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EA200000431A3 - Новые замещенные димерные соединения, способ их получения и фармацевтические композиции, содержащие их - Google Patents

Новые замещенные димерные соединения, способ их получения и фармацевтические композиции, содержащие их

Info

Publication number
EA200000431A3
EA200000431A3 EA200000431A EA200000431A EA200000431A3 EA 200000431 A3 EA200000431 A3 EA 200000431A3 EA 200000431 A EA200000431 A EA 200000431A EA 200000431 A EA200000431 A EA 200000431A EA 200000431 A3 EA200000431 A3 EA 200000431A3
Authority
EA
Eurasian Patent Office
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
new substituted
dimeric compounds
Prior art date
Application number
EA200000431A
Other languages
English (en)
Other versions
EA200000431A2 (ru
EA003391B1 (ru
Inventor
Патрик Депре
Сэд Йус
Гвенаэль Шев
Жеральд Гийоме
Мари-Клод Вио
Карлос Ларрайа
Каролин Беннежан
Филипп Делагранж
Пьер Ренар
Кароль Декамп-Франсуа
Original Assignee
Адир Э Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Адир Э Компани filed Critical Адир Э Компани
Publication of EA200000431A2 publication Critical patent/EA200000431A2/ru
Publication of EA200000431A3 publication Critical patent/EA200000431A3/ru
Publication of EA003391B1 publication Critical patent/EA003391B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/08—Six-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Anesthesiology (AREA)
  • Nutrition Science (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

(57) Изобретение относится к соединениям формулы (I)A-G-Cy-G-Cy'-G-B (I)где А представляет группу NRC(Q)R, C(Q)NRRили NRC(Q)NRR;В представляет группу NRC(Q)R, NRC(Q)NRR, C(Q)NRR, C(Q)OR, NRC(Q)ORили NRR;Gи Gпредставляют необязательно замещенную алкиленовую цепь;Су и Су', которые являются различными, представляют кольцевую структуруилиGпредставляет цепьЛекарственные препараты.
EA200000431A 1999-05-19 2000-05-18 Новые замещенные димерные соединения, способ их получения и фармацевтические композиции, содержащие их EA003391B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9906331A FR2793793B1 (fr) 1999-05-19 1999-05-19 Nouveaux derives dimeriques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (3)

Publication Number Publication Date
EA200000431A2 EA200000431A2 (ru) 2000-12-25
EA200000431A3 true EA200000431A3 (ru) 2001-02-26
EA003391B1 EA003391B1 (ru) 2003-04-24

Family

ID=9545746

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000431A EA003391B1 (ru) 1999-05-19 2000-05-18 Новые замещенные димерные соединения, способ их получения и фармацевтические композиции, содержащие их

Country Status (20)

Country Link
US (1) US6310074B1 (ru)
EP (1) EP1057826B1 (ru)
JP (1) JP3688552B2 (ru)
KR (1) KR100472520B1 (ru)
CN (1) CN1128142C (ru)
AT (1) ATE237610T1 (ru)
AU (1) AU766322B2 (ru)
BR (1) BR0003313A (ru)
DE (1) DE60002126T2 (ru)
DK (1) DK1057826T3 (ru)
EA (1) EA003391B1 (ru)
ES (1) ES2197062T3 (ru)
FR (1) FR2793793B1 (ru)
HU (1) HUP0001961A3 (ru)
NO (1) NO20002548L (ru)
NZ (1) NZ504613A (ru)
PL (1) PL340165A1 (ru)
PT (1) PT1057826E (ru)
SI (1) SI1057826T1 (ru)
ZA (1) ZA200002490B (ru)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004050085A1 (en) * 2002-12-03 2004-06-17 F. Hoffmann-La Roche Ag Aminoalkoxyindoles as 5-ht6-receptor ligands for the treatment of cns-disorders
PT1696920E (pt) 2003-12-19 2015-01-14 Plexxikon Inc Compostos e métodos para o desenvolvimento de moduladores de ret
US7498342B2 (en) * 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
EP1885723A2 (en) * 2005-05-17 2008-02-13 Plexxikon, Inc. Pyrrolo[2,3-b]pyridine derivatives as protein kinase inhibitors
WO2007002325A1 (en) * 2005-06-22 2007-01-04 Plexxikon, Inc. Pyrrolo[2,3-b] pyridine derivatives as protein kinase inhibitors
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
US7872018B2 (en) 2006-12-21 2011-01-18 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
WO2008079909A1 (en) * 2006-12-21 2008-07-03 Plexxikon, Inc. Pyrrolo [2,3-b] pyridines as kinase modulators
PE20081581A1 (es) * 2006-12-21 2008-11-12 Plexxikon Inc COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA
SG183036A1 (en) 2007-07-17 2012-08-30 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
MX2011001062A (es) * 2008-07-30 2011-03-24 Ferrer Int Compuestos de 1,6-dihidro-2h-3-oxa-6-aza-as-indaceno.
AU2010232670B2 (en) 2009-04-03 2015-07-09 F. Hoffmann-La Roche Ag Propane- I-sulfonic acid {3- [5- (4 -chloro-phenyl) -1H-pyrrolo [2, 3-b] pyridine-3-carbonyl] -2, 4-difluoro-pheny l } -amide compositions and uses thereof
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
ES2633317T3 (es) 2009-11-06 2017-09-20 Plexxikon, Inc. Compuestos y métodos para la modulación de quinasas, e indicaciones para ello
CN103517710B (zh) 2011-02-07 2017-05-31 普莱希科公司 用于激酶调节的化合物
TWI558702B (zh) 2011-02-21 2016-11-21 普雷辛肯公司 醫藥活性物質的固態形式
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
WO2025194599A1 (en) * 2024-03-18 2025-09-25 Galixir Technologies (Beijing) Limited Heterocycle ulk1/2 inhibitors and methods of use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1639427A3 (ru) * 1987-07-03 1991-03-30 Глэксо Груп Лимитед (Фирма) Способ получени производных индола или их фармацевтически приемлемых солей
FR2658818B1 (fr) * 1990-02-27 1993-12-31 Adir Cie Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
CA2082839A1 (en) * 1991-11-18 1993-05-19 John Fairhurst Pharmaceutical compounds
FR2689124A1 (fr) * 1992-03-27 1993-10-01 Adir Nouvelles naphtylalkylamines, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
FR2696453B1 (fr) * 1992-10-02 1994-12-23 Adir Nouveaux arylalkyl(thio)amides, leur procédé de préparation, et les compositions pharmaceutiques qui les contiennent.
AU5715494A (en) * 1992-12-21 1994-07-19 Taisho Pharmaceutical Co., Ltd. N-substituted indole derivative
NZ284853A (en) * 1994-06-29 1998-12-23 Pfizer 1-(azacycloalkyl)-7-(arylalkoxy)naphthalene derivatives; medicaments
FR2731223A1 (fr) * 1995-03-02 1996-09-06 Pf Medicament Nouveaux derives bi-tryptaminiques, leur procede de preparation et leur utilisation a titre de medicaments

Also Published As

Publication number Publication date
ZA200002490B (en) 2000-11-20
HK1030937A1 (en) 2001-05-25
EA200000431A2 (ru) 2000-12-25
KR100472520B1 (ko) 2005-03-07
KR20010029729A (ko) 2001-04-16
AU3542000A (en) 2000-11-23
SI1057826T1 (en) 2003-08-31
EP1057826B1 (fr) 2003-04-16
PL340165A1 (en) 2000-11-20
US6310074B1 (en) 2001-10-30
HUP0001961A3 (en) 2002-10-28
EP1057826A1 (fr) 2000-12-06
NO20002548D0 (no) 2000-05-18
DE60002126T2 (de) 2004-03-18
EA003391B1 (ru) 2003-04-24
ATE237610T1 (de) 2003-05-15
FR2793793B1 (fr) 2004-02-27
DE60002126D1 (de) 2003-05-22
CN1128142C (zh) 2003-11-19
FR2793793A1 (fr) 2000-11-24
NO20002548L (no) 2000-11-20
JP3688552B2 (ja) 2005-08-31
PT1057826E (pt) 2003-08-29
CN1277962A (zh) 2000-12-27
NZ504613A (en) 2001-06-29
BR0003313A (pt) 2001-03-13
ES2197062T3 (es) 2004-01-01
AU766322B2 (en) 2003-10-16
HU0001961D0 (en) 2000-07-28
HUP0001961A2 (hu) 2001-08-28
JP2001011035A (ja) 2001-01-16
DK1057826T3 (da) 2003-07-21

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU