[go: up one dir, main page]

DE60311942D1 - Verfahren für die Synthese von Perindopril und seiner pharmazeutischen annehmbaren Salzen - Google Patents

Verfahren für die Synthese von Perindopril und seiner pharmazeutischen annehmbaren Salzen

Info

Publication number
DE60311942D1
DE60311942D1 DE60311942T DE60311942T DE60311942D1 DE 60311942 D1 DE60311942 D1 DE 60311942D1 DE 60311942 T DE60311942 T DE 60311942T DE 60311942 T DE60311942 T DE 60311942T DE 60311942 D1 DE60311942 D1 DE 60311942D1
Authority
DE
Germany
Prior art keywords
perindopril
synthesis
pharmaceutically acceptable
acceptable salts
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60311942T
Other languages
English (en)
Other versions
DE60311942T2 (de
Inventor
Thierry Dubuffet
Pascal Langlois
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Les Laboratoires Servier SAS
Original Assignee
Les Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier SAS filed Critical Les Laboratoires Servier SAS
Application granted granted Critical
Publication of DE60311942D1 publication Critical patent/DE60311942D1/de
Publication of DE60311942T2 publication Critical patent/DE60311942T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE60311942T 2003-11-19 2003-11-19 Verfahren für die Synthese von Perindopril und seiner pharmazeutischen annehmbaren Salzen Expired - Lifetime DE60311942T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03292864A EP1420028B1 (de) 2003-11-19 2003-11-19 Verfahren für die Synthese von Perindopril und seiner pharmazeutischen annehmbaren Salzen

Publications (2)

Publication Number Publication Date
DE60311942D1 true DE60311942D1 (de) 2007-04-05
DE60311942T2 DE60311942T2 (de) 2007-12-06

Family

ID=32116380

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60311942T Expired - Lifetime DE60311942T2 (de) 2003-11-19 2003-11-19 Verfahren für die Synthese von Perindopril und seiner pharmazeutischen annehmbaren Salzen

Country Status (28)

Country Link
US (1) US7208607B1 (de)
EP (1) EP1420028B1 (de)
JP (1) JP4377412B2 (de)
KR (1) KR100863394B1 (de)
CN (1) CN100447152C (de)
AR (1) AR047312A1 (de)
AT (1) ATE354586T1 (de)
AU (1) AU2004295132B2 (de)
BR (1) BRPI0416746B1 (de)
CA (1) CA2546506C (de)
CY (1) CY1106544T1 (de)
DE (1) DE60311942T2 (de)
DK (1) DK1420028T3 (de)
EA (1) EA010102B1 (de)
EG (1) EG26629A (de)
ES (1) ES2282586T3 (de)
GE (1) GEP20084547B (de)
MA (1) MA28144A1 (de)
MX (1) MXPA06005607A (de)
MY (1) MY138550A (de)
NO (1) NO336349B1 (de)
NZ (1) NZ546931A (de)
PL (1) PL210769B1 (de)
PT (1) PT1420028E (de)
SI (1) SI1420028T1 (de)
UA (1) UA83269C2 (de)
WO (1) WO2005054276A1 (de)
ZA (1) ZA200603675B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE310012T1 (de) * 2003-08-29 2005-12-15 Servier Lab Verfahren für die synthese von perindopril und seiner pharmazeutisch annehmbaren salzen
PL380887A1 (pl) 2003-12-29 2007-04-02 Sepracor Inc. Pirolowe i pirazolowe inhibitory DAAO
CA2614282A1 (en) 2005-07-06 2007-01-11 Sepracor Inc. Combinations of eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders
AU2007205114B2 (en) 2006-01-06 2012-11-08 Sunovion Pharmaceuticals Inc. Cycloalkylamines as monoamine reuptake inhibitors
CA2636275C (en) 2006-01-06 2013-02-12 Sepracor Inc. Tetralone-based monoamine reuptake inhibitors
AU2007233041B2 (en) 2006-03-31 2013-05-02 Sepracor Inc. Preparation of chiral amides and amines
US7884124B2 (en) 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US7902252B2 (en) 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
AU2008259841B2 (en) 2007-05-31 2015-02-05 Sunovion Pharmaceuticals Inc. Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
PH12018502155B1 (en) 2016-04-20 2024-03-27 Servier Lab Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid
CN112047869B (zh) * 2020-08-20 2021-12-21 华南理工大学 一种氮杂5,6-并环化合物的合成方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese

Also Published As

Publication number Publication date
BRPI0416746A (pt) 2007-01-16
DE60311942T2 (de) 2007-12-06
NZ546931A (en) 2010-01-29
CA2546506C (fr) 2010-04-06
MY138550A (en) 2009-06-30
MA28144A1 (fr) 2006-09-01
CN1882607A (zh) 2006-12-20
NO336349B1 (no) 2015-08-03
ES2282586T3 (es) 2007-10-16
HK1096689A1 (en) 2007-06-08
PL380409A1 (pl) 2007-01-22
PT1420028E (pt) 2007-05-31
KR20060121202A (ko) 2006-11-28
AU2004295132A1 (en) 2005-06-16
US20070083052A1 (en) 2007-04-12
EA010102B1 (ru) 2008-06-30
JP4377412B2 (ja) 2009-12-02
AR047312A1 (es) 2006-01-18
UA83269C2 (uk) 2008-06-25
NO20062599L (no) 2006-06-06
CN100447152C (zh) 2008-12-31
BRPI0416746B1 (pt) 2018-02-14
EG26629A (en) 2014-04-13
KR100863394B1 (ko) 2008-10-14
DK1420028T3 (da) 2007-06-18
EP1420028A2 (de) 2004-05-19
GEP20084547B (en) 2008-11-25
ATE354586T1 (de) 2007-03-15
CY1106544T1 (el) 2012-01-25
US7208607B1 (en) 2007-04-24
SI1420028T1 (sl) 2007-06-30
EP1420028A3 (de) 2004-05-26
MXPA06005607A (es) 2006-08-17
ZA200603675B (en) 2007-09-26
CA2546506A1 (fr) 2005-06-16
AU2004295132B2 (en) 2010-07-15
WO2005054276A1 (fr) 2005-06-16
JP2008502587A (ja) 2008-01-31
EP1420028B1 (de) 2007-02-21
EA200600898A1 (ru) 2006-10-27
PL210769B1 (pl) 2012-02-29

Similar Documents

Publication Publication Date Title
DE60129800D1 (de) Verfahren für die synthese von perindopril und seiner pharmazeutischen annehmbaren salze
ATE455106T1 (de) Acyl derivate zur behandlung von krankheiten die in zusammenhang mit vla-4 stehen
EP1513403A4 (de) Herzglykoside für die behandlung von mukoviszidose und anderen il-8-bedingten erkrankungen
DE60318839D1 (de) 2,6-chinolinyl- und 2,6-naphthylderivate und deren verwendungen zur behandlung von vla-4 bezogenen krankheiten
EP1730113A4 (de) Verfahren zur synthese eines cxcr4-antagonisten
DE60303101D1 (de) Verfahren für die Synthese von Perindopril und seiner pharmazeutischen annehmbaren Salzen
DE60311942D1 (de) Verfahren für die Synthese von Perindopril und seiner pharmazeutischen annehmbaren Salzen
DE60313391D1 (de) Verfahren für die Synthese von Perindopril und seiner pharmazeutisch geeigneten Salze
FR2868414B1 (fr) Procede de production d'alpha-alumine particulaire et apha-alumine particulaire produite par ce procede
ATE365714T1 (de) Verfahren zur herstellung von hochreinem perindopril und zwischenverbindungen nützlich in der synthese
DE60301820D1 (de) Verfahren für die Synthese von Perindopril und seiner pharmazeutischen annehmbaren Salzen
DE60300581D1 (de) Verfahren für die Synthese von Perindopril und seiner pharmazeutischen annehmbaren Salzen
DE60308102D1 (de) Verfahren für die Synthese von Perindopril und seiner pharmazeutisch annehmbaren Salzen i2003/26ö
EG24152A (en) Novel method for the synthesis of s-indoline-2-carboxylic acid and application thereof in synthesis of perindopril
DE60302287D1 (de) Verfahren für die Synthese von Perindopril und seiner pharmazeutisch annehmbaren Salzen
DE60319196D1 (de) Verfahren für die Synthese von Perindopril und seiner pharmazeutisch annehmbaren Salzen
DE60301930D1 (de) Verfahren für die Synthese von Perindopril und seiner pharmazeutisch annehmbaren Salze
DE60307721D1 (de) Verfahren für die Synthese von Perindopril und seiner pharmazeutischen annehmbaren Salzen
DE60307925D1 (de) Verfahren für die Synthese von Perindopril und seiner pharmazeutischen annehmbaren Salzen
DE60311730D1 (de) Verfahren für die Synthese von Perindopril und seiner pharmazeutisch annehmbaren Salzen
DE60336931D1 (de) Verfahren zur synthese der bisbenzimidazolen und ihren derivaten.
ATE344800T1 (de) Substituierte [1,4öbenzodioxin[2,3-eöisoindol- derivaten, ihr verfahren zur herstellung und ihre pharmazeutische zusammensetzungen
FR2861727B1 (fr) Procede de synthese directe d'alkylhalogenosilanes
DE602005020131D1 (de) Syntheseverfahren und zwischenprodukte zur herstellung von rizatriptan

Legal Events

Date Code Title Description
8364 No opposition during term of opposition