CN1362132A - Nano heart-nourishing biotae medicine and its preparation - Google Patents
Nano heart-nourishing biotae medicine and its preparation Download PDFInfo
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- CN1362132A CN1362132A CN 01100185 CN01100185A CN1362132A CN 1362132 A CN1362132 A CN 1362132A CN 01100185 CN01100185 CN 01100185 CN 01100185 A CN01100185 A CN 01100185A CN 1362132 A CN1362132 A CN 1362132A
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Abstract
The present ivnention discloses a nano Baixi-yangxin preparation medicine. It is made up by using 13 Chinese medicinal materials of nano biota seed, nano codonopsis, nano astragalus, nano ligusticum, nano tangkuei and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to that a kind of mind calming nourishes blood, QI invigorating is enriched blood, the Fructus Alpiniae Oxyphyllae of calming the nerves, cure mainly the neurasthenic nanometer cedar seed preparation medicine that nourishes heart, the invention still further relates to the method for this medication preparation.
Mind-easing tonic bolus with arborvitate seed is a kind of classical Chinese patent medicine, mainly contains effects such as calmness, hypnosis, convulsion, is used for excessive thinking, motive deficiency and coldness and the palpitation and being susceptible to fright that causes, and absentminded, insomnia and dreamful sleep, refreshing tired forgetful.But traditional mind-easing tonic bolus with arborvitate seed disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nanometer cedar seed of the increase evident in efficacy preparation medicine that nourishes heart.
The preparation method that another object of the present invention provides this nanometer cedar seed to nourish heart preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Semen Platycladi 10-50 part nanometer Radix Codonopsis 5-50 part nano astragalus 10-50 part
Nanometer Rhizoma Chuanxiong 5-50 part nano Chinese angelica 5-50 part nano Poria 5-50 part
Nanometer Radix Polygalae 10-60 part nm acid Semen Ziziphi Spinosae 5-50 part nanometer Cortex Cinnamomi 5-40 part
The bent 5-60 part of nanometer Fructus Schisandrae Chinensis 10-60 part nano pinellia nanometer Radix Glycyrrhizae 5-50 part
Nanometer Cinnabaris 3-30 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Semen Platycladi 20-40 part nanometer Radix Codonopsis 10-30 part nano astragalus 20-40 part
Nanometer Rhizoma Chuanxiong 15-40 part nano Chinese angelica 15-40 part nano Poria 10-30 part
Nanometer Radix Polygalae 20-50 part nm acid Semen Ziziphi Spinosae 15-40 part nanometer Cortex Cinnamomi 10-30 part
The bent 15-50 part of nanometer Fructus Schisandrae Chinensis 20-50 part nano pinellia nanometer Radix Glycyrrhizae 10-30 part
Nanometer Cinnabaris 5-25 part
The optimum weight proportioning of medicine of the present invention is:
30 parts of 15 parts of nano astragalus of 30 parts of nanometer Radix Codonopsis of nanometer Semen Platycladi
20 parts of 25 parts of nano Porias of 25 parts of nano Chinese angelicas of nanometer Rhizoma Chuanxiong
20 parts of 25 parts of nanometer Cortex Cinnamomis of 35 parts of nm acid Semen Ziziphi Spinosaes of nanometer Radix Polygalae
15 parts in the bent 28 parts of nanometer Radix Glycyrrhizaes of 30 parts of nano pinellias of nanometer Fructus Schisandrae Chinensis
15 parts in nanometer Cinnabaris
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure, with the instantaneous drying of hypersonic velocity jet, the cedar seed preparation nano powder that nourishes heart;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
It is identical that above-mentioned two kinds of methods are made the nourish heart pharmacological effect of preparation medicine of nanometer cedar seed.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common mind-easing tonic bolus with arborvitate seed preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the nanometer cedar seed new drug formulation that the powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, medicated wine, syrup, oral solution etc. of preparation medicine has no precedent in the past that nourishes heart.
Pharmaceutical preparation of the present invention can be used for heart disease, neurasthenia etc., belongs to deficiency of heart-QI, blood deficiency and cause treatment of conditions such as palpitation and insomnia, and clinical efficacy significantly is better than traditional mind-easing tonic bolus with arborvitate seed.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
30 parts of 15 parts of nano astragalus of 30 parts of nanometer Radix Codonopsis of nanometer Semen Platycladi
20 parts of 25 parts of nano Porias of 25 parts of nano Chinese angelicas of nanometer Rhizoma Chuanxiong
20 parts of 25 parts of nanometer Cortex Cinnamomis of 35 parts of nm acid Semen Ziziphi Spinosaes of nanometer Radix Polygalae
15 parts in the bent 28 parts of nanometer Radix Glycyrrhizaes of 30 parts of nano pinellias of nanometer Fructus Schisandrae Chinensis
15 parts in nanometer Cinnabaris
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes 1-4 time every day, each 1-5 grain.
Embodiment 2:
Prepare nano raw material by preceding method:
30 parts of 15 parts of nano astragalus of 30 parts of nanometer Radix Codonopsis of nanometer Semen Platycladi
20 parts of 25 parts of nano Porias of 25 parts of nano Chinese angelicas of nanometer Rhizoma Chuanxiong
20 parts of 25 parts of nanometer Cortex Cinnamomis of 35 parts of nm acid Semen Ziziphi Spinosaes of nanometer Radix Polygalae
15 parts in the bent 28 parts of nanometer Radix Glycyrrhizaes of 30 parts of nano pinellias of nanometer Fructus Schisandrae Chinensis
15 parts in nanometer Cinnabaris
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent powder needle injection standard, do not add any adjuvant, make the nanometer cedar seed powder needle injection that nourishes heart, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
30 parts of 15 parts of nano astragalus of 30 parts of nanometer Radix Codonopsis of nanometer Semen Platycladi
20 parts of 25 parts of nano Porias of 25 parts of nano Chinese angelicas of nanometer Rhizoma Chuanxiong
20 parts of 25 parts of nanometer Cortex Cinnamomis of 35 parts of nm acid Semen Ziziphi Spinosaes of nanometer Radix Polygalae
15 parts in the bent 28 parts of nanometer Radix Glycyrrhizaes of 30 parts of nano pinellias of nanometer Fructus Schisandrae Chinensis
15 parts in nanometer Cinnabaris
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard, filmogen adopts polyvinyl alcohol, make the nanometer cedar seed membrane that nourishes heart, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nanometer cedar seed preparation medicine that nourishes heart is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Semen Platycladi 10-50 part nanometer Radix Codonopsis 5-50 part nano astragalus 10-50 part
Nanometer Rhizoma Chuanxiong 5-50 part nano Chinese angelica 5-50 part nano Poria 5-50 part
Nanometer Radix Polygalae 10-60 part nm acid Semen Ziziphi Spinosae 5-50 part nanometer Cortex Cinnamomi 5-40 part
The bent 5-60 part of nanometer Fructus Schisandrae Chinensis 10-60 part nano pinellia nanometer Radix Glycyrrhizae 5-50 part
Nanometer Cinnabaris 3-30 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
2, the nanometer cedar seed according to claim 1 preparation medicine that nourishes heart, wherein the weight proportion of each nano raw material is:
Nanometer Semen Platycladi 20-40 part nanometer Radix Codonopsis 10-30 part nano astragalus 20-40 part
Nanometer Rhizoma Chuanxiong 15-40 part nano Chinese angelica 15-40 part nano Poria 10-30 part
Nanometer Radix Polygalae 20-50 part nm acid Semen Ziziphi Spinosae 15-40 part nanometer Cortex Cinnamomi 10-30 part
The bent 15-50 part of nanometer Fructus Schisandrae Chinensis 20-50 part nano pinellia nanometer Radix Glycyrrhizae 10-30 part
Nanometer Cinnabaris 5-25 part
3, the nanometer cedar seed according to claim 1 preparation medicine that nourishes heart, wherein the weight proportion of each nano raw material is:
30 parts of 15 parts of nano astragalus of 30 parts of nanometer Radix Codonopsis of nanometer Semen Platycladi
20 parts of 25 parts of nano Porias of 25 parts of nano Chinese angelicas of nanometer Rhizoma Chuanxiong
20 parts of 25 parts of nanometer Cortex Cinnamomis of 35 parts of nm acid Semen Ziziphi Spinosaes of nanometer Radix Polygalae
15 parts in the bent 28 parts of nanometer Radix Glycyrrhizaes of 30 parts of nano pinellias of nanometer Fructus Schisandrae Chinensis
15 parts in nanometer Cinnabaris
4, according to claim 1 or the 2 or 3 described nanometer cedar seeds preparation medicine that nourishes heart, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5, according to the nourish heart pharmaceutical methods of preparation medicine of claim 1 or 2 or 3 described nanometer cedar seeds, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100185 CN1362132A (en) | 2001-01-04 | 2001-01-04 | Nano heart-nourishing biotae medicine and its preparation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100185 CN1362132A (en) | 2001-01-04 | 2001-01-04 | Nano heart-nourishing biotae medicine and its preparation |
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| Publication Number | Publication Date |
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| CN1362132A true CN1362132A (en) | 2002-08-07 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 01100185 Pending CN1362132A (en) | 2001-01-04 | 2001-01-04 | Nano heart-nourishing biotae medicine and its preparation |
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| CN (1) | CN1362132A (en) |
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2001
- 2001-01-04 CN CN 01100185 patent/CN1362132A/en active Pending
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