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DE60102581D1 - Azabizyklische carbamate und ihre anwendung als antagonisten des alpha-7 nikotinischen acetylcholin rezeptors - Google Patents

Azabizyklische carbamate und ihre anwendung als antagonisten des alpha-7 nikotinischen acetylcholin rezeptors

Info

Publication number
DE60102581D1
DE60102581D1 DE60102581T DE60102581T DE60102581D1 DE 60102581 D1 DE60102581 D1 DE 60102581D1 DE 60102581 T DE60102581 T DE 60102581T DE 60102581 T DE60102581 T DE 60102581T DE 60102581 D1 DE60102581 D1 DE 60102581D1
Authority
DE
Germany
Prior art keywords
azabic
antagonists
alpha
acetylcholine receptor
cyclic carbamates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60102581T
Other languages
English (en)
Other versions
DE60102581T2 (de
Inventor
Joachim Nozulak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Pharma GmbH Austria
Novartis AG
Original Assignee
Novartis Pharma GmbH Austria
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Pharma GmbH Austria, Novartis AG filed Critical Novartis Pharma GmbH Austria
Publication of DE60102581D1 publication Critical patent/DE60102581D1/de
Application granted granted Critical
Publication of DE60102581T2 publication Critical patent/DE60102581T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60102581T 2000-05-05 2001-05-03 Azabizyklische carbamate und ihre anwendung als antagonisten des alpha-7 nikotinischen acetylcholin rezeptors Expired - Lifetime DE60102581T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0010955.3A GB0010955D0 (en) 2000-05-05 2000-05-05 Organic compounds
GB0010955 2000-05-05
PCT/EP2001/005008 WO2001085727A1 (en) 2000-05-05 2001-05-03 Azabicyclic carbamates and their use as alpha-7 nicotinic acetylcholine receptor agonists

Publications (2)

Publication Number Publication Date
DE60102581D1 true DE60102581D1 (de) 2004-05-06
DE60102581T2 DE60102581T2 (de) 2005-02-03

Family

ID=9891092

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60102581T Expired - Lifetime DE60102581T2 (de) 2000-05-05 2001-05-03 Azabizyklische carbamate und ihre anwendung als antagonisten des alpha-7 nikotinischen acetylcholin rezeptors

Country Status (29)

Country Link
US (1) US6780861B2 (de)
EP (1) EP1282620B1 (de)
JP (1) JP4898062B2 (de)
KR (1) KR20020093974A (de)
CN (1) CN1167703C (de)
AR (1) AR028073A1 (de)
AT (1) ATE263167T1 (de)
AU (2) AU2001262257B2 (de)
BR (1) BR0110521A (de)
CA (1) CA2407972C (de)
CZ (1) CZ20023622A3 (de)
DE (1) DE60102581T2 (de)
DK (1) DK1282620T3 (de)
ES (1) ES2218418T3 (de)
GB (1) GB0010955D0 (de)
HK (1) HK1054223B (de)
HU (1) HUP0301866A2 (de)
IL (1) IL152417A0 (de)
MX (1) MXPA02010892A (de)
NO (1) NO20025280D0 (de)
NZ (1) NZ522226A (de)
PE (1) PE20020221A1 (de)
PL (1) PL357435A1 (de)
PT (1) PT1282620E (de)
RU (1) RU2002131886A (de)
SK (1) SK15612002A3 (de)
TR (1) TR200401007T4 (de)
WO (1) WO2001085727A1 (de)
ZA (1) ZA200208969B (de)

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Also Published As

Publication number Publication date
EP1282620B1 (de) 2004-03-31
TR200401007T4 (tr) 2004-07-21
PT1282620E (pt) 2004-07-30
CN1427840A (zh) 2003-07-02
HK1054223A1 (en) 2003-11-21
NO20025280L (no) 2002-11-04
JP2003532731A (ja) 2003-11-05
CN1167703C (zh) 2004-09-22
WO2001085727A1 (en) 2001-11-15
PL357435A1 (en) 2004-07-26
US20030166654A1 (en) 2003-09-04
ATE263167T1 (de) 2004-04-15
GB0010955D0 (en) 2000-06-28
KR20020093974A (ko) 2002-12-16
PE20020221A1 (es) 2002-04-23
CZ20023622A3 (cs) 2003-02-12
HUP0301866A2 (hu) 2003-09-29
JP4898062B2 (ja) 2012-03-14
AU2001262257B2 (en) 2004-11-04
ES2218418T3 (es) 2004-11-16
BR0110521A (pt) 2003-04-08
RU2002131886A (ru) 2004-04-10
NO20025280D0 (no) 2002-11-04
AR028073A1 (es) 2003-04-23
AU6225701A (en) 2001-11-20
DK1282620T3 (da) 2004-07-19
DE60102581T2 (de) 2005-02-03
CA2407972C (en) 2010-03-09
MXPA02010892A (es) 2003-03-27
NZ522226A (en) 2004-08-27
IL152417A0 (en) 2003-05-29
SK15612002A3 (sk) 2003-04-01
US6780861B2 (en) 2004-08-24
CA2407972A1 (en) 2001-11-15
ZA200208969B (en) 2003-10-07
HK1054223B (en) 2005-03-04
EP1282620A1 (de) 2003-02-12

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