CN1368354A - Nano medicine 'Xinyi Biyan' and its preparing process - Google Patents
Nano medicine 'Xinyi Biyan' and its preparing process Download PDFInfo
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- CN1368354A CN1368354A CN 01103644 CN01103644A CN1368354A CN 1368354 A CN1368354 A CN 1368354A CN 01103644 CN01103644 CN 01103644 CN 01103644 A CN01103644 A CN 01103644A CN 1368354 A CN1368354 A CN 1368354A
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- 239000003814 drug Substances 0.000 title claims abstract description 43
- 238000000034 method Methods 0.000 title claims description 12
- 239000000463 material Substances 0.000 claims abstract description 20
- 239000000843 powder Substances 0.000 claims abstract description 11
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 17
- 241000628997 Flos Species 0.000 claims description 16
- 239000006187 pill Substances 0.000 claims description 9
- 240000006851 Duhaldea cappa Species 0.000 claims description 8
- 239000010231 banlangen Substances 0.000 claims description 8
- 239000009670 cang er zi wan Substances 0.000 claims description 8
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 claims description 8
- 239000002775 capsule Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000000284 extract Substances 0.000 claims description 5
- 239000002994 raw material Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 235000014435 Mentha Nutrition 0.000 claims description 4
- 241001072983 Mentha Species 0.000 claims description 4
- 235000004347 Perilla Nutrition 0.000 claims description 4
- 241000229722 Perilla <angiosperm> Species 0.000 claims description 4
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000012528 membrane Substances 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000003390 Chinese drug Substances 0.000 claims 2
- 206010039083 rhinitis Diseases 0.000 abstract description 10
- 230000000694 effects Effects 0.000 abstract description 9
- 241000218378 Magnolia Species 0.000 abstract description 6
- 235000018142 Hedysarum alpinum var americanum Nutrition 0.000 abstract 1
- 240000006461 Hedysarum alpinum var. americanum Species 0.000 abstract 1
- 235000006679 Mentha X verticillata Nutrition 0.000 abstract 1
- 235000002899 Mentha suaveolens Nutrition 0.000 abstract 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 206010028748 Nasal obstruction Diseases 0.000 description 2
- 206010039085 Rhinitis allergic Diseases 0.000 description 2
- 206010039101 Rhinorrhoea Diseases 0.000 description 2
- 201000010105 allergic rhinitis Diseases 0.000 description 2
- 201000009151 chronic rhinitis Diseases 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000002086 nanomaterial Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 208000010753 nasal discharge Diseases 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
A nanometre (0.1-200 nm) medicine "Xinyi Biyan" for treating rhinitis is prepared from the nanometre powders of 13 Chinese medicinal materials including magnolia flower, mint, liquorice root, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to the nano medicine ' Xinyi Biyan ' of a kind of expelling wind and clearing away heat, eliminating inflammation and expelling toxin, the invention still further relates to the method for this medication preparation.
Magnolia flower rhinitis-treating pill is a kind of classical Chinese patent medicine, mainly contains effects such as expelling wind and clearing away heat, eliminating inflammation and expelling toxin, is used for rhinitis (comprising allergic rhinitis, chronic rhinitis etc.), nervous headache, flu watery nasal discharge, nasal obstruction is obstructed.But traditional magnolia flower rhinitis-treating pill disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Xinyi Biyan ' of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Xinyi Biyan '.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Flos Magnoliae 40-90 part nanometer Herba Menthae 500-900 part nanometer Folium Perillae 350-800 part
Nanometer Radix Glycyrrhizae 250-500 part nanometer Herba Pogostemonis 500-900 part nanometer Fructus Xanthii 1000-2500 part
Nanometer Herba Centipedae 200-500 part nano Radix Isatidis 600-1500 part nanometer Inula cappa (Ham.) DC. 400-900 part
Nanometer Radix Saposhnikoviae 350-800 part nanometer Herba Houttuyniae 150-400 part nanometer Flos Chrysanthemi 400-900 part
Nanometer Foliumet Ramulus Evodiae 400-900 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Flos Magnoliae 50-80 part nanometer Herba Menthae 600-800 part nanometer Folium Perillae 400-600 part
Nanometer Radix Glycyrrhizae 300-400 part nanometer Herba Pogostemonis 600-800 part nanometer Fructus Xanthii 1200-2000 part
Nanometer Herba Centipedae 250-400 part nano Radix Isatidis 800-1200 part nanometer Inula cappa (Ham.) DC. 500-800 part
Nanometer Radix Saposhnikoviae 400-600 part nanometer Herba Houttuyniae 200-300 part nanometer Flos Chrysanthemi 500-800 part
Nanometer Foliumet Ramulus Evodiae 500-800 part
The optimum weight proportioning of medicine of the present invention is:
475 parts of 650 parts of nanometer Folium Perillaes of 63 parts of nanometer Herba Menthaes of nanometer Flos Magnoliae
1667 parts of 650 parts of nanometer Fructus Xanthii of 323 parts of nanometer Herba Pogostemonis of nanometer Radix Glycyrrhizae
650 parts of 975 parts of nanometer Inula cappa (Ham.) DC.s of 313 parts of nano Radix Isatidis of nanometer Herba Centipedae
650 parts of 225 parts of nanometer Flos Chrysanthemis of 470 parts of nanometer Herba Houttuyniae of nanometer Radix Saposhnikoviae
650 parts of nanometer Foliumet Ramulus Evodiae
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with hypersonic velocity instantaneous jet drying.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the 'Xinyi Biyan ' nano powder with hypersonic velocity instantaneous jet drying;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Xinyi Biyan ' is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common magnolia flower rhinitis-treating pill preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the novel form that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano medicine ' Xinyi Biyan ' etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as rhinitis (comprising allergic rhinitis, chronic rhinitis etc.), nervous headache, flu watery nasal discharge, nasal obstruction be obstructed, and clinical efficacy significantly is better than traditional magnolia flower rhinitis-treating pill.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
475 parts of 650 parts of nanometer Folium Perillaes of 63 parts of nanometer Herba Menthaes of nanometer Flos Magnoliae
1667 parts of 650 parts of nanometer Fructus Xanthii of 323 parts of nanometer Herba Pogostemonis of nanometer Radix Glycyrrhizae
650 parts of 975 parts of nanometer Inula cappa (Ham.) DC.s of 313 parts of nano Radix Isatidis of nanometer Herba Centipedae
650 parts of 225 parts of nanometer Flos Chrysanthemis of 470 parts of nanometer Herba Houttuyniae of nanometer Radix Saposhnikoviae
650 parts of nanometer Foliumet Ramulus Evodiae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
475 parts of 650 parts of nanometer Folium Perillaes of 63 parts of nanometer Herba Menthaes of nanometer Flos Magnoliae
1667 parts of 650 parts of nanometer Fructus Xanthii of 323 parts of nanometer Herba Pogostemonis of nanometer Radix Glycyrrhizae
650 parts of 975 parts of nanometer Inula cappa (Ham.) DC.s of 313 parts of nano Radix Isatidis of nanometer Herba Centipedae
650 parts of 225 parts of nanometer Flos Chrysanthemis of 470 parts of nanometer Herba Houttuyniae of nanometer Radix Saposhnikoviae
650 parts of nanometer Foliumet Ramulus Evodiae
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer magnolia flower rhinitis-treating powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Claims (6)
1, a kind of nano medicine ' Xinyi Biyan ' is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Flos Magnoliae 40-90 part nanometer Herba Menthae 500-900 part nanometer Folium Perillae 350-800 part
Nanometer Radix Glycyrrhizae 250-500 part nanometer Herba Pogostemonis 500-900 part nanometer Fructus Xanthii 1000-2500 part
Nanometer Herba Centipedae 200-500 part nano Radix Isatidis 600-1500 part nanometer Inula cappa (Ham.) DC. 400-900 part
Nanometer Radix Saposhnikoviae 350-800 part nanometer Herba Houttuyniae 150-400 part nanometer Flos Chrysanthemi 400-900 part
Nanometer Foliumet Ramulus Evodiae 400-900 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Xinyi Biyan ' according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Flos Magnoliae 50-80 part nanometer Herba Menthae 600-800 powder nanometer Folium Perillae 400-600 part
Nanometer Radix Glycyrrhizae 300-400 part nanometer Herba Pogostemonis 600-800 part nanometer Fructus Xanthii 1200-2000 part
Nanometer Herba Centipedae 250-400 part nano Radix Isatidis 800-1200 part nanometer Inula cappa (Ham.) DC. 500-800 part
Nanometer Radix Saposhnikoviae 400-600 part nanometer Herba Houttuyniae 200-300 part nanometer Flos Chrysanthemi 500-800 part
Nanometer Foliumet Ramulus Evodiae 500-800 part
3, nano medicine ' Xinyi Biyan ' according to claim 1, wherein the weight proportion of each nano raw material is:
475 parts of 650 parts of nanometer Folium Perillaes of 63 parts of nanometer Herba Menthaes of nanometer Flos Magnoliae
1667 parts of 650 parts of nanometer Fructus Xanthii of 323 parts of nanometer Herba Pogostemonis of nanometer Radix Glycyrrhizae
650 parts of 975 parts of nanometer Inula cappa (Ham.) DC.s of 313 parts of nano Radix Isatidis of nanometer Herba Centipedae
650 parts of 225 parts of nanometer Flos Chrysanthemis of 470 parts of nanometer Herba Houttuyniae of nanometer Radix Saposhnikoviae
650 parts of nanometer Foliumet Ramulus Evodiae
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Xinyi Biyan 's.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Xinyi Biyan 's; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20-30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01103644 CN1368354A (en) | 2001-02-05 | 2001-02-05 | Nano medicine 'Xinyi Biyan' and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01103644 CN1368354A (en) | 2001-02-05 | 2001-02-05 | Nano medicine 'Xinyi Biyan' and its preparing process |
Publications (1)
| Publication Number | Publication Date |
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| CN1368354A true CN1368354A (en) | 2002-09-11 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01103644 Pending CN1368354A (en) | 2001-02-05 | 2001-02-05 | Nano medicine 'Xinyi Biyan' and its preparing process |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1294931C (en) * | 2004-02-14 | 2007-01-17 | 刘强 | Compound collunarium oil and preparation method thereof |
| CN102247467A (en) * | 2010-05-18 | 2011-11-23 | 汤明昌 | Method for preparing magnolia flower rhinitis-treating pills |
| CN103142738A (en) * | 2013-04-07 | 2013-06-12 | 贵州鸿德中药开发有限公司 | Traditional Chinese medicine for treating bad cold |
| CN108420102A (en) * | 2018-02-22 | 2018-08-21 | 四川艾施派尔新材料科技有限公司 | A kind of cigarette composition and technique for treating rhinitis |
-
2001
- 2001-02-05 CN CN 01103644 patent/CN1368354A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1294931C (en) * | 2004-02-14 | 2007-01-17 | 刘强 | Compound collunarium oil and preparation method thereof |
| CN102247467A (en) * | 2010-05-18 | 2011-11-23 | 汤明昌 | Method for preparing magnolia flower rhinitis-treating pills |
| CN103142738A (en) * | 2013-04-07 | 2013-06-12 | 贵州鸿德中药开发有限公司 | Traditional Chinese medicine for treating bad cold |
| CN108420102A (en) * | 2018-02-22 | 2018-08-21 | 四川艾施派尔新材料科技有限公司 | A kind of cigarette composition and technique for treating rhinitis |
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