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GB2036003A - Alkylation method of 4(5)-mercaptomethyl-imidazol with aziridin derivatives - Google Patents

Alkylation method of 4(5)-mercaptomethyl-imidazol with aziridin derivatives

Info

Publication number
GB2036003A
GB2036003A GB7928551A GB7928551A GB2036003A GB 2036003 A GB2036003 A GB 2036003A GB 7928551 A GB7928551 A GB 7928551A GB 7928551 A GB7928551 A GB 7928551A GB 2036003 A GB2036003 A GB 2036003A
Authority
GB
United Kingdom
Prior art keywords
aziridin
mercaptomethyl
imidazol
derivatives
alkylation method
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7928551A
Other versions
GB2036003B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CRC Compagnie di Ricerca Chimica SpA
Original Assignee
CRC Compagnie di Ricerca Chimica SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25707086&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB2036003(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from CH1634077A external-priority patent/CH631971A5/en
Application filed by CRC Compagnie di Ricerca Chimica SpA filed Critical CRC Compagnie di Ricerca Chimica SpA
Publication of GB2036003A publication Critical patent/GB2036003A/en
Application granted granted Critical
Publication of GB2036003B publication Critical patent/GB2036003B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Compounds of the following formula are obtained by reacting 4 (5)-mercaptomethyl-imidazol with aziridin derivates: (FORMULA) in which R is an alkyl group with one to three carbon atoms. Due to its high yield, the cancelling of a step and the utilization of cheaper raw materials, this method is more economical than known methods.
GB7928551A 1977-12-30 1978-12-28 Alkylation method of 4(5)-mercaptomethyl-imidazol with aziridin derivatives Expired GB2036003B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1634077A CH631971A5 (en) 1977-12-30 1977-12-30 Process for preparing imidazole derivatives
CH1069578 1978-10-16

Publications (2)

Publication Number Publication Date
GB2036003A true GB2036003A (en) 1980-06-25
GB2036003B GB2036003B (en) 1982-08-18

Family

ID=25707086

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7928551A Expired GB2036003B (en) 1977-12-30 1978-12-28 Alkylation method of 4(5)-mercaptomethyl-imidazol with aziridin derivatives

Country Status (16)

Country Link
JP (1) JPS55500026A (en)
CS (1) CS207750B2 (en)
DE (1) DE2857324D2 (en)
DK (1) DK319679A (en)
FI (1) FI784018A7 (en)
FR (1) FR2413373A1 (en)
GB (1) GB2036003B (en)
GR (1) GR65283B (en)
IT (1) IT1102765B (en)
NL (1) NL171054C (en)
NO (1) NO784350L (en)
PL (1) PL113033B1 (en)
SE (1) SE7907148L (en)
SU (1) SU950188A3 (en)
WO (1) WO1979000466A1 (en)
YU (1) YU313178A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4440938A (en) * 1980-01-08 1984-04-03 Glaxo Group Limited Process for the preparation of a furan derivative
EP0190037B1 (en) * 1985-01-31 1988-11-30 Smith Kline & French Laboratories Limited Process for preparing an aziridine derivative

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS213376B2 (en) * 1978-05-12 1982-04-09 Crc Ricerca Chim Method of making the derivatives of n-kyanoazomethines
LU81178A1 (en) * 1978-05-12 1979-09-10 Crc Ricerca Chim NEW THIOLD DERIVATIVES OF IMIDAZOLE
WO1981000255A1 (en) * 1979-07-16 1981-02-05 Rech Syntheses Organ Imino-alkyl and amino-nitril cyano-guanidines
WO1981000405A1 (en) * 1979-07-30 1981-02-19 Rech Syntheses Organ Di-cyano-guanidines
PT72320B (en) * 1980-01-08 1982-07-23 Glaxo Group Ltd Process for preparation of a furan derivative
EP0058286A1 (en) * 1981-02-12 1982-08-25 Société de Recherches et de Synthèses Organiques SA Geometrical isomers of cyano-guanidines, and processes for their preparation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1533380A (en) * 1974-09-02 1978-11-22 Smith Kline French Lab Process for the preparation of heterocyclic substituted thioureas and h-cyanoguanidines
GB1531231A (en) * 1974-09-02 1978-11-08 Smith Kline French Lab Process for the production of cyanoguanidine derivatives
IL56265A (en) * 1977-12-28 1982-08-31 Om Lab Sa Process for preparing imidazolyl methylthio guanidine derivatives and a novel intermediate therefor

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4440938A (en) * 1980-01-08 1984-04-03 Glaxo Group Limited Process for the preparation of a furan derivative
US4460506A (en) * 1980-01-08 1984-07-17 Glaxo Group Limited Nitrovinyl aziridine derivative
EP0190037B1 (en) * 1985-01-31 1988-11-30 Smith Kline & French Laboratories Limited Process for preparing an aziridine derivative

Also Published As

Publication number Publication date
IT7831352A0 (en) 1978-12-28
NL171054C (en) 1983-02-01
NL7812662A (en) 1979-07-03
SE7907148L (en) 1979-08-28
PL212389A1 (en) 1979-08-13
YU313178A (en) 1982-10-31
WO1979000466A1 (en) 1979-07-26
NO784350L (en) 1979-07-03
GB2036003B (en) 1982-08-18
FI784018A7 (en) 1979-07-01
JPS55500026A (en) 1980-01-24
NL171054B (en) 1982-09-01
GR65283B (en) 1980-08-01
DK319679A (en) 1979-08-30
DE2857324D2 (en) 1980-11-20
PL113033B1 (en) 1980-11-29
SU950188A3 (en) 1982-08-07
FR2413373A1 (en) 1979-07-27
CS207750B2 (en) 1981-08-31
IT1102765B (en) 1985-10-07

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee