CN1368242A - Nano medicine 'Fuyankang' and its preparing process - Google Patents
Nano medicine 'Fuyankang' and its preparing process Download PDFInfo
- Publication number
- CN1368242A CN1368242A CN 01102576 CN01102576A CN1368242A CN 1368242 A CN1368242 A CN 1368242A CN 01102576 CN01102576 CN 01102576 CN 01102576 A CN01102576 A CN 01102576A CN 1368242 A CN1368242 A CN 1368242A
- Authority
- CN
- China
- Prior art keywords
- nanometer
- nano
- parts
- chinese
- medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 43
- 238000000034 method Methods 0.000 title claims description 12
- 230000008569 process Effects 0.000 title description 2
- 239000000463 material Substances 0.000 claims abstract description 20
- 239000000843 powder Substances 0.000 claims abstract description 10
- 240000007164 Salvia officinalis Species 0.000 claims abstract description 9
- 235000005412 red sage Nutrition 0.000 claims abstract description 9
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 17
- 241000213006 Angelica dahurica Species 0.000 claims description 8
- 241000218176 Corydalis Species 0.000 claims description 8
- 241000234653 Cyperus Species 0.000 claims description 8
- 244000268590 Euryale ferox Species 0.000 claims description 8
- 235000006487 Euryale ferox Nutrition 0.000 claims description 8
- 241000972673 Phellodendron amurense Species 0.000 claims description 8
- 210000000582 semen Anatomy 0.000 claims description 8
- 239000002775 capsule Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 235000005903 Dioscorea Nutrition 0.000 claims description 4
- 235000000504 Dioscorea villosa Nutrition 0.000 claims description 4
- 230000008859 change Effects 0.000 claims description 4
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 235000004879 dioscorea Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000012528 membrane Substances 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 2
- 239000003390 Chinese drug Substances 0.000 claims 2
- 244000281702 Dioscorea villosa Species 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 9
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 244000170916 Paeonia officinalis Species 0.000 abstract 1
- 235000006484 Paeonia officinalis Nutrition 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 description 7
- 208000029082 Pelvic Inflammatory Disease Diseases 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 241000234273 Dioscorea Species 0.000 description 3
- 239000002671 adjuvant Substances 0.000 description 3
- 230000001684 chronic effect Effects 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 206010049677 Salpingo-oophoritis Diseases 0.000 description 2
- 208000006374 Uterine Cervicitis Diseases 0.000 description 2
- 206010046914 Vaginal infection Diseases 0.000 description 2
- 201000008100 Vaginitis Diseases 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 206010008323 cervicitis Diseases 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000002086 nanomaterial Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 206010003011 Appendicitis Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000004856 capillary permeability Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A nanometre (0.1-200 nm) medicine "Fuyankang" for treating obstetric inflammation is prepared from the nanometre powders of 13 Chinese medicinal materials including red peony root, greonbrier rhizome, red sage root, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to the nano medicine ' Fuyankang ' of a kind of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, anti-inflammatory analgetic, the invention still further relates to the method for this medication preparation.
FUYANKANG PIAN is a kind of classical Chinese patent medicine, mainly contain reduce capillary permeability, reduce ooze out, fortifying fibre protein dissolution enzymatic activity, antiinflammatory and effect such as antibacterial, be used for chronic pelvic inflammatory disease, adnexitis, cervicitis, vaginitis, chronic appendicitis, urinary tract infection.But traditional FUYANKANG PIAN disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Fuyankang ' of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Fuyankang '.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Radix Paeoniae Rubra 40-90 part nanometer Rhizoma Smilacis Glabrae 60-150 part nanometer rhizoma sparganic 40-80 part
Nanometer Fructus Toosendan 40-80 part nanometer Rhizoma Curcumae 40-80 part nanometer Rhizoma Corydalis 40-80 part
Nanometer Semen Euryales 60-150 part nano Chinese angelica 60-150 part nanometer Radix Sophorae Flavescentis 40-80 part
Nano cyperus tuber 30-65 part nano phellodendron bark 40-80 part nano red sage 60-150 part
Nanometer Rhizoma Dioscoreae 80-180 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Radix Paeoniae Rubra 50-80 part nanometer Rhizoma Smilacis Glabrae 80-120 part nanometer rhizoma sparganic 50-70 part
Nanometer Fructus Toosendan 50-70 part nanometer Rhizoma Curcumae 50-70 part nanometer Rhizoma Corydalis 50-70 part
Nanometer Semen Euryales 80-120 part nano Chinese angelica 80-120 part nanometer Radix Sophorae Flavescentis 50-70 part
Nano cyperus tuber 35-55 part nano phellodendron bark 50-70 part nano red sage 80-120 part
Nanometer Rhizoma Dioscoreae 100-150 part
The optimum weight proportioning of medicine of the present invention is:
60 parts of 100 parts of nanometer rhizoma sparganic of 60 parts of nanometer Rhizoma Smilacis Glabraes of nanometer Radix Paeoniae Rubra
60 parts of 60 parts of nanometer Rhizoma Corydalis of 60 parts of nanometer Rhizoma Curcumae of nanometer Fructus Toosendan
60 parts of 100 parts of nanometer Radix Sophorae Flavescentiss of 100 parts of nano Chinese angelicas of nanometer Semen Euryales
100 parts of 60 parts of nano red sages of 40 parts of nano phellodendron barks of nano cyperus tuber
120 parts of nanometer Rhizoma Dioscoreaes
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with hypersonic velocity instantaneous jet drying.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the 'Fuyankang ' nano powder with hypersonic velocity instantaneous jet drying;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Fuyankang ' is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common FUYANKANG PIAN preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the novel form that pill, powder, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano medicine ' Fuyankang ' etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for the treatment of chronic pelvic inflammatory disease, adnexitis, cervicitis, vaginitis, etc, and clinical efficacy significantly is better than traditional FUYANKANG PIAN.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
60 parts of 100 parts of nanometer rhizoma sparganic of 60 parts of nanometer Rhizoma Smilacis Glabraes of nanometer Radix Paeoniae Rubra
60 parts of 60 parts of nanometer Rhizoma Corydalis of 60 parts of nanometer Rhizoma Curcumae of nanometer Fructus Toosendan
60 parts of 100 parts of nanometer Radix Sophorae Flavescentiss of 100 parts of nano Chinese angelicas of nanometer Semen Euryales
100 parts of 60 parts of nano red sages of 40 parts of nano phellodendron barks of nano cyperus tuber
120 parts of nanometer Rhizoma Dioscoreaes
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
60 parts of 100 parts of nanometer rhizoma sparganic of 60 parts of nanometer Rhizoma Smilacis Glabraes of nanometer Radix Paeoniae Rubra
60 parts of 60 parts of nanometer Rhizoma Corydalis of 60 parts of nanometer Rhizoma Curcumae of nanometer Fructus Toosendan
60 parts of 100 parts of nanometer Radix Sophorae Flavescentiss of 100 parts of nano Chinese angelicas of nanometer Semen Euryales
100 parts of 60 parts of nano red sages of 40 parts of nano phellodendron barks of nano cyperus tuber
120 parts of nanometer Rhizoma Dioscoreaes
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer FUYANKANG powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Claims (6)
1, a kind of nano medicine ' Fuyankang ' is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Radix Paeoniae Rubra 40-90 part nanometer Rhizoma Smilacis Glabrae 60-150 part nanometer rhizoma sparganic 40-80 part
Nanometer Fructus Toosendan 40-80 part nanometer Rhizoma Curcumae 40-80 part nanometer Rhizoma Corydalis 40-80 part
Nanometer Semen Euryales 60-150 part nano Chinese angelica 60-150 part nanometer Radix Sophorae Flavescentis 40-80 part
Nano cyperus tuber 30-65 part nano phellodendron bark 40-80 part nano red sage 60-150 part
Nanometer Rhizoma Dioscoreae 80-180 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Fuyankang ' according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Radix Paeoniae Rubra 50-80 part nanometer Rhizoma Smilacis Glabrae 80-120 part nanometer rhizoma sparganic 50-70 part
Nanometer Fructus Toosendan 50-70 part nanometer Rhizoma Curcumae 50-70 part nanometer Rhizoma Corydalis 50-70 part
Nanometer Semen Euryales 80-120 part nano Chinese angelica 80-120 part nanometer Radix Sophorae Flavescentis 50-70 part
Nano cyperus tuber 35-55 part nano phellodendron bark 50-70 part nano red sage 80-120 part
Nanometer Rhizoma Dioscoreae 100-150 part
3, nano medicine ' Fuyankang ' according to claim 1, wherein the weight proportion of each nano raw material is:
60 parts of 100 parts of nanometer rhizoma sparganic of 60 parts of nanometer Rhizoma Smilacis Glabraes of nanometer Radix Paeoniae Rubra
60 parts of 60 parts of nanometer Rhizoma Corydalis of 60 parts of nanometer Rhizoma Curcumae of nanometer Fructus Toosendan
60 parts of 100 parts of nanometer Radix Sophorae Flavescentiss of 100 parts of nano Chinese angelicas of nanometer Semen Euryales
100 parts of 60 parts of nano red sages of 40 parts of nano phellodendron barks of nano cyperus tuber
120 parts of nanometer Rhizoma Dioscoreaes
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Fuyankang 's.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Fuyankang 's; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102576 CN1368242A (en) | 2001-02-01 | 2001-02-01 | Nano medicine 'Fuyankang' and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102576 CN1368242A (en) | 2001-02-01 | 2001-02-01 | Nano medicine 'Fuyankang' and its preparing process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1368242A true CN1368242A (en) | 2002-09-11 |
Family
ID=4652837
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01102576 Pending CN1368242A (en) | 2001-02-01 | 2001-02-01 | Nano medicine 'Fuyankang' and its preparing process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1368242A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102614432A (en) * | 2012-03-22 | 2012-08-01 | 陈蕊 | Traditional Chinese medicine composition for treating cervicitis |
-
2001
- 2001-02-01 CN CN 01102576 patent/CN1368242A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102614432A (en) * | 2012-03-22 | 2012-08-01 | 陈蕊 | Traditional Chinese medicine composition for treating cervicitis |
| CN102614432B (en) * | 2012-03-22 | 2013-11-27 | 陈蕊 | A kind of traditional Chinese medicine composition for treating cervicitis |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1365781A (en) | Nano medicine 'Ruyi Jinhuang' and its preparing process | |
| CN1368235A (en) | Nano medicine for treating leukoderma and its preparing process | |
| CN1368354A (en) | Nano medicine 'Xinyi Biyan' and its preparing process | |
| CN1366915A (en) | Nano brain-benefiting blood pressure-reducing preparation medicine and preparation method | |
| CN1368242A (en) | Nano medicine 'Fuyankang' and its preparing process | |
| CN1368187A (en) | Nano medicine 'Tongqiaobiyan' and its preparing process | |
| CN1368203A (en) | Nano medicine 'Zanglian' and its preparing process | |
| CN1368302A (en) | Nano medicine for treating infantile dysentery and its preparing process | |
| CN1364505A (en) | Nano seven ingredient iron filing medicine and its prepairng method | |
| CN1368061A (en) | Nano meidcine 'Xiaoshuan Tongluo' and its preparing process | |
| CN1366907A (en) | Nano Jianmin throat-benefiting preparation medicine and preparation method thereof | |
| CN1365810A (en) | Nano medicine 'Guishao Dihuang' and its preparing process | |
| CN1366925A (en) | Nano stomach-clearing coptis preparation medicine and preparation method | |
| CN1368087A (en) | Nano medicine for treating cerebral thrombus and its preparing process | |
| CN1368099A (en) | Nano medicine 'Xiaoyin' and its preparing process | |
| CN1366924A (en) | Nano throat-benefiting preparation medicine and preparation method | |
| CN1368183A (en) | Nano medicine for treating diseases due to summer heat and its preparing process | |
| CN1366893A (en) | Nano qingfei yihuo preparation medicine and preparation method thereof | |
| CN1368184A (en) | Nano medicine 'Shujin Huoluo' and its preparing process | |
| CN1364581A (en) | Nano Children heat fast clearing away medicine and its preparing method | |
| CN1368084A (en) | Nano medicine 'Penyanjing' and its preparing process | |
| CN1364583A (en) | Nano chilren heat clearing away medicine and its preparing method | |
| CN1365715A (en) | Nano medicine 'Jiuqi Niantong' and its preparing process | |
| CN1368060A (en) | Nano defervescent and digestion-promoting medicine and its preparing process | |
| CN1368200A (en) | Nano medicine 'Emuqingfei' and its preparing process |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |