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DE60010913D1 - Bizyclische verbindungen zusammenstellung und verfahren zu ihrer stabilisierung - Google Patents

Bizyclische verbindungen zusammenstellung und verfahren zu ihrer stabilisierung

Info

Publication number
DE60010913D1
DE60010913D1 DE60010913T DE60010913T DE60010913D1 DE 60010913 D1 DE60010913 D1 DE 60010913D1 DE 60010913 T DE60010913 T DE 60010913T DE 60010913 T DE60010913 T DE 60010913T DE 60010913 D1 DE60010913 D1 DE 60010913D1
Authority
DE
Germany
Prior art keywords
bizyclic
stabilization
compositions
bizyclic compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60010913T
Other languages
English (en)
Other versions
DE60010913T2 (de
Inventor
Ryuji Ueno
Tsuyoshi Habe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sucampo GmbH
Original Assignee
Sucampo GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22573018&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60010913(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sucampo GmbH filed Critical Sucampo GmbH
Application granted granted Critical
Publication of DE60010913D1 publication Critical patent/DE60010913D1/de
Publication of DE60010913T2 publication Critical patent/DE60010913T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DE60010913T 1999-10-15 2000-10-13 Bizyklische Verbindungen, Zusammenstellung und Verfahren zu ihrer Stabilisierung Expired - Lifetime DE60010913T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15954999P 1999-10-15 1999-10-15
US159549P 1999-10-15
PCT/JP2000/007109 WO2001027099A2 (en) 1999-10-15 2000-10-13 Bicyclic compounds composition and method for stabilizing the same

Publications (2)

Publication Number Publication Date
DE60010913D1 true DE60010913D1 (de) 2004-06-24
DE60010913T2 DE60010913T2 (de) 2005-06-09

Family

ID=22573018

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60039727T Expired - Lifetime DE60039727D1 (de) 1999-10-15 2000-10-13 Neue Zusammensetzung enthaltend eine bicyclische Verbindung und ein Glycerid
DE60010913T Expired - Lifetime DE60010913T2 (de) 1999-10-15 2000-10-13 Bizyklische Verbindungen, Zusammenstellung und Verfahren zu ihrer Stabilisierung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE60039727T Expired - Lifetime DE60039727D1 (de) 1999-10-15 2000-10-13 Neue Zusammensetzung enthaltend eine bicyclische Verbindung und ein Glycerid

Country Status (26)

Country Link
US (5) US6583174B1 (de)
EP (2) EP1220849B1 (de)
JP (2) JP4332316B2 (de)
KR (1) KR100830061B1 (de)
CN (1) CN1268623C (de)
AR (3) AR026046A1 (de)
AT (2) ATE402925T2 (de)
AU (2) AU780342B2 (de)
BR (1) BRPI0014869B8 (de)
CA (1) CA2385732C (de)
CZ (1) CZ303625B6 (de)
DE (2) DE60039727D1 (de)
DK (2) DK1426361T4 (de)
ES (2) ES2309410T5 (de)
HK (1) HK1045693B (de)
HU (2) HU229547B1 (de)
IL (2) IL148803A0 (de)
MX (1) MXPA02003756A (de)
NO (1) NO330258B1 (de)
NZ (1) NZ518020A (de)
PT (2) PT1220849E (de)
RU (1) RU2695274C3 (de)
TR (1) TR200201032T2 (de)
TW (1) TWI281918B (de)
WO (1) WO2001027099A2 (de)
ZA (1) ZA200202312B (de)

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AR037524A1 (es) * 2001-11-14 2004-11-17 Sucampo Ag Unidad de dosificacion que comprende un analogo de prostaglandina para el tratamiento de la constipacion
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NZ539582A (en) * 2002-10-23 2007-07-27 Sucampo Ag Prostaglandin compounds for the treatment of obesity
BRPI0317740B8 (pt) * 2002-12-27 2021-05-25 Sucampo Ag uso do composto 13,14-diidro-15-ceto-16,16-diflúorprostaglandina e1
DE602004030245D1 (de) * 2003-07-03 2011-01-05 Sucampo Ag Pharmazeutische magensaftresistent überzogene zusammensetzung enthaltend prostaglandin-analoga als chloridkanalöffner
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WO2014159679A1 (en) 2013-03-12 2014-10-02 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Methods for using lubiprostone to absorb fluid from the subretinal space
US10736871B2 (en) 2015-04-01 2020-08-11 Cedars-Sinai Medical Center Anti-methanogenic lovastatin analogs or derivatives and uses thereof
JP6954282B2 (ja) 2016-06-30 2021-10-27 小野薬品工業株式会社 二環式化合物の製造方法
JP6957610B2 (ja) 2016-10-06 2021-11-02 スキャンポ・アーゲーＳｕｃａｍｐｏ ＡＧ 医薬品用途のための多層ビーズ
KR20210003877A (ko) * 2018-05-01 2021-01-12 치비 인코포레이티드 약제를 눈에 비침습적으로 지속 전달하기 위한 액체 데포
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Also Published As

Publication number Publication date
HUP0203746A2 (hu) 2003-03-28
HUP1300369A2 (de) 2003-03-28
AU2004242503B2 (en) 2007-06-21
JP4332316B2 (ja) 2009-09-16
BR0014869A (pt) 2002-06-25
MXPA02003756A (es) 2005-09-08
DK1426361T3 (da) 2008-11-17
HUP0203746A3 (en) 2005-02-28
AU7685600A (en) 2001-04-23
CA2385732C (en) 2009-02-10
HK1066792A1 (en) 2005-04-01
WO2001027099A2 (en) 2001-04-19
HK1045693B (en) 2005-01-21
PT1220849E (pt) 2004-10-29
TWI281918B (en) 2007-06-01
HU229547B1 (en) 2014-01-28
NO20021736L (no) 2002-04-12
AR109354A2 (es) 2018-11-21
ES2309410T3 (es) 2008-12-16
RU2695274C3 (ru) 2020-11-09
JP2003511445A (ja) 2003-03-25
EP1426361B1 (de) 2008-07-30
AR089848A2 (es) 2014-09-24
US20080255227A1 (en) 2008-10-16
ES2309410T5 (es) 2015-03-17
US8088934B2 (en) 2012-01-03
WO2001027099A3 (en) 2001-10-25
EP1220849B1 (de) 2004-05-19
KR20020068521A (ko) 2002-08-27
US20120095090A1 (en) 2012-04-19
US6583174B1 (en) 2003-06-24
CZ20021037A3 (cs) 2002-09-11
IL148803A0 (en) 2002-09-12
TR200201032T2 (tr) 2002-08-21
BRPI0014869B8 (pt) 2021-05-25
US7417067B2 (en) 2008-08-26
EP1426361B2 (de) 2015-02-25
RU2695274C9 (ru) 2020-01-22
HK1045693A1 (en) 2002-12-06
DK1426361T4 (en) 2015-03-16
PT1426361E (pt) 2008-10-08
CA2385732A1 (en) 2001-04-19
CN1268623C (zh) 2006-08-09
ATE402925T2 (de) 2008-08-15
RU2695274C2 (ru) 2019-07-22
JP2009235079A (ja) 2009-10-15
AR026046A1 (es) 2002-12-26
NO330258B1 (no) 2011-03-14
DK1220849T3 (da) 2004-09-27
US8097649B1 (en) 2012-01-17
CZ303625B6 (cs) 2013-01-16
CN1379769A (zh) 2002-11-13
US20040235885A1 (en) 2004-11-25
IL148803A (en) 2006-07-05
KR100830061B1 (ko) 2008-05-16
BRPI0014869B1 (pt) 2017-06-13
RU2002112984A (ru) 2004-01-20
DE60010913T2 (de) 2005-06-09
AU2004242503A1 (en) 2005-01-27
EP1220849A2 (de) 2002-07-10
AU780342B2 (en) 2005-03-17
NZ518020A (en) 2004-02-27
HU230484B1 (hu) 2016-07-28
EP1426361A1 (de) 2004-06-09
DE60039727D1 (de) 2008-09-11
NO20021736D0 (no) 2002-04-12
ES2221859T3 (es) 2005-01-16
ATE267189T1 (de) 2004-06-15
ZA200202312B (en) 2002-12-24
AU2004242503C1 (en) 2005-01-27

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