000001544 thienyl group Chemical group 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 239000007868 Raney catalyst Substances 0.000 abstract 1
- NPXOKRUENSOPAO-UHFFFAOYSA-N Raney nickel Chemical compound [Al].[Ni] NPXOKRUENSOPAO-UHFFFAOYSA-N 0.000 abstract 1
- 229910000564 Raney nickel Inorganic materials 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000003396 thiol group Chemical class [H]S* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7821670A | 1970-10-05 | 1970-10-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES420210A1 true ES420210A1 (es) | 1976-06-01 |
Family
ID=22142671
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES395676A Expired ES395676A1 (es) | 1970-10-05 | 1971-10-04 | Un metodo para preparar una 4-amino-6-arilpirimidina. |
| ES420211A Expired ES420211A1 (es) | 1970-10-05 | 1973-11-02 | Un procedimiento para preparar 4-hidroxi-6-arilpirimidinas. |
| ES420210A Expired ES420210A1 (es) | 1970-10-05 | 1973-11-02 | Un procedimiento para preparar 4-hidroxi-6-arilpirimidinas. |
| ES420209A Expired ES420209A1 (es) | 1970-10-05 | 1973-11-02 | Un metodo para preparar 4-amino-6-arilpirimidinas. |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES395676A Expired ES395676A1 (es) | 1970-10-05 | 1971-10-04 | Un metodo para preparar una 4-amino-6-arilpirimidina. |
| ES420211A Expired ES420211A1 (es) | 1970-10-05 | 1973-11-02 | Un procedimiento para preparar 4-hidroxi-6-arilpirimidinas. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES420209A Expired ES420209A1 (es) | 1970-10-05 | 1973-11-02 | Un metodo para preparar 4-amino-6-arilpirimidinas. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US3707560A (es) |
| JP (2) | JPS5648511B1 (es) |
| AT (4) | AT314540B (es) |
| AU (1) | AU465734B2 (es) |
| BE (1) | BE773484A (es) |
| CA (1) | CA988519A (es) |
| CH (4) | CH554875A (es) |
| DE (2) | DE2165962C2 (es) |
| DK (1) | DK131858C (es) |
| ES (4) | ES395676A1 (es) |
| FI (1) | FI55502C (es) |
| FR (1) | FR2110227B1 (es) |
| GB (2) | GB1373536A (es) |
| NL (1) | NL168511C (es) |
| SE (2) | SE385885B (es) |
| ZA (1) | ZA716615B (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3908012A (en) * | 1970-10-05 | 1975-09-23 | Pfizer | Arylpyrimidines-inhibitors of platelet aggregation and bronchodilators |
| US3895112A (en) * | 1970-10-05 | 1975-07-15 | Pfizer | Arylpyrimidines in the relaxation of smooth muscle |
| US3859288A (en) * | 1970-10-05 | 1975-01-07 | Pfizer | Arylpyrimidines - inhibitors of platelet aggregation and bronchodilators |
| US3835132A (en) * | 1972-02-01 | 1974-09-10 | Shell Oil Co | Morpholino-piperazinyl pyrimidines |
| US3950525A (en) * | 1973-06-19 | 1976-04-13 | Pfizer Inc. | Relaxation of smooth muscle in a mammal |
| DE2343419A1 (de) * | 1973-08-29 | 1975-03-13 | Gruenenthal Chemie | Verfahren zur herstellung von pyrimidinderivaten |
| US4725600A (en) * | 1984-07-13 | 1988-02-16 | Fujisawa Pharmaceutical Co., Ltd. | Pyrimidine compounds having activity as a cardiotonic anti-hypertensive cerebrovascular vasodilator and anti-platelet aggregation agent |
| US4935516A (en) * | 1988-01-29 | 1990-06-19 | Ube Industries, Ltd. | Process for preparing 4-hydroxypyrimidine |
| JPH0625157B2 (ja) * | 1988-01-29 | 1994-04-06 | 宇部興産株式会社 | ４―ヒドロキシピリミジン類の製造方法 |
| DE3825647A1 (de) * | 1988-07-28 | 1990-02-01 | Geyer Gmbh & Co Christian | Vorrichtung zur befestigung eines elektrischen schaltgeraetes |
| DE3905364A1 (de) * | 1989-02-22 | 1990-08-23 | Hoechst Ag | Substituierte pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als tool |
| AU777735B2 (en) * | 1999-07-15 | 2004-10-28 | Pharmacopeia, Inc. | Bradykinin B1 receptor antagonists |
| ES2290436T3 (es) * | 2002-03-15 | 2008-02-16 | Ciba Specialty Chemicals Holding Inc. | Uso de 4-aminopiridinas para el tratamiento antimicrobiano de superficies. |
| MXPA04011472A (es) * | 2002-05-22 | 2005-02-14 | Amgen Inc | Derivados de amino-piridina, piridina y piridazina para usarse como ligandos del receptor vaniloide para el tratamiento del dolor. |
| EP1611128A2 (en) * | 2003-03-28 | 2006-01-04 | Pharmacia & Upjohn Company LLC | Positive allosteric modulators of the nicotinic acetylcholine receptor |
| WO2006113769A1 (en) * | 2005-04-15 | 2006-10-26 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| JP2009164373A (ja) * | 2008-01-08 | 2009-07-23 | Toshiba Corp | 半導体装置 |
| NZ601547A (en) * | 2010-01-25 | 2014-04-30 | Chdi Foundation Inc | Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
| PH12017502049A1 (en) | 2011-08-30 | 2018-08-29 | Chdi Foundation Inc | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
| CN103827095A (zh) | 2011-08-30 | 2014-05-28 | Chdi基金会股份有限公司 | 犬尿氨酸-3-单加氧酶抑制剂、其药物组合物及其使用方法 |
| PE20170770A1 (es) | 2014-07-17 | 2017-07-04 | Chdi Foundation Inc | Metodos y composiciones para tratar trastornos relacionados con vih |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3047462A (en) * | 1959-03-06 | 1962-07-31 | Lab Jacques Logeais Soc D Expl | Quinazolone anti-inflammatory composition |
-
1970
- 1970-10-05 US US78216A patent/US3707560A/en not_active Expired - Lifetime
-
1971
- 1971-09-30 FI FI2734/71A patent/FI55502C/fi active
- 1971-10-01 DK DK480171A patent/DK131858C/da not_active IP Right Cessation
- 1971-10-02 DE DE2165962A patent/DE2165962C2/de not_active Expired
- 1971-10-02 DE DE2149249A patent/DE2149249C3/de not_active Expired
- 1971-10-04 ZA ZA716615A patent/ZA716615B/xx unknown
- 1971-10-04 GB GB3831673A patent/GB1373536A/en not_active Expired
- 1971-10-04 SE SE7112534-8A patent/SE385885B/xx unknown
- 1971-10-04 SE SE7410488A patent/SE390304B/xx unknown
- 1971-10-04 GB GB4615871A patent/GB1373535A/en not_active Expired
- 1971-10-04 ES ES395676A patent/ES395676A1/es not_active Expired
- 1971-10-04 CA CA124,312A patent/CA988519A/en not_active Expired
- 1971-10-05 AT AT858071A patent/AT314540B/de not_active IP Right Cessation
- 1971-10-05 FR FR7135815A patent/FR2110227B1/fr not_active Expired
- 1971-10-05 CH CH1521472A patent/CH554875A/fr not_active IP Right Cessation
- 1971-10-05 CH CH772973A patent/CH542218A/fr not_active IP Right Cessation
- 1971-10-05 AT AT605473A patent/AT317229B/de not_active IP Right Cessation
- 1971-10-05 AT AT00148/73A patent/AT315856B/de not_active IP Right Cessation
- 1971-10-05 AT AT00149/73A patent/AT316563B/de not_active IP Right Cessation
- 1971-10-05 JP JP7823771A patent/JPS5648511B1/ja active Pending
- 1971-10-05 BE BE773484A patent/BE773484A/xx not_active IP Right Cessation
- 1971-10-05 CH CH1532172A patent/CH554346A/fr not_active IP Right Cessation
- 1971-10-05 CH CH1452971A patent/CH554876A/fr not_active IP Right Cessation
- 1971-10-05 NL NLAANVRAGE7113670,A patent/NL168511C/xx not_active IP Right Cessation
- 1971-10-06 AU AU34259/71A patent/AU465734B2/en not_active Expired
-
1973
- 1973-11-02 ES ES420211A patent/ES420211A1/es not_active Expired
- 1973-11-02 ES ES420210A patent/ES420210A1/es not_active Expired
- 1973-11-02 ES ES420209A patent/ES420209A1/es not_active Expired
-
1980
- 1980-08-11 JP JP11016380A patent/JPS5636468A/ja active Granted
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