DK174822B1 - Antihypercholesterolæmiske tetrazolforbindelser, mellemprodukter og fremgangsmåde til fremstilling deraf - Google Patents

Antihypercholesterolæmiske tetrazolforbindelser, mellemprodukter og fremgangsmåde til fremstilling deraf Download PDF

Info

Publication number: DK174822B1
Authority: DK; Denmark
Prior art keywords: methyl; tetrazol; bis; fluorophenyl; formula
Prior art date: 1987-02-25

Application number

DK198800972A

Other languages

Danish (da)

English (en)

Other versions

DK97288A (da

DK97288D0 (da

Inventor

John J Wright

Sing-Yuen Sit

Original Assignee

Squibb Bristol Myers Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-02-25

Filing date

1988-02-24

Publication date

2003-12-08

1988-02-24 Application filed by Squibb Bristol Myers Co filed Critical Squibb Bristol Myers Co

1988-02-24 Publication of DK97288D0 publication Critical patent/DK97288D0/da

1988-08-26 Publication of DK97288A publication Critical patent/DK97288A/da

2003-12-08 Application granted granted Critical

2003-12-08 Publication of DK174822B1 publication Critical patent/DK174822B1/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Obesity (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Hematology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK198800972A 1987-02-25 1988-02-24 Antihypercholesterolæmiske tetrazolforbindelser, mellemprodukter og fremgangsmåde til fremstilling deraf DK174822B1 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US1854287A	1987-02-25	1987-02-25
US1854287		1987-02-25
US07/151,513 US4897490A (en)	1987-02-25	1988-02-18	Antihypercholesterolemic tetrazole compounds
US15151388		1988-02-18

Publications (3)

Publication Number	Publication Date
DK97288D0 DK97288D0 (da)	1988-02-24
DK97288A DK97288A (da)	1988-08-26
DK174822B1 true DK174822B1 (da)	2003-12-08

Family

ID=26691223

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198800972A DK174822B1 (da)	1987-02-25	1988-02-24	Antihypercholesterolæmiske tetrazolforbindelser, mellemprodukter og fremgangsmåde til fremstilling deraf

Country Status (31)

Country	Link
US (1)	US4897490A (sv)
JP (1)	JP2603324B2 (sv)
KR (1)	KR960001203B1 (sv)
CN (1)	CN1026110C (sv)
AT (1)	AT395589B (sv)
AU (1)	AU1395088A (sv)
BE (1)	BE1002116A3 (sv)
CA (1)	CA1328268C (sv)
CH (1)	CH676848A5 (sv)
CS (1)	CS271481B2 (sv)
DE (1)	DE3805801C2 (sv)
DK (1)	DK174822B1 (sv)
EG (1)	EG18341A (sv)
ES (2)	ES2010246A6 (sv)
FI (1)	FI96601C (sv)
FR (1)	FR2612924B1 (sv)
GR (1)	GR1000472B (sv)
HU (3)	HU204516B (sv)
IE (1)	IE61619B1 (sv)
IL (1)	IL85529A (sv)
IT (1)	IT1216751B (sv)
LU (1)	LU87144A1 (sv)
MX (1)	MX9202847A (sv)
MY (1)	MY103214A (sv)
NL (1)	NL8800465A (sv)
NO (1)	NO169438C (sv)
NZ (1)	NZ223620A (sv)
PT (1)	PT86820B (sv)
SE (1)	SE503618C2 (sv)
WO (1)	WO1988006584A1 (sv)
YU (1)	YU36388A (sv)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3741509A1 (de) *	1987-12-08	1989-06-22	Hoechst Ag	Verfahren zur herstellung optisch aktiver 3-desmethylmevalonsaeurederivate sowie zwischenprodukte
US4824959A (en) *	1988-02-18	1989-04-25	Bristol-Myers Company	Intermediates for antihypercholesterolemic tetrazole compounds
GB2244706B (en) *	1988-02-18	1992-07-15	Bristol Myers Co	Preparation of antihypercholesterolemic tetrazole intermediates
US5010205A (en) *	1988-08-23	1991-04-23	Bristol-Myers Company	Antihypercholesterolemic tetrazol-1-yl intermediates
US4870187A (en) *	1988-08-23	1989-09-26	Bristol-Myers Company	Antihypercholesterolemic tetrazol-1-yl compounds
US4927944A (en) *	1988-08-25	1990-05-22	Bristol-Myers Company	Antihypercholesterolemic nitrile compounds
FI94339C (sv)	1989-07-21	1995-08-25	Warner Lambert Co	Förfarande för framställning av farmaceutiskt användbar /R-(R,R)/-2-(4-fluorfenyl)- , -dihydroxi-5-(1-metyletyl)-3-fenyl-4-/(fenylamino)karbonyl/-1H-pyrrol-1-heptansyra och farmaceutiskt användbara salter därav
US5413935A (en) *	1991-04-24	1995-05-09	E. R. Squibb & Sons, Inc.	Process for selecting an enantiomer of a hydroxy lactone using pseudomonas lipase
US5134155A (en) *	1991-08-08	1992-07-28	Ortho Pharmaceutical Corporation	Tetrahydroindazole, tetrahydrocyclopentapyrazole, and hexahydrocycloheptapyrazole compounds and their use as HMG-coA reductase inhibitors
US5986095A (en) *	1992-01-06	1999-11-16	E.R. Squibb & Sons, Inc.	Enantioselective preparation of halophenyl alcohols and acylates
US5278313A (en) *	1992-03-27	1994-01-11	E. R. Squibb & Sons, Inc.	Process for the preparation of 1,3-dioxane derivatives useful in the preparation of HMG-COA reductase inhibitors
US5324662A (en) *	1992-05-15	1994-06-28	E. R. Squibb & Sons, Inc.	Stereoselective microbial or enzymatic reduction of 3,5-dioxo esters to 3-hydroxy-5-oxo, 3-oxo-5-hydroxy, and 3,5-dihydroxy esters
US5284957A (en) *	1992-09-03	1994-02-08	Eli Lilly And Company	Excitatory amino acid receptor antagonists
JPH06329679A (ja) *	1993-01-20	1994-11-29	Nissan Chem Ind Ltd	光学活性β−アミノアルコキシボラン錯体
CA2137049A1 (en) *	1993-12-15	1995-06-16	John K. Thottathil	Amino acid salts of and methods for preparing antihypercholesterolemic tetrazole compounds
DE19714343A1 (de) *	1997-04-08	1998-10-15	Bayer Ag	Chromatographische Enantiomerentrennung von Lactonen
JP2001526256A (ja) *	1997-12-19	2001-12-18	ワーナー−ランバート・エクスポート・リミテッド	１，３−ジオールの合成方法
DE10216967A1 (de) *	2002-04-16	2003-11-13	Bayer Ag	Verfahren zur Herstellung spezieller aromatischer Aldehyde
WO2009009153A1 (en) *	2007-07-12	2009-01-15	Teva Pharmaceutical Industries Ltd.	Purification of rosuvastatin intermediate by thin film evaporation and chemical method
KR101681041B1 (ko)	2015-07-15	2016-12-22	경북대학교병원	ＥＲＲγ 비활성화 리간드로서의 신규한 방향족 고리 화합물 유도체

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4160100A (en) *	1973-03-23	1979-07-03	American Home Products Corporation	Oxamic acid derivatives
US4054666A (en) *	1973-03-23	1977-10-18	American Home Products Corporation	Compositions and methods of treating immediate hypersensitivity reactions with thiazolyl oxamic acid derivatives
US4013647A (en) *	1976-03-23	1977-03-22	American Home Products Corporation	Morpholine containing tetrazole-5-carboxamide derivatives
JPS53147073A (en) *	1977-05-24	1978-12-21	Sankyo Co Ltd	Mevalonolactone derivatives
US4375475A (en) *	1979-08-17	1983-03-01	Merck & Co., Inc.	Substituted pyranone inhibitors of cholesterol synthesis
US4567289A (en) *	1979-08-17	1986-01-28	Merck & Co., Inc.	Substituted pyranone inhibitors of cholesterol synthesis
IL60751A (en) *	1979-08-17	1985-04-30	Merck & Co Inc	6-(2'-((substituted phenyl)ethyl and-ethenyl)-4-hydroxy-tetrahydro-2h-pyran-2-one derivatives,their preparation and pharmaceutical compositions containing them
EP0068038B1 (en) *	1981-06-29	1985-09-25	Merck & Co. Inc.	(+)-(4r,6s)-(e)-6-(2-(4'-fluoro-3,3',5-trimethyl-(1,1'-biphenyl)-2-yl)ethenyl)-3,4,5,6-tetrahydro-4-hydroxy-2h-pyran-2-one, a process for preparing and a pharmaceutical composition containing the same
WO1983002131A1 (en) *	1981-12-10	1983-06-23	Willy Bayer	Internal combustion engine
US4739073A (en) *	1983-11-04	1988-04-19	Sandoz Pharmaceuticals Corp.	Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof
WO1984002131A1 (fr) *	1982-11-22	1984-06-07	Sandoz Ag	Produits analogues de mevalolactone et leurs derives, leurs procedes de production, compositions pharmaceutiques les contenant ainsi que leur utilisation en tant que produits pharmaceutiques
CA1268473A (en) *	1983-01-24	1990-05-01	Paul L. Anderson	Analogs of mevalonolactone and derivatives thereof, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals
CA1327360C (en) *	1983-11-14	1994-03-01	William F. Hoffman	Oxo-analogs of mevinolin-like antihypercholesterolemic agents
US4613610A (en) *	1984-06-22	1986-09-23	Sandoz Pharmaceuticals Corp.	Cholesterol biosynthesis inhibiting pyrazole analogs of mevalonolactone and its derivatives
JPS61502467A (ja) *	1984-06-22	1986-10-30	サンド・アクチエンゲゼルシヤフト	メバロノラクトンのピラゾ−ル同族体およびその誘導体、それらの製造方法ならびに用途
US4668794A (en) *	1985-05-22	1987-05-26	Sandoz Pharm. Corp.	Intermediate imidazole acrolein analogs
US4621099A (en) *	1985-09-23	1986-11-04	Usv Pharmaceutical Corporation	Polyene compounds useful in the treatment of allergic responses
US4681893A (en) *	1986-05-30	1987-07-21	Warner-Lambert Company	Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
US4678806A (en) *	1986-09-02	1987-07-07	Merck & Co., Inc.	Prodrugs of antihypercholesterolemic compounds

1988
- 1988-02-18 US US07/151,513 patent/US4897490A/en not_active Expired - Lifetime
- 1988-02-24 IT IT8819525A patent/IT1216751B/it active
- 1988-02-24 EG EG107/88A patent/EG18341A/xx active
- 1988-02-24 ES ES8800532A patent/ES2010246A6/es not_active Expired
- 1988-02-24 CS CS881180A patent/CS271481B2/cs not_active IP Right Cessation
- 1988-02-24 IE IE50188A patent/IE61619B1/en not_active IP Right Cessation
- 1988-02-24 AT AT0046188A patent/AT395589B/de not_active IP Right Cessation
- 1988-02-24 WO PCT/US1988/000462 patent/WO1988006584A1/en not_active Ceased
- 1988-02-24 JP JP63502491A patent/JP2603324B2/ja not_active Expired - Lifetime
- 1988-02-24 PT PT86820A patent/PT86820B/pt not_active IP Right Cessation
- 1988-02-24 NZ NZ223620A patent/NZ223620A/en unknown
- 1988-02-24 HU HU896737A patent/HU204516B/hu unknown
- 1988-02-24 HU HU90669A patent/HU203329B/hu unknown
- 1988-02-24 DE DE3805801A patent/DE3805801C2/de not_active Expired - Lifetime
- 1988-02-24 FI FI880869A patent/FI96601C/sv active IP Right Grant
- 1988-02-24 NO NO880809A patent/NO169438C/no not_active IP Right Cessation
- 1988-02-24 HU HU88886A patent/HU204038B/hu unknown
- 1988-02-24 GR GR880100101A patent/GR1000472B/el not_active IP Right Cessation
- 1988-02-24 FR FR888802211A patent/FR2612924B1/fr not_active Expired - Lifetime
- 1988-02-24 MY MYPI88000178A patent/MY103214A/en unknown
- 1988-02-24 CH CH692/88A patent/CH676848A5/de not_active IP Right Cessation
- 1988-02-24 IL IL85529A patent/IL85529A/xx not_active IP Right Cessation
- 1988-02-24 DK DK198800972A patent/DK174822B1/da not_active IP Right Cessation
- 1988-02-24 KR KR1019880002010A patent/KR960001203B1/ko not_active Expired - Lifetime
- 1988-02-24 CA CA000559667A patent/CA1328268C/en not_active Expired - Fee Related
- 1988-02-24 AU AU13950/88A patent/AU1395088A/en not_active Abandoned
- 1988-02-24 NL NL8800465A patent/NL8800465A/nl not_active Application Discontinuation
- 1988-02-24 SE SE8800638A patent/SE503618C2/sv not_active IP Right Cessation
- 1988-02-25 BE BE8800220A patent/BE1002116A3/fr not_active IP Right Cessation
- 1988-02-25 YU YU00363/88A patent/YU36388A/xx unknown
- 1988-02-25 CN CN88100911A patent/CN1026110C/zh not_active Expired - Lifetime
- 1988-02-25 LU LU87144A patent/LU87144A1/fr unknown
1989
- 1989-06-23 ES ES8902217A patent/ES2026746A6/es not_active Expired - Fee Related
1992
- 1992-06-12 MX MX9202847A patent/MX9202847A/es unknown

Also Published As

Publication number	Publication date
GR1000472B (el)	1992-07-30
PT86820B (pt)	1995-03-01
US4897490A (en)	1990-01-30
WO1988006584A1 (en)	1988-09-07
CS118088A2 (en)	1989-08-14
AU1395088A (en)	1988-09-26
IL85529A0 (en)	1988-08-31
CN88100911A (zh)	1988-09-28
BE1002116A3 (fr)	1990-07-10
ES2026746A6 (es)	1992-05-01
CS271481B2 (en)	1990-10-12
YU36388A (en)	1989-10-31
NO880809D0 (no)	1988-02-24
JPH01502269A (ja)	1989-08-10
NO169438B (no)	1992-03-16
DE3805801C2 (de)	2001-03-01
HU900669D0 (en)	1990-06-28
HUT47259A (en)	1989-02-28
DK97288A (da)	1988-08-26
IE61619B1 (en)	1994-11-16
FR2612924A1 (fr)	1988-09-30
DK97288D0 (da)	1988-02-24
JP2603324B2 (ja)	1997-04-23
GR880100101A (en)	1988-12-16
IE880501L (en)	1988-08-25
NO880809L (no)	1988-08-26
NZ223620A (en)	1991-07-26
SE8800638L (sv)	1988-09-21
CN1026110C (zh)	1994-10-05
KR960001203B1 (ko)	1996-01-24
NL8800465A (nl)	1988-09-16
FI96601B (sv)	1996-04-15
ES2010246A6 (es)	1989-11-01
ATA46188A (de)	1992-06-15
IL85529A (en)	1993-01-31
FI880869A7 (sv)	1988-08-26
IT8819525A0 (it)	1988-02-24
SE8800638D0 (sv)	1988-02-24
HU203329B (en)	1991-07-29
AT395589B (de)	1993-01-25
FI880869A0 (sv)	1988-02-24
LU87144A1 (fr)	1988-09-20
IT1216751B (it)	1990-03-08
EG18341A (en)	1993-08-30
SE503618C2 (sv)	1996-07-15
KR880009947A (ko)	1988-10-06
FI96601C (sv)	1996-07-25
CH676848A5 (sv)	1991-03-15
DE3805801A1 (de)	1988-09-08
CA1328268C (en)	1994-04-05
FR2612924B1 (fr)	1991-01-11
HU204516B (en)	1992-01-28
HU204038B (en)	1991-11-28
NO169438C (no)	1992-06-24
HU896737D0 (en)	1990-02-28
MY103214A (en)	1993-05-29
MX9202847A (es)	1992-06-30
PT86820A (pt)	1989-02-28

Publication	Publication Date	Title
DK174822B1 (da)	2003-12-08	Antihypercholesterolæmiske tetrazolforbindelser, mellemprodukter og fremgangsmåde til fremstilling deraf
SE503618C3 (sv)	1988-09-21	Antihyperkolesterolemiska tetrazolföreningar
US5110940A (en)	1992-05-05	Antihypercholesterolemic tetrazole compounds
JP2922887B2 (ja)	1999-07-26	抗高コレステロール血性テトラゾール化合物およびそれらの中間体
US4870187A (en)	1989-09-26	Antihypercholesterolemic tetrazol-1-yl compounds
JP2603284B2 (ja)	1997-04-23	抗高コレステロール血性テトラゾール化合物の中間体
US4775684A (en)	1988-10-04	1,3-dioxane ethers
AU601264B2 (en)	1990-09-06	Antihypercholesterolemic tetrazole compounds
GB2202846A (en)	1988-10-05	1,1-diphenyl-2tetrazolyl-ethene derivatives
US4939265A (en)	1990-07-03	Intermediates and process for the preparation of antihypercholesterolemic tetrazole compounds
US5068346A (en)	1991-11-26	Tetrazole compounds
US5010205A (en)	1991-04-23	Antihypercholesterolemic tetrazol-1-yl intermediates
US5070206A (en)	1991-12-03	Tetrazol-1-yl containing intermediates
FI96602B (sv)	1996-04-15	Förfarande för framställning av terapeutiskt aktiva tetrazolderivat
DD297818A5 (de)	1992-01-23	Neue tetrazol-zwischenprodukte, ihre herstellung und verwendung zur herstellug von antihypercholesterinaemischen mitteln
NO179207B (no)	1996-05-20	Analogifremgangsmåte til fremstilling av en terapeutisk aktiv forbindelse

Legal Events

Date	Code	Title	Description
2005-10-03	PBP	Patent lapsed	Country of ref document: DK