DE60034157D1 - Bicyclische Aminosäuren als pharmazeutische Mittel - Google Patents

Bicyclische Aminosäuren als pharmazeutische Mittel

Info

Publication number: DE60034157D1
Authority: DE; Germany
Prior art keywords: amino acids; pharmaceutical agents; bicyclic amino; bicyclic; pharmaceutical
Prior art date: 1999-10-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60034157T

Other languages

English (en)

Other versions

DE60034157T2 (de

Inventor

Justin Stephen Bryans

David Clive Blakemore

Simon Osborne

Jean-Marie Receveur

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Warner Lambert Co LLC

Original Assignee

Warner Lambert Co LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-20

Filing date

2000-10-17

Publication date

2007-05-10

2000-10-17 Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC

2007-05-10 Application granted granted Critical

2007-05-10 Publication of DE60034157D1 publication Critical patent/DE60034157D1/de

2007-12-13 Publication of DE60034157T2 publication Critical patent/DE60034157T2/de

2020-10-18 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/20—All rings being cycloaliphatic the ring system containing seven carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/22—All rings being cycloaliphatic the ring system containing eight carbon atoms, e.g. pentalene
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
- C07C2602/28—Hydrogenated naphthalenes

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Physical Education & Sports Medicine (AREA)
Endocrinology (AREA)
Orthopedic Medicine & Surgery (AREA)
Psychology (AREA)
Epidemiology (AREA)
Anesthesiology (AREA)
Hematology (AREA)
Psychiatry (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Immunology (AREA)
Emergency Medicine (AREA)
Rheumatology (AREA)
Obesity (AREA)
Hospice & Palliative Care (AREA)
Reproductive Health (AREA)
Vascular Medicine (AREA)

DE60034157T 1999-10-20 2000-10-17 Bicyclische Aminosäuren als pharmazeutische Mittel Expired - Lifetime DE60034157T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US16072599P	1999-10-20	1999-10-20
US160725		1999-10-20

Publications (2)

Publication Number	Publication Date
DE60034157D1 true DE60034157D1 (de)	2007-05-10
DE60034157T2 DE60034157T2 (de)	2007-12-13

Family

ID=22578159

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DE60034157T Expired - Lifetime DE60034157T2 (de)	1999-10-20	2000-10-17	Bicyclische Aminosäuren als pharmazeutische Mittel
DE60019628T Expired - Lifetime DE60019628T2 (de)	1999-10-20	2000-10-17	Bicyclische aminosäuren als pharmazeutische mittel

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DE60019628T Expired - Lifetime DE60019628T2 (de)	1999-10-20	2000-10-17	Bicyclische aminosäuren als pharmazeutische mittel

Country Status (50)

Country	Link
US (2)	US6689906B1 (de)
EP (2)	EP1506955B1 (de)
JP (2)	JP3632191B2 (de)
KR (2)	KR100566462B1 (de)
CN (1)	CN1165518C (de)
AP (2)	AP2002002517A0 (de)
AR (2)	AR026087A1 (de)
AT (2)	ATE358116T1 (de)
AU (2)	AU778871B2 (de)
BG (2)	BG106719A (de)
BR (1)	BR0014972B1 (de)
CA (1)	CA2386297C (de)
CO (1)	CO5280060A1 (de)
CR (1)	CR6620A (de)
CU (1)	CU23112A3 (de)
CZ (1)	CZ295960B6 (de)
DE (2)	DE60034157T2 (de)
DO (1)	DOP2000000083A (de)
DZ (1)	DZ3197A1 (de)
EA (1)	EA005206B1 (de)
EC (1)	ECSP045393A (de)
EE (1)	EE200200211A (de)
ES (2)	ES2237464T3 (de)
GE (1)	GEP20043297B (de)
GT (2)	GT200000183A (de)
HK (1)	HK1049826B (de)
HN (1)	HN2000000224A (de)
HR (2)	HRP20040709A2 (de)
HU (1)	HUP0203325A3 (de)
IL (3)	IL164060A0 (de)
IS (2)	IS6348A (de)
MA (1)	MA26842A1 (de)
MX (1)	MXPA02003229A (de)
MY (1)	MY127678A (de)
NO (2)	NO20021780D0 (de)
NZ (1)	NZ517961A (de)
OA (1)	OA12070A (de)
PA (1)	PA8505201A1 (de)
PE (1)	PE20010740A1 (de)
PL (1)	PL354607A1 (de)
PT (1)	PT1226110E (de)
SI (1)	SI1226110T1 (de)
SK (1)	SK5232002A3 (de)
SV (1)	SV2001000188A (de)
TR (2)	TR200500221T2 (de)
TW (2)	TWI225855B (de)
UA (1)	UA72931C2 (de)
WO (1)	WO2001028978A1 (de)
YU (2)	YU73004A (de)
ZA (1)	ZA200202543B (de)

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US7164034B2 (en)	1999-06-10	2007-01-16	Pfizer Inc.	Alpha2delta ligands for fibromyalgia and other disorders
SK17922002A3 (sk) *	2000-06-26	2003-11-04	Warner-Lambert Company	Obdoby gabapentínu na liečenie porúch spánku
US6620829B2 (en)	2000-10-17	2003-09-16	Warner-Lambert Company	Method of treating noninflammatory cartilage damage
EP1226820A1 (de) *	2001-01-26	2002-07-31	Warner-Lambert Company	Verwendung von bicyclische Aminosäuren zur Prophylaxe und Behandlung von Eingeweideschmerzen und gastrointestinalen Erkrankungen
YU78803A (sh) *	2001-04-19	2006-08-17	Warner-Lambert Company	Fuzija bicikličnih ili tricikličnih amino kiselina
GB2375108A (en) *	2001-05-04	2002-11-06	Warner Lambert Co	Production of a bicycloheptanone
GB2375109A (en) *	2001-05-04	2002-11-06	Warner Lambert Co	Process for preparing bicyclic amino acid
US7232924B2 (en)	2001-06-11	2007-06-19	Xenoport, Inc.	Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
US6818787B2 (en)	2001-06-11	2004-11-16	Xenoport, Inc.	Prodrugs of GABA analogs, compositions and uses thereof
US8048917B2 (en)	2005-04-06	2011-11-01	Xenoport, Inc.	Prodrugs of GABA analogs, compositions and uses thereof
US7186855B2 (en)	2001-06-11	2007-03-06	Xenoport, Inc.	Prodrugs of GABA analogs, compositions and uses thereof
EP1902714B1 (de) *	2001-06-11	2012-01-11	XenoPort, Inc.	Prodrugs aus GABA-Analoga, Zusammensetzungen und ihre Verwendungen
WO2003063845A1 (en) *	2002-01-31	2003-08-07	Warner-Lambert Company Llc	Alpha 2 delta ligands to treat tinnitus
WO2003070237A1 (en) *	2002-02-22	2003-08-28	Warner-Lambert Company Llc	Combinations of an alpha-2-delta ligand with a selective inhibitor of cyclooxygenase-2
CN1678298A (zh) *	2002-06-27	2005-10-05	沃纳-兰伯特公司	α2δ配体如加巴喷丁或普瑞巴林用于治疗注意力缺陷的过度反应症的用途
GB0219024D0 (en) *	2002-08-15	2002-09-25	Pfizer Ltd	Synergistic combinations
AU2003250481A1 (en) *	2002-08-15	2004-03-03	Pfizer Inc.	Therapeutic use of fused bicyclic or tricyclic amino acids
US7419981B2 (en)	2002-08-15	2008-09-02	Pfizer Inc.	Synergistic combinations of an alpha-2-delta ligand and a cGMP phosphodieterse 5 inhibitor
GB0223072D0 (en)	2002-10-04	2002-11-13	Pfizer Ltd	Cyclic nitromethyl acetic acid derivatives
US7018818B2 (en)	2002-10-04	2006-03-28	Pfizer Inc.	Intermediates in the preparation of therapeutic fused bicyclic amino acids
US7060727B2 (en)	2002-12-11	2006-06-13	Xenoport, Inc.	Prodrugs of fused GABA analogs, pharmaceutical compositions and uses thereof
CA2451267A1 (en)	2002-12-13	2004-06-13	Warner-Lambert Company Llc	Pharmaceutical uses for alpha2delta ligands
EP1572173B1 (de)	2002-12-13	2010-04-28	Warner-Lambert Company LLC	Alpha-2-delta-ligand zur behandlung vonsymptomen der unteren harnwege
AU2003303040B2 (en)	2002-12-13	2009-04-23	Warner-Lambert Company Llc	Pregabalin derivatives for the treatment of fibromyalgia and other disorders
DE602004024317D1 (de)	2003-09-12	2010-01-07	Pfizer	Kombinationen aus alpha-2-delta liganden und serotonin / noradrenalin-wiederaufnahmehemmern
WO2006092692A1 (en) *	2005-03-01	2006-09-08	Pfizer Limited	Use of combinations of pde7 inhibitors and alpha-2-delty ligands for the treatment of neuropathic pain
AR061728A1 (es) *	2006-06-30	2008-09-17	Pfizer Prod Inc	Composicion para tratamiento usando compuestos selectivos alfa-2-delta-1
CA2673545A1 (en)	2006-12-22	2008-07-03	Recordati Ireland Limited	Combination therapy of lower urinary tract disorders with .alpha.2.delta. ligands and nsaids
AU2008304933B2 (en)	2007-09-28	2011-02-24	Daiichi Sankyo Company, Limited	Bicyclic y-amino acid derivative
ES2635354T3 (es)	2009-03-26	2017-10-03	Daiichi Sankyo Company, Limited	Procedimiento de producción de un derivado de ácido gamma-amino bicíclico
WO2012169474A1 (ja)	2011-06-08	2012-12-13	第一三共株式会社	イミニウム塩を経由する二環性化合物の製造方法
EP2719677B1 (de)	2011-06-08	2017-09-06	Daiichi Sankyo Company, Limited	Verfahren zur herstellung einer bicyclischen verbindung durch claisen-umlagerung
BR112014014432B1 (pt)	2011-12-15	2022-03-29	Daiichi Sankyo Company, Limited	Método para produzir um composto
ES2624314T3 (es)	2012-04-10	2017-07-13	Daiichi Sankyo Company, Limited	Procedimiento de resolución óptica para compuestos bicíclicos usando enzima
US9066853B2 (en)	2013-01-15	2015-06-30	Warsaw Orthopedic, Inc.	Clonidine compounds in a biodegradable fiber
TWI635071B (zh)	2013-07-08	2018-09-11	第一三共股份有限公司	光學活性二環γ－胺基酸衍生物及其製造方法
WO2018166855A1 (en)	2017-03-16	2018-09-20	Basf Se	Heterobicyclic substituted dihydroisoxazoles
CN113045410A (zh) *	2021-03-29	2021-06-29	华东理工大学	一种双环降二萜类化合物及其合成基因及制备方法

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US3641129A (en) *	1969-06-17	1972-02-08	Merck & Co Inc	Antifibrinolytic compounds
DE2460891C2 (de) *	1974-12-21	1982-09-23	Gödecke AG, 1000 Berlin	1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
US4087544A (en) *	1974-12-21	1978-05-02	Warner-Lambert Company	Treatment of cranial dysfunctions using novel cyclic amino acids
KR100589066B1 (ko)	1997-10-27	2006-06-13	워너-램버트 캄파니 엘엘씨	약제로서 유용한 시클릭 아미노산 및 그의 유도체

2000
- 2000-10-05 HN HN2000000224A patent/HN2000000224A/es unknown
- 2000-10-06 SV SV2000000188A patent/SV2001000188A/es not_active Application Discontinuation
- 2000-10-17 EA EA200200293A patent/EA005206B1/ru unknown
- 2000-10-17 DZ DZ003197A patent/DZ3197A1/xx active
- 2000-10-17 EP EP04027485A patent/EP1506955B1/de not_active Expired - Lifetime
- 2000-10-17 NZ NZ517961A patent/NZ517961A/xx unknown
- 2000-10-17 HR HRP20040709 patent/HRP20040709A2/xx not_active Application Discontinuation
- 2000-10-17 AT AT04027485T patent/ATE358116T1/de not_active IP Right Cessation
- 2000-10-17 OA OA1200200117A patent/OA12070A/en unknown
- 2000-10-17 GE GE4783A patent/GEP20043297B/en unknown
- 2000-10-17 KR KR1020067002249A patent/KR100566462B1/ko not_active Expired - Fee Related
- 2000-10-17 PT PT00972226T patent/PT1226110E/pt unknown
- 2000-10-17 YU YU73004A patent/YU73004A/sh unknown
- 2000-10-17 ES ES00972226T patent/ES2237464T3/es not_active Expired - Lifetime
- 2000-10-17 US US10/130,023 patent/US6689906B1/en not_active Expired - Fee Related
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- 2000-10-17 HR HR20020428A patent/HRP20020428B1/xx not_active IP Right Cessation
- 2000-10-17 WO PCT/US2000/028687 patent/WO2001028978A1/en not_active Ceased
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- 2000-10-17 EP EP00972226A patent/EP1226110B1/de not_active Expired - Lifetime
- 2000-10-17 TR TR2005/00221T patent/TR200500221T2/xx unknown
- 2000-10-17 BR BRPI0014972-1A patent/BR0014972B1/pt not_active IP Right Cessation
- 2000-10-17 AT AT00972226T patent/ATE293590T1/de not_active IP Right Cessation
- 2000-10-17 EE EEP200200211A patent/EE200200211A/xx unknown
- 2000-10-17 JP JP2001531783A patent/JP3632191B2/ja not_active Expired - Fee Related
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- 2000-10-17 YU YU29302A patent/YU29302A/sh unknown
- 2000-10-17 HU HU0203325A patent/HUP0203325A3/hu unknown
- 2000-10-17 HK HK03101868.4A patent/HK1049826B/zh not_active IP Right Cessation
- 2000-10-17 MX MXPA02003229A patent/MXPA02003229A/es active IP Right Grant
- 2000-10-17 SK SK523-2002A patent/SK5232002A3/sk unknown
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- 2000-10-17 SI SI200030670T patent/SI1226110T1/xx unknown
- 2000-10-17 AU AU10920/01A patent/AU778871B2/en not_active Ceased
- 2000-10-17 AP AP2004003186A patent/AP2004003186A0/xx unknown
- 2000-10-17 KR KR1020027005036A patent/KR100593349B1/ko not_active Expired - Fee Related
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- 2000-10-17 CN CNB008145644A patent/CN1165518C/zh not_active Expired - Fee Related
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- 2000-10-17 PL PL00354607A patent/PL354607A1/xx not_active Application Discontinuation
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2002
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2004
- 2004-01-21 US US10/762,026 patent/US6835751B2/en not_active Expired - Fee Related
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- 2004-09-14 JP JP2004266488A patent/JP3744928B2/ja not_active Expired - Fee Related
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2005
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Also Published As

Publication number	Publication date
CN1382118A (zh)	2002-11-27
IL149143A (en)	2007-02-11
HRP20040709A2 (en)	2004-12-31
AP2002002517A0 (en)	2002-06-30
DOP2000000083A (es)	2002-03-30
OA12070A (en)	2003-11-10
DE60034157T2 (de)	2007-12-13
SI1226110T1 (en)	2005-08-31
DE60019628T2 (de)	2006-01-19
EP1506955B1 (de)	2007-03-28
IL149143A0 (en)	2002-11-10
UA72931C2 (uk)	2005-05-16
YU73004A (sh)	2005-11-28
JP3744928B2 (ja)	2006-02-15
EP1226110A1 (de)	2002-07-31
HN2000000224A (es)	2001-04-11
HUP0203325A2 (hu)	2003-02-28
AU2005201268A1 (en)	2005-04-21
JP2003512348A (ja)	2003-04-02
HK1049826B (zh)	2005-02-25
ZA200202543B (en)	2003-09-23
TW200505824A (en)	2005-02-16
YU29302A (sh)	2005-06-10
KR20060013701A (ko)	2006-02-13
CA2386297A1 (en)	2001-04-26
EA200200293A1 (ru)	2002-10-31
SV2001000188A (es)	2001-09-07
SK5232002A3 (en)	2003-07-01
ATE293590T1 (de)	2005-05-15
MY127678A (en)	2006-12-29
CA2386297C (en)	2010-02-09
PE20010740A1 (es)	2001-07-27
MXPA02003229A (es)	2002-09-30
NZ517961A (en)	2002-12-20
IL164060A0 (en)	2005-12-18
ATE358116T1 (de)	2007-04-15
KR100593349B1 (ko)	2006-06-26
ES2237464T3 (es)	2005-08-01
TR200500221T2 (tr)	2005-03-21
TWI225855B (en)	2005-01-01
KR20020040900A (ko)	2002-05-30
DE60019628D1 (de)	2005-05-25
AU778871B2 (en)	2004-12-23
BR0014972B1 (pt)	2011-09-06
IS7497A (is)	2004-10-08
US20040152779A1 (en)	2004-08-05
PA8505201A1 (es)	2002-08-29
BG106719A (bg)	2003-02-28
AR045456A2 (es)	2005-10-26
ECSP045393A (es)	2004-10-23
HRP20020428B1 (en)	2006-02-28
CN1165518C (zh)	2004-09-08
CZ20021310A3 (cs)	2003-05-14
NO20021780L (no)	2002-04-16
BG108860A (en)	2006-03-31
JP2005036009A (ja)	2005-02-10
ES2282785T3 (es)	2007-10-16
CZ295960B6 (cs)	2005-12-14
JP3632191B2 (ja)	2005-03-23
EE200200211A (et)	2003-06-16
HK1049826A1 (en)	2003-05-30
DZ3197A1 (fr)	2001-04-26
AP2004003186A0 (en)	2004-12-31
US6689906B1 (en)	2004-02-10
NO20021780D0 (no)	2002-04-16
PT1226110E (pt)	2005-07-29
GEP20043297B (en)	2004-01-12
GT200000183A (es)	2000-10-19
US6835751B2 (en)	2004-12-28
NO20043663L (no)	2002-04-16
TR200201094T2 (tr)	2002-09-23
KR100566462B1 (ko)	2006-03-31
WO2001028978A1 (en)	2001-04-26
PL354607A1 (en)	2004-01-26
HRP20020428A2 (en)	2005-02-28
GT200000183AA (es)	2005-06-17
CO5280060A1 (es)	2003-05-30
CR6620A (es)	2004-02-02
AU1092001A (en)	2001-04-30
MA26842A1 (fr)	2004-12-20
EA005206B1 (ru)	2004-12-30
CU23112A3 (es)	2006-02-27
HUP0203325A3 (en)	2003-12-29
AR026087A1 (es)	2002-12-26
EP1506955A1 (de)	2005-02-16
IS6348A (is)	2002-04-17
EP1226110B1 (de)	2005-04-20
BR0014972A (pt)	2002-07-16

Publication	Publication Date	Title
ATE293590T1 (de)	2005-05-15	Bicyclische aminosäuren als pharmazeutische mittel
ATE368041T1 (de)	2007-08-15	Neue pyrrolderivate als pharmazeutische mittel
PT1032555E (pt)	2006-07-31	Aminoacidos ciclicos e derivados uteis como agentes farmaceuticos
ID24654A (id)	2000-07-27	Formulasi farmasi omeprazola
DE69810612D1 (de)	2003-02-13	Pharmazeutische Zusammensetzungen mit Plasmaproteinen
DE59910858D1 (de)	2004-11-18	Pharmazeutische zubereitung von moxifloxacin
NO20003967L (no)	2001-07-27	Farmasöytiske preparater
FIU20000164U0 (fi)	2000-04-11	Uusi farmaseuttinen formulaatio
EE200200038A (et)	2003-04-15	Konservitud farmatseutilised preparaadid
NO980546D0 (no)	1998-02-09	Farmasöytiske midler
NO20020086D0 (no)	2002-01-08	Smaksmaskerte farmasöytiske flytende formuleringer
PT1200092E (pt)	2004-07-30	Farmacos de beta-carbolina
PT1210085E (pt)	2006-05-31	Solucoes farmaceuticas de levosimendano
NO20022606D0 (no)	2002-05-31	Farmasöytiske kombinasjoner
DE69925882D1 (de)	2005-07-28	Aminosäurederivate als Entzündungshemmende Mittel
DE69926012D1 (de)	2005-08-04	Arzneizubereitungen
DE60040903D1 (de)	2009-01-08	Aminosäuren enthaltende albuminpräparationen
NO20016430D0 (no)	2001-12-28	Farmasöytisk kompleks
DE69906934D1 (de)	2003-05-22	Arzneizubereitungen
NO20004816D0 (no)	2000-09-26	Ny farmasøytisk formulering
EP1095026A4 (de)	2001-10-31	Pharmazeutische mittel
DK1226110T3 (da)	2005-06-27	Bicycliske aminosyrer som farmaceutiske midler
FI3862U1 (fi)	1999-03-18	Geelimuotoinen farmaseuttinen valmiste

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