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NO983799L - Hybride proteiner som danner heterodimerer - Google Patents

Hybride proteiner som danner heterodimerer

Info

Publication number
NO983799L
NO983799L NO983799A NO983799A NO983799L NO 983799 L NO983799 L NO 983799L NO 983799 A NO983799 A NO 983799A NO 983799 A NO983799 A NO 983799A NO 983799 L NO983799 L NO 983799L
Authority
NO
Norway
Prior art keywords
subunit
coexpressed
sequence contains
hybrid proteins
form heterodimers
Prior art date
Application number
NO983799A
Other languages
English (en)
Other versions
NO321777B1 (no
NO983799D0 (no
Inventor
Robert K Campbell
Bradford A Jameson
Scott C Chappel
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Publication of NO983799D0 publication Critical patent/NO983799D0/no
Publication of NO983799L publication Critical patent/NO983799L/no
Publication of NO321777B1 publication Critical patent/NO321777B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
    • C07C209/22—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of other functional groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NO19983799A 1996-02-20 1998-08-19 Hybridproteiner som danner heterodimerer, DNA, ekspresjonsvektorer og vertsceller som koder for eller uttrykker disse, samt farmasoytisk sammensetning og anvendelse av hybridproteinene for fremstilling av et medikament for behandling av humane lidelser med behov for inhibering av TNF. NO321777B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1193696P 1996-02-20 1996-02-20
PCT/US1997/002315 WO1997030161A1 (en) 1996-02-20 1997-02-20 Hybrid proteins which form heterodimers

Publications (3)

Publication Number Publication Date
NO983799D0 NO983799D0 (no) 1998-08-19
NO983799L true NO983799L (no) 1998-10-19
NO321777B1 NO321777B1 (no) 2006-07-03

Family

ID=21752599

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19983799A NO321777B1 (no) 1996-02-20 1998-08-19 Hybridproteiner som danner heterodimerer, DNA, ekspresjonsvektorer og vertsceller som koder for eller uttrykker disse, samt farmasoytisk sammensetning og anvendelse av hybridproteinene for fremstilling av et medikament for behandling av humane lidelser med behov for inhibering av TNF.

Country Status (25)

Country Link
US (5) US6193972B1 (no)
EP (1) EP0894141B1 (no)
JP (2) JP4140927B2 (no)
KR (1) KR100369985B1 (no)
CN (1) CN1261579C (no)
AT (1) ATE295887T1 (no)
AU (1) AU706504B2 (no)
BG (1) BG64510B1 (no)
BR (1) BR9707589A (no)
CA (1) CA2245877C (no)
CZ (1) CZ291212B6 (no)
DE (1) DE69733309T2 (no)
DK (1) DK0894141T3 (no)
EA (1) EA002474B1 (no)
EE (1) EE04025B1 (no)
ES (1) ES2241040T3 (no)
HU (1) HUP9900619A3 (no)
IL (1) IL125864A (no)
NO (1) NO321777B1 (no)
NZ (1) NZ331539A (no)
PL (1) PL187400B1 (no)
PT (1) PT894141E (no)
SK (1) SK282326B6 (no)
UA (1) UA52646C2 (no)
WO (1) WO1997030161A1 (no)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA002474B1 (ru) * 1996-02-20 2002-06-27 Апплайд Резеч Системз Арс Холдинг Н.В. Гибридный белок, образующий гетеродимеры, способ его получения и использования
US6635740B1 (en) * 1997-03-27 2003-10-21 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Ligand/lytic peptide compositions and methods of use
EP1009757A1 (en) 1997-09-04 2000-06-21 Gryphon Sciences Modular protein libraries and methods of preparation
ME00296B (me) * 2000-02-22 2011-05-10 Applied Res Systems Ars Holding N V PROCES PREČIŠĆAVANJA hCG I REKOMBINANTNOG hCG PREČIŠĆENOG TOM METODOM
US20030228600A1 (en) * 2000-07-14 2003-12-11 Eppendorf 5 Prime, Inc. DNA isolation method and kit
IL147414A0 (en) * 2001-12-31 2002-08-14 Yeda Res & Dev Ifnar2 mutants, their production and use
US20030157091A1 (en) * 2002-02-14 2003-08-21 Dyax Corporation Multi-functional proteins
DE10247755B4 (de) * 2002-10-14 2006-01-19 Pfizenmaier, Klaus, Prof. Dr. Selektive, lokale Aktivierung von Mitgliedern der TNF-Rezeptorfamilie durch systemisch inaktive nicht-Antikörper-TNF-Liganden-Fusionsproteine
AU2005207960A1 (en) * 2004-01-28 2005-08-11 Syntonix Pharmaceuticals, Inc. Heterodimeric follicle stimulating hormone-Fc (FSH-Fc) fusion proteins for the treatment of infertility
CA2590461A1 (en) 2004-12-23 2006-06-29 Laboratoires Serono S.A. Bcma polypeptides and uses thereof
CA2609060C (en) 2005-06-03 2014-07-15 Urs Weber Production of recombinant il-18 binding protein
JP5591701B2 (ja) * 2007-09-21 2014-09-17 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 強力なアポトーシス活性および抗腫瘍活性を示すターゲティング化インターフェロン
US20100311610A1 (en) * 2008-02-01 2010-12-09 Chromocell Corporation CELL LINES AND METHODS FOR MAKING AND USING THEM (As Amended)
CN102002495B (zh) * 2009-08-31 2012-07-18 成都蓉生药业有限责任公司 用于表达异二聚体糖蛋白激素的表达框、表达载体及制备方法
MX358752B (es) * 2011-03-25 2018-08-31 Glenmark Pharmaceuticals Sa Inmunoglobulinas heterodiméricas.
ES2771478T3 (es) 2013-02-18 2020-07-06 Vegenics Pty Ltd Moléculas de unión a ligando y usos de las mismas
CN112566650A (zh) * 2018-06-21 2021-03-26 沙塔克实验室有限公司 异二聚体蛋白及其用途
KR20220012256A (ko) * 2019-05-24 2022-02-03 프로비바 테라퓨틱스 (홍콩) 리미티드 Il-2 조성물 및 이의 사용 방법

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE140963T1 (de) * 1988-01-22 1996-08-15 Zymogenetics Inc Verfahren zur herstellung von sekretierten rezeptoranalogen
US5705478A (en) * 1989-02-21 1998-01-06 Washington University Covalently linked β subunits of the glycoprotein hormones as antagonists
US6225449B1 (en) * 1991-10-04 2001-05-01 Washington University Hormone analogs with multiple CTP extensions
US5116964A (en) * 1989-02-23 1992-05-26 Genentech, Inc. Hybrid immunoglobulins
WO1990012877A1 (en) * 1989-04-19 1990-11-01 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
US5650150A (en) * 1990-11-09 1997-07-22 Gillies; Stephen D. Recombinant antibody cytokine fusion proteins
IL99120A0 (en) * 1991-08-07 1992-07-15 Yeda Res & Dev Multimers of the soluble forms of tnf receptors,their preparation and pharmaceutical compositions containing them
US5932448A (en) * 1991-11-29 1999-08-03 Protein Design Labs., Inc. Bispecific antibody heterodimers
ES2197149T3 (es) 1992-03-30 2004-01-01 Immunex Corporation Proteinas de fusion que comprende receptores para dos factores de necrosis tumoral.
US5447851B1 (en) * 1992-04-02 1999-07-06 Univ Texas System Board Of Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells
IL111125A0 (en) * 1994-05-11 1994-12-29 Yeda Res & Dev Soluble oligomeric tnf/ngf super family ligand receptors and their use
US6194177B1 (en) * 1996-02-20 2001-02-27 Applied Research Systems Ars Holding N.V. DNA encoding a hybrid heterodimeric protein
EA002474B1 (ru) * 1996-02-20 2002-06-27 Апплайд Резеч Системз Арс Холдинг Н.В. Гибридный белок, образующий гетеродимеры, способ его получения и использования

Also Published As

Publication number Publication date
CN1261579C (zh) 2006-06-28
PT894141E (pt) 2005-09-30
HUP9900619A2 (hu) 1999-06-28
AU2125297A (en) 1997-09-02
NO321777B1 (no) 2006-07-03
CZ264498A3 (cs) 1998-12-16
ES2241040T3 (es) 2005-10-16
CZ291212B6 (cs) 2003-01-15
US7291339B2 (en) 2007-11-06
KR19990082482A (ko) 1999-11-25
NZ331539A (en) 2000-01-28
US6663867B2 (en) 2003-12-16
NO983799D0 (no) 1998-08-19
EA002474B1 (ru) 2002-06-27
BR9707589A (pt) 2000-01-04
KR100369985B1 (ko) 2004-03-26
EE04025B1 (et) 2003-04-15
US20100075402A1 (en) 2010-03-25
WO1997030161A1 (en) 1997-08-21
EE9800256A (et) 1999-02-15
DE69733309D1 (de) 2005-06-23
US20040230034A1 (en) 2004-11-18
BG102705A (en) 1999-04-30
DK0894141T3 (da) 2005-08-22
CN1212017A (zh) 1999-03-24
UA52646C2 (uk) 2003-01-15
AU706504B2 (en) 1999-06-17
US20010014333A1 (en) 2001-08-16
IL125864A (en) 2007-07-04
IL125864A0 (en) 1999-04-11
HUP9900619A3 (en) 2001-11-28
PL187400B1 (pl) 2004-06-30
EA199800744A1 (ru) 1999-02-25
EP0894141B1 (en) 2005-05-18
BG64510B1 (bg) 2005-05-31
JP2000504586A (ja) 2000-04-18
SK114898A3 (en) 1999-07-12
PL328454A1 (en) 1999-02-01
CA2245877A1 (en) 1997-08-21
SK282326B6 (sk) 2002-01-07
US20090240039A1 (en) 2009-09-24
CA2245877C (en) 2013-09-03
DE69733309T2 (de) 2006-01-19
US6193972B1 (en) 2001-02-27
ATE295887T1 (de) 2005-06-15
JP4140927B2 (ja) 2008-08-27
EP0894141A1 (en) 1999-02-03
JP2008019258A (ja) 2008-01-31

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