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WO1992016623A3 - Receptors for bombesin-like peptides - Google Patents

Receptors for bombesin-like peptides Download PDF

Info

Publication number
WO1992016623A3
WO1992016623A3 PCT/US1992/002091 US9202091W WO9216623A3 WO 1992016623 A3 WO1992016623 A3 WO 1992016623A3 US 9202091 W US9202091 W US 9202091W WO 9216623 A3 WO9216623 A3 WO 9216623A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptors
bombesin
peptides
disclosed
purified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1992/002091
Other languages
French (fr)
Other versions
WO1992016623A2 (en
Inventor
James F Battey Jr
Martha H Corjay
Zahra Fathi
Richard I Feldman
Richard N Harkin
Timothy K Slattery
Etsuko Wada
James M Wu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Berlex Laboratories Inc
US Department of Health and Human Services
Government of the United States of America
Original Assignee
Berlex Laboratories Inc
US Department of Health and Human Services
Government of the United States of America
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Berlex Laboratories Inc, US Department of Health and Human Services, Government of the United States of America filed Critical Berlex Laboratories Inc
Priority to JP4510596A priority Critical patent/JPH06509940A/en
Publication of WO1992016623A2 publication Critical patent/WO1992016623A2/en
Publication of WO1992016623A3 publication Critical patent/WO1992016623A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/286—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against neuromediator receptors, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Receptors for bombesin-like peptides are solubilized and purified in active form. The amino acid sequence and DNA encoding various subtypes of the receptors are disclosed. Uses of the purified receptor gene and polypeptide are disclosed, including means for screening for agonists and antagonists of the receptor ligands, for producing diagnostic or therapeutic reagents, and for producing antibodies. Therapeutic or diagnostic reagents and kits are also provided.
PCT/US1992/002091 1991-03-15 1992-03-13 Receptors for bombesin-like peptides Ceased WO1992016623A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4510596A JPH06509940A (en) 1991-03-15 1992-03-13 Receptor for bombesin-like peptides

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US67060391A 1991-03-15 1991-03-15
US670,603 1991-03-15
US77133291A 1991-10-03 1991-10-03
US771,332 1991-10-03

Publications (2)

Publication Number Publication Date
WO1992016623A2 WO1992016623A2 (en) 1992-10-01
WO1992016623A3 true WO1992016623A3 (en) 1992-10-29

Family

ID=27100353

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1992/002091 Ceased WO1992016623A2 (en) 1991-03-15 1992-03-13 Receptors for bombesin-like peptides

Country Status (5)

Country Link
EP (1) EP0576609A1 (en)
JP (1) JPH06509940A (en)
AU (1) AU1793092A (en)
CA (1) CA2105306A1 (en)
WO (1) WO1992016623A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106132993A (en) * 2014-03-27 2016-11-16 兹耶尔生物科学研究,开发和诊断有限公司 Anti gastrin-releasing peptide receptor (GRPR) antibody, it is thus achieved that process, detect process, antibody uses, reagent and gene constructed

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6190912B1 (en) * 1998-03-31 2001-02-20 Thomas Jefferson University Blk genes and uses thereof in apoptosis
US6143521A (en) * 1998-07-22 2000-11-07 Smithkline Beecham Corporation Human bombesin receptor subtype-3sb
GB9925115D0 (en) * 1999-10-22 1999-12-22 Pfizer Ltd Novel polypeptide
WO2003093830A1 (en) * 2002-05-02 2003-11-13 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with neuromedin b receptor (nmb)
US9757330B2 (en) 2013-10-18 2017-09-12 Industrial Technology Research Institute Recipe for in-situ gel, and implant, drug delivery system formed thereby
CN120623273A (en) * 2023-04-10 2025-09-12 湖南中晟全肽生物科技股份有限公司 Bombesin polypeptide compounds and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989009232A1 (en) * 1988-03-21 1989-10-05 Imperial Cancer Research Technology Ltd. Neuropeptide antagonists
WO1991006647A1 (en) * 1989-10-24 1991-05-16 Triton Biosciences, Inc. Gastrin releasing peptide receptor

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989009232A1 (en) * 1988-03-21 1989-10-05 Imperial Cancer Research Technology Ltd. Neuropeptide antagonists
WO1991006647A1 (en) * 1989-10-24 1991-05-16 Triton Biosciences, Inc. Gastrin releasing peptide receptor

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
MOLECULAR ENDOCRINOLOGY vol. 4, no. 12, December 1990, BALTIMORE MD, USA pages 1956 - 1963; E. SPINDEL ET AL.: 'Cloning and functional characterization of a complementary DNA encoding the murine fibroblast bombesin/gastrin-releasing peptide receptor.' *
NEURON vol. 6, no. 3, March 1991, pages 421 - 430; E. WADA ET AL.: 'cDNA cloning, characterization, and brain region-specific expression of a neuromedin-b-preferring bombesin receptor.' cited in the application *
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE USA vol. 88, no. 2, 15 January 1991, WASHINGTON DC, USA pages 395 - 399; J. BATTEY ET AL.: 'Molecular cloning of the bombesin/gastrin-releasing peptide receptor from Swiss 3T3 cells.' cited in the application *
THE JOURNAL OF BIOLOGICAL CHEMISTRY vol. 262, no. 23, 15 August 1987, BALTIMORE MD, USA pages 11215 - 11220; R. KRIS ET AL.: 'Identification of the bombesin receptor on murine and human cells by cross-linking experiments.' cited in the application *
THE JOURNAL OF BIOLOGICAL CHEMISTRY. vol. 266, no. 28, 5 October 1991, BALTIMORE MD, US pages 18771 - 18779; M. CORJAY ET AL.: 'Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells.' *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106132993A (en) * 2014-03-27 2016-11-16 兹耶尔生物科学研究,开发和诊断有限公司 Anti gastrin-releasing peptide receptor (GRPR) antibody, it is thus achieved that process, detect process, antibody uses, reagent and gene constructed

Also Published As

Publication number Publication date
JPH06509940A (en) 1994-11-10
CA2105306A1 (en) 1992-09-16
AU1793092A (en) 1992-10-21
WO1992016623A2 (en) 1992-10-01
EP0576609A1 (en) 1994-01-05

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