DK1420028T3 - Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf - Google Patents

Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf

Info

Publication number: DK1420028T3
Authority: DK; Denmark
Prior art keywords: perindopril; synthesis; pharmaceutically acceptable; acceptable salts; salts
Prior art date: 2003-11-19

Application number

DK03292864T

Other languages

English (en)

Inventor

Thierry Dubuffet

Pascal Langlois

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-11-19

Filing date

2003-11-19

Publication date

2007-06-18

2003-11-19 Application filed by Servier Lab filed Critical Servier Lab

2007-06-18 Application granted granted Critical

2007-06-18 Publication of DK1420028T3 publication Critical patent/DK1420028T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Cardiology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK03292864T 2003-11-19 2003-11-19 Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf DK1420028T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP03292864A EP1420028B1 (fr)	2003-11-19	2003-11-19	Pocédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables

Publications (1)

Publication Number	Publication Date
DK1420028T3 true DK1420028T3 (da)	2007-06-18

Family

ID=32116380

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK03292864T DK1420028T3 (da)	2003-11-19	2003-11-19	Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf

Country Status (28)

Country	Link
US (1)	US7208607B1 (da)
EP (1)	EP1420028B1 (da)
JP (1)	JP4377412B2 (da)
KR (1)	KR100863394B1 (da)
CN (1)	CN100447152C (da)
AR (1)	AR047312A1 (da)
AT (1)	ATE354586T1 (da)
AU (1)	AU2004295132B2 (da)
BR (1)	BRPI0416746B1 (da)
CA (1)	CA2546506C (da)
CY (1)	CY1106544T1 (da)
DE (1)	DE60311942T2 (da)
DK (1)	DK1420028T3 (da)
EA (1)	EA010102B1 (da)
EG (1)	EG26629A (da)
ES (1)	ES2282586T3 (da)
GE (1)	GEP20084547B (da)
MA (1)	MA28144A1 (da)
MX (1)	MXPA06005607A (da)
MY (1)	MY138550A (da)
NO (1)	NO336349B1 (da)
NZ (1)	NZ546931A (da)
PL (1)	PL210769B1 (da)
PT (1)	PT1420028E (da)
SI (1)	SI1420028T1 (da)
UA (1)	UA83269C2 (da)
WO (1)	WO2005054276A1 (da)
ZA (1)	ZA200603675B (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI1380591T1 (sl) *	2003-08-29	2006-02-28	Servier Lab	Nov postopek sinteze perindoprila in njegovih farmacevtsko sprejemljivih soli
BRPI0418244A (pt)	2003-12-29	2007-04-17	Sepracor Inc	composto, métodos para aumentar a concentração de d-serina e/ou diminuir a concentração de produtos tóxicos da oxidação de d-serina pela daao em um mamìfero, para tratar a esquizofrenia, para tratar ou prevenir a perda de memória e/ou cognição associadas com o mal de alzheimer, para tratar a ataxia ou para prevenir a perda da função neuronal caracterìstica de doenças neurodegenerativas, para intensificar a aprendizagem, memória e/ou cognição e para tratar dor neuropática, e, composição farmacêutica
US20080293726A1 (en)	2005-07-06	2008-11-27	Sepracor Inc.	Combinations of Eszopiclone and Trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-N-Methyl-1-Napthalenamine or Trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-1-Napthalenamine, and Methods of Treatment of Menopause and Mood, Anxiety, and Cognitive Disorders
AU2007205114B2 (en)	2006-01-06	2012-11-08	Sunovion Pharmaceuticals Inc.	Cycloalkylamines as monoamine reuptake inhibitors
ES2566479T3 (es)	2006-01-06	2016-04-13	Sunovion Pharmaceuticals Inc.	Inhibidores de reabsorción de monoamina con base en tetralona
EP2013835B1 (en)	2006-03-31	2015-11-04	Sunovion Pharmaceuticals Inc.	Preparation of chiral amides and amines
US7884124B2 (en)	2006-06-30	2011-02-08	Sepracor Inc.	Fluoro-substituted inhibitors of D-amino acid oxidase
US7902252B2 (en)	2007-01-18	2011-03-08	Sepracor, Inc.	Inhibitors of D-amino acid oxidase
CN103936605B (zh)	2007-05-31	2017-09-01	赛诺维信制药公司	苯基取代的环烷胺作为一元胺再摄取抑制剂
WO2016178591A2 (en)	2015-05-05	2016-11-10	Gene Predit, Sa	Genetic markers and treatment of male obesity
PH12018502155B1 (en)	2016-04-20	2024-03-27	Servier Lab	Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid
CN112047869B (zh) *	2020-08-20	2021-12-21	华南理工大学	一种氮杂5,6-并环化合物的合成方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2620709B1 (fr) *	1987-09-17	1990-09-07	Adir	Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese

2003
- 2003-11-19 DK DK03292864T patent/DK1420028T3/da active
- 2003-11-19 AT AT03292864T patent/ATE354586T1/de active
- 2003-11-19 PT PT03292864T patent/PT1420028E/pt unknown
- 2003-11-19 SI SI200330702T patent/SI1420028T1/sl unknown
- 2003-11-19 DE DE60311942T patent/DE60311942T2/de not_active Expired - Lifetime
- 2003-11-19 ES ES03292864T patent/ES2282586T3/es not_active Expired - Lifetime
- 2003-11-19 EP EP03292864A patent/EP1420028B1/fr not_active Expired - Lifetime
2004
- 2004-11-18 JP JP2006540515A patent/JP4377412B2/ja not_active Expired - Fee Related
- 2004-11-18 UA UAA200606747A patent/UA83269C2/uk unknown
- 2004-11-18 AU AU2004295132A patent/AU2004295132B2/en not_active Ceased
- 2004-11-18 KR KR1020067011929A patent/KR100863394B1/ko not_active Expired - Fee Related
- 2004-11-18 US US10/580,148 patent/US7208607B1/en not_active Expired - Fee Related
- 2004-11-18 MY MYPI20044785A patent/MY138550A/en unknown
- 2004-11-18 CA CA2546506A patent/CA2546506C/fr not_active Expired - Fee Related
- 2004-11-18 GE GEAP20049463A patent/GEP20084547B/en unknown
- 2004-11-18 WO PCT/FR2004/002936 patent/WO2005054276A1/fr not_active Ceased
- 2004-11-18 ZA ZA200603675A patent/ZA200603675B/en unknown
- 2004-11-18 AR ARP040104252A patent/AR047312A1/es not_active Application Discontinuation
- 2004-11-18 PL PL380409A patent/PL210769B1/pl unknown
- 2004-11-18 EA EA200600898A patent/EA010102B1/ru not_active IP Right Cessation
- 2004-11-18 CN CNB2004800336869A patent/CN100447152C/zh not_active Expired - Fee Related
- 2004-11-18 BR BRPI0416746-5A patent/BRPI0416746B1/pt not_active IP Right Cessation
- 2004-11-18 NZ NZ546931A patent/NZ546931A/en not_active IP Right Cessation
- 2004-11-18 MX MXPA06005607A patent/MXPA06005607A/es active IP Right Grant
2006
- 2006-05-02 MA MA28993A patent/MA28144A1/fr unknown
- 2006-05-16 EG EGPCTNA2006000459A patent/EG26629A/en active
- 2006-06-06 NO NO20062599A patent/NO336349B1/no not_active IP Right Cessation
2007
- 2007-04-26 CY CY20071100562T patent/CY1106544T1/el unknown

Also Published As

Publication number	Publication date
PT1420028E (pt)	2007-05-31
HK1096689A1 (en)	2007-06-08
UA83269C2 (uk)	2008-06-25
NO20062599L (no)	2006-06-06
EG26629A (en)	2014-04-13
EP1420028A3 (fr)	2004-05-26
EP1420028B1 (fr)	2007-02-21
KR100863394B1 (ko)	2008-10-14
BRPI0416746B1 (pt)	2018-02-14
AR047312A1 (es)	2006-01-18
ES2282586T3 (es)	2007-10-16
JP4377412B2 (ja)	2009-12-02
BRPI0416746A (pt)	2007-01-16
EA010102B1 (ru)	2008-06-30
MA28144A1 (fr)	2006-09-01
US20070083052A1 (en)	2007-04-12
AU2004295132B2 (en)	2010-07-15
DE60311942T2 (de)	2007-12-06
CY1106544T1 (el)	2012-01-25
MXPA06005607A (es)	2006-08-17
NO336349B1 (no)	2015-08-03
CA2546506C (fr)	2010-04-06
KR20060121202A (ko)	2006-11-28
AU2004295132A1 (en)	2005-06-16
SI1420028T1 (sl)	2007-06-30
DE60311942D1 (de)	2007-04-05
EA200600898A1 (ru)	2006-10-27
NZ546931A (en)	2010-01-29
ZA200603675B (en)	2007-09-26
PL210769B1 (pl)	2012-02-29
ATE354586T1 (de)	2007-03-15
CA2546506A1 (fr)	2005-06-16
GEP20084547B (en)	2008-11-25
JP2008502587A (ja)	2008-01-31
PL380409A1 (pl)	2007-01-22
US7208607B1 (en)	2007-04-24
MY138550A (en)	2009-06-30
WO2005054276A1 (fr)	2005-06-16
EP1420028A2 (fr)	2004-05-19
CN100447152C (zh)	2008-12-31
CN1882607A (zh)	2006-12-20

Publication	Publication Date	Title
DK1268424T3 (da)	2007-12-17	Fremgangsmåde til syntese af perindopril og dets farmaceutisk acceptable salte
DK1803718T3 (da)	2008-10-27	4-Tetrazolyl-4-phenylpiperidin-derivater til behandling af smerter
DK1367061T3 (da)	2006-05-15	Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
DK1420028T3 (da)	2007-06-18	Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
DK1362864T3 (da)	2007-09-17	Ny fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
DK1333026T3 (da)	2007-10-22	Fremgangsmåde til fremstilling af perindopril med höj renhed og nyttige mellemforbindelser til syntesen
DK1348684T3 (da)	2006-07-03	Fremgangsmåde til syntese af (2S)-indolin-2-carboxylsyre og anvendelse heraf til syntese af perindopril
DK1371659T3 (da)	2005-11-21	Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
DK1614687T3 (da)	2010-03-29	Fremgangsmåde til fremstilling af 1,3,4,5-tetrahydro-2H-3-benzazepin-2-onderivater og deres anvendelse ved syntese af ivabradin og farmaceutisk acceptable salte deraf
DK1420029T3 (da)	2008-06-16	Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
DK1380591T3 (da)	2006-01-23	Fremgangsmåde til syntese af perindopril og farmaceutiske acceptable salte heraf
DK1380590T3 (da)	2007-01-08	Ny fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
DK1321471T3 (da)	2005-08-29	Ny syntesefremgangsmåde til perindopril og farmaceutisk acceptable salte heraf
DK1403275T3 (da)	2005-12-05	Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
DK1367063T3 (da)	2006-12-27	Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
DK1511724T3 (da)	2014-06-16	Fremgangsmåde til fremstilling af thioalkylaminderivater
DK1753720T3 (da)	2014-06-30	Fremgangsmåde til fremstilling af perindopril og salte deraf
NO20050885D0 (no)	2005-02-18	Ny fremgangsmate for syntesen av 1,3-dihydro-2H-3-benzazepin-2-onforbindelser, og anvendelse i syntesen av ivabradin og addisjonssalter derav med en farmasoytisk akseptabel syre
DK1422236T3 (da)	2007-06-11	Syntesefremgangsmåde for perindopril og farmaceutisk acceptable salte heraf
DK1367062T3 (da)	2007-01-02	Ny fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
DK1567524T3 (da)	2009-11-16	Thia-epothilonderivater til behandling af cancer