ATA46188A - Antihypercholesterinaemische tetrazol-verbindungen - Google Patents

Antihypercholesterinaemische tetrazol-verbindungen

Info

Publication number: ATA46188A
Authority: AT; Austria
Prior art keywords: antihypercholesterinaemic; tetrazole compounds; tetrazole; compounds; antihypercholesterinaemic tetrazole
Prior art date: 1987-02-25

Application number

AT0046188A

Other languages

English (en)

Other versions

AT395589B (de

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-02-25

Filing date

1988-02-24

Publication date

1992-06-15

1988-02-24 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

1992-02-28 Priority to AT0037992A priority Critical patent/AT401518B/de

1992-02-28 Priority to AT0038292A priority patent/AT401175B/de

1992-06-15 Publication of ATA46188A publication Critical patent/ATA46188A/de

1993-01-25 Application granted granted Critical

1993-01-25 Publication of AT395589B publication Critical patent/AT395589B/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Obesity (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Hematology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT0046188A 1987-02-25 1988-02-24 Antihypercholesterinaemische tetrazol-verbindungen AT395589B (de)

Priority Applications (2)

Application Number	Priority Date	Filing Date	Title
AT0037992A AT401518B (de)	1987-02-25	1992-02-28	Neue tetrazol-verbindungen und verfahren zu ihrer herstellung
AT0038292A AT401175B (de)	1987-02-25	1992-02-28	Neue tetrazol-verbindungen und verfahren zu ihrer herstellung

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US1854287A	1987-02-25	1987-02-25
US07/151,513 US4897490A (en)	1987-02-25	1988-02-18	Antihypercholesterolemic tetrazole compounds

Publications (2)

Publication Number	Publication Date
ATA46188A true ATA46188A (de)	1992-06-15
AT395589B AT395589B (de)	1993-01-25

Family

ID=26691223

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT0046188A AT395589B (de)	1987-02-25	1988-02-24	Antihypercholesterinaemische tetrazol-verbindungen

Country Status (31)

Country	Link
US (1)	US4897490A (de)
JP (1)	JP2603324B2 (de)
KR (1)	KR960001203B1 (de)
CN (1)	CN1026110C (de)
AT (1)	AT395589B (de)
AU (1)	AU1395088A (de)
BE (1)	BE1002116A3 (de)
CA (1)	CA1328268C (de)
CH (1)	CH676848A5 (de)
CS (1)	CS271481B2 (de)
DE (1)	DE3805801C2 (de)
DK (1)	DK174822B1 (de)
EG (1)	EG18341A (de)
ES (2)	ES2010246A6 (de)
FI (1)	FI96601C (de)
FR (1)	FR2612924B1 (de)
GR (1)	GR1000472B (de)
HU (3)	HU204516B (de)
IE (1)	IE61619B1 (de)
IL (1)	IL85529A (de)
IT (1)	IT1216751B (de)
LU (1)	LU87144A1 (de)
MX (1)	MX9202847A (de)
MY (1)	MY103214A (de)
NL (1)	NL8800465A (de)
NO (1)	NO169438C (de)
NZ (1)	NZ223620A (de)
PT (1)	PT86820B (de)
SE (1)	SE503618C2 (de)
WO (1)	WO1988006584A1 (de)
YU (1)	YU36388A (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3741509A1 (de) *	1987-12-08	1989-06-22	Hoechst Ag	Verfahren zur herstellung optisch aktiver 3-desmethylmevalonsaeurederivate sowie zwischenprodukte
GB2244705B (en) *	1988-02-18	1992-07-15	Bristol Myers Co	Preparation of antihypercholesterolemic tetrazole compounds and intermediates thereof
US4824959A (en) *	1988-02-18	1989-04-25	Bristol-Myers Company	Intermediates for antihypercholesterolemic tetrazole compounds
US4870187A (en) *	1988-08-23	1989-09-26	Bristol-Myers Company	Antihypercholesterolemic tetrazol-1-yl compounds
US5010205A (en) *	1988-08-23	1991-04-23	Bristol-Myers Company	Antihypercholesterolemic tetrazol-1-yl intermediates
US4927944A (en) *	1988-08-25	1990-05-22	Bristol-Myers Company	Antihypercholesterolemic nitrile compounds
FI94339C (fi)	1989-07-21	1995-08-25	Warner Lambert Co	Menetelmä farmaseuttisesti käyttökelpoisen /R-(R,R)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
US5413935A (en) *	1991-04-24	1995-05-09	E. R. Squibb & Sons, Inc.	Process for selecting an enantiomer of a hydroxy lactone using pseudomonas lipase
US5134155A (en) *	1991-08-08	1992-07-28	Ortho Pharmaceutical Corporation	Tetrahydroindazole, tetrahydrocyclopentapyrazole, and hexahydrocycloheptapyrazole compounds and their use as HMG-coA reductase inhibitors
US5986095A (en) *	1992-01-06	1999-11-16	E.R. Squibb & Sons, Inc.	Enantioselective preparation of halophenyl alcohols and acylates
US5278313A (en) *	1992-03-27	1994-01-11	E. R. Squibb & Sons, Inc.	Process for the preparation of 1,3-dioxane derivatives useful in the preparation of HMG-COA reductase inhibitors
US5324662A (en) *	1992-05-15	1994-06-28	E. R. Squibb & Sons, Inc.	Stereoselective microbial or enzymatic reduction of 3,5-dioxo esters to 3-hydroxy-5-oxo, 3-oxo-5-hydroxy, and 3,5-dihydroxy esters
US5284957A (en) *	1992-09-03	1994-02-08	Eli Lilly And Company	Excitatory amino acid receptor antagonists
JPH06329679A (ja) *	1993-01-20	1994-11-29	Nissan Chem Ind Ltd	光学活性β−アミノアルコキシボラン錯体
CA2137049A1 (en) *	1993-12-15	1995-06-16	John K. Thottathil	Amino acid salts of and methods for preparing antihypercholesterolemic tetrazole compounds
DE19714343A1 (de)	1997-04-08	1998-10-15	Bayer Ag	Chromatographische Enantiomerentrennung von Lactonen
US6433213B1 (en) *	1997-12-19	2002-08-13	Warner-Lambert Company	Process for the synthesis of 1,3-diols
DE10216967A1 (de) *	2002-04-16	2003-11-13	Bayer Ag	Verfahren zur Herstellung spezieller aromatischer Aldehyde
EP2178846A1 (de) *	2007-07-12	2010-04-28	Teva Pharmaceutical Industries Ltd.	Rosuvastatinzwischenprodukte und ihre herstellung
KR101681041B1 (ko)	2015-07-15	2016-12-22	경북대학교병원	ＥＲＲγ 비활성화 리간드로서의 신규한 방향족 고리 화합물 유도체

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4160100A (en) *	1973-03-23	1979-07-03	American Home Products Corporation	Oxamic acid derivatives
US4054666A (en) *	1973-03-23	1977-10-18	American Home Products Corporation	Compositions and methods of treating immediate hypersensitivity reactions with thiazolyl oxamic acid derivatives
US4013647A (en) *	1976-03-23	1977-03-22	American Home Products Corporation	Morpholine containing tetrazole-5-carboxamide derivatives
JPS53147073A (en) *	1977-05-24	1978-12-21	Sankyo Co Ltd	Mevalonolactone derivatives
US4375475A (en) *	1979-08-17	1983-03-01	Merck & Co., Inc.	Substituted pyranone inhibitors of cholesterol synthesis
US4567289A (en) *	1979-08-17	1986-01-28	Merck & Co., Inc.	Substituted pyranone inhibitors of cholesterol synthesis
NZ194557A (en) *	1979-08-17	1984-09-28	Merck & Co Inc	Substituted pyranone derivatives;dihydroxy acids therefrom;pharmaceutical compositions
EP0068038B1 (de) *	1981-06-29	1985-09-25	Merck & Co. Inc.	(+)-(4R.6S)-(E)-6-(2-(4'-Fluor-3,3',5-trimethyl-(1,1'-biphenyl)-2-yl)ethenyl)-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-on, Verfahren zu seiner Herstellung und eine diese Verbindung enthaltende pharmazeutische Zusammensetzung
EP0096025A1 (de) *	1981-12-10	1983-12-21	BAYER, Willy	Verbrennungsmotor
US4739073A (en) *	1983-11-04	1988-04-19	Sandoz Pharmaceuticals Corp.	Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof
WO1984002131A1 (fr) *	1982-11-22	1984-06-07	Sandoz Ag	Produits analogues de mevalolactone et leurs derives, leurs procedes de production, compositions pharmaceutiques les contenant ainsi que leur utilisation en tant que produits pharmaceutiques
IE840153L (en) *	1983-01-24	1984-07-24	Sandoz Ltd	Mevalonolactone analogues and related hydroxy acids for¹control of blood cholesterol levels.
CA1327360C (en) *	1983-11-14	1994-03-01	William F. Hoffman	Oxo-analogs of mevinolin-like antihypercholesterolemic agents
ATE62906T1 (de) *	1984-06-22	1991-05-15	Sandoz Ag	Pyrazolanaloge von mevalonolakton und abkoemmlinge davon, verfahren zu deren herstellung und deren verwendung.
US4613610A (en) *	1984-06-22	1986-09-23	Sandoz Pharmaceuticals Corp.	Cholesterol biosynthesis inhibiting pyrazole analogs of mevalonolactone and its derivatives
US4668794A (en) *	1985-05-22	1987-05-26	Sandoz Pharm. Corp.	Intermediate imidazole acrolein analogs
US4621099A (en) *	1985-09-23	1986-11-04	Usv Pharmaceutical Corporation	Polyene compounds useful in the treatment of allergic responses
US4681893A (en) *	1986-05-30	1987-07-21	Warner-Lambert Company	Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
US4678806A (en) *	1986-09-02	1987-07-07	Merck & Co., Inc.	Prodrugs of antihypercholesterolemic compounds

1988
- 1988-02-18 US US07/151,513 patent/US4897490A/en not_active Expired - Lifetime
- 1988-02-24 DK DK198800972A patent/DK174822B1/da not_active IP Right Cessation
- 1988-02-24 DE DE3805801A patent/DE3805801C2/de not_active Expired - Lifetime
- 1988-02-24 NO NO880809A patent/NO169438C/no not_active IP Right Cessation
- 1988-02-24 MY MYPI88000178A patent/MY103214A/en unknown
- 1988-02-24 WO PCT/US1988/000462 patent/WO1988006584A1/en not_active Ceased
- 1988-02-24 IE IE50188A patent/IE61619B1/en not_active IP Right Cessation
- 1988-02-24 FR FR888802211A patent/FR2612924B1/fr not_active Expired - Lifetime
- 1988-02-24 PT PT86820A patent/PT86820B/pt not_active IP Right Cessation
- 1988-02-24 ES ES8800532A patent/ES2010246A6/es not_active Expired
- 1988-02-24 EG EG107/88A patent/EG18341A/xx active
- 1988-02-24 SE SE8800638A patent/SE503618C2/xx not_active IP Right Cessation
- 1988-02-24 CS CS881180A patent/CS271481B2/cs not_active IP Right Cessation
- 1988-02-24 KR KR1019880002010A patent/KR960001203B1/ko not_active Expired - Lifetime
- 1988-02-24 IL IL85529A patent/IL85529A/xx not_active IP Right Cessation
- 1988-02-24 CA CA000559667A patent/CA1328268C/en not_active Expired - Fee Related
- 1988-02-24 HU HU896737A patent/HU204516B/hu unknown
- 1988-02-24 FI FI880869A patent/FI96601C/fi active IP Right Grant
- 1988-02-24 GR GR880100101A patent/GR1000472B/el not_active IP Right Cessation
- 1988-02-24 JP JP63502491A patent/JP2603324B2/ja not_active Expired - Lifetime
- 1988-02-24 HU HU88886A patent/HU204038B/hu unknown
- 1988-02-24 AT AT0046188A patent/AT395589B/de not_active IP Right Cessation
- 1988-02-24 NZ NZ223620A patent/NZ223620A/en unknown
- 1988-02-24 IT IT8819525A patent/IT1216751B/it active
- 1988-02-24 AU AU13950/88A patent/AU1395088A/en not_active Abandoned
- 1988-02-24 NL NL8800465A patent/NL8800465A/nl not_active Application Discontinuation
- 1988-02-24 HU HU90669A patent/HU203329B/hu unknown
- 1988-02-24 CH CH692/88A patent/CH676848A5/de not_active IP Right Cessation
- 1988-02-25 LU LU87144A patent/LU87144A1/fr unknown
- 1988-02-25 BE BE8800220A patent/BE1002116A3/fr not_active IP Right Cessation
- 1988-02-25 CN CN88100911A patent/CN1026110C/zh not_active Expired - Lifetime
- 1988-02-25 YU YU00363/88A patent/YU36388A/xx unknown
1989
- 1989-06-23 ES ES8902217A patent/ES2026746A6/es not_active Expired - Fee Related
1992
- 1992-06-12 MX MX9202847A patent/MX9202847A/es unknown

Also Published As

Publication number	Publication date
MX9202847A (es)	1992-06-30
FR2612924B1 (fr)	1991-01-11
SE8800638L (sv)	1988-09-21
KR880009947A (ko)	1988-10-06
CS271481B2 (en)	1990-10-12
NO169438B (no)	1992-03-16
YU36388A (en)	1989-10-31
IL85529A (en)	1993-01-31
IT8819525A0 (it)	1988-02-24
IE61619B1 (en)	1994-11-16
AT395589B (de)	1993-01-25
GR1000472B (el)	1992-07-30
HU896737D0 (en)	1990-02-28
SE503618C2 (sv)	1996-07-15
HU204516B (en)	1992-01-28
FI96601B (fi)	1996-04-15
HU203329B (en)	1991-07-29
BE1002116A3 (fr)	1990-07-10
CA1328268C (en)	1994-04-05
HU204038B (en)	1991-11-28
CN1026110C (zh)	1994-10-05
WO1988006584A1 (en)	1988-09-07
MY103214A (en)	1993-05-29
NZ223620A (en)	1991-07-26
FR2612924A1 (fr)	1988-09-30
SE8800638D0 (sv)	1988-02-24
NO169438C (no)	1992-06-24
NO880809D0 (no)	1988-02-24
JP2603324B2 (ja)	1997-04-23
ES2026746A6 (es)	1992-05-01
CH676848A5 (de)	1991-03-15
KR960001203B1 (ko)	1996-01-24
GR880100101A (en)	1988-12-16
HUT47259A (en)	1989-02-28
PT86820B (pt)	1995-03-01
DK97288D0 (da)	1988-02-24
IL85529A0 (en)	1988-08-31
FI880869A0 (fi)	1988-02-24
JPH01502269A (ja)	1989-08-10
NO880809L (no)	1988-08-26
AU1395088A (en)	1988-09-26
DE3805801A1 (de)	1988-09-08
LU87144A1 (fr)	1988-09-20
CN88100911A (zh)	1988-09-28
CS118088A2 (en)	1989-08-14
IT1216751B (it)	1990-03-08
FI96601C (fi)	1996-07-25
PT86820A (pt)	1989-02-28
US4897490A (en)	1990-01-30
FI880869A7 (fi)	1988-08-26
NL8800465A (nl)	1988-09-16
DE3805801C2 (de)	2001-03-01
HU900669D0 (en)	1990-06-28
ES2010246A6 (es)	1989-11-01
EG18341A (en)	1993-08-30
IE880501L (en)	1988-08-25
DK174822B1 (da)	2003-12-08
DK97288A (da)	1988-08-26

Publication	Publication Date	Title
DK85993A (da)	1993-07-20	2-anilino-4-formyl-pyrimidinforbindelser
BA98296A (bs)	2001-09-14	Piperazinil-heterociklicna jedinjenja
FI893632A7 (fi)	1989-07-31	Yhdisteitä
PT86651A (pt)	1988-02-01	Chemical compounds
BR8807217A (pt)	1989-10-17	Compostos heterocilicos
DK321688A (da)	1988-12-25	Heterocykliske forbindelser
FI895936A7 (fi)	1990-06-14	Yhdisteitä
DK90788D0 (da)	1988-02-22	Kemiske forbindelser
ATA46188A (de)	1992-06-15	Antihypercholesterinaemische tetrazol-verbindungen
FI890438A7 (fi)	1989-08-09	Yhdisteet
NO168305C (no)	1992-02-05	Heterocykliske forbindelser
DK64788A (da)	1988-08-11	Heterocycliske forbindelser
PT86766A (pt)	1988-03-01	Arylpiperazinyl-alkylene-phenyl-heterocyclic compounds
AT387258B (de)	1988-12-27	Fallbremse
IT1221792B (it)	1990-07-12	Composti metossimetilici
FI893924A7 (fi)	1989-08-21	Yhdisteitä
NO178432C (no)	1996-03-27	Tetrazolmellomprodukt
ATE93512T1 (de)	1993-09-15	Oximino-aether-verbindungen.
KR890700561A (ko)	1989-04-25	살충성 시클로프로필-치환된 디 화합물
DE3878192D1 (de)	1993-03-18	N-phenyltetrahydrophthalimidverbindungen.
DK429588A (da)	1989-02-04	Heterocykliske forbindelser
FI103793B1 (fi)	1999-09-30	Tetratsolijohdannaisia
KR890002990U (ko)	1989-04-12	관계수
SE8705089D0 (sv)	1987-12-21	New compounds
SE8702228D0 (sv)	1987-05-27	New compounds

Legal Events

Date	Code	Title
1990-02-15	UEP	Publication of translation of european patent specification
1994-02-15	REN	Ceased due to non-payment of the annual fee
2008-11-15	ELA	Expired due to lapse of time