CN1368327A - Nano medicine 'Xiaoer Qingfeihuatan' and its preparing process - Google Patents
Nano medicine 'Xiaoer Qingfeihuatan' and its preparing process Download PDFInfo
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- CN1368327A CN1368327A CN 01103616 CN01103616A CN1368327A CN 1368327 A CN1368327 A CN 1368327A CN 01103616 CN01103616 CN 01103616 CN 01103616 A CN01103616 A CN 01103616A CN 1368327 A CN1368327 A CN 1368327A
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- 239000003814 drug Substances 0.000 title claims abstract description 46
- 238000000034 method Methods 0.000 title claims description 13
- 239000000463 material Substances 0.000 claims abstract description 20
- 239000000843 powder Substances 0.000 claims abstract description 11
- 241000207929 Scutellaria Species 0.000 claims abstract description 6
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 210000000582 semen Anatomy 0.000 claims description 27
- 229940079593 drug Drugs 0.000 claims description 18
- 241000244155 Taenia Species 0.000 claims description 9
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 239000000284 extract Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 2
- 239000003390 Chinese drug Substances 0.000 claims 2
- 206010062717 Increased upper airway secretion Diseases 0.000 abstract description 12
- 208000026435 phlegm Diseases 0.000 abstract description 12
- 210000004072 lung Anatomy 0.000 abstract description 10
- 230000000694 effects Effects 0.000 abstract description 9
- 241000218671 Ephedra Species 0.000 abstract 1
- 241000244269 Peucedanum Species 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 5
- 230000001131 transforming effect Effects 0.000 description 5
- 206010011224 Cough Diseases 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 208000000059 Dyspnea Diseases 0.000 description 2
- 206010013975 Dyspnoeas Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 239000006196 drop Substances 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 210000000867 larynx Anatomy 0.000 description 2
- 239000002086 nanomaterial Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 230000029058 respiratory gaseous exchange Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- 208000008203 tachypnea Diseases 0.000 description 2
- 206010043089 tachypnoea Diseases 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
A nanometre (0.1-200 nm) medicine for removing heat from infantile lung and dissolving phlegm is prepared from the nanometre powders of 8 Chinese medicinal materials including ephedra, peucedanum root, scutellaria root, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to the nano medicine ' Xiaoer Qingfeihuatan ' of a kind of removing heat-phlegm, relieving cough and asthma, the invention still further relates to the method for this medication preparation.
The infantile lung clearing phlegm transforming oral liquid is a kind of classical Chinese patent medicine, mainly contains effects such as removing heat-phlegm, relieving cough and asthma, is used for breathing tachypnea, cough phlegm dyspnea, larynx that infantile lung heat flu causes and makes a sound.But traditional infantile lung clearing phlegm transforming oral liquid absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Xiaoer Qingfeihuatan ' of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Xiaoer Qingfeihuatan '.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Herba Ephedrae 50-150 part nanometer Radix Peucedani 150-400 part nanometer Radix Scutellariae 150-400 part
Nanometer Fructus Perillae 150-400 part nanometer Gypsum Fibrosum 500-950 part nanometer Semen Armeniacae Amarum 150-400 part
Nanometer Semen Lepidii (Semen Descurainiae) 200-400 part nanometer Caulis Bambusae In Taenia 150-400 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Herba Ephedrae 70-120 part nanometer Radix Peucedani 200-300 part nanometer Radix Scutellariae 200-300 part
Nanometer Fructus Perillae 200-300 part nanometer Gypsum Fibrosum 600-900 part nanometer Semen Armeniacae Amarum 200-300 part
Nanometer Semen Lepidii (Semen Descurainiae) 250-300 part nanometer Caulis Bambusae In Taenia 200-300 part
The optimum weight proportioning of medicine of the present invention is:
225 parts of 225 parts of nanometer Radix Scutellariaes of 90 parts of nanometer Radix Peucedanis of nanometer Herba Ephedrae
225 parts of 675 portions of nanometer Semen Armeniacae Amarums of 225 parts of nanometer Gypsum Fibrosum of nanometer Fructus Perillae
225 parts of 279 parts of nanometer Caulis Bambusae In Taenia of nanometer Semen Lepidii (Semen Descurainiae)
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with hypersonic velocity instantaneous jet drying.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get infantile lung clearing phlegm transforming preparation nano powder with hypersonic velocity instantaneous jet drying;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Xiaoer Qingfeihuatan ' is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common infantile lung clearing phlegm transforming oral liquid formulations material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the novel form that pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup of nano medicine ' Xiaoer Qingfeihuatan ' etc. had no precedent in the past.
Treatment of conditions such as pharmaceutical preparation of the present invention can be used for making a sound in breathing tachypnea that infantile lung heat flu causes, cough phlegm dyspnea, the larynx, clinical efficacy significantly is better than traditional infantile lung clearing phlegm transforming oral liquid.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
225 parts of 225 parts of nanometer Radix Scutellariaes of 90 parts of nanometer Radix Peucedanis of nanometer Herba Ephedrae
225 parts of 675 portions of nanometer Semen Armeniacae Amarums of 225 parts of nanometer Gypsum Fibrosum of nanometer Fructus Perillae
225 parts of 279 parts of nanometer Caulis Bambusae In Taenia of nanometer Semen Lepidii (Semen Descurainiae)
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
225 parts of 225 parts of nanometer Radix Scutellariaes of 90 parts of nanometer Radix Peucedanis of nanometer Herba Ephedrae
225 parts of 675 portions of nanometer Semen Armeniacae Amarums of 225 parts of nanometer Gypsum Fibrosum of nanometer Fructus Perillae
225 parts of 279 parts of nanometer Caulis Bambusae In Taenia of nanometer Semen Lepidii (Semen Descurainiae)
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nano children's removing heat from the lung and dissipating phlegm powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
225 parts of 225 parts of nanometer Radix Scutellariaes of 90 parts of nanometer Radix Peucedanis of nanometer Herba Ephedrae
225 parts of 675 portions of nanometer Semen Armeniacae Amarums of 225 parts of nanometer Gypsum Fibrosum of nanometer Fructus Perillae
225 parts of 279 parts of nanometer Caulis Bambusae In Taenia of nanometer Semen Lepidii (Semen Descurainiae)
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nano children's removing heat from the lung and dissipating phlegm membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, chest.
Claims (6)
1, a kind of nano medicine ' Xiaoer Qingfeihuatan ' is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Herba Ephedrae 50-150 part nanometer Radix Peucedani 150-400 part nanometer Radix Scutellariae 150-400 part
Nanometer Fructus Perillae 150-400 part nanometer Gypsum Fibrosum 500-950 part nanometer Semen Armeniacae Amarum 150-400 part
Nanometer Semen Lepidii (Semen Descurainiae) 200-400 part nanometer Caulis Bambusae In Taenia 150-400 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Xiaoer Qingfeihuatan ' according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Herba Ephedrae 70-120 part nanometer Radix Peucedani 200-300 part nanometer Radix Scutellariae 200-300 part
Nanometer Fructus Perillae 200-300 part nanometer Gypsum Fibrosum 600-900 part nanometer Semen Armeniacae Amarum 200-300 part
Nanometer Semen Lepidii (Semen Descurainiae) 250-300 part nanometer Caulis Bambusae In Taenia 200-300 part
3, nano medicine ' Xiaoer Qingfeihuatan ' according to claim 1, wherein the weight proportion of each nano raw material is:
225 parts of 225 parts of nanometer Radix Scutellariaes of 90 parts of nanometer Radix Peucedanis of nanometer Herba Ephedrae
225 parts of 675 portions of nanometer Semen Armeniacae Amarums of 225 parts of nanometer Gypsum Fibrosum of nanometer Fructus Perillae
225 parts of 279 parts of nanometer Caulis Bambusae In Taenia of nanometer Semen Lepidii (Semen Descurainiae)
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, clear pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Xiaoer Qingfeihuatan 's.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Xiaoer Qingfeihuatan 's; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01103616 CN1368327A (en) | 2001-02-05 | 2001-02-05 | Nano medicine 'Xiaoer Qingfeihuatan' and its preparing process |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01103616 CN1368327A (en) | 2001-02-05 | 2001-02-05 | Nano medicine 'Xiaoer Qingfeihuatan' and its preparing process |
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| Publication Number | Publication Date |
|---|---|
| CN1368327A true CN1368327A (en) | 2002-09-11 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01103616 Pending CN1368327A (en) | 2001-02-05 | 2001-02-05 | Nano medicine 'Xiaoer Qingfeihuatan' and its preparing process |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107773688A (en) * | 2016-08-30 | 2018-03-09 | 北京盈科瑞创新医药股份有限公司 | A kind of infantile lung clearing phlegm transforming Neulized inhalation pharmaceutical solutions and preparation method thereof |
-
2001
- 2001-02-05 CN CN 01103616 patent/CN1368327A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107773688A (en) * | 2016-08-30 | 2018-03-09 | 北京盈科瑞创新医药股份有限公司 | A kind of infantile lung clearing phlegm transforming Neulized inhalation pharmaceutical solutions and preparation method thereof |
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| WD01 | Invention patent application deemed withdrawn after publication |