CN1362108A - Nano rhinitis-treating drop medicine and its preparation - Google Patents
Nano rhinitis-treating drop medicine and its preparation Download PDFInfo
- Publication number
- CN1362108A CN1362108A CN 01100159 CN01100159A CN1362108A CN 1362108 A CN1362108 A CN 1362108A CN 01100159 CN01100159 CN 01100159 CN 01100159 A CN01100159 A CN 01100159A CN 1362108 A CN1362108 A CN 1362108A
- Authority
- CN
- China
- Prior art keywords
- nanometer
- nano
- parts
- rhinitis
- chinese
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The present invention discloses a nano Ditong-biyan preparation medicine. It is made up by using 8 Chinese medicinal materials of nano dandelion, nano asarum, nano scutellaria, nano ephedra, nano xanthium and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to a kind of expelling wind and clearing away heat, lung qi dispersing is sensible, cures mainly the nano rhinitis-treating drop preparation medicine of cold nasal obstruction, chronic rhinitis, allergic rhinitis, sinusitis, the invention still further relates to the method for this medication preparation.
DITONG BIYAN SHUI is a kind of classical Chinese patent medicine, mainly contains effects such as expelling wind and clearing away heat, lung qi dispersing be sensible, and diseases such as nasal obstruction, chronic rhinitis, allergic rhinitis, sinusitis are used to catch cold.But traditional DITONG BIYAN SHUI absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano rhinitis-treating drop preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano rhinitis-treating drop preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Herba Taraxaci 80-160 part nanometric Herbra Asarum 5-15 part nanometer Radix Scutellariae 40-80 part
Nanometer Herba Ephedrae 30-70 part nanometer Fructus Xanthii 30-70 part nanometer Rhizoma Acori Graminei 40-80 part
Nano angelica root 10-60 part nanometer Flos Magnoliae 10-60 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Herba Taraxaci 100-140 part nanometric Herbra Asarum 5-10 part nanometer Radix Scutellariae 50-70 part
Nanometer Herba Ephedrae 40-60 part nanometer Fructus Xanthii 40-60 part nanometer Rhizoma Acori Graminei 50-70 part
Nano angelica root 20-50 part nanometer Flos Magnoliae 20-50 part
The optimum weight of medicine of the present invention is:
60 parts of 5 parts of nanometer Radix Scutellariaes of 120 parts of nanometric Herbra Asarums of nanometer Herba Taraxaci
60 parts of 50 parts of nanometer Rhizoma Acori Graminei of 50 parts of nanometer Fructus Xanthii of nanometer Herba Ephedrae
25 parts of 25 parts of nanometer Flos Magnoliaes of nano angelica root
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get rhinitis preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made the nano rhinitis-treating drop preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common DITONG BIYAN SHUI preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano rhinitis-treating drop preparation medicine etc. is had no precedent in the past.
The pharmaceutical preparation of the present invention treatment of conditions such as nasal obstruction, chronic rhinitis, allergic rhinitis, sinusitis that can be used for catching cold, clinical efficacy significantly is better than traditional DITONG BIYAN SHUI.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
60 parts of 5 parts of nanometer Radix Scutellariaes of 120 parts of nanometric Herbra Asarums of nanometer Herba Taraxaci
60 parts of 50 parts of nanometer Rhizoma Acori Graminei of 50 parts of nanometer Fructus Xanthii of nanometer Herba Ephedrae
25 parts of 25 parts of nanometer Flos Magnoliaes of nano angelica root
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
60 parts of 5 parts of nanometer Radix Scutellariaes of 120 parts of nanometric Herbra Asarums of nanometer Herba Taraxaci
60 parts of 50 parts of nanometer Rhizoma Acori Graminei of 50 parts of nanometer Fructus Xanthii of nanometer Herba Ephedrae
25 parts of 25 parts of nanometer Flos Magnoliaes of nano angelica root
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make the nano rhinitis-treating drop powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Be equipped with nano raw material by preceding method:
60 parts of 5 parts of nanometer Radix Scutellariaes of 120 parts of nanometric Herbra Asarums of nanometer Herba Taraxaci
60 parts of 50 parts of nanometer Rhizoma Acori Graminei of 50 parts of nanometer Fructus Xanthii of nanometer Herba Ephedrae
25 parts of 25 parts of nanometer Flos Magnoliaes of nano angelica root
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia water preparation standard, make the nano rhinitis-treating drop water preparation, 10 milliliters every, 1-5 drips at every turn, every day 1-3 time, is better than collunarium.
Claims (6)
1, a kind of nano rhinitis-treating drop preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Herba Taraxaci 80-160 part nanometric Herbra Asarum 5-15 part nanometer Radix Scutellariae 40-80 part
Nanometer Herba Ephedrae 30-70 part nanometer Fructus Xanthii 30-70 part nanometer Rhizoma Acori Graminei 40-80 part
Nano angelica root 10-60 part nanometer Flos Magnoliae 10-60 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano rhinitis-treating drop preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Herba Taraxaci 100-140 part nanometric Herbra Asarum 5-10 part nanometer Radix Scutellariae 50-70 part
Nanometer Herba Ephedrae 40-60 part nanometer Fructus Xanthii 40-60 part nanometer Rhizoma Acori Graminei 50-70 part
Nano angelica root 20-50 part nanometer Flos Magnoliae 20-50 part
3, nano rhinitis-treating drop preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
60 parts of 5 parts of nanometer Radix Scutellariaes of 120 parts of nanometric Herbra Asarums of nanometer Herba Taraxaci
60 parts of 50 parts of nanometer Rhizoma Acori Graminei of 50 parts of nanometer Fructus Xanthii of nanometer Herba Ephedrae
25 parts of 25 parts of nanometer Flos Magnoliaes of nano angelica root
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano rhinitis-treating drop preparation medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano rhinitis-treating drop preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100159 CN1362108A (en) | 2001-01-04 | 2001-01-04 | Nano rhinitis-treating drop medicine and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100159 CN1362108A (en) | 2001-01-04 | 2001-01-04 | Nano rhinitis-treating drop medicine and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1362108A true CN1362108A (en) | 2002-08-07 |
Family
ID=4651340
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01100159 Pending CN1362108A (en) | 2001-01-04 | 2001-01-04 | Nano rhinitis-treating drop medicine and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1362108A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106214859A (en) * | 2016-08-29 | 2016-12-14 | 凯里市新元药店 | A kind of Chinese medicine formula treating allergic rhinitis |
-
2001
- 2001-01-04 CN CN 01100159 patent/CN1362108A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106214859A (en) * | 2016-08-29 | 2016-12-14 | 凯里市新元药店 | A kind of Chinese medicine formula treating allergic rhinitis |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1368110A (en) | Nano medicine 'Yaoai' and its preparing process | |
| CN1366947A (en) | Nano Fufang Qianzheng preparation medicine and preparation method | |
| CN1368208A (en) | Nano medicine 'Ganfu' and its preparing process | |
| CN1368354A (en) | Nano medicine 'Xinyi Biyan' and its preparing process | |
| CN1368187A (en) | Nano medicine 'Tongqiaobiyan' and its preparing process | |
| CN1362108A (en) | Nano rhinitis-treating drop medicine and its preparation | |
| CN1365676A (en) | Nano medicine 'Compound berberine' and its preparing process | |
| CN1364505A (en) | Nano seven ingredient iron filing medicine and its prepairng method | |
| CN1368343A (en) | Nano medicine 'Kanglebiyan' and its preparing process | |
| CN1368302A (en) | Nano medicine for treating infantile dysentery and its preparing process | |
| CN1365703A (en) | Nano medicine for child to induce diaphoresis and its preparing process | |
| CN1368092A (en) | Nano medicine 'Mahuangzhike' and its preparing process | |
| CN1368122A (en) | Nano antivirus medicine and its preparing process | |
| CN1368183A (en) | Nano medicine for treating diseases due to summer heat and its preparing process | |
| CN1368099A (en) | Nano medicine 'Xiaoyin' and its preparing process | |
| CN1364581A (en) | Nano Children heat fast clearing away medicine and its preparing method | |
| CN1368071A (en) | Nano medicine 'Qianzihong' and its preparing process | |
| CN1368337A (en) | Nano medicine 'Wanbao' and its preparing process | |
| CN1362246A (en) | Nano Bupleuric medicine for regulating Shaoyang and it spreparation | |
| CN1364506A (en) | Nano seven ingredient grape medicine and its preparing method | |
| CN1366899A (en) | Nano dizziness-clearing preparation medicine and preparation method thereof | |
| CN1364582A (en) | Nano children heat clearing away and cough arresting medicine and its preparing method | |
| CN1365796A (en) | Nano medicine 'Xiaoer Qingyan' and its preparing process | |
| CN1368207A (en) | Nano medicine 'Ganshule' and its preparing process | |
| CN1364585A (en) | Nano children's dyspneic cough curing medicine and its preparing method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |