EE04025B1 - Heterodimeere moodustavad hübriidvalgud - Google Patents

Heterodimeere moodustavad hübriidvalgud

Info

Publication number: EE04025B1
Authority: EE; Estonia
Prior art keywords: subunit; heterodimers; coexpressed; sequence contains; fusion proteins
Prior art date: 1996-02-20

Application number

EE9800256A

Other languages

English (en)

Estonian (et)

Other versions

EE9800256A (et

Inventor

A. Jameson Bradford

C. Chappel Scott

K. Campbell Robert

Original Assignee

Applied Research Systems Ars Holding N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-20

Filing date

1997-02-20

Publication date

2003-04-15

1997-02-20 Application filed by Applied Research Systems Ars Holding N.V. filed Critical Applied Research Systems Ars Holding N.V.

1999-02-15 Publication of EE9800256A publication Critical patent/EE9800256A/xx

2003-04-15 Publication of EE04025B1 publication Critical patent/EE04025B1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
- C07C209/22—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of other functional groups
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Endocrinology (AREA)
Medicinal Chemistry (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Reproductive Health (AREA)
Gastroenterology & Hepatology (AREA)
Biomedical Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Diabetes (AREA)
Immunology (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Cell Biology (AREA)
Microbiology (AREA)
Epidemiology (AREA)
Pregnancy & Childbirth (AREA)
Gynecology & Obstetrics (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

EE9800256A 1996-02-20 1997-02-20 Heterodimeere moodustavad hübriidvalgud EE04025B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US1193696P	1996-02-20	1996-02-20
PCT/US1997/002315 WO1997030161A1 (en)	1996-02-20	1997-02-20	Hybrid proteins which form heterodimers

Publications (2)

Publication Number	Publication Date
EE9800256A EE9800256A (et)	1999-02-15
EE04025B1 true EE04025B1 (et)	2003-04-15

Family

ID=21752599

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EE9800256A EE04025B1 (et)	1996-02-20	1997-02-20	Heterodimeere moodustavad hübriidvalgud

Country Status (25)

Country	Link
US (5)	US6193972B1 (uk)
EP (1)	EP0894141B1 (uk)
JP (2)	JP4140927B2 (uk)
KR (1)	KR100369985B1 (uk)
CN (1)	CN1261579C (uk)
AT (1)	ATE295887T1 (uk)
AU (1)	AU706504B2 (uk)
BG (1)	BG64510B1 (uk)
BR (1)	BR9707589A (uk)
CA (1)	CA2245877C (uk)
CZ (1)	CZ291212B6 (uk)
DE (1)	DE69733309T2 (uk)
DK (1)	DK0894141T3 (uk)
EA (1)	EA002474B1 (uk)
EE (1)	EE04025B1 (uk)
ES (1)	ES2241040T3 (uk)
HU (1)	HUP9900619A3 (uk)
IL (1)	IL125864A (uk)
NO (1)	NO321777B1 (uk)
NZ (1)	NZ331539A (uk)
PL (1)	PL187400B1 (uk)
PT (1)	PT894141E (uk)
SK (1)	SK282326B6 (uk)
UA (1)	UA52646C2 (uk)
WO (1)	WO1997030161A1 (uk)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL187400B1 (pl) *	1996-02-20	2004-06-30	Applied Research Systems	Białka hybrydowe tworzące heterodimery
US6635740B1 (en) *	1997-03-27	2003-10-21	Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College	Ligand/lytic peptide compositions and methods of use
US6844161B2 (en)	1997-09-04	2005-01-18	Gryphon Therapeutics, Inc.	Modular protein libraries and methods of preparation
EP1257564B1 (en) *	2000-02-22	2008-08-27	Laboratoires Serono SA	Process for purification of recombinant hcg having a specific bioactivity
US20030228600A1 (en) *	2000-07-14	2003-12-11	Eppendorf 5 Prime, Inc.	DNA isolation method and kit
IL147414A0 (en) *	2001-12-31	2002-08-14	Yeda Res & Dev	Ifnar2 mutants, their production and use
US20030157091A1 (en) *	2002-02-14	2003-08-21	Dyax Corporation	Multi-functional proteins
DE10247755B4 (de) *	2002-10-14	2006-01-19	Pfizenmaier, Klaus, Prof. Dr.	Selektive, lokale Aktivierung von Mitgliedern der TNF-Rezeptorfamilie durch systemisch inaktive nicht-Antikörper-TNF-Liganden-Fusionsproteine
BRPI0507174A (pt) *	2004-01-28	2008-04-01	Syntonix Pharmaceuticals Inc	proteìnas de fusão hormÈnio-fc (fsh-fc) heterodiméricas estimuladoras de folìculo para o tratamento da infertilidade
JP2008525002A (ja)	2004-12-23	2008-07-17	ラボラトワールセローノソシエテアノニム	Ｂｃｍａポリペプチド及びその使用
PL1885753T3 (pl)	2005-06-03	2011-12-30	Ares Trading Sa	Wytwarzanie rekombinowanego białka wiążącego IL-18
KR101759460B1 (ko) *	2007-09-21	2017-07-18	더 리전트 오브 더 유니버시티 오브 캘리포니아	표적화된 인터페론이 강력한 아폽토시스 및 항-종양 활성을 발휘함
AU2009215106B2 (en) *	2008-02-01	2015-07-23	Chromocell Corporation	Cell lines and methods for making and using them
CN102002495B (zh) *	2009-08-31	2012-07-18	成都蓉生药业有限责任公司	用于表达异二聚体糖蛋白激素的表达框、表达载体及制备方法
KR20200052383A (ko) *	2011-03-25	2020-05-14	아이크노스 사이언스 에스. 아.	헤테로 이량체 면역글로불린
RU2699007C2 (ru)	2013-02-18	2019-09-02	Ведженикс Пти Лимитед	Молекулы, связывающие лиганды, и их применение
BR112020026112A2 (pt) *	2018-06-21	2021-04-06	Shattuck Labs, Inc.	Proteínas heterodiméricas e usos das mesmas
CN113874390A (zh) *	2019-05-24	2021-12-31	普罗维瓦疗法香港有限公司	Il-2组合物及其使用方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE68926888T2 (de) *	1988-01-22	1997-01-09	Zymogenetics Inc	Verfahren zur Herstellung von sekretierten Rezeptoranalogen
US6225449B1 (en) *	1991-10-04	2001-05-01	Washington University	Hormone analogs with multiple CTP extensions
US5705478A (en) *	1989-02-21	1998-01-06	Washington University	Covalently linked β subunits of the glycoprotein hormones as antagonists
US5116964A (en) *	1989-02-23	1992-05-26	Genentech, Inc.	Hybrid immunoglobulins
WO1990012877A1 (en) *	1989-04-19	1990-11-01	Cetus Corporation	Multifunctional m-csf proteins and genes encoding therefor
US5650150A (en) *	1990-11-09	1997-07-22	Gillies; Stephen D.	Recombinant antibody cytokine fusion proteins
IL99120A0 (en) *	1991-08-07	1992-07-15	Yeda Res & Dev	Multimers of the soluble forms of tnf receptors,their preparation and pharmaceutical compositions containing them
US5932448A (en) *	1991-11-29	1999-08-03	Protein Design Labs., Inc.	Bispecific antibody heterodimers
CA2133326C (en)	1992-03-30	2005-03-01	Craig A. Smith	Fusion proteins comprising tumor necrosis factor receptor
US5447851B1 (en) *	1992-04-02	1999-07-06	Univ Texas System Board Of	Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells
IL111125A0 (en) *	1994-05-11	1994-12-29	Yeda Res & Dev	Soluble oligomeric tnf/ngf super family ligand receptors and their use
US6194177B1 (en) *	1996-02-20	2001-02-27	Applied Research Systems Ars Holding N.V.	DNA encoding a hybrid heterodimeric protein
PL187400B1 (pl) *	1996-02-20	2004-06-30	Applied Research Systems	Białka hybrydowe tworzące heterodimery

1997
- 1997-02-20 PL PL97328454A patent/PL187400B1/pl not_active IP Right Cessation
- 1997-02-20 WO PCT/US1997/002315 patent/WO1997030161A1/en not_active Ceased
- 1997-02-20 PT PT97906604T patent/PT894141E/pt unknown
- 1997-02-20 NZ NZ331539A patent/NZ331539A/xx unknown
- 1997-02-20 AT AT97906604T patent/ATE295887T1/de not_active IP Right Cessation
- 1997-02-20 SK SK1148-98A patent/SK282326B6/sk unknown
- 1997-02-20 JP JP52949897A patent/JP4140927B2/ja not_active Expired - Fee Related
- 1997-02-20 KR KR10-1998-0706215A patent/KR100369985B1/ko not_active Expired - Fee Related
- 1997-02-20 UA UA98094928A patent/UA52646C2/uk unknown
- 1997-02-20 CA CA2245877A patent/CA2245877C/en not_active Expired - Fee Related
- 1997-02-20 DE DE69733309T patent/DE69733309T2/de not_active Expired - Lifetime
- 1997-02-20 ES ES97906604T patent/ES2241040T3/es not_active Expired - Lifetime
- 1997-02-20 US US08/804,166 patent/US6193972B1/en not_active Expired - Lifetime
- 1997-02-20 CZ CZ19982644A patent/CZ291212B6/cs not_active IP Right Cessation
- 1997-02-20 BR BR9707589-2A patent/BR9707589A/pt not_active Application Discontinuation
- 1997-02-20 HU HU9900619A patent/HUP9900619A3/hu unknown
- 1997-02-20 IL IL125864A patent/IL125864A/en not_active IP Right Cessation
- 1997-02-20 DK DK97906604T patent/DK0894141T3/da active
- 1997-02-20 EP EP97906604A patent/EP0894141B1/en not_active Expired - Lifetime
- 1997-02-20 AU AU21252/97A patent/AU706504B2/en not_active Ceased
- 1997-02-20 EA EA199800744A patent/EA002474B1/ru not_active IP Right Cessation
- 1997-02-20 CN CNB971924112A patent/CN1261579C/zh not_active Expired - Fee Related
- 1997-02-20 EE EE9800256A patent/EE04025B1/xx not_active IP Right Cessation
1998
- 1998-08-19 NO NO19983799A patent/NO321777B1/no unknown
- 1998-08-20 BG BG102705A patent/BG64510B1/bg unknown
2001
- 2001-01-09 US US09/756,186 patent/US6663867B2/en not_active Expired - Fee Related
2003
- 2003-12-01 US US10/724,226 patent/US7291339B2/en not_active Expired - Fee Related
2007
- 2007-07-10 JP JP2007181534A patent/JP2008019258A/ja active Pending
- 2007-09-26 US US11/861,835 patent/US20100075402A1/en not_active Abandoned
- 2007-10-30 US US11/929,292 patent/US20090240039A1/en not_active Abandoned

Also Published As

Publication number	Publication date
DE69733309D1 (de)	2005-06-23
HUP9900619A3 (en)	2001-11-28
BR9707589A (pt)	2000-01-04
US20040230034A1 (en)	2004-11-18
NO983799L (no)	1998-10-19
ATE295887T1 (de)	2005-06-15
BG64510B1 (bg)	2005-05-31
CA2245877C (en)	2013-09-03
EA199800744A1 (ru)	1999-02-25
IL125864A (en)	2007-07-04
US6193972B1 (en)	2001-02-27
DE69733309T2 (de)	2006-01-19
BG102705A (en)	1999-04-30
DK0894141T3 (da)	2005-08-22
NO321777B1 (no)	2006-07-03
US20090240039A1 (en)	2009-09-24
CN1212017A (zh)	1999-03-24
EE9800256A (et)	1999-02-15
AU2125297A (en)	1997-09-02
CA2245877A1 (en)	1997-08-21
KR100369985B1 (ko)	2004-03-26
US6663867B2 (en)	2003-12-16
SK282326B6 (sk)	2002-01-07
JP2000504586A (ja)	2000-04-18
SK114898A3 (en)	1999-07-12
ES2241040T3 (es)	2005-10-16
EP0894141B1 (en)	2005-05-18
UA52646C2 (uk)	2003-01-15
US7291339B2 (en)	2007-11-06
PT894141E (pt)	2005-09-30
PL328454A1 (en)	1999-02-01
US20010014333A1 (en)	2001-08-16
NZ331539A (en)	2000-01-28
EP0894141A1 (en)	1999-02-03
CZ264498A3 (cs)	1998-12-16
HUP9900619A2 (hu)	1999-06-28
NO983799D0 (no)	1998-08-19
PL187400B1 (pl)	2004-06-30
CN1261579C (zh)	2006-06-28
JP4140927B2 (ja)	2008-08-27
AU706504B2 (en)	1999-06-17
WO1997030161A1 (en)	1997-08-21
JP2008019258A (ja)	2008-01-31
CZ291212B6 (cs)	2003-01-15
EA002474B1 (ru)	2002-06-27
KR19990082482A (ko)	1999-11-25
US20100075402A1 (en)	2010-03-25
IL125864A0 (en)	1999-04-11

Publication	Publication Date	Title
EE04025B1 (et)	2003-04-15	Heterodimeere moodustavad hübriidvalgud
ES2147558T3 (es)	2000-09-16	Nuevos polipeptidos para promover la fijacion celular.
ATE393222T1 (de)	2008-05-15	Dcr3 polypeptid, ein tnfr homolog
DE69737415D1 (de)	2007-04-12	Gespannte, helixformende peptide und verfahren um sie herzustellen
RU94045919A (ru)	1996-11-10	Антитела, клетки, полипептид, днк векторы, способ получения полипептида, способ получения антитела, фармацевтическая композиция
ATE464067T1 (de)	2010-04-15	Bindegewebs wachstumsfaktor (ctgf)
ATE142645T1 (de)	1996-09-15	Rezeptoren für wachstumshormone
EP2829549A3 (en)	2015-06-03	Hybrid and tandem expression of neisserial derived proteins
DE69939327D1 (de)	2008-09-25	Funktionelle antagonisten von hedgehog-aktivität
EP0180878A3 (en)	1987-05-06	Heterodimeric t lymphocyte receptor
CA2440596A1 (en)	2002-09-19	Soluble heterodimeric cytokine receptor
BR9708518A (pt)	1999-08-03	Moduladores de fator associado a receptor tnf (traf) sua preparação e uso
WO2003104282A8 (en)	2004-04-29	Glycoprotein vi - fc fusion protein for treating vascular disorders
Katsoyannis et al.	1966	Insulin Peptides. XII. Human Insulin Generation by Combination of Synthetic A and B Chains1
BRPI0413426A (pt)	2006-10-17	antagonistas de receptor novo
ES549185A0 (es)	1987-04-01	Procedimiento para sintetizar peptidos a partir de aminoaci-dos
Paul et al.	1992	Design of a natural cis peptide bond motif to form type VI β-turn mimetic
NO930428D0 (no)	1993-02-08	Proteinstrukturen til plantetoksingelonin
KR970070198A (ko)	1997-11-07	항-파스 재조합 항체 및 이에 대한 디엔아이
EA200600376A1 (ru)	2006-12-29	Антагонисты nogo-рецептора
DE69635161D1 (de)	2005-10-13	Rekombinante hetero-multimerische proteine von dem alpha-beta c4 bp typ
EP1557432A3 (en)	2008-03-05	Hybrid proteins which form heterodimers
WO1992016623A3 (en)	1992-10-29	Receptors for bombesin-like peptides
ATE447008T1 (de)	2009-11-15	Rre und cte umfassende gentechnische konstrukte und zusammensetzungen und verwendungen davon
DE69631624D1 (de)	2004-04-01	Antikörper gegen menschliches restrictin

Legal Events

Date	Code	Title	Description
2004-02-16	KB4A	Valid patent at the end of a year	Effective date: 20031231
2005-02-15	KB4A	Valid patent at the end of a year	Effective date: 20041231
2006-02-15	KB4A	Valid patent at the end of a year	Effective date: 20051231
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2007-10-15	GB1A	Change in the ownership or in the address of the owner
2008-02-15	KB4A	Valid patent at the end of a year	Effective date: 20071231
2009-02-16	KB4A	Valid patent at the end of a year	Effective date: 20081231
2009-10-15	MM4A	Lapsed by not paying the annual fees	Effective date: 20090220