DE60320008D1 - Heterozyklische beta-aminoverbindungen als inhibitoren des dipeptidylpeptidase zur behandlung bzw. prevention von diabetes - Google Patents

Heterozyklische beta-aminoverbindungen als inhibitoren des dipeptidylpeptidase zur behandlung bzw. prevention von diabetes

Info

Publication number: DE60320008D1
Authority: DE; Germany
Prior art keywords: diabetes; inhibitors; prevention; treatment; dipeptidylpeptidase
Prior art date: 2002-10-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60320008T

Other languages

English (en)

Other versions

DE60320008T2 (de

Inventor

Tesfaye Biftu

Gui-Bai Liang

Xiaoxia Qian

Ann E Weber

Danqing Dennis Feng

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck Sharp and Dohme LLC

Original Assignee

Merck and Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-10-18

Filing date

2003-10-14

Publication date

2008-05-08

2003-10-14 Application filed by Merck and Co Inc filed Critical Merck and Co Inc

2008-05-08 Publication of DE60320008D1 publication Critical patent/DE60320008D1/de

2009-06-18 Application granted granted Critical

2009-06-18 Publication of DE60320008T2 publication Critical patent/DE60320008T2/de

2023-10-15 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Hematology (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Obesity (AREA)
Biophysics (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Urology & Nephrology (AREA)
Neurology (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Child & Adolescent Psychology (AREA)
Ophthalmology & Optometry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)

DE60320008T 2002-10-18 2003-10-14 Heterozyklische beta-aminoverbindungen als inhibitoren des dipeptidylpeptidase zur behandlung bzw. prevention von diabetes Expired - Lifetime DE60320008T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US41970302P	2002-10-18	2002-10-18
US419703P		2002-10-18
PCT/US2003/032222 WO2004037169A2 (en)	2002-10-18	2003-10-14	Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes

Publications (2)

Publication Number	Publication Date
DE60320008D1 true DE60320008D1 (de)	2008-05-08
DE60320008T2 DE60320008T2 (de)	2009-06-18

Family

ID=32176478

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60320008T Expired - Lifetime DE60320008T2 (de)	2002-10-18	2003-10-14	Heterozyklische beta-aminoverbindungen als inhibitoren des dipeptidylpeptidase zur behandlung bzw. prevention von diabetes

Country Status (28)

Country	Link
US (1)	US7101871B2 (de)
EP (1)	EP1556362B1 (de)
JP (1)	JP4352001B2 (de)
KR (1)	KR20050067418A (de)
CN (1)	CN100383129C (de)
AT (1)	ATE390416T1 (de)
AU (1)	AU2003298596B2 (de)
BR (1)	BR0315381A (de)
CA (1)	CA2502269C (de)
CL (1)	CL2004000437A1 (de)
CY (1)	CY1108146T1 (de)
DE (1)	DE60320008T2 (de)
DK (1)	DK1556362T3 (de)
EC (1)	ECSP055732A (de)
ES (1)	ES2301879T3 (de)
HR (1)	HRP20050343A2 (de)
IS (1)	IS7753A (de)
MA (1)	MA27548A1 (de)
MX (1)	MXPA05004063A (de)
NO (1)	NO333815B1 (de)
NZ (1)	NZ538897A (de)
PL (1)	PL216527B1 (de)
PT (1)	PT1556362E (de)
RU (1)	RU2301803C2 (de)
TW (1)	TWI249529B (de)
UA (1)	UA78612C2 (de)
WO (1)	WO2004037169A2 (de)
ZA (1)	ZA200502162B (de)

Families Citing this family (123)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1990469A (zh)	2001-06-27	2007-07-04	史密丝克莱恩比彻姆公司	作为二肽酶抑制剂的氟代吡咯烷
US7407955B2 (en)	2002-08-21	2008-08-05	Boehringer Ingelheim Pharma Gmbh & Co., Kg	8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
KR20050122220A (ko)	2003-03-25	2005-12-28	다케다 샌디에고, 인코포레이티드	디펩티딜 펩티다제 억제제
WO2004103993A1 (en)	2003-05-14	2004-12-02	Syrrx, Inc.	Dipeptidyl peptidase inhibitors
US7259160B2 (en) *	2003-07-31	2007-08-21	Merck & Co., Inc.	Hexahydrodiazepinones as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
US7678909B1 (en)	2003-08-13	2010-03-16	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
US7169926B1 (en)	2003-08-13	2007-01-30	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
BRPI0413452A (pt)	2003-08-13	2006-10-17	Takeda Pharmaceutical	composto, composição farmacêutica, kit, artigo de fabricação, e, métodos de inibir dpp-iv, terapêutico e de tratar um estado de doença, cáncer, distúrbios autoimunes, uma condição einfecção por hiv
WO2005026148A1 (en)	2003-09-08	2005-03-24	Takeda San Diego, Inc.	Dipeptidyl peptidase inhibitors
CA2545641A1 (en)	2003-11-17	2005-06-02	Novartis Ag	Use of organic compounds
RU2766487C2 (ru)	2004-01-20	2022-03-15	Новартис Аг	Композиция и способ прямого прессования
US7732446B1 (en)	2004-03-11	2010-06-08	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
CN102079743B (zh)	2004-03-15	2020-08-25	武田药品工业株式会社	二肽基肽酶抑制剂
JP2008501714A (ja)	2004-06-04	2008-01-24	武田薬品工業株式会社	ジペプチジルペプチダーゼインヒビター
AU2005265148B2 (en) *	2004-06-21	2011-01-20	Merck Sharp & Dohme Corp.	Aminocyclohexanes as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
WO2006019965A2 (en)	2004-07-16	2006-02-23	Takeda San Diego, Inc.	Dipeptidyl peptidase inhibitors
CN101087756B (zh)	2004-07-23	2011-04-06	纽阿达有限责任公司	肽酶抑制剂
JP2008510810A (ja)	2004-08-23	2008-04-10	メルクエンドカムパニーインコーポレーテッド	糖尿病の治療または予防のためのジペプチジルペプチダーゼ−ｉｖ阻害剤としての縮合トリアゾール誘導体
AR050615A1 (es)	2004-08-27	2006-11-08	Novartis Ag	Composiciones farmaceuticas para la administracion oral
JP4797021B2 (ja)	2004-10-01	2011-10-19	メルク・シャープ・エンド・ドーム・コーポレイション	糖尿病の治療または予防用のジペプチジルペプチダ−ゼ−ｉｖ阻害剤としてのアミノピペリジン
DE102004054054A1 (de)	2004-11-05	2006-05-11	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
CN102127023B (zh) *	2004-12-02	2013-02-06	第一三共株式会社	7-元环化合物及其制备方法和用途
WO2006065826A2 (en) *	2004-12-15	2006-06-22	Merck & Co., Inc.	Process to chiral beta amino acid derivatives by asymmetric hydrogenation
WO2006068978A2 (en)	2004-12-21	2006-06-29	Takeda Pharmaceutial Company Limited	Dipeptidyl peptidase inhibitors
DOP2006000008A (es)	2005-01-10	2006-08-31	Arena Pharm Inc	Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1
US20090124601A1 (en) *	2005-03-29	2009-05-14	Song Zhiguo J	Tartaric Acid Salts of a Dipeptidyl Peptidase-IV Inhibitor
MY152185A (en)	2005-06-10	2014-08-29	Novartis Ag	Modified release 1-[(3-hydroxy-adamant-1-ylamino)-acetyl]-pyrrolidine-2(s)-carbonitrile formulation
DE602006007012D1 (de)	2005-07-20	2009-07-09	Lilly Co Eli	Pyridinderivate als dipeptedyl-peptidase-hemmer
US8076514B2 (en)	2005-07-20	2011-12-13	Eli Lilly And Company	Phenyl compounds and their use in the treatment of Type II diabetes
US8106090B2 (en)	2005-07-20	2012-01-31	Eli Lilly And Company	1-amino linked compounds
GEP20135838B (en)	2005-09-14	2013-06-10	Takeda Pharmaceutical	Dipeptidyl peptidase inhibitors usage at diabetes treatment
CA2622642C (en)	2005-09-16	2013-12-31	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
WO2007078726A2 (en) *	2005-12-16	2007-07-12	Merck & Co., Inc.	Pharmaceutical compositions of combinations of dipeptidyl peptidase-4 inhibitors with metformin
GB0526291D0 (en)	2005-12-23	2006-02-01	Prosidion Ltd	Therapeutic method
US20090156465A1 (en)	2005-12-30	2009-06-18	Sattigeri Jitendra A	Derivatives of beta-amino acid as dipeptidyl peptidase-iv inhibitors
WO2007112347A1 (en)	2006-03-28	2007-10-04	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
PE20071221A1 (es)	2006-04-11	2007-12-14	Arena Pharm Inc	Agonistas del receptor gpr119 en metodos para aumentar la masa osea y para tratar la osteoporosis y otras afecciones caracterizadas por masa osea baja, y la terapia combinada relacionada a estos agonistas
AU2007235876A1 (en)	2006-04-12	2007-10-18	Probiodrug Ag	Enzyme inhibitors
MX2008013468A (es) *	2006-04-20	2008-10-30	Hoffmann La Roche	Nuevos derivados de diazepano.
PE20080251A1 (es)	2006-05-04	2008-04-25	Boehringer Ingelheim Int	Usos de inhibidores de dpp iv
EP1852108A1 (de)	2006-05-04	2007-11-07	Boehringer Ingelheim Pharma GmbH & Co.KG	Zusammensetzungen von DPP-IV-Inhibitoren
MX2008014024A (es)	2006-05-04	2008-11-14	Boehringer Ingelheim Int	Formas poliformas.
CN101495463B (zh) *	2006-05-31	2012-08-15	第一三共株式会社	7-元环化合物、其制备方法和药物用途
KR20090047458A (ko)	2006-08-08	2009-05-12	사노피-아벤티스	아릴아미노아릴-알킬-치환된 이미다졸리딘-2,4-디온, 이의 제조방법, 이들 화합물을 포함하는 약제 및 이의 용도
US8324383B2 (en)	2006-09-13	2012-12-04	Takeda Pharmaceutical Company Limited	Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
JP5379692B2 (ja)	2006-11-09	2013-12-25	プロビオドルグエージー	潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体
TW200838536A (en)	2006-11-29	2008-10-01	Takeda Pharmaceutical	Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
EP2091948B1 (de)	2006-11-30	2012-04-18	Probiodrug AG	Neue inhibitoren von glutaminylcyclase
US8093236B2 (en)	2007-03-13	2012-01-10	Takeda Pharmaceuticals Company Limited	Weekly administration of dipeptidyl peptidase inhibitors
WO2008128985A1 (en)	2007-04-18	2008-10-30	Probiodrug Ag	Thiourea derivatives as glutaminyl cyclase inhibitors
RU2419615C1 (ru)	2007-04-19	2011-05-27	Донг-А Фарм.Ко., Лтд.	Ингибитор dpp-iv, включающий бета-аминогруппу, способ его получения и содержащая его фармацевтическая композиция для предупреждения и лечения диабета или ожирения
CA2688187C (en)	2007-05-07	2016-10-11	Merck & Co., Inc.	Method of treament using fused aromatic compounds having anti-diabetic activity
EP2025674A1 (de)	2007-08-15	2009-02-18	sanofi-aventis	Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
RU2361581C2 (ru)	2007-09-14	2009-07-20	Закрытое Акционерное Общество "Мастерклон"	Фармацевтическая композиция, обладающая противодиабетической, гиполипидемической, гипогликемической и гипохолестеринемической активностью, способ ее получения и способы лечения указанных заболеваний
US8455479B2 (en) *	2008-01-24	2013-06-04	Panacea Biotec Limited	Heterocyclic compounds
PE20091730A1 (es)	2008-04-03	2009-12-10	Boehringer Ingelheim Int	Formulaciones que comprenden un inhibidor de dpp4
EP2146210A1 (de)	2008-04-07	2010-01-20	Arena Pharmaceuticals, Inc.	Verfahren zur Verwendung eines AG-Protein-gekoppelten Rezeptors zur Identifikation von Peptid-YY (PPY)-Sekretagogen sowie Verbindungen zur Behandlung durch PYY modulierter Leiden
UY31968A (es)	2008-07-09	2010-01-29	Sanofi Aventis	Nuevos derivados heterocíclicos, sus procesos para su preparación, y sus usos terapéuticos
CN101633625B (zh) *	2008-07-23	2013-02-13	江苏恒瑞医药股份有限公司	R-β-氨基苯丁酸衍生物的制备方法
KR20200118243A (ko)	2008-08-06	2020-10-14	베링거 인겔하임 인터내셔날 게엠베하	메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
US20200155558A1 (en)	2018-11-20	2020-05-21	Boehringer Ingelheim International Gmbh	Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
KR101054911B1 (ko) *	2008-10-17	2011-08-05	동아제약주식회사	디펩티딜펩티다아제-ⅳ의 활성을 저해하는 화합물 및 다른 항당뇨 또는 항비만 약물을 유효성분으로 함유하는 당뇨 또는 비만의 예방 및 치료용 약학적 조성물
JP5514831B2 (ja)	2008-11-17	2014-06-04	メルク・シャープ・アンド・ドーム・コーポレーション	糖尿病の治療のための置換二環式アミン
WO2010068601A1 (en)	2008-12-08	2010-06-17	Sanofi-Aventis	A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
RU2398572C1 (ru) *	2009-05-18	2010-09-10	Государственное образовательное учреждение высшего профессионального образования "Санкт-Петербургская государственная медицинская академия им. И.И. Мечникова Федерального агентства по здравоохранению и социальному развитию"	Способ лечения больных сахарным диабетом 2 типа
AR077642A1 (es)	2009-07-09	2011-09-14	Arena Pharm Inc	Moduladores del metabolismo y el tratamiento de trastornos relacionados con el mismo
CA2768577A1 (en)	2009-07-23	2011-01-27	Schering Corporation	Benzo-fused oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors
WO2011011506A1 (en)	2009-07-23	2011-01-27	Schering Corporation	Spirocyclic oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors
WO2011023754A1 (en)	2009-08-26	2011-03-03	Sanofi-Aventis	Novel crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use
WO2011029920A1 (en)	2009-09-11	2011-03-17	Probiodrug Ag	Heterocylcic derivatives as inhibitors of glutaminyl cyclase
CN107115530A (zh)	2009-11-27	2017-09-01	勃林格殷格翰国际有限公司	基因型糖尿病患者利用dpp‑iv抑制剂例如利拉利汀的治疗
WO2011107530A2 (en)	2010-03-03	2011-09-09	Probiodrug Ag	Novel inhibitors
WO2011107494A1 (de)	2010-03-03	2011-09-09	Sanofi	Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
ES2481823T3 (es)	2010-03-10	2014-07-31	Probiodrug Ag	Inhibidores heterocíclicos de glutaminil ciclasa (QC, EC 2.3.2.5)
WO2011127051A1 (en)	2010-04-06	2011-10-13	Arena Pharmaceuticals, Inc.	Modulators of the gpr119 receptor and the treatment of disorders related thereto
EP2560953B1 (de)	2010-04-21	2016-01-06	Probiodrug AG	Hemmer der glutaminylzyklase
CA2797310C (en)	2010-05-05	2020-03-31	Boehringer Ingelheim International Gmbh	Glp-1 receptor agonist and dpp-4 inhibitor combination therapy
EP2571876B1 (de)	2010-05-21	2016-09-07	Merck Sharp & Dohme Corp.	Substituierte siebenteilige heterozyklische verbindungen als dipeptidyl-peptidase-iv-hemmer zur behandlung von diabetes
US8933024B2 (en)	2010-06-18	2015-01-13	Sanofi	Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US8530413B2 (en)	2010-06-21	2013-09-10	Sanofi	Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en)	2010-07-05	2012-06-01	Sanofi Sa	Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en)	2010-07-05	2012-04-16	Sanofi Aventis	Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en)	2010-07-05	2012-04-16	Sanofi Sa	(2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
IN2010DE02164A (de)	2010-09-13	2015-07-24	Panacea Biotec Ltd
CN103221410B (zh)	2010-09-22	2017-09-15	艾尼纳制药公司	Gpr119受体调节剂和对与其相关的障碍的治疗
AR083878A1 (es)	2010-11-15	2013-03-27	Boehringer Ingelheim Int	Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
EP2648517B1 (de)	2010-12-06	2015-08-05	Merck Sharp & Dohme Corp.	Trizyklische heterozyklen als dipeptidylpeptidase-iv-hemmer
US8828994B2 (en)	2011-03-08	2014-09-09	Sanofi	Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120056A1 (de)	2011-03-08	2012-09-13	Sanofi	Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8710050B2 (en)	2011-03-08	2014-04-29	Sanofi	Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120053A1 (de)	2011-03-08	2012-09-13	Sanofi	Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120052A1 (de)	2011-03-08	2012-09-13	Sanofi	Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
ES2570167T3 (es)	2011-03-16	2016-05-17	Probiodrug Ag	Derivados de benzimidazol como inhibidores de glutaminil ciclasa
US20140018371A1 (en)	2011-04-01	2014-01-16	Arena Pharmaceuticals, Inc.	Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
WO2012145361A1 (en)	2011-04-19	2012-10-26	Arena Pharmaceuticals, Inc.	Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2012145603A1 (en)	2011-04-22	2012-10-26	Arena Pharmaceuticals, Inc.	Modulators of the gpr119 receptor and the treatment of disorders related thereto
US20140051714A1 (en)	2011-04-22	2014-02-20	Arena Pharmaceuticals, Inc.	Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
WO2012170702A1 (en)	2011-06-08	2012-12-13	Arena Pharmaceuticals, Inc.	Modulators of the gpr119 receptor and the treatment of disorders related thereto
RU2014102764A (ru)	2011-06-29	2015-08-10	Мерк Шарп И Доум Корп.	Способ получения хиральных ингибиторов дипептидилпептидазы iv
WO2013006526A2 (en)	2011-07-05	2013-01-10	Merck Sharp & Dohme Corp.	Tricyclic heterocycles useful as dipeptidyl peptidase-iv inhibitors
WO2013037390A1 (en)	2011-09-12	2013-03-21	Sanofi	6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en)	2011-09-27	2013-04-04	Sanofi	6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013055910A1 (en)	2011-10-12	2013-04-18	Arena Pharmaceuticals, Inc.	Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2013122920A1 (en)	2012-02-17	2013-08-22	Merck Sharp & Dohme Corp.	Dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
US9555001B2 (en)	2012-03-07	2017-01-31	Boehringer Ingelheim International Gmbh	Pharmaceutical composition and uses thereof
EP3685839A1 (de)	2012-05-14	2020-07-29	Boehringer Ingelheim International GmbH	Linagliptin zur verwendung in der behandlung von albuminuria und nierenbedingten erkrankungen
EP4151218A1 (de)	2012-05-14	2023-03-22	Boehringer Ingelheim International GmbH	Linagliptin, ein xanthinderivat als dpp-4-inhibitor zur verwendung bei der behandlung von sirs und/oder sepsis
WO2013174767A1 (en)	2012-05-24	2013-11-28	Boehringer Ingelheim International Gmbh	A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
WO2014018350A1 (en)	2012-07-23	2014-01-30	Merck Sharp & Dohme Corp.	Treating diabetes with dipeptidyl peptidase-iv inhibitors
WO2014018355A1 (en)	2012-07-23	2014-01-30	Merck Sharp & Dohme Corp.	Treating diabetes with dipeptidyl peptidase-iv inhibitors
IN2015DN03795A (de)	2012-10-24	2015-10-02	Inserm Inst Nat De La Santé Et De La Rech Médicale
WO2014074668A1 (en)	2012-11-08	2014-05-15	Arena Pharmaceuticals, Inc.	Modulators of gpr119 and the treatment of disorders related thereto
WO2015128453A1 (en)	2014-02-28	2015-09-03	Boehringer Ingelheim International Gmbh	Medical use of a dpp-4 inhibitor
US9862725B2 (en)	2014-07-21	2018-01-09	Merck Sharp & Dohme Corp.	Process for preparing chiral dipeptidyl peptidase-IV inhibitors
GB201415598D0 (en)	2014-09-03	2014-10-15	Univ Birmingham	Elavated Itercranial Pressure Treatment
KR20180006881A (ko)	2015-03-09	2018-01-19	인테크린 테라퓨틱스, 아이엔씨.	비알코올성 지방간 질환 및/또는 지방이영양증의 치료 방법
US10426818B2 (en)	2015-03-24	2019-10-01	Inserm (Institut National De La Sante Et De La Recherche Medicale)	Method and pharmaceutical composition for use in the treatment of diabetes
CN105330657B (zh) *	2015-12-08	2019-05-21	华润双鹤药业股份有限公司	5-氯-2-[5-(r)-甲基-1,4-二氮杂环庚烷-1-]苯并恶唑的制备方法
CN105367506B (zh) *	2015-12-08	2021-02-05	华润双鹤药业股份有限公司	手性高哌嗪环的制备方法
US10155000B2 (en)	2016-06-10	2018-12-18	Boehringer Ingelheim International Gmbh	Medical use of pharmaceutical combination or composition
AU2018249822A1 (en)	2017-04-03	2019-10-31	Coherus Biosciences Inc.	PPArgamma agonist for treatment of progressive supranuclear palsy
EP3461819B1 (de)	2017-09-29	2020-05-27	Probiodrug AG	Hemmer der glutaminylcyclase
WO2021126799A1 (en) *	2019-12-18	2021-06-24	Merck Sharp & Dohme Corp.	Macrocyclic peptides as potent inhibitors of k-ras g12d mutant

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL111785A0 (en)	1993-12-03	1995-01-24	Ferring Bv	Dp-iv inhibitors and pharmaceutical compositions containing them
US6673927B2 (en) *	1996-02-16	2004-01-06	Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S.	Farnesyl transferase inhibitors
DE122010000020I1 (de)	1996-04-25	2010-07-08	Prosidion Ltd	Verfahren zur Senkung des Blutglukosespiegels in Säugern
TW492957B (en)	1996-11-07	2002-07-01	Novartis Ag	N-substituted 2-cyanopyrrolidnes
US6011155A (en)	1996-11-07	2000-01-04	Novartis Ag	N-(substituted glycyl)-2-cyanopyrrolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV
CO5150173A1 (es)	1998-12-10	2002-04-29	Novartis Ag	Compuestos n-(glicilo sustituido)-2-cianopirrolidinas inhibidores de peptidasa de dipeptidilo-iv (dpp-iv) los cuales son efectivos en el tratamiento de condiciones mediadas por la inhibicion de dpp-iv
EP1228061A4 (de)	1999-11-12	2004-12-15	Guilford Pharm Inc	Dipeptidyl-peptidase-iv-inhibitoren, verfahren zu deren herstellung sowie deren verwendung
AU776053B2 (en) *	2000-03-31	2004-08-26	Astellas Pharma Inc.	Diazepan derivatives or salts thereof
GB0010183D0 (en) *	2000-04-26	2000-06-14	Ferring Bv	Inhibitors of dipeptidyl peptidase IV
GB0010188D0 (en) *	2000-04-26	2000-06-14	Ferring Bv	Inhibitors of dipeptidyl peptidase IV
US6432969B1 (en)	2000-06-13	2002-08-13	Novartis Ag	N-(substituted glycyl)-2 cyanopyrrolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV
TW583185B (en)	2000-06-13	2004-04-11	Novartis Ag	N-(substituted glycyl)-2-cyanopyrrolidines and pharmaceutical composition for inhibiting dipeptidyl peptidase-IV (DPP-IV) or for the prevention or treatment of diseases or conditions associated with elevated levels of DPP-IV comprising the same
WO2002002560A2 (en)	2000-07-04	2002-01-10	Novo Nordisk A/S	Purine-2,6-diones which are inhibitors of the enzyme dipeptidyl peptidase iv (dpp-iv)
JP2003040784A (ja) *	2001-01-31	2003-02-13	Japan Science & Technology Corp	血糖降下剤
EP1385508B1 (de)	2001-03-27	2008-05-21	Merck & Co., Inc.	Dipeptidylpeptidase-hemmer für die behandlung oder prävention von diabetes
WO2003000181A2 (en)	2001-06-20	2003-01-03	Merck & Co., Inc.	Dipeptidyl peptidase inhibitors for the treatment of diabetes
US7098239B2 (en)	2001-06-20	2006-08-29	Merck & Co., Inc	Dipeptidyl peptidase inhibitors for the treatment of diabetes
UA74912C2 (en)	2001-07-06	2006-02-15	Merck & Co Inc	Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes
DE60316416T2 (de)	2002-03-25	2008-06-26	Merck & Co., Inc.	Heterocyclische beta-aminoverbindungen als inhibitoren der dipeptidylpeptidase zur behandlung bzw. prävention von diabetes
EP1554256B1 (de)	2002-07-15	2009-12-09	Merck & Co., Inc.	Piperidinopyrimidindipeptidylpeptidaseinhibitoren zur behandlung von diabetes
ATE370141T1 (de)	2002-10-07	2007-09-15	Merck & Co Inc	Antidiabetische heterocyclische beta- aminoverbindungen als inhibitoren von dipeptidylpeptidase
US7309714B2 (en)	2002-12-04	2007-12-18	Merck & Co., Inc.	Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
CA2508947A1 (en)	2002-12-20	2004-07-15	Merck & Co., Inc.	3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
WO2004064778A2 (en)	2003-01-17	2004-08-05	Merck & Co. Inc.	3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
JP2006516573A (ja)	2003-01-31	2006-07-06	メルク　エンド　カムパニー　インコーポレーテッド	糖尿病の治療および予防のためのジペプチジルペプチダーゼ阻害薬としての３−アミノ−４−フェニルブタン酸誘導体

2003
- 2003-10-14 KR KR1020057006722A patent/KR20050067418A/ko not_active Ceased
- 2003-10-14 RU RU2005115092/04A patent/RU2301803C2/ru not_active IP Right Cessation
- 2003-10-14 CA CA002502269A patent/CA2502269C/en not_active Expired - Fee Related
- 2003-10-14 ES ES03796347T patent/ES2301879T3/es not_active Expired - Lifetime
- 2003-10-14 JP JP2004546826A patent/JP4352001B2/ja not_active Expired - Fee Related
- 2003-10-14 DK DK03796347T patent/DK1556362T3/da active
- 2003-10-14 WO PCT/US2003/032222 patent/WO2004037169A2/en not_active Ceased
- 2003-10-14 AT AT03796347T patent/ATE390416T1/de active
- 2003-10-14 PT PT03796347T patent/PT1556362E/pt unknown
- 2003-10-14 BR BR0315381-9A patent/BR0315381A/pt not_active IP Right Cessation
- 2003-10-14 UA UAA200504628A patent/UA78612C2/uk unknown
- 2003-10-14 EP EP03796347A patent/EP1556362B1/de not_active Expired - Lifetime
- 2003-10-14 NZ NZ538897A patent/NZ538897A/en unknown
- 2003-10-14 US US10/501,059 patent/US7101871B2/en not_active Expired - Fee Related
- 2003-10-14 PL PL375992A patent/PL216527B1/pl not_active IP Right Cessation
- 2003-10-14 MX MXPA05004063A patent/MXPA05004063A/es active IP Right Grant
- 2003-10-14 DE DE60320008T patent/DE60320008T2/de not_active Expired - Lifetime
- 2003-10-14 HR HR20050343A patent/HRP20050343A2/xx not_active Application Discontinuation
- 2003-10-14 AU AU2003298596A patent/AU2003298596B2/en not_active Ceased
- 2003-10-14 CN CNB2003801016172A patent/CN100383129C/zh not_active Expired - Fee Related
2004
- 2004-03-04 CL CL200400437A patent/CL2004000437A1/es unknown
- 2004-03-05 TW TW093105887A patent/TWI249529B/zh not_active IP Right Cessation
2005
- 2005-03-15 ZA ZA200502162A patent/ZA200502162B/en unknown
- 2005-03-17 IS IS7753A patent/IS7753A/is unknown
- 2005-05-06 MA MA28262A patent/MA27548A1/fr unknown
- 2005-05-13 NO NO20052380A patent/NO333815B1/no not_active IP Right Cessation
- 2005-05-14 EC EC2005005732A patent/ECSP055732A/es unknown
2008
- 2008-06-18 CY CY20081100642T patent/CY1108146T1/el unknown

Also Published As

Publication number	Publication date
JP4352001B2 (ja)	2009-10-28
KR20050067418A (ko)	2005-07-01
DE60320008T2 (de)	2009-06-18
CL2004000437A1 (es)	2005-06-03
NO333815B1 (no)	2013-09-23
EP1556362A4 (de)	2006-08-23
WO2004037169A2 (en)	2004-05-06
AU2003298596A1 (en)	2004-05-13
RU2005115092A (ru)	2006-01-20
CA2502269A1 (en)	2004-05-06
EP1556362B1 (de)	2008-03-26
DK1556362T3 (da)	2008-06-09
EP1556362A2 (de)	2005-07-27
CN100383129C (zh)	2008-04-23
UA78612C2 (en)	2007-04-10
CA2502269C (en)	2009-12-22
ZA200502162B (en)	2006-02-22
IS7753A (is)	2005-03-17
CN1705647A (zh)	2005-12-07
BR0315381A (pt)	2005-08-23
CY1108146T1 (el)	2014-02-12
ES2301879T3 (es)	2008-07-01
TWI249529B (en)	2006-02-21
ATE390416T1 (de)	2008-04-15
MXPA05004063A (es)	2005-06-08
HRP20050343A2 (en)	2007-03-31
US20040254167A1 (en)	2004-12-16
HK1086265A1 (zh)	2006-09-15
JP2006510608A (ja)	2006-03-30
AU2003298596B2 (en)	2008-12-18
NZ538897A (en)	2007-02-23
US7101871B2 (en)	2006-09-05
TW200530202A (en)	2005-09-16
RU2301803C2 (ru)	2007-06-27
ECSP055732A (es)	2005-07-06
PT1556362E (pt)	2008-06-16
WO2004037169A3 (en)	2004-08-05
MA27548A1 (fr)	2005-10-03
PL375992A1 (en)	2005-12-12
NO20052380L (no)	2005-06-16
PL216527B1 (pl)	2014-04-30

Publication	Publication Date	Title
ATE390416T1 (de)	2008-04-15	Heterozyklische beta-aminoverbindungen als inhibitoren des dipeptidylpeptidase zur behandlung bzw. prevention von diabetes
ATE373660T1 (de)	2007-10-15	Heterocyclische beta-aminoverbindungen als inhibitoren der dipeptidylpeptidase zur behandlung bzw. prävention von diabetes
DE60330485D1 (de)	2010-01-21	Zur behandlung von diabetes
ATE447574T1 (de)	2009-11-15	3-amino-4-phenylbutansäurederivate als dipeptidylpeptidase-hemmer zur behandlung oder vorbeugung von diabetes
ATE417832T1 (de)	2009-01-15	Hexahydrodiazepinone als inhibitoren des dipeptidylpeptidase-iv zur behandlung bzw. prävention von diabetes
ATE473742T1 (de)	2010-07-15	Kondensierte triazolderivate als dipeptidylpeptidase-iv-hemmer zur behandlung bzw. prävention von diabetes
DE60310991D1 (de)	2007-02-15	Phenylalaninderivate als hemmer der dipeptidyl peptidase zur behandlung oder prävention von diabetes
ATE370141T1 (de)	2007-09-15	Antidiabetische heterocyclische beta- aminoverbindungen als inhibitoren von dipeptidylpeptidase
MY127961A (en)	2007-01-31	Beta-amino heterocyclic dipetidyl peptidase inhibitors for the treament or prevention of diabetes
ATE540950T1 (de)	2012-01-15	Aminocyclohexane als dipeptidylpeptidase-iv- hemmer zur behandlung bzw. prävention von diabetes
DE602004026440D1 (de)	2010-05-20	Kondensierte indole als dipeptidyl-peptidase-hemmer zur behandlung oder prävention von diabetes
ATE448229T1 (de)	2009-11-15	Bicyclische pyrimidine als dipeptidylpeptidase-iv-hemmer zur behandlung bzw. prävention von diabetes
ATE481969T1 (de)	2010-10-15	Aminopiperidine als dipeptidylpeptidase-iv- inhibitoren zur behandlung oder prävention von diabetes
ATE527259T1 (de)	2011-10-15	Kondensierte aminopiperidine als dipeptidylpeptidase-iv-inhibitoren zur behandlung oder prävention von diabetes
ATE395912T1 (de)	2008-06-15	Dipeptidylpeptidase-hemmer für die behandlung oder prävention von diabetes
ATE549926T1 (de)	2012-04-15	Kondensierte aminopiperidine als dipeptidylpeptidase-iv-inhibitoren zur behandlung oder prävention von diabetes
MY138965A (en)	2009-08-28	Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
TW200500338A (en)	2005-01-01	Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes

Legal Events

Date	Code	Title	Description
2009-04-16	8364	No opposition during term of opposition
2010-08-12	8327	Change in the person/name/address of the patent owner	Owner name: MERCK SHARP & DOHME CORP., RAHWAY, N.J., US
2010-08-12	8328	Change in the person/name/address of the agent	Representative=s name: MARKS & CLERK (LUXEMBOURG) LLP, LUXEMBOURG, LU
2013-02-07	R081	Change of applicant/patentee	Ref document number: 1556362 Country of ref document: EP Owner name: SCHERING CORPORATION, US Free format text: FORMER OWNER: MERCK SHARP & DOHME CORP., RAHWAY, US Effective date: 20121213
2013-02-07	R082	Change of representative	Ref document number: 1556362 Country of ref document: EP Representative=s name: MARKS & CLERK (LUXEMBOURG) LLP, LU Effective date: 20121213