CN1267144C - Compound diabetes-treating sugar-decreasing fat-reducing preparation and preparation method thereof - Google Patents
Compound diabetes-treating sugar-decreasing fat-reducing preparation and preparation method thereof Download PDFInfo
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Abstract
一种复方消渴清糖降脂制剂及其制备方法。制剂由佩兰叶、天花粉、石斛、地骨皮、山药、玄参、天冬、麦冬、蔓荆子、菊花、地草果、黄柏、青箱子、密蒙花、栀子、知母、苍术、太子参、三七粉、丹参、白花蛇舌草、白茅根、茜草根、葛根、白僵蚕、谷精草、络石藤、大黄、柏子仁、乌梅肉、八仙草、芍药、炒麦芽、金银花、石决明、牡蛎、何首乌、当归、五味子、熟地黄、山萸肉、肉苁蓉、生黄芪、泽泻、牡丹皮、甘草、冰片和珍珠组成。本发明提供的复方消渴清糖降脂制剂为纯中药制剂，患者长期服用后不会产生毒副作用，不仅能治疗I、II型糖尿病，而且还能治疗由此而引发的眼底出血症、晶体混浊及视网膜充血等综合性眼病，总有效率达86%。A compound Xiaoke clearing sugar and lipid-lowering preparation and a preparation method thereof. The preparation is composed of peylan leaves, trichosanthum powder, dendrobium, digupi, yam, scrophulariaceae, asparagus, radix radix, vitex, chrysanthemum, chrysanthemum, phellodendron, green box, dense mongolia, gardenia, anemarrhena, atractylodes , Radix Pseudostellariae, Panax notoginseng powder, Salvia miltiorrhiza, Hedyotis diffusa, Imperata root, Rubia root, Pueraria radix, White silkworm, Gu Jingcao, Rhizoma vine, Rhubarb, Cypress kernel, Black plum meat, Hydrangea, Paeoniae officinalis, Roasted malt , honeysuckle, cassia, oyster, fleece-flower root, angelica, schisandra, rehmannia glutinosa, cornus, cistanche, raw astragalus, Alisma, peony bark, licorice, borneol and pearls. The compound Xiaoke Qingtang lipid-lowering preparation provided by the present invention is a pure Chinese medicine preparation, which will not produce toxic and side effects after long-term use by patients, and can not only treat type I and type II diabetes, but also treat fundus hemorrhage, crystal For comprehensive eye diseases such as turbidity and retinal congestion, the total effective rate is 86%.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of diabetes and preparation method thereof, particularly relate to a kind of treated diabetes that with Chinese medicine are raw material is made and reach compound diabetes-treating sugar-decreasing fat-reducing preparation of the comprehensive oculopathy that causes therefrom and preparation method thereof.
Background technology
Diabetes are a kind of chronic endocrine metabolism diseases, and it is absolute or relative deficiency or the carbohydrate metabolism disturbance that insulin insensitivity caused with peripheral tissues by insulin secretion, comprises the systemic disease that fat and protein metabolism disorder cause.At present, diabetes have become the chronic disease of the third-largest harm health of people after coronary heart disease and cancer, and patient's quantity rises year by year, its main clinical manifestation is polydipsia polyuria polyphagia, emaciated physique or urinates pleasantly sweet, and very easily cause multiple complications, wherein the diabetes complicated retinopathy that is caused by diabetes (being called for short retinal hemorrhage sugar net disease) is the most common, this disease is because retina neural has sugar to disturb, when the stasis of blood in the capillary tube long-pending too much when sugared and the ophthalmic that causes, be called for short sugared net, can cause at last losing one's sight.Treat diabetes at present clinically and adopt doctor trained in Western medicine and two kinds of methods of the traditional Chinese medical science more.As everyone knows, this chronic disease needs the patient to take medicine all the year round, because the side effect of Western medicine is bigger, so causes that the Liver and kidney poisoner is a lot of after taking Western medicine for a long time.In addition, though the Chinese medicine preparation of treatment diabetes has a hundred or so surplus kind on the market, but these medicines substantially all are the medicines for the treatment of diabetes merely, i.e. product one merit, thereby up to the present do not see the Chinese medicine preparation of any comprehensive oculopathy that can treat diabetes and cause therefrom as yet.
Summary of the invention
In order to address the above problem, the object of the present invention is to provide compound diabetes-treating sugar-decreasing fat-reducing preparation of a kind of comprehensive oculopathy that can treat I, type ii diabetes and cause therefrom and preparation method thereof.
In order to achieve the above object, compound diabetes-treating sugar-decreasing fat-reducing preparation provided by the invention is to make (consumption is a weight portion) by following drug component:
Folium Eupatorii 9-15 Radix Trichosanthis 9-12 Herba Dendrobii 9-20
Cortex Lycii 9-15 Rhizoma Dioscoreae 15-20 Radix Scrophulariae 9-15
Radix Asparagi 6-9 Fructus Viticis 10 Radix Ophiopogonis 9-12
Flos Chrysanthemi 9-15 Herba Violae mundae 10 Cortex Phellodendri 3-12
Semen Celosiae 9-12 Flos Buddlejae 9-12 Fructus Gardeniae 9-15
Rhizoma Anemarrhenae 9-15 Rhizoma Atractylodis 9-25 Radix Pseudostellariae 9-12
Radix Notoginseng powder 9-15 Radix Salviae Miltiorrhizae 9-20 Herba Hedyotidis Diffusae 9-15
Rhizoma Imperatae 12 Radix Rubiae 9-15 Radix Puerariae 9-25
Bombyx Batryticatus 4-9 Flos Eriocauli 9-25 Caulis Trachelospermi 15
Radix Et Rhizoma Rhei 3 Semen Platycladi 9 Fructus Mume 4.5-6
Herba Galii Teneri 5-15 Radix Paeoniae 9-20 Fructus Hordei Germinatus (parched) 4-15
Flos Lonicerae 10 Concha Haliotidis 15 Concha Ostreaes 15
Radix Polygoni Multiflori 15 Radix Angelicae Sinensis 10-30 Fructus Schisandrae Chinensis 9-12
Radix Rehmanniae Preparata 5-15 Fructus Corni 15 Herba Cistanches 9-15
Radix Astragali 9-15 Rhizoma Alismatis 15 Cortex Moutans 10
Radix Glycyrrhizae 9-15 Borneolum Syntheticum 0.3-0.8 Margarita 0.8-2.5
The preparation method of compound diabetes-treating sugar-decreasing fat-reducing preparation provided by the invention is to carry out according to the following step order:
1) at first, impurities in raw materials is removed, and crossed the 40-80 mesh sieve behind the pulverize separately;
2) then according to the said ratio weighing, and mix homogeneously;
3) be 25% and consumption is that the ethanol of 3 times of raw materials was with mixed raw material soaking 4 hours with concentration;
4) supernatant light impurities in the mixed liquor and the heavy impurity that sinks to the bottom are removed;
5) in the mixed liquor that keeps, add one times water and under 98-100 ℃ temperature, decocting, until the concentration that is concentrated to 85%;
6) dry then, grind, and cross the 60-80 mesh sieve;
7) make granule, tablet, capsule, syrup, oral liquid, pill and unguentum commonly used clinically according to the preparation technique of Chinese patent medicine routine at last.
Compound diabetes-treating sugar-decreasing fat-reducing preparation provided by the invention is a pure Chinese medicinal preparation, thereby the patient can not produce toxic and side effects after taking for a long time, not only can treat I, type ii diabetes, and can also prevent and treat and treat the comprehensive oculopathy such as retinal hemorrhage disease, lenticular opacity and retina hyperemia that cause therefrom, total effective rate reaches 86%, belongs to safe dosage form.In addition, preparation method technology of the present invention is simple, easy to operate.
The specific embodiment
The traditional Chinese medical science claims that diabetes are diabetes, and it can be divided into I, II type and 14 kinds of complication, comprises that mainly lung-heat Tianjin hinders the scorching with the passing of time type of type, intense stomach-heat type, kidney-yin deficiency type, type of deficiency of both QI and YIN, deficiency of both YIN and YANG type and yang deficiency.The basic pathogenesis of this disease is that the deficiency of YIN is this, red-hotly is mark, so clearing heat and moistening dryness, YIN nourishing and the production of body fluid promoting are the principle of treatment of primary disease.In compound diabetes-treating sugar-decreasing fat-reducing preparation provided by the invention, Fructus Gardeniae, the Rhizoma Anemarrhenae, Flos Lonicerae, Cortex Phellodendri, Radix Et Rhizoma Rhei are product on the clearing away lung-heat, can stand to be monarch drug.Because the primary symptom of diabetes is heat, full and large pulse, xerostomia hectic fever due to YIN-deficiency, night sweat sweating due to debility spontaneous perspiration oliguria with reddish urine, constipation etc. all come from lung-heat, the dryness of the lung and burn gold, and body fluid is burnt and is fried in shallow oil in the intestinal.This compound recipe utilizes Folium Eupatorii, Cortex Lycii, Radix Scrophulariae, Rhizoma Dioscoreae, the Radix Asparagi and Radix Ophiopogonis in the monarch drug to convert Radix Et Rhizoma Rhei again and plays and moisturize removing dampness, increase the effect that liquid is sailed a boat.Earlier logical the five internal organs peace six internal organs are held arcane truth, the nourishing the liver of purging heat of reuse ministerial drug Rhizoma Atractylodis, Radix Pseudostellariae, Radix Salviae Miltiorrhizae, Radix Paeoniae, Radix Rubiae, light imbibition is wet, Radix Astragali enriching spleen-QI, burnt heat during Fructus Hordei Germinatus (parched) is dived, Radix Angelicae Sinensis, the treating blood disorders of Radix Polygoni Multiflori hemopoietic, Herba Cistanches, Fructus Schisandrae Chinensis the kidney invigorating essence, each Guan Yifang of monarch, Lignum Aquilariae Resinatum, the Radix Aucklandiae have the effect of being amusing, and this compound recipe multiselect is with containing the wider Chinese herbal medicine of enzyme, for a long time clothes can the human activin islets of langerhans, makes insulin reach self-centered effect.Strong its few fire of Fructus Schisandrae Chinensis, Fructus Corni, pay rise at the bottom of the kitchen range on the one hand, solid gold is moisturized, and withered on the other hand cage steams humid, and the temperature male wind-supplying kidney astringency inducing gets rain as the original text standing grain, and business is reformed, and causes one thriving healthy energy, anxious fear of cold, two do not fear the dryness of the lung burns gold.Concha Haliotidis in this compound recipe, Semen Celosiae, Semen Cassiae, Fructus Viticis four son unifications, the cloud seeding nebula removing drives more to be caught up with secretly, can make people's order bright; The Radix Notoginseng powder stasis of blood hemostasis of invigorating blood circulation clearly, and be equipped with the defeated and healthy energy of Radix Salviae Miltiorrhizae, Radix Rubiae, Caulis Trachelospermi is winding to be taken the lead to dash secretly, the anti-two gusts of power that help four gentleman again of Fructus Viticis, the Bombyx Batryticatus inducing resuscitation, it is fine that Flos Eriocauli, Margarita are drawn the dragon point, its power battalion of many medicines defends the sterilizing powdered medicine transconversion into heat stasis of blood, Borneolum Syntheticum leads to nine orifices, and first weighing apparatus is decided blood glucose and other unstable factor, and second ophthalmics such as retinal hemorrhage disease, lenticular opacity and retina hyperemia that cause owing to diabetes for the mutual root of specimen can play good therapeutical effect.
Below in conjunction with specific embodiment compound diabetes-treating sugar-decreasing fat-reducing preparation of the present invention and preparation method thereof is elaborated.
The prescription of type diabetes is hindered in embodiment 1:(treatment lung-heat Tianjin, in weight portion)
Folium Eupatorii 15 Radix Trichosanthis 12 Herba Dendrobiis 20
Cortex Lycii 15 Rhizoma Dioscoreaes 20 Radix Scrophulariaes 15
Radix Asparagi Fructus Viticis 12 10 Radix Ophiopogonis 9
Flos Chrysanthemi 15 Herba Violae mundaes 10 Cortex Phellodendris 12
Semen Celosiae 12 Flos Buddlejaes 12 Fructus Gardeniaes 15
The Rhizoma Anemarrhenae 15 Rhizoma Atractylodis 25 Radix Pseudostellariaes 12
Radix Notoginseng powder 15 Radix Salviae Miltiorrhizaes 20 Herba Hedyotidis Diffusaes 15
Rhizoma Imperatae 12 Radix Rubiae 15 Radix Puerariaes 25
Bombyx Batryticatus 9 Flos Eriocaulis 25 Caulis Trachelospermis 15
Radix Et Rhizoma Rhei 3 Semen Platycladi 9 Fructus Mume 6
Herba Galii Teneri 15 Radix Paeoniaes 20 Fructus Hordei Germinatus (parched)s 15
Flos Lonicerae 10 Concha Haliotidis 15 Concha Ostreaes 15
Radix Polygoni Multiflori 15 Radix Angelicae Sinensis 30 Fructus Schisandrae Chinensis 12
Radix Rehmanniae Preparata 15 Fructus Corni 15 Herba Cistanches 15
Radix Astragali 15 Rhizoma Alismatis 15 Cortex Moutans 10
Radix Glycyrrhizae 15 Borneolum Syntheticums 0.8 Margarita 2.5
The preparation method of compound diabetes-treating sugar-decreasing fat-reducing preparation provided by the invention is to carry out according to the following step order:
1) at first, impurities in raw materials is removed, and crossed 80 mesh sieves behind the pulverize separately;
2) then according to the said ratio weighing, and mix homogeneously;
3) be 25% and consumption is that the ethanol of 3 times of raw materials was with mixed raw material soaking 4 hours with concentration;
4) supernatant light impurities in the mixed liquor and the heavy impurity that sinks to the bottom are removed;
5) in the mixed liquor that keeps, add one times water and under 100 ℃ temperature, decocting, until the concentration that is concentrated to 85%;
6) dry then, grind, and cross 60 mesh sieves;
7) make granule, tablet, capsule, syrup, oral liquid, pill and unguentum commonly used clinically according to the preparation technique of Chinese patent medicine routine at last.
The prescription of embodiment 2:(treatment intense stomach-heat type diabetes is in weight portion)
Folium Eupatorii 12 Radix Trichosanthis 10 Herba Dendrobiis 14
Cortex Lycii 12 Rhizoma Dioscoreaes 17 Radix Scrophulariaes 12
Radix Asparagi Fructus Viticis 10 10 Radix Ophiopogonis 7
Flos Chrysanthemi 12 Herba Violae mundaes 10 Cortex Phellodendris 7
Semen Celosiae 10 Flos Buddlejaes 10 Fructus Gardeniaes 12
The Rhizoma Anemarrhenae 12 Rhizoma Atractylodis 17 Radix Pseudostellariaes 10
Radix Notoginseng powder 12 Radix Salviae Miltiorrhizaes 14 Herba Hedyotidis Diffusaes 12
Rhizoma Imperatae 12 Radix Rubiae 12 Radix Puerariaes 17
Bombyx Batryticatus 7 Flos Eriocaulis 17 Caulis Trachelospermis 15
Radix Et Rhizoma Rhei 3 Semen Platycladi 9 Fructus Mume 5
Herba Galii Teneri 10 Radix Paeoniaes 14 Fructus Hordei Germinatus (parched)s 9
Flos Lonicerae 10 Concha Haliotidis 15 Concha Ostreaes 15
Radix Polygoni Multiflori 15 Radix Angelicae Sinensis 20 Fructus Schisandrae Chinensis 10
Radix Rehmanniae Preparata 10 Fructus Corni 15 Herba Cistanches 12
Radix Astragali 12 Rhizoma Alismatis 15 Cortex Moutans 10
Radix Glycyrrhizae 12 Borneolum Syntheticums 0.5 Margarita 1.7
Preparation method is with embodiment 1.
The prescription of embodiment 3:(treatment kidney-yin deficiency type diabetes is in weight portion)
Folium Eupatorii 15 Radix Trichosanthis 12 Herba Dendrobiis 15
Cortex Lycii 15 Rhizoma Dioscoreaes 15 Radix Scrophulariaes 12
Radix Asparagi Fructus Viticis 12 10 Radix Ophiopogonis 10
Flos Chrysanthemi 10 Herba Violae mundaes 10 Cortex Phellodendris 6
Semen Celosiae 12 Flos Buddlejaes 10 Fructus Gardeniaes 12
The Rhizoma Anemarrhenae 12 Rhizoma Atractylodis 15 Radix Pseudostellariaes 12
Radix Notoginseng powder 9 Radix Salviae Miltiorrhizaes 20 Herba Hedyotidis Diffusaes 15
Rhizoma Imperatae 12 Radix Rubiae 9 Radix Puerariaes 20
Bombyx Batryticatus 9 Flos Eriocaulis 12 Caulis Trachelospermis 15
Radix Et Rhizoma Rhei 3 Semen Platycladi 9 Fructus Mume 4.5
Herba Galii Teneri 9 Radix Paeoniaes 15 Fructus Hordei Germinatus (parched)s 15
Flos Lonicerae 10 Concha Haliotidis 15 Concha Ostreaes 15
Radix Polygoni Multiflori 15 Radix Angelicae Sinensis 18 Fructus Schisandrae Chinensis 12
Radix Rehmanniae Preparata 15 Fructus Corni 15 Herba Cistanches 12
Radix Astragali 10 Rhizoma Alismatis 15 Cortex Moutans 10
Radix Glycyrrhizae 15 Borneolum Syntheticums 0.3 Margarita 0.8
Preparation method is with embodiment 1.
The retina occupying lesion prescription that embodiment 4:(treatment is caused by diabetes is in weight portion)
Folium Eupatorii 9 Radix Trichosanthis 9 Herba Dendrobiis 9
Cortex Lycii 9 Rhizoma Dioscoreaes 15 Radix Scrophulariaes 9
Radix Asparagi Fructus Viticis 9 10 Radix Ophiopogonis 6
Flos Chrysanthemi 9 Herba Violae mundaes 10 Cortex Phellodendris 3
Semen Celosiae 9 Flos Buddlejaes 9 Fructus Gardeniaes 9
The Rhizoma Anemarrhenae 9 Rhizoma Atractylodis 9 Radix Pseudostellariaes 9
Radix Notoginseng powder 9 Radix Salviae Miltiorrhizaes 9 Herba Hedyotidis Diffusaes 9
Rhizoma Imperatae 12 Radix Rubiae 9 Radix Puerariaes 9
Bombyx Batryticatus 4 Flos Eriocaulis 9 Caulis Trachelospermis 15
Radix Et Rhizoma Rhei 3 Semen Platycladi 9 Fructus Mume 4.5
Herba Galii Teneri 5 Radix Paeoniaes 9 Fructus Hordei Germinatus (parched)s 4
Flos Lonicerae 10 Concha Haliotidis 15 Concha Ostreaes 15
Radix Polygoni Multiflori 15 Radix Angelicae Sinensis 10 Fructus Schisandrae Chinensis 9
Radix Rehmanniae Preparata 5 Fructus Corni 15 Herba Cistanches 9
Radix Astragali 9 Rhizoma Alismatis 15 Cortex Moutans 10
Radix Glycyrrhizae 9 Borneolum Syntheticums 0.3 Margarita 0.8
Preparation method is with embodiment 1.
The inventor can both reduce to secure digital with blood glucose after utilizing the sick general 12 doses of medicines of this compound treatment retinal hemorrhage retina sugar net, treats sugared net 15 examples (30 eyes) simultaneously, 13 eyes of fully recovering, 10 eyes of produce effects, 3 eyes that take a turn for the better, invalid 4 eyes, total effective rate is 86%.In addition, the inventor utilizes this compound treatment diabetics a lot of, and it is fabulous to produce effects.
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Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101601794B (en) * | 2008-06-13 | 2011-01-26 | 任淑君 | Traditional Chinese medicine preparation for reducing glucose and removing thirst |
| CN101757423B (en) * | 2008-10-24 | 2011-08-10 | 常州善美药物研究开发中心有限公司 | Traditional Chinese medicine composition for treating myocarditis and preparation method thereof |
| CN101904994B (en) * | 2010-07-16 | 2011-11-09 | 赵双全 | Chinese medicinal preparation for treating diabetes mellitus |
| CN102258709B (en) * | 2011-07-13 | 2012-08-29 | 贵阳中医学院第二附属医院 | Traditional Chinese medicine preparation for treating diabetic retinopathy, and preparation method thereof |
| CN102293941B (en) * | 2011-09-09 | 2013-03-27 | 刘晶 | Chinese medicinal composition for treating diabetes mellitus |
| CN102755530B (en) * | 2012-07-15 | 2013-12-25 | 王俊茹 | Traditional Chinese medicine composition for treating diabetic foot and application thereof |
| CN102836322B (en) * | 2012-09-07 | 2013-09-18 | 俞培良 | Chinese medicine for treating diabetes |
| CN102988723B (en) * | 2012-10-08 | 2014-02-26 | 黄传峰 | Preparation method and application of traditional Chinese medicine |
| CN102949598B (en) * | 2012-12-04 | 2014-04-16 | 曹法政 | Pill for alleviating diabetic symptoms and preparation method thereof |
| CN103385968A (en) * | 2013-07-19 | 2013-11-13 | 苏州市天灵中药饮片有限公司 | Traditional Chinese medicine containing pseudo-ginseng powder and preparation method thereof |
| CN103566349B (en) * | 2013-11-07 | 2016-02-24 | 陈晓娟 | A kind of pharmaceutical composition for the treatment of hyperglycemia hyperlipidemia |
| CN103623292B (en) * | 2013-12-24 | 2016-05-18 | 山东省中医药研究院 | A kind of Chinese medicine composition for the treatment of diabetes |
| CN108114201A (en) * | 2018-02-01 | 2018-06-05 | 重庆跃龙生物制药有限公司 | Chinese medicine composition for treating diabetes and its preparation method and application |
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