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CN1596256A - 左氧氟沙星的纯化方法 - Google Patents

左氧氟沙星的纯化方法 Download PDF

Info

Publication number
CN1596256A
CN1596256A CNA028236440A CN02823644A CN1596256A CN 1596256 A CN1596256 A CN 1596256A CN A028236440 A CNA028236440 A CN A028236440A CN 02823644 A CN02823644 A CN 02823644A CN 1596256 A CN1596256 A CN 1596256A
Authority
CN
China
Prior art keywords
levofloxacin
described method
solvent
purifying
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA028236440A
Other languages
English (en)
Chinese (zh)
Inventor
V·尼丹-希尔德谢姆
N·格尔雄
E·施瓦茨
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Original Assignee
Teva Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/263,192 external-priority patent/US7629458B2/en
Application filed by Teva Pharmaceutical Industries Ltd filed Critical Teva Pharmaceutical Industries Ltd
Publication of CN1596256A publication Critical patent/CN1596256A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Epoxy Compounds (AREA)
CNA028236440A 2001-11-29 2002-11-27 左氧氟沙星的纯化方法 Pending CN1596256A (zh)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US33431601P 2001-11-29 2001-11-29
US60/334,316 2001-11-29
US35493902P 2002-02-11 2002-02-11
US60/354,939 2002-02-11
US26296502A 2002-10-03 2002-10-03
US10/262,965 2002-10-03
US10/263,192 2002-10-03
US10/263,192 US7629458B2 (en) 2001-10-03 2002-10-03 Preparation of levofloxacin and hemihydrate thereof

Publications (1)

Publication Number Publication Date
CN1596256A true CN1596256A (zh) 2005-03-16

Family

ID=31892240

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA028236440A Pending CN1596256A (zh) 2001-11-29 2002-11-27 左氧氟沙星的纯化方法

Country Status (13)

Country Link
EP (1) EP1460997A4 (is)
JP (3) JP2005527484A (is)
CN (1) CN1596256A (is)
AU (1) AU2002365416A1 (is)
CA (1) CA2466860A1 (is)
HR (1) HRP20040546A2 (is)
HU (1) HUP0500285A3 (is)
IL (1) IL162172A0 (is)
IS (1) IS7288A (is)
MX (1) MXPA04005196A (is)
NO (1) NO20042731L (is)
PL (1) PL374558A1 (is)
WO (1) WO2003045329A2 (is)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1321121C (zh) * 2005-04-21 2007-06-13 浙江医药股份有限公司新昌制药厂 左氧氟沙星制备及后处理方法
CN102070650A (zh) * 2011-01-28 2011-05-25 山东省药品检验所 左氧氟沙星-n-氧化物的制备方法
CN105823851A (zh) * 2015-12-15 2016-08-03 浙江海洋学院 一种检测海水中氧氟沙星对映体的方法
CN108218892A (zh) * 2018-03-16 2018-06-29 乐山职业技术学院 一种左氧氟沙星的纯化方法
CN112174981A (zh) * 2020-11-03 2021-01-05 深圳市祥根生物科技有限公司 一种左氧氟沙星脱氟杂质的制备方法
CN114507242A (zh) * 2022-01-26 2022-05-17 上虞京新药业有限公司 高光学纯度左氧氟沙星的制备方法

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2272781T5 (es) 2001-10-03 2010-04-06 Teva Pharmaceutical Industries Ltd. Preparacion de levofloxacino hemihidratado.
CN1735620A (zh) * 2002-12-16 2006-02-15 兰贝克赛实验室有限公司 纯的左氧氟沙星半水合物和它的制备方法
KR100704641B1 (ko) * 2004-07-21 2007-04-06 주식회사유한양행 고순도의 레보플록사신 제조방법
JP2006273718A (ja) * 2005-03-28 2006-10-12 Shiono Chemical Co Ltd レボフロキサシン・１／２水和物の製法
US7964723B2 (en) 2008-08-02 2011-06-21 Apeloa-Kangyu And practical process for exclusively producing (S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido-[1,2,3,de][1,4]benzoxazine-6-carboxylic acid hemihydrate
US20120251685A1 (en) * 2011-04-04 2012-10-04 Martek Biosciences Corporation Oil-in-Water Emulsions Comprising a Polyunsaturated Fatty Acid and Methods of Making the Same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO166131C (no) * 1985-06-20 1991-06-05 Daiichi Seiyaku Co Analogifremgangsmaate for fremstilling av s(-)-pyridobenzoksazinforbindelser.
US5237060A (en) * 1985-12-10 1993-08-17 Bayer Aktiengesellschaft Process of preparing enantiomerically pure 1,8-bridged 4-quinolone-3-carboxylic acids
TW208013B (is) * 1990-03-01 1993-06-21 Daiichi Co Ltd
JPH07501835A (ja) * 1992-10-07 1995-02-23 デリバドス・デル・エチロ・ソシエダッド・アノニマ オフロキサジン，レボフロキサジン及び誘導体の合成に使用されるベンゾキサジンの製造法
KR0125115B1 (ko) * 1994-03-22 1997-12-05 김은영 (-)피페라진 벤즈옥사진 유도체의 제조방법
KR100309871B1 (ko) * 1999-02-24 2001-10-29 윤종용 (-)피리도벤즈옥사진 카르복실산 유도체의 제조방법
ES2272781T5 (es) * 2001-10-03 2010-04-06 Teva Pharmaceutical Industries Ltd. Preparacion de levofloxacino hemihidratado.

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1321121C (zh) * 2005-04-21 2007-06-13 浙江医药股份有限公司新昌制药厂 左氧氟沙星制备及后处理方法
CN102070650A (zh) * 2011-01-28 2011-05-25 山东省药品检验所 左氧氟沙星-n-氧化物的制备方法
CN102070650B (zh) * 2011-01-28 2012-06-27 山东省药品检验所 左氧氟沙星-n-氧化物的制备方法
CN105823851A (zh) * 2015-12-15 2016-08-03 浙江海洋学院 一种检测海水中氧氟沙星对映体的方法
CN108218892A (zh) * 2018-03-16 2018-06-29 乐山职业技术学院 一种左氧氟沙星的纯化方法
CN112174981A (zh) * 2020-11-03 2021-01-05 深圳市祥根生物科技有限公司 一种左氧氟沙星脱氟杂质的制备方法
CN114507242A (zh) * 2022-01-26 2022-05-17 上虞京新药业有限公司 高光学纯度左氧氟沙星的制备方法

Also Published As

Publication number Publication date
JP2006219496A (ja) 2006-08-24
WO2003045329A3 (en) 2004-02-19
HRP20040546A2 (en) 2004-10-31
NO20042731L (no) 2004-06-29
CA2466860A1 (en) 2003-06-05
EP1460997A4 (en) 2005-06-15
AU2002365416A1 (en) 2003-06-10
IS7288A (is) 2004-06-21
HUP0500285A2 (hu) 2005-06-28
IL162172A0 (en) 2005-11-20
JP2005527484A (ja) 2005-09-15
MXPA04005196A (es) 2005-11-23
HUP0500285A3 (en) 2009-03-30
PL374558A1 (en) 2005-10-31
JP2008007517A (ja) 2008-01-17
EP1460997A2 (en) 2004-09-29
WO2003045329A2 (en) 2003-06-05

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