CN1375280A - Micron level Chinese medicine granule and its prepn. - Google Patents
Micron level Chinese medicine granule and its prepn. Download PDFInfo
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- CN1375280A CN1375280A CN 01106564 CN01106564A CN1375280A CN 1375280 A CN1375280 A CN 1375280A CN 01106564 CN01106564 CN 01106564 CN 01106564 A CN01106564 A CN 01106564A CN 1375280 A CN1375280 A CN 1375280A
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- 239000003814 drug Substances 0.000 title claims abstract description 156
- 239000008187 granular material Substances 0.000 title claims abstract description 103
- 238000000034 method Methods 0.000 claims abstract description 88
- 239000000203 mixture Substances 0.000 claims abstract description 77
- 238000002156 mixing Methods 0.000 claims abstract description 19
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Chemical compound OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract description 18
- 239000000126 substance Substances 0.000 claims abstract description 11
- 239000000284 extract Substances 0.000 claims description 73
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- 238000002360 preparation method Methods 0.000 claims description 39
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- 238000010298 pulverizing process Methods 0.000 claims description 30
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 23
- 239000008101 lactose Substances 0.000 claims description 16
- 229920002472 Starch Polymers 0.000 claims description 15
- 239000008107 starch Substances 0.000 claims description 15
- 235000019698 starch Nutrition 0.000 claims description 15
- 229920001353 Dextrin Polymers 0.000 claims description 14
- 239000004375 Dextrin Substances 0.000 claims description 14
- 235000019425 dextrin Nutrition 0.000 claims description 14
- 235000002917 Fraxinus ornus Nutrition 0.000 claims description 12
- 239000007921 spray Substances 0.000 claims description 12
- 238000011156 evaluation Methods 0.000 claims description 11
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- 238000003756 stirring Methods 0.000 claims description 9
- 238000000605 extraction Methods 0.000 claims description 6
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- 241001289435 Astragalus brachycalyx Species 0.000 claims 5
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000012567 medical material Substances 0.000 claims 1
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- 241000180649 Panax notoginseng Species 0.000 description 5
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Abstract
The present invention has opened a granular formulation of micron Chinese medicine and its preparing method to the public. The method is to identify, process and dry Chinese medicine crop or Chinese medicine compound firstly and then to grind them into granules as granularities of bigger than one micron but smaller than seventy five micron by ultrasound of ultramicro grinding method after they being preground or the medicinal effectiveness matters being picked up, at least to add milk sugar, to make granules according to spraying method via granule refinishing and general blending to obtain the final micron Chinese medicine granular formulation. The invented formulation can raise biological utilization rate and curative effect, keep substance basis of medicinal effectiveness, save resources of Chinese medicine crop and benefit to enhance the competitive force of Chinese medicine on the international medicine market.
Description
The present invention relates to Chinese medicine preparation and preparation method thereof, more specifically relate to micron Chinese medicine granule and preparation method thereof.
Chinese medicine and Chinese medicine preparation thereof are traditional rarities of the Chinese nation, for the prosperity of the Chinese nation has been made indelible contribution.Chinese medicine granules is a kind of of Chinese medicine preparation, is a kind of preparation of conventional Chinese medicine easily easy to carry and use.The following method of the general employing of the processing of existing Chinese medicine granules, at first carry out Chinese crude drug or herbal mixture evaluation, the process of preparing Chinese medicine, drying, carrying out conventional Chinese crude drug then pulverizes or extracts, or after extracting the active ingredient of herbal mixture, granulate by granulating process again, after granulate, total mixing, make granule.The granule that this processing mode is made, its weak point is that the effective ingredient availability of Chinese crude drug or herbal mixture is low, curative effect is not high, onset is slower, dose is big, the processing added value is low, be unfavorable for that Chinese medicine steps into international medical main flow market, and limited natural resources of Chinese medicinal materials is utilized insufficient, particularly unfortunate to the waste of some rare natural resources of Chinese medicinal materials.
The micron Chinese medicine granule is meant the granule made from micron Chinese medicine or micron herbal mixture or Chinese medicine micron extract or herbal mixture micron extract.
Micron Chinese medicine is meant that the Chinese crude drug granularity is greater than 1 micron and less than 75 microns Chinese crude drug ultramicro powder.
The micron herbal mixture is meant that its granularity of herbal mixture is greater than 1 micron and less than 75 microns herbal mixture ultramicro powder.
Chinese medicine micron extract is meant that the granularity of Chinese medicine through extracting the resulting extract of effective substance is greater than 1 micron and less than 75 microns Chinese medicine extract.
Herbal mixture micron extract is meant that the granularity of herbal mixture through extracting the resulting extract of effective substance is greater than 1 micron and less than 75 microns herbal mixture extract.
The objective of the invention is to make the micron Chinese medicine granule, and its preparation method is provided with micron Chinese medicine or micron herbal mixture or Chinese medicine micron extract or herbal mixture micron extract.The micron Chinese medicine granule can be improved the absorbance and the curative effect of Chinese medicine or herbal mixture effective substance, reduces dose, and improves the Chinese traditional medicine biology availability, saves Chinese material medicine resource.
In order to achieve the above object, the present invention makes the micron Chinese medicine granule with micron Chinese medicine or micron herbal mixture or Chinese medicine micron extract or herbal mixture micron extract, and its preparation method adopts following technical scheme:
Choose Chinese crude drug or herbal mixture, earlier through evaluation, the process of preparing Chinese medicine, drying, then it is ground into micron Chinese medicine or micron herbal mixture or after extracting effective substance, is ground into Chinese medicine micron extract or herbal mixture micron extract, make the micron Chinese medicine granule through granulation, granulate, total mixing again.
The present invention compared with prior art has following advantage:
1, since the granularity of micron Chinese medicine or micron herbal mixture or Chinese medicine micron extract or herbal mixture micron extract greater than 1 micron and less than 75 microns, particle diameter does not relate to the aspect of atom and molecular structure in this scope, so do not influence the original Chinese medicine attribute of effective substance, pharmacodynamic properties substantially and cure mainly function, but this particle size range can make most of crude drug cell breaking cellular walls, therefore, the micron Chinese medicine granule can improve bioavailability.
2, the diffusion rate of release owing to solid drugs is directly proportional with its area, and the granularity of micron Chinese medicine or micron herbal mixture or Chinese medicine micron extract or herbal mixture micron extract is significantly smaller than existing Chinese crude drug and Chinese medicine extract, thereby its surface area and drug solubility have been increased greatly, therefore, after the micron Chinese medicine granule made from micron Chinese medicine or micron herbal mixture or Chinese medicine micron extract or herbal mixture micron extract is taken, more convenient and rapid in the intravital absorption of people, can improve clinical therapeutic efficacy effectively.
3, because of of the raising of micron Chinese medicine granule than Chinese medicine granule effective substance availability, can reduce the use amount of Chinese crude drug, extenuate growing Chinese crude drug demand and the contradiction between tight market and resource, limited Chinese material medicine resource is utilized fully.
4, because the micron Chinese medicine granule has above advantage, can improve the surcharge of Chinese crude drug greatly, make commensurability Chinese material medicine resource obtain better economic benefit.
5, same drug effect, the micron Chinese medicine granule is compared with the Chinese medicine granule can reduce dose, thereby more easily accepted by people, and the competitiveness of Chinese medicine in the international market improved in the easier international market that enters.
Fig. 1 is the block diagram of micron Chinese medicine process for producing granula of the present invention.
Do further according to the preparation method of accompanying drawing to micron level Chinese medicine granule of the present invention below Explanation.
Micron level Chinese medicine granule of the present invention has following 5 kinds of preparation methods, is now narrated respectively.
First kind of preparation method:
1, the evaluation of Chinese medicine or herbal mixture is in order to confirm the true of Chinese medicine or herbal mixture Puppet and quality;
2, the process of preparing Chinese medicine is to concoct by the concocting method of traditional Chinese medicine;
3, drying is that Chinese medicine or herbal mixture after concocting are carried out drying;
4, precomminution is to Chinese medicine or herbal mixture powder after processing through the above method Broken machine is pulverized, and makes its granularity reach 76 microns to 800 microns;
5, ultramicro grinding be with air-flow crushing, ball mill grinding, vibration pulverizing, Ultrasonic Pulverization, Stir to pulverize, one of them breaking method or two kinds of breaking methods wherein of centrifugal pulverizing In conjunction with, Chinese medicine or herbal mixture are made granularity greater than 1 micron and little less than 75 microns Rice Chinese medicine or micron herbal mixture;
6, granulate be with above-mentioned micron Chinese medicine or a micron herbal mixture add lactose or C6H14O6 and Starch or dextrin are made with broken granulation or spraying granulation method or fluidized bed prilling method or stirring The grain method is granulated;
7, whole grain, always mixed granulation agent all are to be undertaken by traditional handicraft.
The second preparation method:
1, Chinese medicine or herbal mixture identify it is in order to confirm the true and false of Chinese medicine or herbal mixture And quality;
2, the process of preparing Chinese medicine is to concoct by the concocting method of traditional Chinese medicine;
3, drying is that Chinese medicine or herbal mixture after concocting are carried out drying;
4, precomminution is that Chinese crude drug or herbal mixture after handling through the above method are pulverized with pulverizer, makes its granularity reach 76 microns to 800 microns;
5, extract be to the Chinese medicine after the precomminution or herbal mixture by adding the solvent-water or the ethanol of 4～10 times of its weight, adopt infusion process or percolation or circumfluence method or extraction to extract the effective substance of Chinese crude drug or herbal mixture;
6, be condensed into clear paste or thick paste, relative density is 1.2-1.6, drying;
7, micronizing be with comminution by gas stream, ball mill pulverizing, vibrant pulverization, Ultrasonic Pulverization, stirring pulverize, one of them breaking method or the wherein combination of two kinds of breaking methods of centrifugal pulverizing, Chinese crude drug extract or herbal mixture extract are made granularity greater than 1 micron and less than 75 microns Chinese medicine micron extract or herbal mixture micron extract;
8, granulating is that above-mentioned Chinese crude drug or herbal mixture micron extract are added that lactose or manna alcohol and starch or dextrin are with broken granulation or spray granulation method or fluidized bed granulation or the granulation of stirring-granulating method;
9, granulate, it is total mixed that to make granule all be to be undertaken by traditional handicraft.
The third preparation method:
1, the evaluation of Chinese crude drug or herbal mixture is the true and false and the quality in order to confirm Chinese crude drug or herbal mixture;
2, the process of preparing Chinese medicine is to concoct by the concocting method of traditional Chinese crude drug;
3, drying is that Chinese medicine or herbal mixture after concocting are carried out drying;
4, extract be to Chinese crude drug or herbal mixture by adding the solvent-water or the ethanol of 4～10 times of its weight, adopt infusion process or percolation or circumfluence method or extraction to extract the effective substance of Chinese crude drug or herbal mixture.
5, be condensed into clear paste or thick paste, relative density is 1.2-1.6, drying;
6, micronizing be with comminution by gas stream, ball mill pulverizing, vibrant pulverization, Ultrasonic Pulverization, stirring pulverize, one of them breaking method or the wherein combination of two kinds of breaking methods of centrifugal pulverizing, Chinese crude drug extract or herbal mixture extract are made granularity greater than 1 micron and less than 75 microns Chinese medicine micron extract and herbal mixture micron extract;
7, granulating is that above-mentioned Chinese medicine micron extract or herbal mixture micron extract are added that lactose or manna alcohol and starch or dextrin are with broken granulation or spray granulation method or fluidized bed granulation or the granulation of stirring-granulating method;
8, granulate, it is total mixed that to make granule all be to be undertaken by traditional handicraft.
The 4th kind of preparation method:
1, the evaluation of Chinese crude drug or herbal mixture is the true and false and the quality in order to confirm Chinese crude drug or herbal mixture;
2, the process of preparing Chinese medicine is to concoct by the concocting method of traditional Chinese crude drug;
3, drying is that Chinese medicine or herbal mixture after concocting are carried out drying;
4, precomminution is that Chinese crude drug or herbal mixture after handling through the above method are pulverized with pulverizer, and making its granularity is 800 microns to 76 microns;
5, supercritical fluid extraction is by medium-CO
2Or noble gas extracts, and obtains granularity greater than 1 micron and less than 75 microns Chinese medicine micron extract or herbal mixture micron extract;
6, granulating is that above-mentioned micron Chinese medicine or a micron herbal mixture are added that lactose or manna alcohol and starch or dextrin are with broken granulation or spray granulation method or fluidized bed granulation or the granulation of stirring-granulating method;
7, granulate, it is total mixed that to make granule all be to be undertaken by traditional handicraft.
The 5th kind of preparation method:
1, the evaluation of Chinese crude drug or herbal mixture is the true and false and the quality in order to confirm Chinese crude drug or herbal mixture;
2, the process of preparing Chinese medicine is to concoct by the concocting method of traditional Chinese crude drug;
3, drying is that Chinese medicine or herbal mixture after concocting are carried out drying;
4, supercritical fluid extraction is by medium-CO
2Or noble gas extracts, and obtains granularity greater than 1 micron and less than 75 microns Chinese medicine micron extract or herbal mixture micron extract;
5, granulating is that above-mentioned micron Chinese medicine or herbal mixture are added that lactose or manna alcohol and starch or dextrin are with broken granulation or spray granulation method or fluidized bed granulation or the granulation of stirring-granulating method;
6, granulate, it is total mixed that to make granule all be to be undertaken by traditional handicraft.
Embodiment 1
The preparation method of the instant indigowoad root granules of micron
1, identifies the true and false and the quality of Radix Isatidis; Get Radix Isatidis 500g;
2, concoct;
3, drying;
4, pulverize with pulverizer, make its granularity between 76 microns～800 microns;
5, adopt ball mill pulverizing, Radix Isatidis powder is broken into granularity greater than 1 micron and less than 75 microns ultramicro powder;
6, granulate with broken comminution granulation;
7, granulate, total mixing are made a micron indigowoad root granules.
Embodiment 2
The preparation method of micron Xuanmai Ganju granule
1, identifies the true and false and the quality of Radix Scrophulariae, Radix Ophiopogonis, Radix Platycodonis, Radix Glycyrrhizae; Get Radix Scrophulariae 400g, Radix Ophiopogonis 400g, Radix Platycodonis 400g, Radix Glycyrrhizae 400g;
2, concoct;
3, drying;
4, adding the 8000g hydromining extracts with infusion process;
5, being condensed into relative density is 1.32～1.35 thick paste, drying;
6, adopt Ultrasonic Pulverization, extract is ground into granularity greater than 1 micron and less than 75 microns extract;
7, Xuanmai Ganju micron extract is added lactose and starch, granulate with the stirring-granulating method;
8, granulate, total mixing are made a micron Xuanmai Ganju granule.
Embodiment 3
The preparation method of micron seven ingredient beard beautifying granule
1, identifies the true and false and the quality and the process of preparing Chinese medicine of Radix Polygoni Multiflori, Radix Angelicae Sinensis, Fructus Psoraleae, Fructus Lycii, Semen Cuscutae, Poria, Radix Achyranthis Bidentatae; Get Radix Polygoni Multiflori 640g, Radix Angelicae Sinensis 160g, Fructus Psoraleae (stir-fry) 160g, Fructus Lycii 160g, Semen Cuscutae (stir-fry) 160g, Poria 160g, Radix Achyranthis Bidentatae 160g;
2, drying;
3, adding 8000g ethanol adopts circumfluence method to extract;
4, be condensed into clear paste or thick paste, relative density is 1.2-1.6, drying;
5, adopt the method for comminution by gas stream, extract is ground into granularity greater than 1 micron and less than 75 microns extract;
6, seven ingredient beard beautifying micron extract is added lactose and dextrin, granulate with spray granulation;
7, granulate, total mixing are made a micron seven ingredient beard beautifying granule.
Embodiment 4
The preparation method of the sub-granule of micron XIANGSHALIUJUNZI
1, identifies the true and false and the quality and the process of preparing Chinese medicine of the Radix Aucklandiae, Fructus Amomi, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, the Rhizoma Pinelliae; Get Radix Aucklandiae 70g, Fructus Amomi 80g, Radix Codonopsis 100g, the Rhizoma Atractylodis Macrocephalae (stir-fry) 200g, Poria 200g, Radix Glycyrrhizae (processing) 70g, Pericarpium Citri Reticulatae 80g, Rhizoma Pinelliae (processed) 100g;
2, drying;
3, above-mentioned herbal mixture is ground into 76 microns～800 microns granule with pulverizer;
4, adding 6000g ethanol adopts percolation to extract;
5, be condensed into clear paste or thick paste, relative density is 1.2-1.6, drying;
6, adopt the method for vibrant pulverization, extract is ground into granularity greater than 1 micron and less than 75 microns extract;
7, the sub-micron of an XIANGSHALIUJUNZI extract is added the pure and mild starch of manna is with vulcanizing the granulation of bed comminution granulation;
8, granulate, total mixing are made the sub-granule of micron XIANGSHALIUJUNZI.
Embodiment 5
The preparation method of micron six drugs containing rehmanniae granule
1, identifies the true and false and the quality and the process of preparing Chinese medicine of Radix Rehmanniae Preparata, Fructus Corni, Cortex Moutan, Rhizoma Dioscoreae, Poria, Rhizoma Alismatis; Get Radix Rehmanniae Preparata 160g, Fructus Corni (system) 80g, Cortex Moutan 60g, Rhizoma Dioscoreae 80g, Poria 60g, Rhizoma Alismatis 60g;
2, drying;
3, above-mentioned herbal mixture is ground into 76 microns～800 microns granule with pulverizer;
4, with CO
2Make medium,, obtain granularity greater than 1 micron and less than 75 microns extract with supercritical fluid extraction extraction;
5, six drugs containing rehmanniae micron extract is added the pure and mild dextrin of manna, granulate with broken granulation;
6, granulate, total mixing are made a micron six drugs containing rehmanniae granule.
Embodiment 6
The preparation method of micron invigorating the spleen and replenishing QI granule
1, identifies the true and false and the quality and the process of preparing Chinese medicine of the Radix Astragali, Radix Codonopsis, Radix Glycyrrhizae, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Rhizoma Cimicifugae, Radix Bupleuri, Pericarpium Citri Reticulatae; Get the Radix Astragali (processing) 200g, Radix Codonopsis 60g, Radix Glycyrrhizae (processing) 100g, the Rhizoma Atractylodis Macrocephalae (stir-fry) 60g, Radix Angelicae Sinensis 60g, Rhizoma Cimicifugae 60g, Radix Bupleuri 60g, Pericarpium Citri Reticulatae 60g;
2, drying;
3, with CO
2Make medium,, obtain granularity greater than 1 micron and less than 75 microns extract with supercritical fluid extraction extraction;
4, invigorating the spleen and replenishing QI micron extract is added lactose and starch, granulate with stirring granulation;
5, granulate, total mixing are made a micron invigorating the spleen and replenishing QI granule.
Embodiment 7
The preparation method of micron five Siberian cocklebur granules
1, identifies the true and false and the quality and the process of preparing Chinese medicine of Poria, Rhizoma Alismatis, Polyporus, Cortex Cinnamomi, the Rhizoma Atractylodis Macrocephalae; Get Poria 60g, Rhizoma Alismatis 300g, Polyporus 180g, Cortex Cinnamomi 120g, the Rhizoma Atractylodis Macrocephalae (stir-fry) 180g;
2, drying;
3, with pulverizer above-mentioned herbal mixture is pulverized, made its granularity between 76 microns～800 microns;
4, the water that adds 8400g adopts infusion process to extract;
5, be condensed into clear paste or thick paste, relative density is 1.2-1.6, drying;
6, adopt the method for ball mill pulverizing and centrifugal pulverizing, extract is ground into granularity greater than 1 micron and less than 75 microns extract;
7, five Siberian cocklebur micron extracts are added lactose and starch are with vulcanizing the granulation of bed comminution granulation;
8, granulate, total mixing are made micron five Siberian cocklebur granules.
Embodiment 8
Micron is returned the preparation method of spleen granule
1, identifies the true and false and the quality and the process of preparing Chinese medicine of Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, Radix Glycyrrhizae, Poria, Radix Polygalae, Semen Ziziphi Spinosae, Arillus Longan, Radix Angelicae Sinensis, the Radix Aucklandiae, Fructus Jujubae; Get Radix Codonopsis 80g, the Rhizoma Atractylodis Macrocephalae (stir-fry) 160g, the Radix Astragali (processing) 80g, Radix Glycyrrhizae (processing) 40g, Poria 160g, Radix Polygalae (system) 160g, Semen Ziziphi Spinosae (stir-fry) 80g, Arillus Longan 160g, Radix Angelicae Sinensis 160g, Radix Aucklandiae 40g, Fructus Jujubae (enucleation) 40g;
2, drying;
3, with pulverizer above-mentioned herbal mixture is pulverized, made its granularity between 76 microns～800 microns;
4, the water that adds 6000g adopts circumfluence method to extract;
5, be condensed into clear paste or thick paste, relative density is 1.2-1.6, drying;
6, adopt to stir pulverize the method that gentle stream is pulverized, extract is ground into granularity greater than 1 micron and less than 75 microns extract;
7, will return spleen micron extract to add that the pure and mild dextrin of manna granulates with spray granulation;
8, granulate, total mixing are made micron and are returned the spleen granule.
Embodiment 9
The preparation method of the instant 'Sheng Mai ' powder of micron
1, identifies the true and false and the quality of Radix Ginseng, winter wheat, Fructus Schisandrae Chinensis; Get Radix Ginseng 100g, winter wheat 200g, Fructus Schisandrae Chinensis 100g;
2, concoct;
3, drying;
4, pulverize with pulverizer, make its granularity between 76 microns～800 microns;
5, adopt the method for vibrant pulverization, Radix Ginseng, winter wheat, Fructus Schisandrae Chinensis powder are broken into granularity greater than 1 micron and less than 75 microns ultramicro powder;
6, granulate with the stirring-granulating method;
7, granulate, total mixing are made the instant 'Sheng Mai ' powder of micron.
Embodiment 10
The preparation method of micron five tastes sea-buckthorn particle agent
1, identify that Fructus Hippophae height, the Radix Aucklandiae, Fructus Vins are done, the true and false and the quality of Radix Glycyrrhizae, Fructus Gardeniae; Get the high 180g of Fructus Hippophae, Radix Aucklandiae 150g, Fructus Vins dried 120g, Radix Glycyrrhizae 90g, Fructus Gardeniae 60g;
2, concoct;
3, drying;
4, the ethanol that adds 1800g adopts circumfluence method to extract;
5, being condensed into relative density is 1.20～1.50 clear paste, drying;
6, adopt the method for comminution by gas stream, extract is ground into granularity greater than 1 micron and less than 75 microns extract;
7, the micron extract of five tastes Fructus Hippophae adds that lactose and dextrin granulate with spray granulation;
8, granulate, total mixing are made a micron five tastes sea-buckthorn particle agent.
Embodiment 11
The preparation method of micron Granular notoginseng preparation
1, identifies the true and false and the quality of Radix Notoginseng; Get Radix Notoginseng 1000g;
2, concoct;
3, drying;
4, above-mentioned herbal mixture is ground into 76 microns～800 microns granule with pulverizer;
5, adopt the method for ball mill pulverizing, extract is ground into granularity greater than 1 micron and less than 75 microns granule;
6, Radix Notoginseng micron extract is added lactose and starch granulates with broken comminution granulation;
7, granulate, total mixing are made a micron Granular notoginseng preparation.
Claims (6)
1, a kind of micron Chinese medicine granule is the Chinese medicine granules of being made by Chinese crude drug or Chinese medicine extract, it is characterized in that, the micron Chinese medicine granule is to make with micron Chinese medicine or micron herbal mixture or Chinese medicine micron extract or herbal mixture micron extract.
2, a kind of preparation method that realizes the described micron Chinese medicine granule of claim 1 is characterized in that, this preparation method follows these steps to order and carries out:
A, medical material or herbal mixture evaluation, the process of preparing Chinese medicine, drying;
B, pulverize with pulverizer, making its granularity is 76 microns to 800 microns;
C, with comminution by gas stream, ball mill pulverizing, vibrant pulverization, Ultrasonic Pulverization, stirring pulverize, one of them breaking method or the wherein combination of two kinds of breaking methods of centrifugal pulverizing, make granularity greater than 1 micron and less than 75 microns granule;
D, add adjuvant: lactose or manna alcohol and starch or dextrin;
E, granulate with broken granulation or spray granulation method or fluidized bed granulation or stirring-granulating method;
F, granulate, total mixing are made the micron Chinese medicine granule.
3, a kind of preparation method that realizes the described micron Chinese medicine granule of claim 1 is characterized in that, this preparation method follows these steps to order and carries out:
The evaluation of a, Chinese crude drug or herbal mixture, the process of preparing Chinese medicine, drying;
B, pulverize with pulverizer, making its granularity is 76 microns to 800 microns;
C, add the solvent-water or the ethanol of 4～10 times of its weight;
D, employing infusion process or percolation or circumfluence method or extraction extract effective substance;
E, drying;
F, with comminution by gas stream, ball mill pulverizing, vibrant pulverization, Ultrasonic Pulverization, stirring pulverize, one of them breaking method or the wherein combination of two kinds of breaking methods of centrifugal pulverizing, make granularity greater than 1 micron and less than 75 microns granule;
G, add lactose or manna alcohol and starch or dextrin;
H, granulate with broken granulation or spray granulation method or fluidized bed granulation or stirring-granulating method;
I. granulate, total mixing are made the micron Chinese medicine granule.
4, a kind of preparation method that realizes the described micron Chinese medicine granule of claim 1 is characterized in that, this preparation method follows these steps to order and carries out:
The evaluation of a, Chinese crude drug or herbal mixture, the process of preparing Chinese medicine, drying;
B, add the solvent-water or the ethanol of 4～10 times of its weight;
C, employing infusion process or percolation or circumfluence method or extraction extract effective substance;
D, drying;
E, with comminution by gas stream, ball mill pulverizing, vibrant pulverization, Ultrasonic Pulverization, stirring pulverize, one of them breaking method or the wherein combination of two kinds of breaking methods of centrifugal pulverizing, make granularity greater than 1 micron and less than 75 microns granule;
F, add lactose or manna alcohol and starch or dextrin;
G, granulate with broken granulation or spray granulation method or fluidized bed granulation or stirring-granulating method;
H, granulate, total mixing are made the micron Chinese medicine granule.
5, a kind of preparation method that realizes the described micron Chinese medicine granule of claim 1 is characterized in that, this preparation method follows these steps to order and carries out:
The evaluation of a, Chinese crude drug or herbal mixture, the process of preparing Chinese medicine, drying;
B, pulverize with pulverizer, making its granularity is 76 microns to 800 microns;
C, by medium-CO
2Or noble gas carries out supercritical fluid extraction, obtains granularity greater than 1 micron and less than 75 microns Chinese crude drug or herbal mixture micron extract;
D, add lactose or manna alcohol and starch or dextrin;
E, granulate with broken granulation or spray granulation method or fluidized bed granulation or stirring-granulating method;
F, granulate, total mixing are made the micron Chinese medicine granule.
6, a kind of preparation method that realizes the described micron Chinese medicine granule of claim 1 is characterized in that, this preparation method follows these steps to order and carries out:
The evaluation of a, Chinese crude drug or herbal mixture, the process of preparing Chinese medicine, drying;
B, by medium-CO
2Or noble gas carries out supercritical fluid extraction, obtains granularity greater than 1 micron and less than 75 microns Chinese crude drug or herbal mixture micron extract;
C, add lactose or manna alcohol and starch or dextrin;
D, granulate with broken granulation or spray granulation method or fluidized bed granulation or stirring-granulating method;
E, granulate, total mixing are made the micron Chinese medicine granule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01106564 CN1375280A (en) | 2001-03-21 | 2001-03-21 | Micron level Chinese medicine granule and its prepn. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01106564 CN1375280A (en) | 2001-03-21 | 2001-03-21 | Micron level Chinese medicine granule and its prepn. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1375280A true CN1375280A (en) | 2002-10-23 |
Family
ID=4655557
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01106564 Pending CN1375280A (en) | 2001-03-21 | 2001-03-21 | Micron level Chinese medicine granule and its prepn. |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1375280A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107397158A (en) * | 2016-05-21 | 2017-11-28 | 广州今典精方医药科技有限公司 | The quality standard and manufacturing process of fruit of Chinese wolfberry breaking-wall cell powder |
| CN110898092A (en) * | 2019-11-25 | 2020-03-24 | 上海强德食品科技有限公司 | Liquid hemostatic and detumescence patch composition and preparation method thereof |
| CN119745961A (en) * | 2024-12-02 | 2025-04-04 | 苏州市中医医院 | External application ointment for treating short stature and preparation method thereof |
-
2001
- 2001-03-21 CN CN 01106564 patent/CN1375280A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107397158A (en) * | 2016-05-21 | 2017-11-28 | 广州今典精方医药科技有限公司 | The quality standard and manufacturing process of fruit of Chinese wolfberry breaking-wall cell powder |
| CN110898092A (en) * | 2019-11-25 | 2020-03-24 | 上海强德食品科技有限公司 | Liquid hemostatic and detumescence patch composition and preparation method thereof |
| CN119745961A (en) * | 2024-12-02 | 2025-04-04 | 苏州市中医医院 | External application ointment for treating short stature and preparation method thereof |
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