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EA201301130A1 - Имидазопиридазины в качестве ингибиторов акт киназы - Google Patents

Имидазопиридазины в качестве ингибиторов акт киназы

Info

Publication number
EA201301130A1
EA201301130A1 EA201301130A EA201301130A EA201301130A1 EA 201301130 A1 EA201301130 A1 EA 201301130A1 EA 201301130 A EA201301130 A EA 201301130A EA 201301130 A EA201301130 A EA 201301130A EA 201301130 A1 EA201301130 A1 EA 201301130A1
Authority
EA
Eurasian Patent Office
Prior art keywords
imidazopiridazines
inhibitors kinase
kinase act
act
inhibitors
Prior art date
Application number
EA201301130A
Other languages
English (en)
Other versions
EA024890B1 (ru
Inventor
Ларс Берфаккер
Уилльям Джонстон Скотт
Андреа Хегебарт
Стьюарт Инс
Хартмут Ревинкель
Оливер Политц
Роланд Нойхаус
Ханс Брим
Ульф Бёмер
Original Assignee
Байер Интеллектчуал Проперти Гмбх
Байер Фарма Акциенгезельшафт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Байер Интеллектчуал Проперти Гмбх, Байер Фарма Акциенгезельшафт filed Critical Байер Интеллектчуал Проперти Гмбх
Publication of EA201301130A1 publication Critical patent/EA201301130A1/ru
Publication of EA024890B1 publication Critical patent/EA024890B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Имидазопиридазины формулы (I)способ их получения и их применение.
EA201301130A 2011-04-07 2012-04-05 Имидазопиридазины в качестве ингибиторов akt киназы EA024890B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161472732P 2011-04-07 2011-04-07
PCT/EP2012/056300 WO2012136776A1 (en) 2011-04-07 2012-04-05 Imidazopyridazines as akt kinase inhibitors

Publications (2)

Publication Number Publication Date
EA201301130A1 true EA201301130A1 (ru) 2014-07-30
EA024890B1 EA024890B1 (ru) 2016-10-31

Family

ID=45953129

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201301130A EA024890B1 (ru) 2011-04-07 2012-04-05 Имидазопиридазины в качестве ингибиторов akt киназы

Country Status (43)

Country Link
US (2) US9206185B2 (ru)
EP (1) EP2694510B1 (ru)
JP (1) JP5906303B2 (ru)
KR (1) KR20140022057A (ru)
CN (1) CN103596957B (ru)
AP (1) AP3597A (ru)
AR (1) AR087148A1 (ru)
AU (1) AU2012238589B2 (ru)
BR (1) BR112013025777A2 (ru)
CA (1) CA2832374A1 (ru)
CL (1) CL2013002878A1 (ru)
CO (1) CO6862145A2 (ru)
CR (1) CR20130515A (ru)
CU (1) CU24263B1 (ru)
CY (1) CY1117163T1 (ru)
DK (1) DK2694510T3 (ru)
DO (1) DOP2013000226A (ru)
EA (1) EA024890B1 (ru)
EC (1) ECSP13013008A (ru)
ES (1) ES2558780T3 (ru)
GT (1) GT201300238A (ru)
HR (1) HRP20160011T1 (ru)
HU (1) HUE026323T2 (ru)
IL (1) IL228567A0 (ru)
JO (1) JO3068B1 (ru)
MA (1) MA35016B1 (ru)
ME (1) ME02316B (ru)
MX (1) MX336865B (ru)
NI (1) NI201300105A (ru)
PE (1) PE20141380A1 (ru)
PH (1) PH12013502073A1 (ru)
PL (1) PL2694510T3 (ru)
PT (1) PT2694510E (ru)
RS (1) RS54480B1 (ru)
SG (1) SG193631A1 (ru)
SI (1) SI2694510T1 (ru)
SM (1) SMT201600001B (ru)
TN (1) TN2013000400A1 (ru)
TW (1) TWI535719B (ru)
UA (1) UA111739C2 (ru)
UY (1) UY34006A (ru)
WO (1) WO2012136776A1 (ru)
ZA (1) ZA201307223B (ru)

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LT3289876T (lt) 2008-06-16 2022-11-10 University Of Tennessee Research Foundation Junginiai, skirti vėžio gydymui
US9447049B2 (en) 2010-03-01 2016-09-20 University Of Tennessee Research Foundation Compounds for treatment of cancer
US9029408B2 (en) 2008-06-16 2015-05-12 Gtx, Inc. Compounds for treatment of cancer
JP5879273B2 (ja) 2010-03-01 2016-03-08 ジーティーエックス・インコーポレイテッド 癌を処置するための化合物
US11084811B2 (en) 2010-03-01 2021-08-10 Oncternal Therapeutics, Inc. Compounds for treatment of cancer
HUE026323T2 (en) * 2011-04-07 2016-05-30 Bayer Ip Gmbh Imidazopyridazines as akt kinase inhibitors
EP2802588B1 (en) * 2012-01-10 2016-05-25 Bayer Intellectual Property GmbH Substituted pyrazolopyrimidines as akt kinase inhibitors
ES2588186T3 (es) * 2012-01-10 2016-10-31 Bayer Intellectual Property Gmbh Imidazopirazinas sustituidas como inhibidores de la quinasa Akt
IL300664A (en) * 2012-11-30 2023-04-01 Novartis Ag Innovative pharmaceutical composition
MX375059B (es) * 2013-03-05 2025-03-06 Univ Tennessee Res Found Compuestos para el tratamiento de cancer.
WO2014158467A1 (en) * 2013-03-12 2014-10-02 Glaxosmithkline Llc Combination
AU2014236348B2 (en) * 2013-03-14 2018-05-10 Epizyme, Inc. Combination therapy for treating cancer
EP3092242A1 (en) * 2014-01-09 2016-11-16 Bayer Pharma Aktiengesellschaft Amido-substituted imidazopyridazines useful in the treatment of hyper-proliferative and/or angiogenesis disorders
MA46888A (fr) * 2016-11-28 2021-06-02 Bristol Myers Squibb Co Inhibiteurs de gsk-3
EP3453706A1 (en) 2017-09-08 2019-03-13 Basf Se Pesticidal imidazole compounds
GB2600384A (en) 2020-09-30 2022-05-04 Vaderis Therapeutics Ag Allosteric AKT inhibitors for use in the treatment of hereditary hemorrhagic telangiectasia

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CA2393724A1 (en) 1999-12-23 2001-06-28 Nitromed, Inc. Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
ATE361297T1 (de) 2000-03-31 2007-05-15 Ortho Mcneil Pharm Inc Phenyl-substituierte imidazopyridine
DE60112272T2 (de) 2000-04-27 2006-05-24 Astellas Pharma Inc. Imidazopyridin-derivate
KR20050122210A (ko) 2003-03-17 2005-12-28 다케다 샌디에고, 인코포레이티드 히스톤 탈아세틸화 효소 억제제
AU2004233828B2 (en) 2003-04-24 2009-05-28 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
EP1660500B1 (en) 2003-07-30 2007-12-12 Laboratorios S.A.L.V.A.T., S.A. Substituted imidazopyrimidines for the prevention and treatment of cancer
US7655649B2 (en) 2004-04-09 2010-02-02 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
CN101217958A (zh) 2004-08-23 2008-07-09 默克公司 Akt活性抑制剂
EP1786780A1 (de) 2004-08-24 2007-05-23 Basf Aktiengesellschaft Imidazolium-methylsulfite als ausgangsverbindungen zur herstellung ionischer flüssigkeiten
EP1827436A4 (en) 2004-12-15 2011-08-10 Merck Sharp & Dohme INHIBITORS OF ACT ACTIVITY
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AU2006258124B8 (en) 2005-06-10 2010-01-07 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
US20070049591A1 (en) 2005-08-25 2007-03-01 Kalypsys, Inc. Inhibitors of MAPK/Erk Kinase
PE20070978A1 (es) 2006-02-14 2007-11-15 Novartis Ag COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE FOSFATIDILINOSITOL 3-QUINASAS (PI3Ks)
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MX2009013213A (es) * 2007-06-08 2010-03-30 Abbott Lab Indazoles 5-sustituidos 5-heteroarilo como inhibidores de cinasa.
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JP2011522048A (ja) 2008-06-03 2011-07-28 メルク・シャープ・エンド・ドーム・コーポレイション Ａｋｔ活性の阻害剤
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PA8854101A1 (es) 2008-12-18 2010-07-27 Ortho Mcneil Janssen Pharm Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa
JP2012516847A (ja) 2009-02-02 2012-07-26 メルク・シャープ・エンド・ドーム・コーポレイション Ａｋｔ活性の阻害剤
CA2752105C (en) * 2009-02-13 2017-10-31 Matthias Vennemann Fused pyrimidines
WO2010104933A1 (en) 2009-03-11 2010-09-16 Merck Sharp & Dohme Corp. Inhibitors of akt activity
US8691825B2 (en) 2009-04-01 2014-04-08 Merck Sharp & Dohme Corp. Inhibitors of AKT activity
AR076936A1 (es) 2009-06-02 2011-07-20 Vitae Pharmaceuticals Inc Inhibidores de carbamato y urea de la 11 beta hidroxiesteroide deshidrogenasa 1
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EP2593451B1 (en) * 2010-07-12 2015-08-19 Bayer Intellectual Property GmbH Substituted imidazo[1,2-a]pyrimidines and -pyridines
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HUE026323T2 (en) * 2011-04-07 2016-05-30 Bayer Ip Gmbh Imidazopyridazines as akt kinase inhibitors

Also Published As

Publication number Publication date
AU2012238589B2 (en) 2017-02-16
EP2694510A1 (en) 2014-02-12
CA2832374A1 (en) 2012-10-11
DK2694510T3 (en) 2016-01-18
EA024890B1 (ru) 2016-10-31
CR20130515A (es) 2013-12-04
JO3068B1 (ar) 2017-03-15
KR20140022057A (ko) 2014-02-21
US20140113901A1 (en) 2014-04-24
TW201245204A (en) 2012-11-16
US9604989B2 (en) 2017-03-28
EP2694510B1 (en) 2015-10-14
MA35016B1 (fr) 2014-04-03
GT201300238A (es) 2015-04-06
US20150368250A1 (en) 2015-12-24
HRP20160011T1 (hr) 2016-02-12
ES2558780T3 (es) 2016-02-08
CO6862145A2 (es) 2014-02-10
PE20141380A1 (es) 2014-10-18
CY1117163T1 (el) 2017-04-05
SMT201600001B (it) 2016-02-25
WO2012136776A1 (en) 2012-10-11
CN103596957A (zh) 2014-02-19
HUE026323T2 (en) 2016-05-30
US9206185B2 (en) 2015-12-08
BR112013025777A2 (pt) 2016-12-20
AP2013007215A0 (en) 2013-10-31
UA111739C2 (uk) 2016-06-10
AP3597A (en) 2016-02-19
UY34006A (es) 2012-10-31
JP5906303B2 (ja) 2016-04-20
SI2694510T1 (sl) 2016-02-29
NI201300105A (es) 2014-07-14
JP2014510127A (ja) 2014-04-24
MX336865B (es) 2016-02-04
NZ616270A (en) 2015-09-25
MX2013011699A (es) 2014-01-31
TWI535719B (zh) 2016-06-01
CU20130135A7 (es) 2014-02-28
PL2694510T3 (pl) 2016-03-31
IL228567A0 (en) 2013-12-31
AR087148A1 (es) 2014-02-26
DOP2013000226A (es) 2013-11-15
AU2012238589A1 (en) 2013-11-07
SG193631A1 (en) 2013-11-29
ME02316B (me) 2016-06-20
ZA201307223B (en) 2014-12-23
PT2694510E (pt) 2016-02-08
CN103596957B (zh) 2016-12-07
ECSP13013008A (es) 2013-12-31
PH12013502073A1 (en) 2014-01-13
TN2013000400A1 (en) 2015-03-30
RS54480B1 (sr) 2016-06-30
CL2013002878A1 (es) 2014-05-02
CU24263B1 (es) 2017-07-04

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY KZ RU