[go: up one dir, main page]

AR089848A2 - Un compuesto biciclico, composicion farmaceutica y metodo para estabilizarlo - Google Patents

Un compuesto biciclico, composicion farmaceutica y metodo para estabilizarlo

Info

Publication number
AR089848A2
AR089848A2 ARP130100275A ARP130100275A AR089848A2 AR 089848 A2 AR089848 A2 AR 089848A2 AR P130100275 A ARP130100275 A AR P130100275A AR P130100275 A ARP130100275 A AR P130100275A AR 089848 A2 AR089848 A2 AR 089848A2
Authority
AR
Argentina
Prior art keywords
hydroxy
alkyl
aryl
group
alkoxy
Prior art date
Application number
ARP130100275A
Other languages
English (en)
Inventor
Ueno Ryuji
Habe Tsuyoshi
Original Assignee
Sucampo Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22573018&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR089848(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sucampo Ag filed Critical Sucampo Ag
Publication of AR089848A2 publication Critical patent/AR089848A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Un compuesto bicíclico representado por las formulas (1), (2), (3) y (4). Composiciones farmacéuticas y método para estabilizar el compuesto bicíclico de la formula (5), en donde A es -CH₂OH, -COCH₂OH, -COOH o un derivado funcional del mismo; X¹ y X² son átomos de hidrogeno, alquilo interior o átomo de halógeno; V¹ y V² son átomos de carbono; W¹ y W² son seleccionados del grupo de formulas (6), donde R⁴ y R⁵ son átomos de hidrógeno, hidroxi, átomo de halógeno, alquilo inferior, alcoxi o hidroxi-alquilo (inferior) con la provisión que R⁴ y R⁵ no sean hidroxi o alcoxi inferior al mismo tiempo; Z es un átomo de oxígeno; R¹ es un residuo bivalente saturado o no saturado hidrocarbonado inferior-medio alifático el cual es no sustituido o sustituido con átomo de halógeno, un grupo alquilo, hidroxi, oxo, arilo o grupo heterociclilo; R² es un residuo saturado o no saturado hidrocarbonado inferior o medio alifático el cual es no sustituido o sustituido con átomo de halógeno, oxo, hidroxi, alquilo inferior, alcoxi inferior, alcanoiloxi inferior, cicloalquilo inferior, cicloalquiloxi inferior, arilo, ariloxi, grupo heterocíclico o grupo oxi heterocíclico; cicloalquilo inferior; cicloalquiloxi inferior; arilo, ariloxi, grupo heterocíclico o grupo oxi heterocíclico; R³ es átomo de hidrogeno, alquilo inferior, cicloalquilo inferior, grupo arilo o heterocíclico; que comprende el paso de mezclar el mismo con un glicérido.
ARP130100275A 1999-10-15 2013-01-30 Un compuesto biciclico, composicion farmaceutica y metodo para estabilizarlo AR089848A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15954999P 1999-10-15 1999-10-15

Publications (1)

Publication Number Publication Date
AR089848A2 true AR089848A2 (es) 2014-09-24

Family

ID=22573018

Family Applications (3)

Application Number Title Priority Date Filing Date
ARP000105407A AR026046A1 (es) 1999-10-15 2000-10-13 NUEVA COMPOSICIoN Y MÉTODO PARA ESTABILIZAR LA MISMA
ARP130100275A AR089848A2 (es) 1999-10-15 2013-01-30 Un compuesto biciclico, composicion farmaceutica y metodo para estabilizarlo
ARP170102288A AR109354A2 (es) 1999-10-15 2017-08-16 Una composición que comprende un compuesto bicíclico y compuesto

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP000105407A AR026046A1 (es) 1999-10-15 2000-10-13 NUEVA COMPOSICIoN Y MÉTODO PARA ESTABILIZAR LA MISMA

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP170102288A AR109354A2 (es) 1999-10-15 2017-08-16 Una composición que comprende un compuesto bicíclico y compuesto

Country Status (26)

Country Link
US (5) US6583174B1 (es)
EP (2) EP1220849B1 (es)
JP (2) JP4332316B2 (es)
KR (1) KR100830061B1 (es)
CN (1) CN1268623C (es)
AR (3) AR026046A1 (es)
AT (2) ATE402925T2 (es)
AU (2) AU780342B2 (es)
BR (1) BRPI0014869B8 (es)
CA (1) CA2385732C (es)
CZ (1) CZ303625B6 (es)
DE (2) DE60010913T2 (es)
DK (2) DK1426361T4 (es)
ES (2) ES2221859T3 (es)
HK (1) HK1045693B (es)
HU (2) HU229547B1 (es)
IL (2) IL148803A0 (es)
MX (1) MXPA02003756A (es)
NO (1) NO330258B1 (es)
NZ (1) NZ518020A (es)
PT (2) PT1426361E (es)
RU (1) RU2695274C3 (es)
TR (1) TR200201032T2 (es)
TW (1) TWI281918B (es)
WO (1) WO2001027099A2 (es)
ZA (1) ZA200202312B (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1426361E (pt) * 1999-10-15 2008-10-08 Sucampo Ag Nova composição contendo um composto bicíclico e um glicérido
US6414016B1 (en) 2000-09-05 2002-07-02 Sucampo, A.G. Anti-constipation composition
TWI331920B (en) * 2001-11-14 2010-10-21 Sucampo Ag Unit dosage form for relieving or treating constipation in human patients
FR2842810B1 (fr) * 2002-07-25 2006-01-27 Inst Nat Sciences Appliq Nouveaux composes gem difluores, leur procedes de preparation et leurs applications.
NZ539582A (en) * 2002-10-23 2007-07-27 Sucampo Ag Prostaglandin compounds for the treatment of obesity
EP1575596B1 (en) * 2002-12-27 2016-06-22 Sucampo AG Derivatives of prostaglandins for treating irritable bowel syndrome and/or functional dyspepsia
US8337891B2 (en) * 2003-07-03 2012-12-25 Sucampo Ag Enteric coated composition comprising prostaglandin analogs as chloride channel opener
TWI495471B (zh) * 2003-08-12 2015-08-11 R Tech Ueno Ltd 促進毛髮生長之組成物及方法
TWI387454B (zh) 2004-09-02 2013-03-01 蘇坎波公司 治療胃腸道疾病之方法及組成物
US8962688B2 (en) * 2005-04-12 2015-02-24 Sucampo Ag Method for the treatment of gastrointestinal disorders
CN104983712A (zh) 2006-01-24 2015-10-21 株式会社·R-技术上野 软明胶胶囊制剂
JP5265369B2 (ja) * 2006-01-24 2013-08-14 株式会社アールテック・ウエノ 二環式化合物を含む医薬組成物およびその二環式化合物の安定化方法
CA2856675C (en) * 2006-02-07 2016-04-26 R-Tech Ueno, Ltd. Prostaglandin derivatives
US20090030072A1 (en) 2007-07-03 2009-01-29 Sucampo Ag Pharmaceutical combination of opioid and prostaglandin compound
US20090012165A1 (en) 2007-07-03 2009-01-08 Sucampo Ag Pharmaceutical combination of nsaid and prostaglandin compound
KR101485212B1 (ko) * 2007-07-19 2015-01-22 가부시키가이샤 아루떼꾸 우에노 11-데옥시-프로스타글란딘 화합물을 포함하는 약학 조성물 및 상기 화합물을 안정화시키는 방법
US20090082442A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched lubiprostone
CN101318948B (zh) * 2008-04-01 2011-04-27 上海天伟生物制药有限公司 鲁比前列酮晶体、其制备方法及用途
US8569279B2 (en) * 2009-05-27 2013-10-29 Sucampo Ag Method for modulating claudin mediated functions
US20110034424A1 (en) * 2009-06-30 2011-02-10 Sucampo Ag Method for the long term nsaid use
US8614340B2 (en) 2009-07-28 2013-12-24 Ono Pharmaceuticals Co., Ltd. Bicyclic compound and use thereof for medical purposes
CA2774021A1 (en) * 2009-09-18 2011-03-24 Adolor Corporation Use of opioid receptor antagonist for gastrointestinal tract disorders
CA2779736A1 (en) 2009-11-03 2011-05-12 Bernard Charles Sherman Stable pharmaceutical formulations comprising lubiprostone
WO2012102355A1 (ja) * 2011-01-27 2012-08-02 小野薬品工業株式会社 二環式化合物およびその医薬用途
WO2012102357A1 (ja) 2011-01-27 2012-08-02 小野薬品工業株式会社 二環式化合物およびその医薬用途
WO2014159679A1 (en) 2013-03-12 2014-10-02 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Methods for using lubiprostone to absorb fluid from the subretinal space
US10736871B2 (en) 2015-04-01 2020-08-11 Cedars-Sinai Medical Center Anti-methanogenic lovastatin analogs or derivatives and uses thereof
EP3480191B1 (en) 2016-06-30 2021-09-01 ONO Pharmaceutical Co., Ltd. Method for producing bicyclic compound
US11534404B2 (en) 2016-10-06 2022-12-27 Sucampo Ag Multilayer beads for pharmaceutical use
EP4670713A1 (en) * 2018-05-01 2025-12-31 Chibi, Inc. LIQUID DEPOSIT FOR THE PROLONGED NON-INVASIVE ADMINISTRATION OF AGENTS TO THE IL
JPWO2019221215A1 (ja) * 2018-05-18 2021-05-27 ニプロ株式会社 ルビプロストン含有粒子状医薬組成物
JP7518661B2 (ja) * 2020-05-14 2024-07-18 沢井製薬株式会社 ルビプロストン含有整粒物、ルビプロストン含有錠剤およびそれらの製造方法

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US18202A (en) * 1857-09-15 Improvement in feathering paddle-wheels
JPS5720305B2 (es) 1973-02-28 1982-04-27
US4034003A (en) 1974-04-11 1977-07-05 Ono Pharmaceutical Co., Ltd. 15-Cycloalkyl-prostaglandins
US3966962A (en) * 1975-03-27 1976-06-29 The Upjohn Company Triacetin solutions of PGE-type compounds
JPS5350141A (en) * 1976-10-18 1978-05-08 Ono Pharmaceut Co Ltd Stabilization of prostaglandin and prostaglandin analogues
JPS5919524B2 (ja) 1976-12-17 1984-05-07 中外製薬株式会社 安定な１α−ヒドロキシビタミンＤ類含有製剤
JPS5391110A (en) 1977-01-20 1978-08-10 Yamanouchi Pharmaceut Co Ltd Novel drug composition for rectal infusion
CA1184906A (en) * 1977-04-19 1985-04-02 Roy A. Johnson 9-deoxy-5,9-epoxy-prostaglandins
JPS6022708B2 (ja) 1977-07-14 1985-06-03 小野薬品工業株式会社 プロスタグランジン類似化合物
JPS5452717A (en) * 1977-09-29 1979-04-25 Chugai Pharmaceut Co Ltd Stable oily pharmaceuticals containing 1alpha-hydroxyvitamin d
US4130566A (en) * 1977-10-27 1978-12-19 Sumitomo Chemical Company, Limited Process for producing 5-carboxy-2-acetylthiophene
AT358530B (de) 1978-04-25 1980-09-10 Plc Pharma Licences Stabilisierungsverfahren
JPS55136219A (en) 1979-04-11 1980-10-23 Sumitomo Chem Co Ltd Diazepam oily drug
US4670569A (en) 1981-04-02 1987-06-02 G. D. Searle & Co. 5-fluoro-PGI2 compounds
JPS59137413A (ja) * 1983-01-25 1984-08-07 Teijin Ltd ７−チアプロスタグランジンｅ↓１類を含有する医薬品組成物
US4579958A (en) 1983-12-23 1986-04-01 G. D. Searle & Co. 5-fluoro-3-oxa-6,7-didehydro-PGI1 compounds
US4687864A (en) 1983-12-23 1987-08-18 G. D. Searle & Co. 5-fluoro-3-oxa-prostacyclin compounds
US5166174A (en) 1987-01-28 1992-11-24 K.K. Ueno Seiyaku Oyo Kenkyujo Prostaglandins E and anti-ulcers containing same
US5380709A (en) 1987-01-28 1995-01-10 K.K. Ueno Seiyaku Oyo Kenkyujo Prostaglandins E and anti ulcers containing same
US5225439A (en) 1987-01-28 1993-07-06 K.K. Ueno Seiyaku Oyo Kenkyujo Prostaglandins E and anti ulcers containing same
US4758880A (en) 1987-03-27 1988-07-19 The Grass Valley Group, Inc. Video matte generator
KR920003601B1 (ko) 1987-09-03 1992-05-04 유니버시티 어브 죠지아 리서취 화운데이션 인코포레이티드 점안 싸이클로스포린(cyclosporin)의 조성물
ES2051862T3 (es) 1987-10-02 1994-07-01 Ueno Seiyaku Oyo Kenkyujo Kk Un metodo para producir un medicamento que tiene un efecto catartico.
US5317032A (en) * 1987-10-02 1994-05-31 Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo Prostaglandin cathartic
JP2597649B2 (ja) † 1988-05-11 1997-04-09 株式会社上野製薬応用研究所 気管・気管支拡張剤
DK299089A (da) * 1988-06-17 1989-12-18 Wellcome Found Anvendelse af prostaglandiner til fremstilling af laegemidler
JP2579193B2 (ja) 1988-07-19 1997-02-05 小野薬品工業株式会社 １６，１６−ジフルオロ−１５−オキソ−１５−デオキシｐｇｅ誘導体
JPH0745504B2 (ja) 1988-07-29 1995-05-17 株式会社上野製薬応用研究所 プロスタグランジン前駆体およびその製法
JP2794433B2 (ja) 1989-02-02 1998-09-03 丸善製薬株式会社 甘草疎水性フラボノイド製剤
CA2030345C (en) * 1989-11-22 1998-12-08 Ryuji Ueno Use of 15-keto-prostaglandin compound for improvement of encephalic function
CA2030346C (en) * 1989-11-22 2000-04-11 Ryuji Ueno Treatment of cardiac dysfunction with 15-keto-prostaglandin compounds
CA2030344C (en) † 1989-11-22 2000-04-18 Ryuji Ueno Treatment of pulmonary dysfunction with 15-keto-prostaglandin compounds
US5256696A (en) * 1989-11-22 1993-10-26 Kabushikikaisha Ueno Seiyaku Oyo Kenkyujo Treatment of cardiac dysfunction with 15-ketoprostaglandin compounds
US5254588A (en) * 1989-11-22 1993-10-19 Kabushikikaisha Ueno Seiyaku Oyo Kenkyujo Treatment of pulmonary dysfunction with 15-ketoprostaglandin compounds
DE69130586T2 (de) 1990-05-01 1999-06-17 R-Tech Ueno, Ltd., Osaka Behandlung von Pankreaskrankheit mit 15-keto-Prostaglandin E-Derivaten
JPH0446122A (ja) 1990-06-13 1992-02-17 Nippon Iyakuhin Kogyo Kk 活性型ビタミンｄ↓３類含有製剤
CA2046069C (en) 1990-07-10 2002-04-09 Ryuji Ueno Treatment of inflammatory diseases with 15-keto-prostaglandin compounds
JP2938579B2 (ja) 1990-12-15 1999-08-23 株式会社上野製薬応用研究所 消化管壁保護剤
JP2746800B2 (ja) * 1991-09-03 1998-05-06 株式会社アールテック・ウエノ プロスタグランジン中間体の製法
US5274130A (en) * 1991-09-03 1993-12-28 R-Tech Ueno Ltd. Process for production of prostaglandin intermediates
US5474979A (en) 1994-05-17 1995-12-12 Allergan, Inc. Nonirritating emulsions for sensitive tissue
CA2150287C (en) 1994-06-03 2004-08-10 Ryuji Ueno Agent for treating hepato-biliary diseases
US5981607A (en) 1998-01-20 1999-11-09 Allergan Emulsion eye drop for alleviation of dry eye related symptoms in dry eye patients and/or contact lens wearers
PT1426361E (pt) * 1999-10-15 2008-10-08 Sucampo Ag Nova composição contendo um composto bicíclico e um glicérido
US6414016B1 (en) 2000-09-05 2002-07-02 Sucampo, A.G. Anti-constipation composition
JP4210631B2 (ja) 2004-06-24 2009-01-21 株式会社日立製作所 ブレーキ制御装置

Also Published As

Publication number Publication date
BR0014869A (pt) 2002-06-25
DE60010913D1 (de) 2004-06-24
US6583174B1 (en) 2003-06-24
AU2004242503A1 (en) 2005-01-27
US8088934B2 (en) 2012-01-03
NZ518020A (en) 2004-02-27
US8097649B1 (en) 2012-01-17
ES2309410T3 (es) 2008-12-16
NO20021736L (no) 2002-04-12
EP1426361B1 (en) 2008-07-30
ATE402925T2 (de) 2008-08-15
HK1045693A1 (en) 2002-12-06
JP4332316B2 (ja) 2009-09-16
US20080255227A1 (en) 2008-10-16
HK1045693B (en) 2005-01-21
HUP0203746A3 (en) 2005-02-28
ZA200202312B (en) 2002-12-24
RU2695274C3 (ru) 2020-11-09
HU229547B1 (en) 2014-01-28
US20040235885A1 (en) 2004-11-25
EP1220849A2 (en) 2002-07-10
TWI281918B (en) 2007-06-01
CN1379769A (zh) 2002-11-13
MXPA02003756A (es) 2005-09-08
CA2385732C (en) 2009-02-10
DK1426361T3 (da) 2008-11-17
HU230484B1 (hu) 2016-07-28
PT1426361E (pt) 2008-10-08
CZ20021037A3 (cs) 2002-09-11
HUP0203746A2 (hu) 2003-03-28
AU2004242503C1 (en) 2005-01-27
RU2002112984A (ru) 2004-01-20
US7417067B2 (en) 2008-08-26
ES2309410T5 (es) 2015-03-17
IL148803A (en) 2006-07-05
TR200201032T2 (tr) 2002-08-21
EP1426361B2 (en) 2015-02-25
EP1220849B1 (en) 2004-05-19
DE60010913T2 (de) 2005-06-09
EP1426361A1 (en) 2004-06-09
RU2695274C9 (ru) 2020-01-22
WO2001027099A3 (en) 2001-10-25
JP2009235079A (ja) 2009-10-15
BRPI0014869B1 (pt) 2017-06-13
AU780342B2 (en) 2005-03-17
NO20021736D0 (no) 2002-04-12
AR026046A1 (es) 2002-12-26
WO2001027099A2 (en) 2001-04-19
AR109354A2 (es) 2018-11-21
AU2004242503B2 (en) 2007-06-21
CN1268623C (zh) 2006-08-09
US20120095090A1 (en) 2012-04-19
IL148803A0 (en) 2002-09-12
PT1220849E (pt) 2004-10-29
NO330258B1 (no) 2011-03-14
DK1220849T3 (da) 2004-09-27
ES2221859T3 (es) 2005-01-16
DE60039727D1 (de) 2008-09-11
ATE267189T1 (de) 2004-06-15
AU7685600A (en) 2001-04-23
RU2695274C2 (ru) 2019-07-22
DK1426361T4 (en) 2015-03-16
CZ303625B6 (cs) 2013-01-16
BRPI0014869B8 (pt) 2021-05-25
CA2385732A1 (en) 2001-04-19
HK1066792A1 (en) 2005-04-01
JP2003511445A (ja) 2003-03-25
KR100830061B1 (ko) 2008-05-16
KR20020068521A (ko) 2002-08-27
HUP1300369A2 (es) 2003-03-28

Similar Documents

Publication Publication Date Title
AR089848A2 (es) Un compuesto biciclico, composicion farmaceutica y metodo para estabilizarlo
CO5580815A2 (es) Derivados de adamantana, procesos para su preparacion y composiciones farmaceuticas que los contienen
CO6180506A2 (es) Inhibidores de la proteasa ns3 del hcv
AR098744A2 (es) Composición catártica
ES2196772T3 (es) Compuestos amino ciclicos.
CO5700720A2 (es) Derivados de n-(quinolin-5l) alquilamida-sustituida; n-alquilquinolin-5-carboxamida-sustituida; n-alquilisoquinolin-5-carboxamida-sustituida; n-(isoquinolin-5-yl) alquilamida-sustituida y procesos para su preparacion
AR042668A1 (es) Derivados de fosfonoxi quinazolinas y su uso farmaceutico
AR044874A1 (es) Derivados de 4- cianopirazol-3 - carboxamida, su preparacion y su aplicacion en terapeutica
ES2192520T3 (es) Composicion farmaceutica.
AR044749A1 (es) Inhibidor de la arn polimerasa dependiente de arn del virus de la hepatitis c y composiciones y tratamientos que lo usan
AR033344A1 (es) Compuestos derivados de benzofenonas como inhibidores de la transcriptasa inversa, su uso en la fabricacion de medicamentos, intermediarios y composiciones farmaceuticas
PE20231190A1 (es) Degradadores de moleculas pequenas de piperidinilo de helios y procedimientos de uso
AR057703A1 (es) INHIBIDORES MACROCíCLICOS DEL VIRUS DE LA HEPATITIS C. PROCESO DE PREPARACIoN Y COMPOSICIONES FARMACÉUTICAS.
AR073498A1 (es) Derivados de tieno [2-3-d] pirimidin
AR054789A1 (es) Antagonistas del receptor 1 de triazolopiridina canabinoide
AR052458A1 (es) Amino-imidazolonas para la inhibicion de beta-secretasa
ECSP099395A (es) Nuevos derivados de los ácidos amino-nicotínico y amino-isonicotínico
AR048362A1 (es) Derivados de tetrahidronaftiridina y proceso para la preparacion de los mismos
ES2179822T3 (es) Nuevas 4-arilpiperazinas y 4-arilpiperidinas.
AR015528A1 (es) Compuestos heterociclicos como inhibidores de enzimas rotamasas, composiciones, su uso para la preparacion de medicinas, proceso para su preparacion ycompuestos intermediarios
AR059184A1 (es) Derivados de sulfonamidas, su preparacion y su aplicacion en tarapeutica
AR111682A1 (es) Derivados de imidazopirimidina con sustituyentes fenilo y piridilo que contienen azufre
ES2159462A1 (es) Preparacion de eteres aminicos estericamente impedidos.
AR043055A1 (es) Derivados de 1-(4-benzil-piperazin-1-il)-3- fenil-propenona
AR007128A1 (es) Un compuesto antipicornaviral, composicion farmaceutica que lo contiene y metodos para preparar a dicho compuesto

Legal Events

Date Code Title Description
FC Refusal