[go: up one dir, main page]

DE60308102D1 - Verfahren für die Synthese von Perindopril und seiner pharmazeutisch annehmbaren Salzen i2003/26ö - Google Patents

Verfahren für die Synthese von Perindopril und seiner pharmazeutisch annehmbaren Salzen i2003/26ö

Info

Publication number
DE60308102D1
DE60308102D1 DE60308102T DE60308102T DE60308102D1 DE 60308102 D1 DE60308102 D1 DE 60308102D1 DE 60308102 T DE60308102 T DE 60308102T DE 60308102 T DE60308102 T DE 60308102T DE 60308102 D1 DE60308102 D1 DE 60308102D1
Authority
DE
Germany
Prior art keywords
perindopril
synthesis
pharmaceutically acceptable
acceptable salts
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60308102T
Other languages
English (en)
Other versions
DE60308102T2 (de
Inventor
Thierry Dubuffet
Jean-Pierre Lecouve
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Les Laboratoires Servier SAS
Original Assignee
Les Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier SAS filed Critical Les Laboratoires Servier SAS
Application granted granted Critical
Publication of DE60308102D1 publication Critical patent/DE60308102D1/de
Publication of DE60308102T2 publication Critical patent/DE60308102T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE60308102T 2003-08-29 2003-08-29 Verfahren für die Synthese von Perindopril und seiner pharmazeutisch annehmbaren Salzen Expired - Lifetime DE60308102T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03292131A EP1380590B1 (de) 2003-08-29 2003-08-29 Verfahren für die Synthese von Perindopril und seiner pharmazeutisch annehmbaren Salzen ¬2003/26|

Publications (2)

Publication Number Publication Date
DE60308102D1 true DE60308102D1 (de) 2006-10-19
DE60308102T2 DE60308102T2 (de) 2007-06-21

Family

ID=29724623

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60308102T Expired - Lifetime DE60308102T2 (de) 2003-08-29 2003-08-29 Verfahren für die Synthese von Perindopril und seiner pharmazeutisch annehmbaren Salzen

Country Status (19)

Country Link
US (1) US7183308B1 (de)
EP (1) EP1380590B1 (de)
JP (1) JP4331205B2 (de)
CN (1) CN100395264C (de)
AR (1) AR045515A1 (de)
AT (1) ATE338766T1 (de)
AU (1) AU2004270427B2 (de)
CY (1) CY1105790T1 (de)
DE (1) DE60308102T2 (de)
DK (1) DK1380590T3 (de)
EA (1) EA008485B1 (de)
ES (1) ES2272922T3 (de)
MY (1) MY139348A (de)
NZ (1) NZ545335A (de)
PL (1) PL211509B1 (de)
PT (1) PT1380590E (de)
SI (1) SI1380590T1 (de)
WO (1) WO2005023841A1 (de)
ZA (1) ZA200601428B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1380591B1 (de) * 2003-08-29 2005-11-16 Les Laboratoires Servier Verfahren für die Synthese von Perindopril und seiner pharmazeutisch annehmbaren Salzen
WO2005108365A1 (en) * 2004-05-07 2005-11-17 Glenmark Pharmaceuticals Limited Processes for the preparation of alpha polymorph of perindopril erbumine
ATE409036T1 (de) 2005-01-06 2008-10-15 Ipca Lab Ltd Verfahren zur synthese von (2s,3as,7as)-1-(s)- alanyl-octahydro-1h-2-carbonsäurederivaten und verwendung in der synthese von perindopril
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
PH12018502155B1 (en) 2016-04-20 2024-03-27 Servier Lab Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid
CN108752259A (zh) * 2018-07-04 2018-11-06 南京方生和医药科技有限公司 培哚普利消旋体及其中间体的制备方法
CN112047998B (zh) * 2020-09-07 2024-01-09 上海阿达玛斯试剂有限公司 一种培哚普利的制备方法
CN113980096A (zh) * 2021-11-29 2022-01-28 绍兴市上虞区武汉理工大学高等研究院 一种吨级培哚普利叔丁胺的合成工艺方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
SI1323729T1 (en) * 2003-03-12 2005-02-28 Les Laboratoires Servier Method for synthesis of (2S,3aS,7aS)-perhydroindole-2-carboxylic acid and esters thereof derivatives; and use in the synthesis of perindopril
DK1321471T3 (da) * 2003-03-12 2005-08-29 Servier Lab Ny syntesefremgangsmåde til perindopril og farmaceutisk acceptable salte heraf
ATE306496T1 (de) * 2003-08-29 2005-10-15 Servier Lab Verfahren für die synthese von perindopril und seiner pharmazeutischen annehmbaren salzen

Also Published As

Publication number Publication date
EA008485B1 (ru) 2007-06-29
DE60308102T2 (de) 2007-06-21
DK1380590T3 (da) 2007-01-08
US20070043103A1 (en) 2007-02-22
SI1380590T1 (sl) 2006-12-31
EA200600456A1 (ru) 2006-08-25
CN1839147A (zh) 2006-09-27
NZ545335A (en) 2009-08-28
HK1096409A1 (en) 2007-06-01
PT1380590E (pt) 2006-12-29
AU2004270427B2 (en) 2008-08-21
ZA200601428B (en) 2007-05-30
AR045515A1 (es) 2005-11-02
ATE338766T1 (de) 2006-09-15
CY1105790T1 (el) 2011-02-02
MY139348A (en) 2009-09-30
PL379629A1 (pl) 2006-10-30
JP2007526901A (ja) 2007-09-20
EP1380590B1 (de) 2006-09-06
EP1380590A1 (de) 2004-01-14
PL211509B1 (pl) 2012-05-31
CN100395264C (zh) 2008-06-18
ES2272922T3 (es) 2007-05-01
US7183308B1 (en) 2007-02-27
JP4331205B2 (ja) 2009-09-16
AU2004270427A1 (en) 2005-03-17
WO2005023841A1 (fr) 2005-03-17

Similar Documents

Publication Publication Date Title
DE60129800D1 (de) Verfahren für die synthese von perindopril und seiner pharmazeutischen annehmbaren salze
NO20050741D0 (no) Ny fremgangsmate for syntesen og ny krystallinsk form av agomelatin og farmasoytiske sammensetninger inneholdende den
EP1730113A4 (de) Verfahren zur synthese eines cxcr4-antagonisten
DE60313391D1 (de) Verfahren für die Synthese von Perindopril und seiner pharmazeutisch geeigneten Salze
DE60303101D1 (de) Verfahren für die Synthese von Perindopril und seiner pharmazeutischen annehmbaren Salzen
DE60311942D1 (de) Verfahren für die Synthese von Perindopril und seiner pharmazeutischen annehmbaren Salzen
FR2868414B1 (fr) Procede de production d'alpha-alumine particulaire et apha-alumine particulaire produite par ce procede
ATE365714T1 (de) Verfahren zur herstellung von hochreinem perindopril und zwischenverbindungen nützlich in der synthese
DE60308102D1 (de) Verfahren für die Synthese von Perindopril und seiner pharmazeutisch annehmbaren Salzen i2003/26ö
EP1957474A4 (de) Synthese von ftsz-hemmern
DE60301820D1 (de) Verfahren für die Synthese von Perindopril und seiner pharmazeutischen annehmbaren Salzen
DE60300581D1 (de) Verfahren für die Synthese von Perindopril und seiner pharmazeutischen annehmbaren Salzen
EG24152A (en) Novel method for the synthesis of s-indoline-2-carboxylic acid and application thereof in synthesis of perindopril
DE60319196D1 (de) Verfahren für die Synthese von Perindopril und seiner pharmazeutisch annehmbaren Salzen
DE60302287D1 (de) Verfahren für die Synthese von Perindopril und seiner pharmazeutisch annehmbaren Salzen
DE60301930D1 (de) Verfahren für die Synthese von Perindopril und seiner pharmazeutisch annehmbaren Salze
ATE444283T1 (de) Geschützte 3,5-dihydroxy-2,2-dimethyl- valeronitrile für die synthese von epothilonen- und derivaten und verfahren zur herstellung und die verwendung
DE60311730D1 (de) Verfahren für die Synthese von Perindopril und seiner pharmazeutisch annehmbaren Salzen
DE60307925D1 (de) Verfahren für die Synthese von Perindopril und seiner pharmazeutischen annehmbaren Salzen
DE60307721D1 (de) Verfahren für die Synthese von Perindopril und seiner pharmazeutischen annehmbaren Salzen
DE602005020603D1 (de) Synthese von trithiocarbonat-raft-agentia und zwischenprodukte daraus
DE60336931D1 (de) Verfahren zur synthese der bisbenzimidazolen und ihren derivaten.
DE60300068D1 (de) Metallschaum und Verfahren zu seiner Herstellung
FR2850973B1 (fr) Produit bi-composant
FR2861727B1 (fr) Procede de synthese directe d'alkylhalogenosilanes

Legal Events

Date Code Title Description
8332 No legal effect for de
8370 Indication related to discontinuation of the patent is to be deleted
8364 No opposition during term of opposition