DE60019628D1 - Bicyclische aminosäuren als pharmazeutische mittel - Google Patents

Bicyclische aminosäuren als pharmazeutische mittel

Info

Publication number: DE60019628D1
Authority: DE; Germany
Prior art keywords: amino acids; pharmaceutical agents; bicyclic amino; bicyclic; pharmaceutical
Prior art date: 1999-10-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60019628T

Other languages

English (en)

Other versions

DE60019628T2 (de

Inventor

Justin Stephen Bryans

Clive Blakemore

Simon Osborne

Jean-Marie Receveur

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Warner Lambert Co LLC

Original Assignee

Warner Lambert Co LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-20

Filing date

2000-10-17

Publication date

2005-05-25

2000-10-17 Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC

2005-05-25 Application granted granted Critical

2005-05-25 Publication of DE60019628D1 publication Critical patent/DE60019628D1/de

2006-01-19 Publication of DE60019628T2 publication Critical patent/DE60019628T2/de

2020-10-18 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/20—All rings being cycloaliphatic the ring system containing seven carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/22—All rings being cycloaliphatic the ring system containing eight carbon atoms, e.g. pentalene
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
- C07C2602/28—Hydrogenated naphthalenes

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Endocrinology (AREA)
Orthopedic Medicine & Surgery (AREA)
Hematology (AREA)
Psychology (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Anesthesiology (AREA)
Immunology (AREA)
Dermatology (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Reproductive Health (AREA)
Hospice & Palliative Care (AREA)
Pulmonology (AREA)
Vascular Medicine (AREA)

DE60019628T 1999-10-20 2000-10-17 Bicyclische aminosäuren als pharmazeutische mittel Expired - Lifetime DE60019628T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US16072599P	1999-10-20	1999-10-20
US160725P		1999-10-20
PCT/US2000/028687 WO2001028978A1 (en)	1999-10-20	2000-10-17	Bicyclic amino acids as pharmaceutical agents

Publications (2)

Publication Number	Publication Date
DE60019628D1 true DE60019628D1 (de)	2005-05-25
DE60019628T2 DE60019628T2 (de)	2006-01-19

Family

ID=22578159

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DE60019628T Expired - Lifetime DE60019628T2 (de)	1999-10-20	2000-10-17	Bicyclische aminosäuren als pharmazeutische mittel
DE60034157T Expired - Lifetime DE60034157T2 (de)	1999-10-20	2000-10-17	Bicyclische Aminosäuren als pharmazeutische Mittel

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DE60034157T Expired - Lifetime DE60034157T2 (de)	1999-10-20	2000-10-17	Bicyclische Aminosäuren als pharmazeutische Mittel

Country Status (50)

Country	Link
US (2)	US6689906B1 (de)
EP (2)	EP1226110B1 (de)
JP (2)	JP3632191B2 (de)
KR (2)	KR100593349B1 (de)
CN (1)	CN1165518C (de)
AP (2)	AP2004003186A0 (de)
AR (2)	AR026087A1 (de)
AT (2)	ATE293590T1 (de)
AU (2)	AU778871B2 (de)
BG (2)	BG106719A (de)
BR (1)	BR0014972B1 (de)
CA (1)	CA2386297C (de)
CO (1)	CO5280060A1 (de)
CR (1)	CR6620A (de)
CU (1)	CU23112A3 (de)
CZ (1)	CZ295960B6 (de)
DE (2)	DE60019628T2 (de)
DO (1)	DOP2000000083A (de)
DZ (1)	DZ3197A1 (de)
EA (1)	EA005206B1 (de)
EC (1)	ECSP045393A (de)
EE (1)	EE200200211A (de)
ES (2)	ES2237464T3 (de)
GE (1)	GEP20043297B (de)
GT (2)	GT200000183AA (de)
HK (1)	HK1049826B (de)
HN (1)	HN2000000224A (de)
HR (2)	HRP20040709A2 (de)
HU (1)	HUP0203325A3 (de)
IL (3)	IL149143A0 (de)
IS (2)	IS6348A (de)
MA (1)	MA26842A1 (de)
MX (1)	MXPA02003229A (de)
MY (1)	MY127678A (de)
NO (2)	NO20021780L (de)
NZ (1)	NZ517961A (de)
OA (1)	OA12070A (de)
PA (1)	PA8505201A1 (de)
PE (1)	PE20010740A1 (de)
PL (1)	PL354607A1 (de)
PT (1)	PT1226110E (de)
SI (1)	SI1226110T1 (de)
SK (1)	SK5232002A3 (de)
SV (1)	SV2001000188A (de)
TR (2)	TR200500221T2 (de)
TW (2)	TWI225855B (de)
UA (1)	UA72931C2 (de)
WO (1)	WO2001028978A1 (de)
YU (2)	YU29302A (de)
ZA (1)	ZA200202543B (de)

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US7164034B2 (en)	1999-06-10	2007-01-16	Pfizer Inc.	Alpha2delta ligands for fibromyalgia and other disorders
AU6473601A (en) *	2000-06-26	2002-01-08	Warner Lambert Co	Gabapentin analogues for sleep disorders
US6620829B2 (en)	2000-10-17	2003-09-16	Warner-Lambert Company	Method of treating noninflammatory cartilage damage
EP1226820A1 (de) *	2001-01-26	2002-07-31	Warner-Lambert Company	Verwendung von bicyclische Aminosäuren zur Prophylaxe und Behandlung von Eingeweideschmerzen und gastrointestinalen Erkrankungen
WO2002085839A1 (en) *	2001-04-19	2002-10-31	Warner-Lambert Company Llc	Fused bicyclic or tricyclic amino acids
GB2375108A (en) *	2001-05-04	2002-11-06	Warner Lambert Co	Production of a bicycloheptanone
GB2375109A (en) *	2001-05-04	2002-11-06	Warner Lambert Co	Process for preparing bicyclic amino acid
US6818787B2 (en)	2001-06-11	2004-11-16	Xenoport, Inc.	Prodrugs of GABA analogs, compositions and uses thereof
US7232924B2 (en)	2001-06-11	2007-06-19	Xenoport, Inc.	Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
US8048917B2 (en)	2005-04-06	2011-11-01	Xenoport, Inc.	Prodrugs of GABA analogs, compositions and uses thereof
ATE540678T1 (de) *	2001-06-11	2012-01-15	Xenoport Inc	Prodrugs aus gaba-analoga, zusammensetzungen und ihre verwendungen
US7186855B2 (en)	2001-06-11	2007-03-06	Xenoport, Inc.	Prodrugs of GABA analogs, compositions and uses thereof
NZ532624A (en) *	2002-01-31	2007-05-31	Warner Lambert Co	Alpha2delta ligands to treat tinnitus
WO2003070237A1 (en) *	2002-02-22	2003-08-28	Warner-Lambert Company Llc	Combinations of an alpha-2-delta ligand with a selective inhibitor of cyclooxygenase-2
EP1515709A2 (de) *	2002-06-27	2005-03-23	Warner-Lambert Company LLC	Verwendung eines alpha2delta liganden wie zum beispiel gabapentin oder pregabalin zur behandlung von hyperaktivität mit aufmerksamkeitsstörungen
GB0219024D0 (en) *	2002-08-15	2002-09-25	Pfizer Ltd	Synergistic combinations
WO2004016260A1 (en) *	2002-08-15	2004-02-26	Pfizer Limited	Therapeutic use of fused bicyclic or tricyclic amino acids
US7419981B2 (en)	2002-08-15	2008-09-02	Pfizer Inc.	Synergistic combinations of an alpha-2-delta ligand and a cGMP phosphodieterse 5 inhibitor
GB0223072D0 (en)	2002-10-04	2002-11-13	Pfizer Ltd	Cyclic nitromethyl acetic acid derivatives
US7018818B2 (en)	2002-10-04	2006-03-28	Pfizer Inc.	Intermediates in the preparation of therapeutic fused bicyclic amino acids
AU2003297927A1 (en)	2002-12-11	2004-06-30	Xenoport, Inc.	Prodrugs of fused gaba analogs, pharmaceutical compositions and uses thereof
NZ540591A (en)	2002-12-13	2008-03-28	Warner Lambert Co	Pregabalin derivatives for the treatment of fibromyalgia and other disorders
CA2451267A1 (en)	2002-12-13	2004-06-13	Warner-Lambert Company Llc	Pharmaceutical uses for alpha2delta ligands
PT1572173E (pt)	2002-12-13	2010-05-10	Warner Lambert Co	Ligando alfa-2-delta para tratar sintomas do tracto urinário inferior
CA2537402C (en)	2003-09-12	2009-05-05	Pfizer Inc.	Combinations comprising alpha-2-delta ligands and serotonin / noradrenaline re-uptake inhibitors
WO2006092692A1 (en) *	2005-03-01	2006-09-08	Pfizer Limited	Use of combinations of pde7 inhibitors and alpha-2-delty ligands for the treatment of neuropathic pain
AR061728A1 (es) *	2006-06-30	2008-09-17	Pfizer Prod Inc	Composicion para tratamiento usando compuestos selectivos alfa-2-delta-1
CN101600458A (zh)	2006-12-22	2009-12-09	瑞蔻达蒂爱尔兰有限公司	采用α2δ配体和NSAID的下泌尿道疾病的联合治疗
CN101878193B (zh)	2007-09-28	2014-07-09	第一三共株式会社	双环γ-氨基酸衍生物
ES2635354T3 (es)	2009-03-26	2017-10-03	Daiichi Sankyo Company, Limited	Procedimiento de producción de un derivado de ácido gamma-amino bicíclico
KR101816336B1 (ko)	2011-06-08	2018-01-08	다이이찌 산쿄 가부시키가이샤	이미늄염을 경유하는 2 고리성 화합물의 제조 방법
JP5980780B2 (ja)	2011-06-08	2016-08-31	第一三共株式会社	クライゼン転位反応による二環性化合物の製造方法
CA2859003C (en)	2011-12-15	2016-11-01	Daiichi Sankyo Company, Limited	Optical resolution method for bicyclic compound using asymmetric catalyst
BR112014025158B1 (pt)	2012-04-10	2021-09-21	Daiichi Sankyo Company, Limited	Método para produzir um composto
US9066853B2 (en)	2013-01-15	2015-06-30	Warsaw Orthopedic, Inc.	Clonidine compounds in a biodegradable fiber
TWI635071B (zh)	2013-07-08	2018-09-11	第一三共股份有限公司	光學活性二環γ－胺基酸衍生物及其製造方法
WO2018166855A1 (en)	2017-03-16	2018-09-20	Basf Se	Heterobicyclic substituted dihydroisoxazoles
CN113045410A (zh) *	2021-03-29	2021-06-29	华东理工大学	一种双环降二萜类化合物及其合成基因及制备方法

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US3641129A (en) *	1969-06-17	1972-02-08	Merck & Co Inc	Antifibrinolytic compounds
US4087544A (en) *	1974-12-21	1978-05-02	Warner-Lambert Company	Treatment of cranial dysfunctions using novel cyclic amino acids
DE2460891C2 (de) *	1974-12-21	1982-09-23	Gödecke AG, 1000 Berlin	1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
ES2260850T3 (es)	1997-10-27	2006-11-01	Warner-Lambert Company Llc	Aminoaciods ciclicos y sus derivados utiles como agentes farmaceuticos.

2000
- 2000-10-05 HN HN2000000224A patent/HN2000000224A/es unknown
- 2000-10-06 SV SV2000000188A patent/SV2001000188A/es not_active Application Discontinuation
- 2000-10-17 YU YU29302A patent/YU29302A/sh unknown
- 2000-10-17 TR TR2005/00221T patent/TR200500221T2/xx unknown
- 2000-10-17 DE DE60019628T patent/DE60019628T2/de not_active Expired - Lifetime
- 2000-10-17 EA EA200200293A patent/EA005206B1/ru unknown
- 2000-10-17 ES ES00972226T patent/ES2237464T3/es not_active Expired - Lifetime
- 2000-10-17 PL PL00354607A patent/PL354607A1/xx not_active Application Discontinuation
- 2000-10-17 SI SI200030670T patent/SI1226110T1/xx unknown
- 2000-10-17 HR HRP20040709 patent/HRP20040709A2/xx not_active Application Discontinuation
- 2000-10-17 WO PCT/US2000/028687 patent/WO2001028978A1/en not_active Ceased
- 2000-10-17 DZ DZ003197A patent/DZ3197A1/xx active
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- 2000-10-17 EP EP00972226A patent/EP1226110B1/de not_active Expired - Lifetime
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2002
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2004
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Also Published As

Publication number	Publication date
DE60034157T2 (de)	2007-12-13
ES2282785T3 (es)	2007-10-16
IS7497A (is)	2004-10-08
ES2237464T3 (es)	2005-08-01
US6835751B2 (en)	2004-12-28
NO20021780D0 (no)	2002-04-16
KR100593349B1 (ko)	2006-06-26
GEP20043297B (en)	2004-01-12
GT200000183A (es)	2000-10-19
BR0014972B1 (pt)	2011-09-06
ATE358116T1 (de)	2007-04-15
HRP20040709A2 (en)	2004-12-31
DE60034157D1 (de)	2007-05-10
AU1092001A (en)	2001-04-30
EP1506955B1 (de)	2007-03-28
JP3632191B2 (ja)	2005-03-23
BG108860A (en)	2006-03-31
PT1226110E (pt)	2005-07-29
YU73004A (sh)	2005-11-28
EE200200211A (et)	2003-06-16
TWI225855B (en)	2005-01-01
NO20021780L (no)	2002-04-16
MXPA02003229A (es)	2002-09-30
DOP2000000083A (es)	2002-03-30
GT200000183AA (es)	2005-06-17
SK5232002A3 (en)	2003-07-01
TR200500221T2 (tr)	2005-03-21
IL149143A (en)	2007-02-11
JP3744928B2 (ja)	2006-02-15
HN2000000224A (es)	2001-04-11
KR100566462B1 (ko)	2006-03-31
AU778871B2 (en)	2004-12-23
BG106719A (bg)	2003-02-28
ECSP045393A (es)	2004-10-23
DE60019628T2 (de)	2006-01-19
HK1049826B (zh)	2005-02-25
YU29302A (sh)	2005-06-10
AP2002002517A0 (en)	2002-06-30
PL354607A1 (en)	2004-01-26
MA26842A1 (fr)	2004-12-20
HK1049826A1 (en)	2003-05-30
TW200505824A (en)	2005-02-16
HRP20020428B1 (en)	2006-02-28
HRP20020428A2 (en)	2005-02-28
NO20043663L (no)	2002-04-16
MY127678A (en)	2006-12-29
OA12070A (en)	2003-11-10
AP2004003186A0 (en)	2004-12-31
PE20010740A1 (es)	2001-07-27
CZ295960B6 (cs)	2005-12-14
PA8505201A1 (es)	2002-08-29
AR026087A1 (es)	2002-12-26
SV2001000188A (es)	2001-09-07
IL149143A0 (en)	2002-11-10
CO5280060A1 (es)	2003-05-30
CN1165518C (zh)	2004-09-08
CA2386297C (en)	2010-02-09
HUP0203325A2 (hu)	2003-02-28
DZ3197A1 (fr)	2001-04-26
EA200200293A1 (ru)	2002-10-31
US20040152779A1 (en)	2004-08-05
EA005206B1 (ru)	2004-12-30
AR045456A2 (es)	2005-10-26
TR200201094T2 (tr)	2002-09-23
CU23112A3 (es)	2006-02-27
CN1382118A (zh)	2002-11-27
US6689906B1 (en)	2004-02-10
KR20020040900A (ko)	2002-05-30
JP2005036009A (ja)	2005-02-10
KR20060013701A (ko)	2006-02-13
EP1226110A1 (de)	2002-07-31
CR6620A (es)	2004-02-02
IS6348A (is)	2002-04-17
EP1226110B1 (de)	2005-04-20
ZA200202543B (en)	2003-09-23
AU2005201268A1 (en)	2005-04-21
UA72931C2 (uk)	2005-05-16
WO2001028978A1 (en)	2001-04-26
NZ517961A (en)	2002-12-20
CA2386297A1 (en)	2001-04-26
BR0014972A (pt)	2002-07-16
CZ20021310A3 (cs)	2003-05-14
EP1506955A1 (de)	2005-02-16
SI1226110T1 (en)	2005-08-31
JP2003512348A (ja)	2003-04-02
HUP0203325A3 (en)	2003-12-29
IL164060A0 (en)	2005-12-18
ATE293590T1 (de)	2005-05-15

Publication	Publication Date	Title
ATE358116T1 (de)	2007-04-15	Bicyclische aminosäuren als pharmazeutische mittel
ATE368041T1 (de)	2007-08-15	Neue pyrrolderivate als pharmazeutische mittel
PT1032555E (pt)	2006-07-31	Aminoacidos ciclicos e derivados uteis como agentes farmaceuticos
ID24654A (id)	2000-07-27	Formulasi farmasi omeprazola
DE69810612D1 (de)	2003-02-13	Pharmazeutische Zusammensetzungen mit Plasmaproteinen
ATE279193T1 (de)	2004-10-15	Pharmazeutische zubereitung von moxifloxacin
NO20033556D0 (no)	2003-08-11	Farmasöytiske preparater
FIU20000164U0 (fi)	2000-04-11	Uusi farmaseuttinen formulaatio
EE200200038A (et)	2003-04-15	Konservitud farmatseutilised preparaadid
NO980546D0 (no)	1998-02-09	Farmasöytiske midler
NO20020086L (no)	2002-03-05	Smaksmaskerte farmasöytiske flytende formuleringer
PT1200092E (pt)	2004-07-30	Farmacos de beta-carbolina
PT1210085E (pt)	2006-05-31	Solucoes farmaceuticas de levosimendano
NO20022606D0 (no)	2002-05-31	Farmasöytiske kombinasjoner
DE69925882D1 (de)	2005-07-28	Aminosäurederivate als Entzündungshemmende Mittel
DE69926012D1 (de)	2005-08-04	Arzneizubereitungen
DE60040903D1 (de)	2009-01-08	Aminosäuren enthaltende albuminpräparationen
NO20016430L (no)	2002-02-26	Farmasöytisk kompleks
DE69906934D1 (de)	2003-05-22	Arzneizubereitungen
NO20004816D0 (no)	2000-09-26	Ny farmasøytisk formulering
EP1095026A4 (de)	2001-10-31	Pharmazeutische mittel
DK1226110T3 (da)	2005-06-27	Bicycliske aminosyrer som farmaceutiske midler
FI3862U1 (fi)	1999-03-18	Geelimuotoinen farmaseuttinen valmiste

Legal Events

Date	Code	Title	Description
2006-05-24	8364	No opposition during term of opposition
2006-06-01	8381	Inventor (new situation)	Inventor name: BLAKEMORE, CLIVE, DAVID, CAMBRIDGE CB1 8TH, GB Inventor name: RECEVEUR, JEAN-MARIE, CAMBRIDGE CB1 2LG, GB

Date

Code

Title

Description

2006-05-24

8364

No opposition during term of opposition

2006-06-01

8381

Inventor (new situation)

Inventor name: BLAKEMORE, CLIVE, DAVID, CAMBRIDGE CB1 8TH, GB

Inventor name: RECEVEUR, JEAN-MARIE, CAMBRIDGE CB1 2LG, GB