HUP0500285A3 - Methods for the purification of levofloxacin - Google Patents

Methods for the purification of levofloxacin

Info

Publication number: HUP0500285A3
Authority: HU; Hungary
Prior art keywords: levofloxacin; purification; methods
Prior art date: 2001-11-29

Application number

HU0500285A

Other languages

Hungarian (hu)

Original Assignee

Teva Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-11-29

Filing date

2002-11-27

Publication date

2009-03-30

2002-10-03 Priority claimed from US10/263,192 external-priority patent/US7629458B2/en

2002-11-27 Application filed by Teva Pharma filed Critical Teva Pharma

2005-06-28 Publication of HUP0500285A2 publication Critical patent/HUP0500285A2/en

2009-03-30 Publication of HUP0500285A3 publication Critical patent/HUP0500285A3/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Epoxy Compounds (AREA)

HU0500285A 2001-11-29 2002-11-27 Methods for the purification of levofloxacin HUP0500285A3 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US33431601P	2001-11-29	2001-11-29
US35493902P	2002-02-11	2002-02-11
US26296502A	2002-10-03	2002-10-03
US10/263,192 US7629458B2 (en)	2001-10-03	2002-10-03	Preparation of levofloxacin and hemihydrate thereof
PCT/US2002/038182 WO2003045329A2 (en)	2001-11-29	2002-11-27	Methods for the purification of levofloxacin

Publications (2)

Publication Number	Publication Date
HUP0500285A2 HUP0500285A2 (en)	2005-06-28
HUP0500285A3 true HUP0500285A3 (en)	2009-03-30

Family

ID=31892240

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU0500285A HUP0500285A3 (en)	2001-11-29	2002-11-27	Methods for the purification of levofloxacin

Country Status (13)

Country	Link
EP (1)	EP1460997A4 (en)
JP (3)	JP2005527484A (en)
CN (1)	CN1596256A (en)
AU (1)	AU2002365416A1 (en)
CA (1)	CA2466860A1 (en)
HR (1)	HRP20040546A2 (en)
HU (1)	HUP0500285A3 (en)
IL (1)	IL162172A0 (en)
IS (1)	IS7288A (en)
MX (1)	MXPA04005196A (en)
NO (1)	NO20042731L (en)
PL (1)	PL374558A1 (en)
WO (1)	WO2003045329A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2003028665A2 (en)	2001-10-03	2003-04-10	Teva Pharmaceutical Industries Ltd.	Methods for the purification of levofloxacin
CN1735620A (en) *	2002-12-16	2006-02-15	兰贝克赛实验室有限公司	Pure levofloxacin hemihydrate and its preparation method
KR100704641B1 (en) *	2004-07-21	2007-04-06	주식회사유한양행	High purity levofloxacin production method
JP2006273718A (en) *	2005-03-28	2006-10-12	Shiono Chemical Co Ltd	Method for producing levofloxacin-1/2 hydrate
CN1321121C (en) *	2005-04-21	2007-06-13	浙江医药股份有限公司新昌制药厂	Preparation and post-treatment method of levofloxacin
US7964723B2 (en) *	2008-08-02	2011-06-21	Apeloa-Kangyu	And practical process for exclusively producing (S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido-[1,2,3,de][1,4]benzoxazine-6-carboxylic acid hemihydrate
CN102070650B (en) *	2011-01-28	2012-06-27	山东省药品检验所	Preparation method for levofloxacin-N-oxide
US20120251685A1 (en) *	2011-04-04	2012-10-04	Martek Biosciences Corporation	Oil-in-Water Emulsions Comprising a Polyunsaturated Fatty Acid and Methods of Making the Same
CN105823851A (en) *	2015-12-15	2016-08-03	浙江海洋学院	A method for detecting ofloxacin enantiomers in seawater
CN108218892A (en) *	2018-03-16	2018-06-29	乐山职业技术学院	A kind of purification process of lavo-ofloxacin
CN112174981A (en) *	2020-11-03	2021-01-05	深圳市祥根生物科技有限公司	A kind of preparation method of levofloxacin defluorination impurity
CN114507242B (en) *	2022-01-26	2023-05-19	上虞京新药业有限公司	Preparation method of levofloxacin with high optical purity

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NO166131C (en) *	1985-06-20	1991-06-05	Daiichi Seiyaku Co	ANALOGUE PROCEDURE FOR THE PREPARATION OF S (-) - PYRIDOBENZOKSAZINE COMPOUNDS.
US5237060A (en) *	1985-12-10	1993-08-17	Bayer Aktiengesellschaft	Process of preparing enantiomerically pure 1,8-bridged 4-quinolone-3-carboxylic acids
TW208013B (en) *	1990-03-01	1993-06-21	Daiichi Co Ltd
KR0131914B1 (en) *	1992-10-07	1998-04-17	조아퀸 가리데 센트멘나트	Process for obtaining benzoxanines useful for the synthesis of ofloxacin, levofloxacin and derivatives and derivatives thereof
KR0125115B1 (en) *	1994-03-22	1997-12-05	김은영	Method for preparing (-) piperazine benzoxazine derivative
KR100309871B1 (en) *	1999-02-24	2001-10-29	윤종용	Process for Preparing (-)Pyridobenzoxazine Carboxylic Acid Derivatives
WO2003028665A2 (en) *	2001-10-03	2003-04-10	Teva Pharmaceutical Industries Ltd.	Methods for the purification of levofloxacin

2002
- 2002-11-27 PL PL02374558A patent/PL374558A1/en not_active Application Discontinuation
- 2002-11-27 AU AU2002365416A patent/AU2002365416A1/en not_active Abandoned
- 2002-11-27 IL IL16217202A patent/IL162172A0/en unknown
- 2002-11-27 WO PCT/US2002/038182 patent/WO2003045329A2/en not_active Ceased
- 2002-11-27 HR HR20040546A patent/HRP20040546A2/en not_active Application Discontinuation
- 2002-11-27 CN CNA028236440A patent/CN1596256A/en active Pending
- 2002-11-27 EP EP02791339A patent/EP1460997A4/en not_active Withdrawn
- 2002-11-27 CA CA002466860A patent/CA2466860A1/en not_active Abandoned
- 2002-11-27 MX MXPA04005196A patent/MXPA04005196A/en not_active Application Discontinuation
- 2002-11-27 HU HU0500285A patent/HUP0500285A3/en unknown
- 2002-11-27 JP JP2003546834A patent/JP2005527484A/en active Pending
2004
- 2004-05-27 IS IS7288A patent/IS7288A/en unknown
- 2004-06-29 NO NO20042731A patent/NO20042731L/en not_active Application Discontinuation
2006
- 2006-05-01 JP JP2006127862A patent/JP2006219496A/en not_active Withdrawn
2007
- 2007-08-22 JP JP2007216178A patent/JP2008007517A/en active Pending

Also Published As

Publication number	Publication date
IS7288A (en)	2004-06-21
EP1460997A2 (en)	2004-09-29
EP1460997A4 (en)	2005-06-15
PL374558A1 (en)	2005-10-31
WO2003045329A3 (en)	2004-02-19
NO20042731L (en)	2004-06-29
AU2002365416A1 (en)	2003-06-10
JP2006219496A (en)	2006-08-24
JP2005527484A (en)	2005-09-15
IL162172A0 (en)	2005-11-20
WO2003045329A2 (en)	2003-06-05
HRP20040546A2 (en)	2004-10-31
MXPA04005196A (en)	2005-11-23
JP2008007517A (en)	2008-01-17
CN1596256A (en)	2005-03-16
HUP0500285A2 (en)	2005-06-28
CA2466860A1 (en)	2003-06-05

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AU2002325755A1 (en)	2003-04-01	Methods and apparatuses for purification
IL143106A (en)	2005-11-20	Process for the preparation of diphenylmethylthioacetamide
HUP0401600A3 (en)	2008-05-28	Process for the preparation of 14-hydroxymorphine derivatives
IL162172A0 (en)	2005-11-20	Methods for the purification of levofloxacin
SI1697383T1 (en)	2014-09-30	Process for the purification of tacrolimus
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GB0209222D0 (en)	2002-06-05	Purification process
GB0123145D0 (en)	2001-11-14	Apparatus for the purification of water
PL373627A1 (en)	2005-09-05	Process for the preparation of melamine
PL371583A1 (en)	2005-06-27	Process for the preparation of 7alpha-methylsteroids
HUP0303025A3 (en)	2012-01-30	Process for the preparation of arylethanoldiamines
PT1698338E (en)	2008-06-03	S-methyl-dihydro-ziprasidone for the treatment of schizophrenia
GB0113300D0 (en)	2001-07-25	Purification process
SG111997A1 (en)	2005-06-29	Improved process for the preparation of polyalkylphenoxyaminoalkanes
IL164788A0 (en)	2005-12-18	Process for the preparation of 3-isochromanone
AU2002366004A1 (en)	2003-06-10	Process for the purification of contaminated oils
GB0116022D0 (en)	2001-08-22	Purification process
IL159508A0 (en)	2004-06-01	Apparatus for the purification of water
PL368905A1 (en)	2005-04-04	Process for the preparation of beta-ionylideneacetaldehyde
AU2003248597A1 (en)	2003-09-16	The purification of 2-methoxy-5-trifluoromethoxybenzaldehyde
SI1395580T1 (en)	2005-04-30	Method for the purification of triazolylmethylepoxides
AU2002316900A1 (en)	2002-12-03	Method for the purification of triazolylmethylepoxides

Legal Events

Date	Code	Title	Description
2009-11-30	FA9A	Lapse of provisional patent protection due to relinquishment or protection considered relinquished