ES404876A1 - PROCEDURE FOR THE PRODUCTION OF 5-PHENYL-1, 3, 4, 4A, 5,9B-HEXAHYDRO-2H-INDENE (1,2-C) PYRIDINES. - Google Patents
PROCEDURE FOR THE PRODUCTION OF 5-PHENYL-1, 3, 4, 4A, 5,9B-HEXAHYDRO-2H-INDENE (1,2-C) PYRIDINES.Info
- Publication number
- ES404876A1 ES404876A1 ES404876A ES404876A ES404876A1 ES 404876 A1 ES404876 A1 ES 404876A1 ES 404876 A ES404876 A ES 404876A ES 404876 A ES404876 A ES 404876A ES 404876 A1 ES404876 A1 ES 404876A1
- Authority
- ES
- Spain
- Prior art keywords
- trans
- hydrogen atoms
- hydrogen
- signifies
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- RQMWVVBHJMUJNZ-UHFFFAOYSA-N 4-chloropyridin-2-amine Chemical compound NC1=CC(Cl)=CC=N1 RQMWVVBHJMUJNZ-UHFFFAOYSA-N 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 229910052794 bromium Inorganic materials 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 239000000460 chlorine Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 239000011737 fluorine Substances 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical compound [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 abstract 1
- 239000012280 lithium aluminium hydride Substances 0.000 abstract 1
- -1 lithium aluminum hydride Chemical compound 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003222 pyridines Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Landscapes
- Pyridine Compounds (AREA)
Abstract
Process for the production of 5-phenyl-1,3,4,4a, 5,9b-hexahydro-2H-indene [1,2-c] pyridines, of formula Id, **(See formula)** wherein RIII1 signifies hydrogen or a lower alkyl radical, R2 signifies chlorine, bromine, fluorine, or a lower alkyl radical, and signifies hydrogen, chlorine, bromine, fluorine, an alkyl, alkylthio or lower alkoxy radical, or trifluoromethyl, characterized in that a compound is reduced in which the 4a/5 hydrogen atoms are trans and the 4a/9b hydrogen atoms are trans, or in which the 4a/5 hydrogen atoms are trans and the 4a/9b hydrogen atoms are cis, respectively, of formula Ie, **(See formula)** wherein RIV1 signifies hydrogen, a lower alkyl or alkoxy radical, and R2 and R3 have the above meanings, with lithium aluminum hydride, aluminum hydride or diborane, in a solvent that is inert under the reaction conditions, and where necessary, mixtures of compounds are separated where the 4a/5 hydrogen atoms are trans and the 4a/9b hydrogen atoms are trans, and where the 4a/5 hydrogen atoms are trans and the Hydrogen 4a/9b are cis, in order to isolate one isomer or each of the isomers. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1837969 | 1969-12-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES404876A1 true ES404876A1 (en) | 1976-01-01 |
Family
ID=4432597
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES404874A Expired ES404874A1 (en) | 1969-12-10 | 1972-07-14 | Procedure for the obtaining of derivatives of the pyridine. (Machine-translation by Google Translate, not legally binding) |
| ES404876A Expired ES404876A1 (en) | 1969-12-10 | 1972-07-14 | PROCEDURE FOR THE PRODUCTION OF 5-PHENYL-1, 3, 4, 4A, 5,9B-HEXAHYDRO-2H-INDENE (1,2-C) PYRIDINES. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES404874A Expired ES404874A1 (en) | 1969-12-10 | 1972-07-14 | Procedure for the obtaining of derivatives of the pyridine. (Machine-translation by Google Translate, not legally binding) |
Country Status (1)
| Country | Link |
|---|---|
| ES (2) | ES404874A1 (en) |
-
1972
- 1972-07-14 ES ES404874A patent/ES404874A1/en not_active Expired
- 1972-07-14 ES ES404876A patent/ES404876A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES404874A1 (en) | 1976-01-01 |
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