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DE60301930D1 - Verfahren für die Synthese von Perindopril und seiner pharmazeutisch annehmbaren Salze - Google Patents

Verfahren für die Synthese von Perindopril und seiner pharmazeutisch annehmbaren Salze

Info

Publication number
DE60301930D1
DE60301930D1 DE60301930T DE60301930T DE60301930D1 DE 60301930 D1 DE60301930 D1 DE 60301930D1 DE 60301930 T DE60301930 T DE 60301930T DE 60301930 T DE60301930 T DE 60301930T DE 60301930 D1 DE60301930 D1 DE 60301930D1
Authority
DE
Germany
Prior art keywords
perindopril
synthesis
pharmaceutically acceptable
acceptable salts
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60301930T
Other languages
English (en)
Other versions
DE60301930T2 (de
Inventor
Thierry Dubuffet
Pascal Langlois
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Les Laboratoires Servier SAS
Original Assignee
Les Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier SAS filed Critical Les Laboratoires Servier SAS
Application granted granted Critical
Publication of DE60301930D1 publication Critical patent/DE60301930D1/de
Publication of DE60301930T2 publication Critical patent/DE60301930T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE60301930T 2003-02-28 2003-02-28 Verfahren für die Synthese von Perindopril und seiner pharmazeutisch annehmbaren Salze Expired - Lifetime DE60301930T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03290485A EP1403275B1 (de) 2003-02-28 2003-02-28 Verfahren für die Synthese von Perindopril und seiner pharmazeutisch annehmbaren Salze

Publications (2)

Publication Number Publication Date
DE60301930D1 true DE60301930D1 (de) 2006-03-02
DE60301930T2 DE60301930T2 (de) 2006-07-27

Family

ID=31970533

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60301930T Expired - Lifetime DE60301930T2 (de) 2003-02-28 2003-02-28 Verfahren für die Synthese von Perindopril und seiner pharmazeutisch annehmbaren Salze

Country Status (17)

Country Link
US (1) US7166633B2 (de)
EP (1) EP1403275B1 (de)
JP (1) JP4563372B2 (de)
CN (1) CN1326871C (de)
AR (1) AR043409A1 (de)
AT (1) ATE307139T1 (de)
AU (1) AU2004217599B2 (de)
DE (1) DE60301930T2 (de)
DK (1) DK1403275T3 (de)
EA (1) EA009066B1 (de)
ES (1) ES2250846T3 (de)
MY (1) MY136989A (de)
NZ (1) NZ541424A (de)
PL (1) PL215131B1 (de)
SI (1) SI1403275T1 (de)
WO (1) WO2004078107A2 (de)
ZA (1) ZA200505781B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1403275T3 (da) * 2003-02-28 2005-12-05 Servier Lab Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
ES2366705T3 (es) * 2004-12-28 2011-10-24 Dsm Ip Assets B.V. Procedimiento para la preparación de ácido indolin-2-carboxílico enriquecido enantioméricamente.
KR102370892B1 (ko) 2013-12-27 2022-03-04 가부시키가이샤 모루텐 볼
PH12018502155B1 (en) 2016-04-20 2024-03-27 Servier Lab Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE55867B1 (en) * 1981-12-29 1991-02-14 Hoechst Ag New derivatives of bicyclic aminoacids,processes for their preparation,agents containing these compounds and their use,and new bicyclic aminoacids as intermediates and processes for their preparation
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
FR2807431B1 (fr) * 2000-04-06 2002-07-19 Adir Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
FR2827860B1 (fr) * 2001-07-24 2004-12-10 Servier Lab Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
CN100448675C (zh) * 2002-02-07 2009-01-07 株式会社理光 喷墨装置、压强调节机构及喷墨打印机
DK1403275T3 (da) * 2003-02-28 2005-12-05 Servier Lab Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf

Also Published As

Publication number Publication date
CN1753906A (zh) 2006-03-29
SI1403275T1 (sl) 2006-02-28
NZ541424A (en) 2008-03-28
DE60301930T2 (de) 2006-07-27
JP2006519177A (ja) 2006-08-24
PL377238A1 (pl) 2006-01-23
ZA200505781B (en) 2006-11-29
EP1403275B1 (de) 2005-10-19
EA200501258A1 (ru) 2006-04-28
ATE307139T1 (de) 2005-11-15
EP1403275A1 (de) 2004-03-31
HK1086281A1 (zh) 2006-09-15
WO2004078107A3 (fr) 2004-10-21
AU2004217599A1 (en) 2004-09-16
US20060149081A1 (en) 2006-07-06
PL215131B1 (pl) 2013-10-31
ES2250846T3 (es) 2006-04-16
DK1403275T3 (da) 2005-12-05
WO2004078107A2 (fr) 2004-09-16
MY136989A (en) 2008-12-31
AR043409A1 (es) 2005-07-27
JP4563372B2 (ja) 2010-10-13
AU2004217599B2 (en) 2009-07-30
EA009066B1 (ru) 2007-10-26
CN1326871C (zh) 2007-07-18
US7166633B2 (en) 2007-01-23

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