CN1362241A - Nano gastrodia and sharpleaf gambirplant medicine and its preparation - Google Patents
Nano gastrodia and sharpleaf gambirplant medicine and its preparation Download PDFInfo
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- CN1362241A CN1362241A CN 01100743 CN01100743A CN1362241A CN 1362241 A CN1362241 A CN 1362241A CN 01100743 CN01100743 CN 01100743 CN 01100743 A CN01100743 A CN 01100743A CN 1362241 A CN1362241 A CN 1362241A
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- 239000003814 drug Substances 0.000 title claims abstract description 46
- 241000305492 Gastrodia Species 0.000 title claims abstract description 24
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 239000000463 material Substances 0.000 claims abstract description 20
- 238000000034 method Methods 0.000 claims abstract description 12
- 241001061264 Astragalus Species 0.000 claims abstract description 10
- 235000006533 astragalus Nutrition 0.000 claims abstract description 10
- 210000004233 talus Anatomy 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 20
- 241000345998 Calamus manan Species 0.000 claims description 9
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 claims description 9
- 241000207925 Leonurus Species 0.000 claims description 9
- 235000000802 Leonurus cardiaca ssp. villosus Nutrition 0.000 claims description 9
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 9
- 240000001341 Reynoutria japonica Species 0.000 claims description 9
- 235000018167 Reynoutria japonica Nutrition 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 9
- 235000012950 rattan cane Nutrition 0.000 claims description 9
- 239000008187 granular material Substances 0.000 claims description 8
- 239000002775 capsule Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 241000241550 Cyathula Species 0.000 claims description 5
- 239000000284 extract Substances 0.000 claims description 5
- 239000006187 pill Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 2
- 229940100688 oral solution Drugs 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 239000003390 Chinese drug Substances 0.000 claims 2
- 240000001972 Gardenia jasminoides Species 0.000 abstract 1
- 241000157352 Uncaria Species 0.000 abstract 1
- 241000400007 Uncarina Species 0.000 abstract 1
- 238000000874 microwave-assisted extraction Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 5
- 239000008853 tianma gouteng Substances 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
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- 239000007962 solid dispersion Substances 0.000 description 2
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- 206010063006 Facial spasm Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
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- 210000003734 kidney Anatomy 0.000 description 1
- -1 lipid peroxide Chemical class 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
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- 208000011580 syndromic disease Diseases 0.000 description 1
- 206010044652 trigeminal neuralgia Diseases 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
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Abstract
The present invention discloses a nano gastrodis uncaria preparation medicine. It is made up by using 11 Chinese medicinal materials of nano gastrodia, nano uncarina, nano abalone shell, nano gardenia, nano astragalus and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to the nano gastrodia Ramulus Uncariae Cum Uncis preparation medicine of a kind of suppressing the hyperactive liver to relieve the wind syndrome, heat clearing and blood circulation promoting, liver and kidney tonifying, the invention still further relates to the method for this medication preparation.
The TIANMAGOUTENG granule is a kind of classical Chinese patent medicine, mainly contains blood pressure lowering, regulates the central nervous system, the effects such as generation of antiplatelet aggregation, inhibition lipid peroxide, is used for that liver-yang is high partially, disturbs on the liver-wind, diseases such as headache, dizzy, insomnia.But traditional TIANMAGOUTENG granule absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano gastrodia Ramulus Uncariae Cum Uncis preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano gastrodia Ramulus Uncariae Cum Uncis preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano gastrodia 5-50 part nanometer Ramulus Uncariae Cum Uncis 10-60 part nano abalone shell 5-50 part
Nanometer Fructus Gardeniae 5-50 part nano astragalus 10-60 part nanometer Radix Cyathulae 5-50 part
Nanometer Cortex Eucommiae 5-50 part nanometer motherwort 5-60 part nanometer Herba Taxilli 5-50 part
Nano fleece flower root rattan 5-50 part nano Poria 3-40 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano gastrodia 15-40 part nanometer Ramulus Uncariae Cum Uncis 20-50 part nano abalone shell 10-30 part
Nanometer Fructus Gardeniae 15-40 part nano astragalus 20-50 part nanometer Radix Cyathulae 15-40 part
Nanometer Cortex Eucommiae 10-40 part nanometer motherwort 10-40 part nanometer Herba Taxilli 10-40 part
Nano fleece flower root rattan 10-40 part nano Poria 8-30 part
The optimum weight proportioning of medicine of the present invention is:
20 parts of 28 parts of nano abalone shells of 25 parts of nanometer Ramulus Uncariae Cum Uncis of nano gastrodia
25 parts of 30 parts of nanometer Radix Cyathulaes of 25 parts of nano astragalus of nanometer Fructus Gardeniae
26 parts of 20 parts of nanometer Herba Taxillis of 20 parts of nanometer motherworts of the nanometer Cortex Eucommiae
15 parts of 20 parts of nano Porias of nano fleece flower root rattan
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get TIANMAGOUTENG preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano gastrodia Ramulus Uncariae Cum Uncis preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common TIANMAGOUTENG granular preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that suppository, membrane, microcapsule, drop pill, aerosol, injection, medicated wine, syrup of nano gastrodia Ramulus Uncariae Cum Uncis preparation medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as hypertension, interior M, trigeminal neuralgia, facial spasm, contusion and laceration of brain, and clinical efficacy significantly is better than traditional TIANMAGOUTENG granule.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
20 parts of 28 parts of nano abalone shells of 25 parts of nanometer Ramulus Uncariae Cum Uncis of nano gastrodia
25 parts of 30 parts of nanometer Radix Cyathulaes of 25 parts of nano astragalus of nanometer Fructus Gardeniae
26 parts of 20 parts of nanometer Herba Taxillis of 20 parts of nanometer motherworts of the nanometer Cortex Eucommiae
15 parts of 20 parts of nano Porias of nano fleece flower root rattan
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes 1-4 time every day, each 1-5 grain.
Embodiment 2:
Prepare nano raw material by preceding method:
20 parts of 28 parts of nano abalone shells of 25 parts of nanometer Ramulus Uncariae Cum Uncis of nano gastrodia
25 parts of 30 parts of nanometer Radix Cyathulaes of 25 parts of nano astragalus of nanometer Fructus Gardeniae
26 parts of 20 parts of nanometer Herba Taxillis of 20 parts of nanometer motherworts of the nanometer Cortex Eucommiae
15 parts of 20 parts of nano Porias of nano fleece flower root rattan
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent powder needle injection standard, do not add any adjuvant, make nano gastrodia Ramulus Uncariae Cum Uncis powder needle injection, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
20 parts of 28 parts of nano abalone shells of 25 parts of nanometer Ramulus Uncariae Cum Uncis of nano gastrodia
25 parts of 30 parts of nanometer Radix Cyathulaes of 25 parts of nano astragalus of nanometer Fructus Gardeniae
26 parts of 20 parts of nanometer Herba Taxillis of 20 parts of nanometer motherworts of the nanometer Cortex Eucommiae
15 parts of 20 parts of nano Porias of nano fleece flower root rattan
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard, filmogen adopts polyvinyl alcohol, make nano gastrodia Ramulus Uncariae Cum Uncis membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest, cervical region.
Claims (6)
1, a kind of nano gastrodia Ramulus Uncariae Cum Uncis preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nano gastrodia 5-50 part nanometer Ramulus Uncariae Cum Uncis 10-60 part nano abalone shell 5-50 part
Nanometer Fructus Gardeniae 5-50 part nano astragalus 10-60 part nanometer Radix Cyathulae 5-50 part
Nanometer Cortex Eucommiae 5-50 part nanometer motherwort 5-60 part nanometer Herba Taxilli 5-50 part
Nano fleece flower root rattan 5-50 part nano Poria 3-40 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
2, nano gastrodia Ramulus Uncariae Cum Uncis preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nano gastrodia 15-40 part nanometer Ramulus Uncariae Cum Uncis 20-50 part nano abalone shell 10-30 part
Nanometer Fructus Gardeniae 15-40 part nano astragalus 20-50 part nanometer Radix Cyathulae 15-40 part
Nanometer Cortex Eucommiae 10-40 part nanometer motherwort 10-40 part nanometer Herba Taxilli 10-40 part
Nano fleece flower root rattan 10-40 part nano Poria 8-30 part
3, nano gastrodia Ramulus Uncariae Cum Uncis preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
20 parts of 28 parts of nano abalone shells of 25 parts of nanometer Ramulus Uncariae Cum Uncis of nano gastrodia
25 parts of 30 parts of nanometer Radix Cyathulaes of 25 parts of nano astragalus of nanometer Fructus Gardeniae
26 parts of 20 parts of nanometer Herba Taxillis of 20 parts of nanometer motherworts of the nanometer Cortex Eucommiae
15 parts of 20 parts of nano Porias of nano fleece flower root rattan
4, according to claim 1 or 2 or 3 described nano gastrodia Ramulus Uncariae Cum Uncis preparation medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano gastrodia Ramulus Uncariae Cum Uncis preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100743 CN1362241A (en) | 2001-01-08 | 2001-01-08 | Nano gastrodia and sharpleaf gambirplant medicine and its preparation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100743 CN1362241A (en) | 2001-01-08 | 2001-01-08 | Nano gastrodia and sharpleaf gambirplant medicine and its preparation |
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| Publication Number | Publication Date |
|---|---|
| CN1362241A true CN1362241A (en) | 2002-08-07 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01100743 Pending CN1362241A (en) | 2001-01-08 | 2001-01-08 | Nano gastrodia and sharpleaf gambirplant medicine and its preparation |
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| Country | Link |
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| CN (1) | CN1362241A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007006203A1 (en) * | 2005-07-07 | 2007-01-18 | Shirong Duan | A capsule formulation for treating hypertension and coronary heart disease and process for preparation thereof |
| CN102091239A (en) * | 2011-01-07 | 2011-06-15 | 孙建英 | Uncaria abalone sour soup for treating trigeminal neuralgia |
| CN102526530A (en) * | 2012-02-20 | 2012-07-04 | 迟建波 | Chinese medicine for treating hypertension and preparation method for Chinese medicine |
| CN103055164A (en) * | 2012-12-26 | 2013-04-24 | 中国中医科学院中医临床基础医学研究所 | Traditional Chinese medicine composition for treating isolated diastolic hypertension |
-
2001
- 2001-01-08 CN CN 01100743 patent/CN1362241A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007006203A1 (en) * | 2005-07-07 | 2007-01-18 | Shirong Duan | A capsule formulation for treating hypertension and coronary heart disease and process for preparation thereof |
| CN102091239A (en) * | 2011-01-07 | 2011-06-15 | 孙建英 | Uncaria abalone sour soup for treating trigeminal neuralgia |
| CN102091239B (en) * | 2011-01-07 | 2012-07-04 | 孙建英 | Uncaria abalone sour soup for treating trigeminal neuralgia |
| CN102526530A (en) * | 2012-02-20 | 2012-07-04 | 迟建波 | Chinese medicine for treating hypertension and preparation method for Chinese medicine |
| CN102526530B (en) * | 2012-02-20 | 2014-02-26 | 迟建波 | Chinese medicine for treating hypertension and preparation method for Chinese medicine |
| CN103055164A (en) * | 2012-12-26 | 2013-04-24 | 中国中医科学院中医临床基础医学研究所 | Traditional Chinese medicine composition for treating isolated diastolic hypertension |
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