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CR9314A - Derivado de espirocetal y uso del mismo como medicina para la diabetes - Google Patents

Derivado de espirocetal y uso del mismo como medicina para la diabetes

Info

Publication number
CR9314A
CR9314A CR9314A CR9314A CR9314A CR 9314 A CR9314 A CR 9314A CR 9314 A CR9314 A CR 9314A CR 9314 A CR9314 A CR 9314A CR 9314 A CR9314 A CR 9314A
Authority
CR
Costa Rica
Prior art keywords
optionally substituted
group
optionally
compound
spirocetal
Prior art date
Application number
CR9314A
Other languages
English (en)
Inventor
Takamitsu Kobayashi
Tsutomu Sato
Masahiro Nishimoto
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of CR9314A publication Critical patent/CR9314A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C07D491/153—Ortho-condensed systems the condensed system containing two rings with oxygen as ring hetero atom and one ring with nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invencion provee un compuesto de la formula (I): (en la formula, R1, R2, R3 y R4 representan independientemente un atomo de hidrogeno, un grupo alquilo de C1-C6 opcionalmente sustituido, un grupo aralquilo de C7-C14 opcionalmente sustituido, o -C(=O)Rx; Rx representa un grupo alquilo de C1-C6 opcionalmente sustituido, un grupo arilo opcionalmente sustituido, un grupo heteroarilo opcionalmente sustituido, un grupo alcoxi de C1-C6 opcionalmente sustituido o -NReRf; Ar1 representa un anillo de hidrocarburo aromatico opcionalmente sustituido o un anillo heterociclico aromatico opcionalmente 1 -sustituido; Q representa -(CH2)m-(L)p o -(L)p(CH2)m-; m representa un entero de 0-2; n representa 1 y 2; p representa O o 1; L representa -O-, -S- o -NR5- y A representa un grupo arilo opcionalmente sustituido o un grupo heteroarilo opcionalmente sustituido); tambien se describe un profarmaco de dicho compuesto, una sal farmaceuticamente aceptable de ellos, un producto farmaceutico o composicion farmaceutica que contiene dicho compuesto, y similares.
CR9314A 2005-01-28 2007-08-15 Derivado de espirocetal y uso del mismo como medicina para la diabetes CR9314A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005020901 2005-01-28
JP2005176690 2005-06-16

Publications (1)

Publication Number Publication Date
CR9314A true CR9314A (es) 2007-10-04

Family

ID=36740445

Family Applications (1)

Application Number Title Priority Date Filing Date
CR9314A CR9314A (es) 2005-01-28 2007-08-15 Derivado de espirocetal y uso del mismo como medicina para la diabetes

Country Status (23)

Country Link
US (1) US7767651B2 (es)
EP (2) EP1852439B1 (es)
JP (1) JP4093587B2 (es)
KR (2) KR101322980B1 (es)
AR (1) AR054612A1 (es)
AU (1) AU2006209523B2 (es)
BR (1) BRPI0606367B1 (es)
CA (1) CA2596235C (es)
CR (1) CR9314A (es)
DK (1) DK1852439T3 (es)
ES (1) ES2567439T3 (es)
HR (1) HRP20160333T1 (es)
HU (1) HUE027078T2 (es)
IL (1) IL184838A (es)
MA (1) MA29272B1 (es)
MY (1) MY140528A (es)
NO (1) NO341263B1 (es)
NZ (1) NZ556343A (es)
PL (1) PL1852439T3 (es)
RU (1) RU2416617C2 (es)
SI (1) SI1852439T1 (es)
TW (1) TW200637869A (es)
WO (1) WO2006080421A1 (es)

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NO20074310L (no) 2007-10-29
IL184838A (en) 2012-02-29
DK1852439T3 (en) 2016-05-02
CA2596235A1 (en) 2006-08-03
AR054612A1 (es) 2007-07-04
CA2596235C (en) 2014-09-16
EP1852439B1 (en) 2016-03-23
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JPWO2006080421A1 (ja) 2008-06-19
US20090030006A1 (en) 2009-01-29
EP1852439A4 (en) 2010-01-13
KR20130102648A (ko) 2013-09-17
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BRPI0606367B1 (pt) 2023-03-21
HRP20160333T1 (hr) 2016-05-06
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US7767651B2 (en) 2010-08-03
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