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ECSP12012323A - Derivados de carbamato de hexafluoroisopropilo, su preparación y su aplicación en terapéutica - Google Patents

Derivados de carbamato de hexafluoroisopropilo, su preparación y su aplicación en terapéutica

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Publication number
ECSP12012323A
ECSP12012323A ECSP12012323A ECSP12012323A EC SP12012323 A ECSP12012323 A EC SP12012323A EC SP12012323 A ECSP12012323 A EC SP12012323A EC SP12012323 A ECSP12012323 A EC SP12012323A
Authority
EC
Ecuador
Prior art keywords
hexafluoroisopropil
therapeutics
preparation
application
carbamate derivatives
Prior art date
Application number
Other languages
English (en)
Inventor
Luc Even
Regine Bartsch
Dorothee Cheuret
Jean Jeunesse
Frank Marguet
Christian Hoornaert
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43402192&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP12012323(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of ECSP12012323A publication Critical patent/ECSP12012323A/es

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    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
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    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
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Abstract

La invención se refiere a los derivados de carbamatos de hexafluoroisopropilo, de fórmula general (I): en donde R, Z, A, m y n son como se definen en la memoria descriptiva, en forma de la base o de una sal de adición con un ácido. Los compuestos se pueden usar como inhibidores de la enzima MGL (monoacil glicerol lipasa)
ECSP12012323 2010-06-04 2012-12-03 Derivados de carbamato de hexafluoroisopropilo, su preparación y su aplicación en terapéutica ECSP12012323A (es)

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