DE60307721D1 - Verfahren für die Synthese von Perindopril und seiner pharmazeutischen annehmbaren Salzen - Google Patents

Verfahren für die Synthese von Perindopril und seiner pharmazeutischen annehmbaren Salzen

Info

Publication number: DE60307721D1
Authority: DE; Germany
Prior art keywords: perindopril; synthesis; pharmaceutically acceptable; acceptable salts; salts
Prior art date: 2003-07-31
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60307721T

Other languages

English (en)

Other versions

DE60307721T2 (de

Inventor

Claude Fugier

Thierry Dubuffet

Pascal Langlois

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Les Laboratoires Servier SAS

Original Assignee

Les Laboratoires Servier SAS

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-07-31

Filing date

2003-07-31

Publication date

2006-10-05

2003-07-31 Application filed by Les Laboratoires Servier SAS filed Critical Les Laboratoires Servier SAS

2006-10-05 Application granted granted Critical

2006-10-05 Publication of DE60307721D1 publication Critical patent/DE60307721D1/de

2007-10-18 Publication of DE60307721T2 publication Critical patent/DE60307721T2/de

2023-08-01 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Heart & Thoracic Surgery (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Hospice & Palliative Care (AREA)
Indole Compounds (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DE60307721T 2003-07-31 2003-07-31 Verfahren für die Synthese von Perindopril und seiner pharmazeutischen annehmbaren Salzen Expired - Lifetime DE60307721T2 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP03291931A EP1367063B1 (de)	2003-07-31	2003-07-31	Verfahren für die Synthese von Perindopril und seiner pharmazeutischen annehmbaren Salzen

Publications (2)

Publication Number	Publication Date
DE60307721D1 true DE60307721D1 (de)	2006-10-05
DE60307721T2 DE60307721T2 (de)	2007-10-18

Family

ID=29414890

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60307721T Expired - Lifetime DE60307721T2 (de)	2003-07-31	2003-07-31	Verfahren für die Synthese von Perindopril und seiner pharmazeutischen annehmbaren Salzen

Country Status (27)

Country	Link
US (1)	US7358372B2 (de)
EP (1)	EP1367063B1 (de)
JP (1)	JP4263743B2 (de)
KR (1)	KR100798560B1 (de)
CN (1)	CN100404548C (de)
AR (1)	AR045151A1 (de)
AT (1)	ATE337332T1 (de)
AU (1)	AU2004261439B2 (de)
BR (1)	BRPI0413169A (de)
CA (1)	CA2533005C (de)
CY (1)	CY1105791T1 (de)
DE (1)	DE60307721T2 (de)
DK (1)	DK1367063T3 (de)
EA (1)	EA008685B1 (de)
ES (1)	ES2271498T3 (de)
GE (1)	GEP20094740B (de)
MA (1)	MA27911A1 (de)
MX (1)	MXPA06001243A (de)
MY (1)	MY139443A (de)
NO (1)	NO333957B1 (de)
NZ (1)	NZ544879A (de)
PL (1)	PL211892B1 (de)
PT (1)	PT1367063E (de)
SI (1)	SI1367063T1 (de)
UA (1)	UA80905C2 (de)
WO (1)	WO2005012333A2 (de)
ZA (1)	ZA200600479B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI21800A (sl) *	2004-05-14	2005-12-31	Krka, Tovarna Zdravil, D.D., Novo Mesto	Nov postopek sinteze perindoprila
WO2016178591A2 (en)	2015-05-05	2016-11-10	Gene Predit, Sa	Genetic markers and treatment of male obesity
PH12018502155B1 (en)	2016-04-20	2024-03-27	Servier Lab	Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES8604144A1 (es) *	1984-11-21	1986-01-16	Farmhispania	Procedimiento para la obtencion del acido (2s, 3as, 7as)-1-((s)-1-etoxicarbonil-3-fenilpropil) alanil) exahidro-2-indolincarboxilico
FR2807431B1 (fr) *	2000-04-06	2002-07-19	Adir	Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
FR2827860B1 (fr) *	2001-07-24	2004-12-10	Servier Lab	Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril

2003
- 2003-07-31 PT PT03291931T patent/PT1367063E/pt unknown
- 2003-07-31 DE DE60307721T patent/DE60307721T2/de not_active Expired - Lifetime
- 2003-07-31 AT AT03291931T patent/ATE337332T1/de active
- 2003-07-31 ES ES03291931T patent/ES2271498T3/es not_active Expired - Lifetime
- 2003-07-31 EP EP03291931A patent/EP1367063B1/de not_active Expired - Lifetime
- 2003-07-31 SI SI200330430T patent/SI1367063T1/sl unknown
- 2003-07-31 DK DK03291931T patent/DK1367063T3/da active
2004
- 2004-07-29 US US10/566,562 patent/US7358372B2/en not_active Expired - Fee Related
- 2004-07-29 KR KR1020067001920A patent/KR100798560B1/ko not_active Expired - Fee Related
- 2004-07-29 CN CNB2004800212090A patent/CN100404548C/zh not_active Expired - Fee Related
- 2004-07-29 AR ARP040102693A patent/AR045151A1/es not_active Application Discontinuation
- 2004-07-29 EA EA200600250A patent/EA008685B1/ru not_active IP Right Cessation
- 2004-07-29 PL PL379631A patent/PL211892B1/pl unknown
- 2004-07-29 GE GEAP20049261A patent/GEP20094740B/en unknown
- 2004-07-29 UA UAA200602130A patent/UA80905C2/xx unknown
- 2004-07-29 WO PCT/FR2004/002035 patent/WO2005012333A2/fr not_active Ceased
- 2004-07-29 BR BRPI0413169-0A patent/BRPI0413169A/pt active Search and Examination
- 2004-07-29 CA CA2533005A patent/CA2533005C/fr not_active Expired - Fee Related
- 2004-07-29 JP JP2006521621A patent/JP4263743B2/ja not_active Expired - Fee Related
- 2004-07-29 AU AU2004261439A patent/AU2004261439B2/en not_active Ceased
- 2004-07-29 ZA ZA200600479A patent/ZA200600479B/en unknown
- 2004-07-29 MX MXPA06001243A patent/MXPA06001243A/es active IP Right Grant
- 2004-07-29 MY MYPI20043053A patent/MY139443A/en unknown
- 2004-07-29 NZ NZ544879A patent/NZ544879A/en not_active IP Right Cessation
2006
- 2006-01-17 MA MA28731A patent/MA27911A1/fr unknown
- 2006-02-24 NO NO20060922A patent/NO333957B1/no not_active IP Right Cessation
- 2006-11-16 CY CY20061101673T patent/CY1105791T1/el unknown

Also Published As

Publication number	Publication date
WO2005012333A3 (fr)	2005-03-24
EA008685B1 (ru)	2007-06-29
UA80905C2 (en)	2007-11-12
DE60307721T2 (de)	2007-10-18
EA200600250A1 (ru)	2006-06-30
EP1367063B1 (de)	2006-08-23
SI1367063T1 (sl)	2006-10-31
CA2533005A1 (fr)	2005-02-10
PT1367063E (pt)	2006-12-29
ATE337332T1 (de)	2006-09-15
AU2004261439A1 (en)	2005-02-10
WO2005012333A2 (fr)	2005-02-10
US20060183920A1 (en)	2006-08-17
KR20060032209A (ko)	2006-04-14
PL379631A1 (pl)	2006-10-30
DK1367063T3 (da)	2006-12-27
CY1105791T1 (el)	2011-02-02
EP1367063A1 (de)	2003-12-03
MA27911A1 (fr)	2006-05-02
GEP20094740B (en)	2009-07-27
ES2271498T3 (es)	2007-04-16
JP4263743B2 (ja)	2009-05-13
CN100404548C (zh)	2008-07-23
PL211892B1 (pl)	2012-07-31
MXPA06001243A (es)	2006-04-11
HK1096406A1 (en)	2007-06-01
AU2004261439B2 (en)	2008-03-13
US7358372B2 (en)	2008-04-15
AR045151A1 (es)	2005-10-19
NZ544879A (en)	2009-03-31
BRPI0413169A (pt)	2006-10-03
CN1826352A (zh)	2006-08-30
MY139443A (en)	2009-10-30
JP2007526896A (ja)	2007-09-20
ZA200600479B (en)	2007-05-30
NO333957B1 (no)	2013-10-28
KR100798560B1 (ko)	2008-01-28
CA2533005C (fr)	2010-04-06
NO20060922L (no)	2006-02-24

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Legal Events

Date	Code	Title	Description
2007-09-13	8364	No opposition during term of opposition